Search Results - "proteins"

CNS drug design

Table of Contents: “…Contents: Central nervous system diseases -- Drug market for CNS disorders -- Traditional CNS drug targets -- Novel CNS drug targets -- Multiple obstacles for drug delivery to CNS -- Pathways for drug exchange within the CNS -- The structure of brain capillaries impedes uptake -- Measures of drug uptake and distribution in brain -- BBB permeability and solute lipid solubility -- Tissues capillary PS and 95 per cent equilibration time -- Cerebral blood flow affects drug uptake and Kin -- Initial uptake vs. steady-state distribution -- Plasma protein binding and brain drug uptake -- Brain capillary drug transporters -- Transporters and drug distribution across BBB -- "Enzymatic" blood-brain barrier -- Relation between bound and free drug -- Free drug distribution ratio at steady state -- BBB changes in pathology and disease -- Drug-like properties to cross the BBB -- Early findings in BBB drug uptake -- Measures of lipophilicity -- Passive permeability across lipid membranes -- Drug ionization -- Influence of pH on neutral fraction -- Lipinski "rule of five" -- Impact of hydrogen bonds and alkyl groups -- Positive CNS drugs -- Poor CNS drug -- in vitro measures -- In vivo measures -- Methods to improve brain uptake -- Simple rules for efflux transporters -- % drug distribution to brain -- Biologic compounds -- Brain pharmacokinetics.…”
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Series (Blood-brain barrier)
Series (Small molecule drug discovery)

Animal Sourced Foods for Developing Economies : Preservation, Nutrition, and Safety /

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Deferred development : setting aside cells for future use in development in evolution /

Table of Contents: “…3.3 The Molecular Mechanisms Coordinating the Cell Cycle with Stem Cell Self-Renewal and Differentiation3.4 Cell Division, Epigenetic Memory, and Mitotic Bookmarking; 3.5 Cell Cycle Regulation and Terminal Differentiation; 3.5.1 Cyclin-Dependent Kinases and Cyclin-Dependent Kinase Inhibitors; 3.5.2 Retinoblastoma Family Proteins; 3.6 Conclusions; References; SECTION II: Origin of Deferred-Use Cells and Their Niches: Phylogenetic Approaches; Chapter 4 The Early Evolution of Cellular Reprogramming in Animals; 4.1 Introduction; 4.2 Cnidaria; 4.3 Porifera; 4.4 Ctenophora; 4.5 Choanoflagellata…”
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Sport and exercise nutrition

Table of Contents: “…Jeukendrup and C. Williams -- Protein and amino acids / P.W.R. Lemon -- Fat metabolism / B. …”
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Biosensors properties, materials and applications /

Table of Contents: “….] -- Electrochemiluminescent sensors : fabrications and applications / Hui Wei and Erkang Wang -- An overview of selected lux-marked biosensors and its application as a tool to ecotoxicological analysis / Mwinyikione Mwinyihija -- A yellow fluorescent protein variant as an intracellular iodide biosensor in thyroid cells / Kerry J. …”
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Beans nutrition, consumption and health /

Table of Contents: “….] -- Angiotensin I-converting enzyme inhibitory and antioxidant activities of protein hydrolysates from four tropical legumes / Maira Segura-Campos ... …”
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The origins of schizophrenia

Table of Contents: “….] -- Animal models of prenatal protein malnutrition relevant for schizophrenia / Lisa M. …”
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Drug efficacy, safety, and biologics discovery emerging technologies and tools /

Table of Contents: “…Yu -- High-throughput protein-based technologies and computational models for drug development, efficacy, and toxicity / Leonidas G. …”
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Blood-brain barrier in drug discovery : optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs /

Table of Contents: “…Uptake transport at the BBB - examples and SAR / Zack Cheng (AstraZeneca)8. Uptake of proteins and antibodies at the BBB / William Pardridge (UCLA)Predicting and Measuring Brain Exposure of Drugs9. …”
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Human Life (Before Birth by Dye, Frank J. (Frank John), 1942-

Table of Contents: “…Role and types of cell divisionMitosis; The cell cycle; Chromosomes; Genes; Spindle; Meiosis; Reduction of the number of chromosomes; Random segregation of chromosomes; Crossing over; Significance of meiosis; Epigenesis-histone proteins and deoxyribonucleic acid methylation; Stem cells; Study questions; Critical thinking; 4. …”
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Bacterial pathogenomics

