Search Results - "proteins"

Cell signalling pathways and RNAi

Table of Contents: “…Contents: Use of functional cell-based reporter system (Cell Sensor(tm) technology) with RNAi -- From target knockdown to compound screening and verification in biochemical assays -- Analysis of small-molecule protein kinase inhibitors -- Epidermal growth factor receptor (EGFR) signalling pathway -- StealthTM RNAi, second-generation RNAi compounds -- Integration of a cell-based assay system, RNAi and biochemical assay technologies -- Kinase discovery platform to identify biologically relevant kinase targets -- Characterization of kinase inhibitors in systems -- Possible synergistic effects of combining RNAi and kinase inhibitors.…”
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From germ cell specification to gonad formation

Table of Contents: “…Contents: Germ cells: the ultimate stem cell -- Germ plasm specifies germ cells -- The genetics of early Drosophila development: maternal effect mutations -- The body pattern of the embryo is preformed during oogenesis by localization of RNA -- In Drosophila, the Oskar protein is necessary and sufficient to organize germ plasm -- Oskar RNA transport, localization and translation are regulated at many levels -- Epigenetic control of early germ cell development -- Transcription -- Germ cell migration -- Wunen -- Signaling pathways -- The life cycle of germ cells -- Growth of the gonad -- Genetic analysis of stem cell maintenance and differentiation -- Conserved aspects of germ cells.…”
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Vitamin D endocrine system mechanisms to produce biological responses /

Table of Contents: “…Contents: Optimal ligand shapes -- Modes of action of hormone-D -- Shape of ligand for VDRNUC -- Three dimensional shape of the VDR -- Shape of ligand for DBP -- DBP structure domains A, B, C -- Shape of ligand for rapid responses -- Steroid receptor superfamily -- Steroid receptor domains -- Structural organization of VDR gene, mRNA and protein -- Model of steroid hormone mode of action -- Model of hormone-D transcriptional activation -- Determination of a VDR mediated genomic response -- Examples of rapid responses -- Caveolae membrane and rapid responses -- VDR knock out mouse and rapid responses.…”
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Innate recognition of viruses

Table of Contents: “…Contents: Induction of the adaptive Immunity -- Pattern recognition receptors: coupling innate to adaptive immunity -- Induction of type I IFNs: an example of recognition of viral patterns -- Cytosolic pathway for influenza virus recognition and inhibition by the viral -- NSI protein -- RIG-I-mediated recognition of influenza virus genomes and 5'-PPP-RNA -- Cytosolic 5'-PPP-RNA as a PAMP -- Plasmacytoid DC and the discovery of a second pathway for innate recognition of influenza virus -- Endosomal pathways for virus recognition: TLR7, TLR9 -- TLR3 as a sensor of virally-infected cells.…”
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Streptococcus pyogenes disease and molecular pathogenesis

Table of Contents: “…Contents: Important Streptococcal species -- S. pyogenes: the chain that links the throat to the heart -- Life threatening complications -- Rheumatic fever -- Acute post streptococcal glomerulonephritis -- Invasive S. pyogenes disease -- Strep throat activates psoriasis and obsessive compulsive behavior -- Identification of group A streptococcus -- S. pyogenes expresses a complex array of factors that interact with host defenses -- Molecular mimicry hides bacterium from host's defenses -- Key complement components -- Destruction of host chemotactic signals is critical for initiation of infection -- C5a peptidase -- M protein -- Tonsils are reservoir for recurrent infection -- Superantigens.…”
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The mycobacterial cell envelope

Table of Contents: “…[et al.] -- Enigmatic proteins from the surface : the Erp, PE, and PPE protein families / Giovanni Delogu ... …”
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Physiology of the heart / by Katz, Arnold M.

Table of Contents: “…Energy Utilization (Work and Heat) 4. The Contractile Proteins 5. The Cytoskeleton 6. Active State, Length-Tension Relationship, Cardiac Mechanics 7. …”
An electronic book accessible through the World Wide Web; click to view

Advanced Structural and Chemical Imaging

Open Access

Advanced Structural and Chemical Imaging

Open Access

RNAi and heterochromatin in plants and fission yeast

Table of Contents: “…Contents: Heterochromatin is composed of transposable elements (TEs) and related repeats -- heterochromatic gene silencing and TE-mediated silencing are related and may be important in large genomes -- tiling microarrays can be used to examine heterochromatic transcripts as well as DNA and histone modification -- small interfering RNA (siRNA) corresponds to transposons and repeats -- in plants TE siRNA depend on DNA methyltransferase MET1 and the SWI/SNF ATPase DDM1 which silence TEs via DNA and histone H3 lysine-9 (H3K9) methylation -- in fission yeast and plants centromeric repeats are transcribed on one strand but rapidly turned over by RNA interference (RNAi) -- RNAi of centromeric transcripts is required for transcriptional silencing of reporter genes -- RNA polymerase II, the Argonaute (RITS) and RNA dependent RNA polymerase (RDRC) complexes are associated with heterochromatin and required for silencing -- H3K9me2 depends on RNAi and on the Rik1-Clr4 complex -- Clr4 is the histone H3K9 dimethyltransferase -- Rik1 resembles both DNA and RNA binding proteins and is required for RNAi along with Clr4 -- LTR retrotransposon silencing depends on histone deacetylation and silences pericentromeric repeats in Arabidopsis in addition to RNAi.…”
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Series (Epigenetics)
Series (RNA interference)