Table of Contents: “…Read and Brendan Thomason -- Impact of phages on evolution of bacterial pathogenicity / Harald Brüssow -- What genomics has taught us about gram-positive protein secretion and targeting / Olaf Schneewind and Dominique Missiakas -- What genomics has taught us about bacterial cell wall biosynthesis / Lynn G. …”
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Endogenous bioelectrical signals in development, regeneration, and neoplasm

Table of Contents: “…Contents: Defining bioelectricity -- Sources of bioelectrical signals -- Big questions about bioelectricity -- Membrane voltage and cell plasticity -- History of the field of bioelectricity -- Applying exogenous electric fields in vitro -- Microelectrode impalement -- Detection of extracellular ion flux -- Investigating signals in pattern formation -- Inverse pharmacological screen -- Transmembrane voltage gradient characterization -- Loss- and gain-of-function analyses -- Synthesizing data into a predictive model -- Control of cell behavior by electric fields -- Mammalian stem cell differentiation -- Cell orientation and outgrowth -- Transepithelial potentials, electric fields, cancer -- Mechanisms of electric field sensing by cells -- Bioelectric signals in 3D morphogenesis -- A pathway for tail regeneration -- Transmembrane potential in tail regeneration -- V-ATPase function in tail regeneration -- Using voltage- and pH-sensitive dyes -- Induction of the V-ATPase following injury -- Electrogenic targets in mitosis upregulation -- Axon patterning requires specific ion fluxes -- Gene expression requires specific ion flows -- Ion flux and induction of regeneration -- Voltage gradients control large-scale axial polarity -- Transmembrane potential and cell behavior -- The Goldman equation -- Missexpressing specific ion transporter mRNAs -- Melanocyte behavior & transmembrane potential -- Taking advantage of endogenous ion transport -- Controlling transmembrane potential -- Modulation of transmembrane potential -- Controlling proliferation rates using K channels -- Cell-autonomous mechanisms -- Non-cell-autonomous mechanisms -- Bioelectrical signals and canonical pathways -- Bioelectric gradients and gene expression -- Information carried by bioelectric signals -- Bioelectrical mechanisms, DNA, mRNA & protein -- Control of ion flux as a master regulator -- Applications in cancer, stem cells & regeneration -- Light-gated ion transporters.…”
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Biocatalysis and Nanotechnology / by Grunwald, Peter

Table of Contents: “…Biocatalysis: An Introduction -- chapter 3 Environmentally Benign Nanomaterial Synthesis Mediated by Culture Broths -- chapter 4 Rational Design of Enzyme{u2013}Polymer Biocatalysts -- chapter 5 Biological Strategies in Nanobiocatalyst Assembly -- chapter 6 Graphene-Based Nanobiocatalytic Systems -- chapter 7 Immobilization of Biocatalysts onto Nanosupports: Advantages for Green Technologies -- chapter 8 Enzyme Immobilization on Membrane and Its Application in Bioreactors -- chapter 9 Potential Applications of Nanobiocatalysis for Industrial Biodiesel Production -- chapter 10 Enzymogel Nanoparticles Chemistry for Highly Efficient Phase Boundary Biocatalysis -- chapter 11 Recent Advances in Nanostructured Enzyme Catalysis for Chemical Synthesis in Organic Solvents -- chapter 12 Probing Enzymatic Activity by Combining Luminescent Quantum Dots, Gold Nanoparticles, and Energy Transfer -- chapter 13 FRET Reporter Molecules for Identification of Enzyme Functions -- chapter 14 Quantum Dot Architectures on Electrodes for Photoelectrochemical Analyte Detection -- chapter 15 Inorganic Nanoparticles as Enzyme Mimics -- chapter 16 Enzyme Nanocapsules for Glucose Sensing and Insulin Delivery -- chapter 17 Nanostructured Materials for Enzymatic Biofuel Cells -- chapter 18 Enzymatic Biofuel Cells on Porous Nanostructures -- chapter 19 Nanoplasmonic Biosensors -- chapter 20 Enzyme Biocomputing: Logic Gates and Logic Networks to Interface and Control Materials -- chapter 21 Functional Nano-Bioconjugates for Targeted Cellular Uptake and Specific Nanoparticle{u2013}Protein Interactions -- chapter 22 Cell-Free Expression Based Microarrays: Applications and Future Prospects -- chapter 23 Overview of the Current Knowledge and Challenges Associated with Human Exposure to Nanomaterials.…”
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Biotechnology of microorganisms : diversity, improvement, and application of microbes for food processing, health sector, environmental safety, and agricultural industry /

Table of Contents: “…Comparative studies on cfu determination by pure and/or mixed culture cultivations / Subir Kumar Nandy -- Cultivation strategies with special reference to bioreactor design and operation for industrial production in biotechnology / Anupreet Kaur and Jaspreet Kaur -- Diversity and application of acetic acid bacteria in asia / Somboon Tanasupawat, Taweesak Malimas, Nittaya Pitiwittayakul, Huong Thi Lan Vu, Pattaraporn Yukphan, and Yuzo Yamada -- Secondary metabolites and biological activity of actinomycetes / Khomsan Supong and Somboon Tanasupawat -- Serratiopeptidase : a multifaceted microbial enzyme in health care / Subathra Devi Chandrasekaran, Jemimah Naine Selvakumar, and Mohanasrinivasan Vaithilingam -- Production of bacteriorhodopsin, an industrially important membrane protein of halophilic archaea : a biotechnological challenge / Pradnya Pralhad Kanekar, Snehal Omkar Kulkarni, and Sagar Pralhad Kanekar -- Properties and biotechnological applications of ss-glucuronidases / Nasser El-Din Ibrahim, Weilan Shao, and Kesen Ma -- Microbial collagenases: an overview of their production and applications / Jyotsna Jotshi and Pradnya Pralhad Kanekar -- Characterization, production, and application of microbial lipases for food, agriculture, health, and environment / Jeyabalan Sangeetha, Ravichandra Hospet, Devarajan Thangadurai, Abhishek Channayya Mundaragi, Purushotham Prathima, and Muniswamy David -- Microorganisms as potential biosorbents of heavy metals / Antony Alex Kennedy Ajilda, Nagarajan Padmini, Natesan Sivakumar, and Gopal Selvakumar -- Bioremediation processes and molecular tools for detoxification of heavy metals and rehabilitation of contaminated environments using microbial genetic and genomic resources / Jeyabalan Sangeetha, Devarajan Thangadurai, Ravichandra Hospet, Purushotham Prathima, Shrinivas Jadhav, and Muniswamy David -- Microbial applications in nanotechnology industry / Essam A. …”
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Endogenous bioelectrical signals in development, regeneration, and neoplasm

Table of Contents: “…Contents: Defining bioelectricity -- Sources of bioelectrical signals -- Big questions about bioelectricity -- Membrane voltage and cell plasticity -- History of the field of bioelectricity -- Applying exogenous electric fields in vitro -- Microelectrode impalement -- Detection of extracellular ion flux -- Investigating signals in pattern formation -- Inverse pharmacological screen -- Transmembrane voltage gradient characterization -- Loss- and gain-of-function analyses -- Synthesizing data into a predictive model -- Control of cell behavior by electric fields -- Mammalian stem cell differentiation -- Cell orientation and outgrowth -- Transepithelial potentials, electric fields, cancer -- Mechanisms of electric field sensing by cells -- Bioelectric signals in 3D morphogenesis -- A pathway for tail regeneration -- Transmembrane potential in tail regeneration -- V-ATPase function in tail regeneration -- Using voltage- and pH-sensitive dyes -- Induction of the V-ATPase following injury -- Electrogenic targets in mitosis upregulation -- Axon patterning requires specific ion fluxes -- Gene expression requires specific ion flows -- Ion flux and induction of regeneration -- Voltage gradients control large-scale axial polarity -- Transmembrane potential and cell behavior -- The Goldman equation -- Missexpressing specific ion transporter mRNAs -- Melanocyte behavior & transmembrane potential -- Taking advantage of endogenous ion transport -- Controlling transmembrane potential -- Modulation of transmembrane potential -- Controlling proliferation rates using K channels -- Cell-autonomous mechanisms -- Non-cell-autonomous mechanisms -- Bioelectrical signals and canonical pathways -- Bioelectric gradients and gene expression -- Information carried by bioelectric signals -- Bioelectrical mechanisms, DNA, mRNA & protein -- Control of ion flux as a master regulator -- Applications in cancer, stem cells & regeneration -- Light-gated ion transporters.…”
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Principles of cellular engineering understanding the biomolecular interface /

Table of Contents: “…McGrath -- Glycocalyx regulation of cell adhesion / Philippe Robert, Laurent Limozin, Anne-Marie Benoliel, Anne Pierres, and Pierre Bongrand -- Atomistic modeling of protein adsorption to ceramic biomaterials in water: a first step toward realistic simulation of the biomaterials surface in vivo / by Alan H. …”
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Endogenous bioelectrical signals in development, regeneration, and neoplasm

Table of Contents: “…Contents: Defining bioelectricity -- Sources of bioelectrical signals -- Big questions about bioelectricity -- Membrane voltage and cell plasticity -- History of the field of bioelectricity -- Applying exogenous electric fields in vitro -- Microelectrode impalement -- Detection of extracellular ion flux -- Investigating signals in pattern formation -- Inverse pharmacological screen -- Transmembrane voltage gradient characterization -- Loss- and gain-of-function analyses -- Synthesizing data into a predictive model -- Control of cell behavior by electric fields -- Mammalian stem cell differentiation -- Cell orientation and outgrowth -- Transepithelial potentials, electric fields, cancer -- Mechanisms of electric field sensing by cells -- Bioelectric signals in 3D morphogenesis -- A pathway for tail regeneration -- Transmembrane potential in tail regeneration -- V-ATPase function in tail regeneration -- Using voltage- and pH-sensitive dyes -- Induction of the V-ATPase following injury -- Electrogenic targets in mitosis upregulation -- Axon patterning requires specific ion fluxes -- Gene expression requires specific ion flows -- Ion flux and induction of regeneration -- Voltage gradients control large-scale axial polarity -- Transmembrane potential and cell behavior -- The Goldman equation -- Missexpressing specific ion transporter mRNAs -- Melanocyte behavior & transmembrane potential -- Taking advantage of endogenous ion transport -- Controlling transmembrane potential -- Modulation of transmembrane potential -- Controlling proliferation rates using K channels -- Cell-autonomous mechanisms -- Non-cell-autonomous mechanisms -- Bioelectrical signals and canonical pathways -- Bioelectric gradients and gene expression -- Information carried by bioelectric signals -- Bioelectrical mechanisms, DNA, mRNA & protein -- Control of ion flux as a master regulator -- Applications in cancer, stem cells & regeneration -- Light-gated ion transporters.…”
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Companion diagnostics (CDx) in precision medicine /

Table of Contents: “…; 3.3 Current Uses of qPCR in Precision Medicine; 3.4 qPCR in Oncology; 3.4.1 Lung Cancer; 3.4.2 Leukemia; 3.4.3 Breast Cancer; 3.4.4 Colorectal Cancer; 3.4.5 Gastric Cancer; 3.5 qPCR in Infectious Disease; 3.5.1 Bacteria; 3.5.2 Viruses; 3.6 Limitations of qPCR; 3.7 Future Use of qPCR in Precision Medicine; 4: Protein Biomarker Signatures in Precision Diagnostics of Cancer; 4.1 Early Diagnosis and Biomarker Profiling within Cancer…”
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Sub- and Supercritical Hydrothermal Technology Industrial Applications. by Kumar, Sandeep

Table of Contents: “…2.7 Biological PretreatmentReferences; 3: Hydrothermal Liquefaction of Terrestrial and Aquatic Biomass; 3.1 Introduction; 3.2 HTL of Biomass-Reaction Pathways; 3.3 Conversions of Carbohydrates; 3.3.1 Cellulose; 3.3.2 Hemicelluloses; 3.3.3 Starch; 3.3.4 Saccharides; 3.4 Conversion of Lignin; 3.5 Conversion of Lipids; 3.5.1 Glycerol; 3.5.2 Fatty Acids; 3.6 Conversion of Proteins; 3.6.1 Amino Acids; 3.7 HTL of Lignocellulosic Biomass; 3.8 HTL of Wet/Algal Biomass; 3.9 Industrial Applications; 3.10 Conclusions; References; 4: Hydrothermal Carbonization for Producing Carbon Materials…”
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Motor neuron diseases causes, classification and treatments /

Table of Contents: “….] -- Expert commentary : motor neuron disease : assistive technology / Louisa Ng, Fary Khan -- Comparative study on application of invasive ventilation and non-invasive ventilation to ALS patients in Europe, the USA, and Japan / Rika Yamauchi, Jun Kawamata, Shun Shimohama -- Motor speech disorder in patients with motor neuron disease / Hideto Saigusa -- Non-viral gene delivery of the GDNF, either alone or fused to the C-fragment of tetanus toxin protein, prolongs survival in a mouse ALS model / Rosario Osta -- Motor neuron disease / Kazumi Murai -- Motor neuron disease / Anil Kumar -- Bulbospinal muscular atrophy (BSMA) Kennedy's disease / J. …”
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