RNAi and heterochromatin in plants and fission yeast

Table of Contents: “…Contents: Heterochromatin is composed of transposable elements (TEs) and related repeats -- heterochromatic gene silencing and TE-mediated silencing are related and may be important in large genomes -- tiling microarrays can be used to examine heterochromatic transcripts as well as DNA and histone modification -- small interfering RNA (siRNA) corresponds to transposons and repeats -- in plants TE siRNA depend on DNA methyltransferase MET1 and the SWI/SNF ATPase DDM1 which silence TEs via DNA and histone H3 lysine-9 (H3K9) methylation -- in fission yeast and plants centromeric repeats are transcribed on one strand but rapidly turned over by RNA interference (RNAi) -- RNAi of centromeric transcripts is required for transcriptional silencing of reporter genes -- RNA polymerase II, the Argonaute (RITS) and RNA dependent RNA polymerase (RDRC) complexes are associated with heterochromatin and required for silencing -- H3K9me2 depends on RNAi and on the Rik1-Clr4 complex -- Clr4 is the histone H3K9 dimethyltransferase -- Rik1 resembles both DNA and RNA binding proteins and is required for RNAi along with Clr4 -- LTR retrotransposon silencing depends on histone deacetylation and silences pericentromeric repeats in Arabidopsis in addition to RNAi.…”
Get full text
Series (Epigenetics)
Series (RNA interference)

RNAi and heterochromatin in plants and fission yeast

Table of Contents: “…Contents: Heterochromatin is composed of transposable elements (TEs) and related repeats -- heterochromatic gene silencing and TE-mediated silencing are related and may be important in large genomes -- tiling microarrays can be used to examine heterochromatic transcripts as well as DNA and histone modification -- small interfering RNA (siRNA) corresponds to transposons and repeats -- in plants TE siRNA depend on DNA methyltransferase MET1 and the SWI/SNF ATPase DDM1 which silence TEs via DNA and histone H3 lysine-9 (H3K9) methylation -- in fission yeast and plants centromeric repeats are transcribed on one strand but rapidly turned over by RNA interference (RNAi) -- RNAi of centromeric transcripts is required for transcriptional silencing of reporter genes -- RNA polymerase II, the Argonaute (RITS) and RNA dependent RNA polymerase (RDRC) complexes are associated with heterochromatin and required for silencing -- H3K9me2 depends on RNAi and on the Rik1-Clr4 complex -- Clr4 is the histone H3K9 dimethyltransferase -- Rik1 resembles both DNA and RNA binding proteins and is required for RNAi along with Clr4 -- LTR retrotransposon silencing depends on histone deacetylation and silences pericentromeric repeats in Arabidopsis in addition to RNAi.…”
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Series (Epigenetics)
Series (RNA interference)

Use of isolated populations in disease gene identification

Table of Contents: “…Contents: Disease mutations in Finland - Molecular background of Finnish disease heritage - Finnish disease genes, novel pathways exposed - Example: APECED - AIRE protein - AIRE regulates ectopic expression in thymus - AIRE deficiency - Simplifying the complex genetic background of common diseases - Advantages of isolated populations - Internal isolates: increased genetic homogeneity - Lactose intolerance - Adult type hypolactasia - Severe coronary heart disease - Familial combined hyperlipidemia, FCHL - USF1: a transcription factor - Effect of genetic association on target cells, coronary wall and impact in population - Population based cohorts in Finland - Global effort is needed.…”
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Obesity and adiponectin

Table of Contents: “…Contents: Adipose tissue as an endocrine organ -- Local and systemic inflammation increases due to dysfunctional adipose tissue -- Dysfunctional adipose tissue is more fibrotic -- Factors involved in inflammation -- Factors involved in energy homeostasis -- The Adipokine panel for clinical studies -- Impact of visceral fat pad on liver -- Retinol binding protein 4 (RBP4) -- Resistin -- Adiponectin -- Adiponectin multimerization -- Prospective marker of CVD -- Hepatic insulin sensitizer -- Anti-steatotic action of Adiponectin -- A mediator of PPARg agonist action -- Type 2 diabetic patients -- Hypertension -- Renal failure -- Cancer -- Transgenic overexpression of Adiponectin in ob/ob mice.…”
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Use of isolated populations in disease gene identification

Table of Contents: “…Contents: Disease mutations in Finland - Molecular background of Finnish disease heritage - Finnish disease genes, novel pathways exposed - Example: APECED - AIRE protein - AIRE regulates ectopic expression in thymus - AIRE deficiency - Simplifying the complex genetic background of common diseases - Advantages of isolated populations - Internal isolates: increased genetic homogeneity - Lactose intolerance - Adult type hypolactasia - Severe coronary heart disease - Familial combined hyperlipidemia, FCHL - USF1: a transcription factor - Effect of genetic association on target cells, coronary wall and impact in population - Population based cohorts in Finland - Global effort is needed.…”
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Obesity and adiponectin

Table of Contents: “…Contents: Adipose tissue as an endocrine organ -- Local and systemic inflammation increases due to dysfunctional adipose tissue -- Dysfunctional adipose tissue is more fibrotic -- Factors involved in inflammation -- Factors involved in energy homeostasis -- The Adipokine panel for clinical studies -- Impact of visceral fat pad on liver -- Retinol binding protein 4 (RBP4) -- Resistin -- Adiponectin -- Adiponectin multimerization -- Prospective marker of CVD -- Hepatic insulin sensitizer -- Anti-steatotic action of Adiponectin -- A mediator of PPARg agonist action -- Type 2 diabetic patients -- Hypertension -- Renal failure -- Cancer -- Transgenic overexpression of Adiponectin in ob/ob mice.…”
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Use of isolated populations in disease gene identification

Table of Contents: “…Contents: Disease mutations in Finland - Molecular background of Finnish disease heritage - Finnish disease genes, novel pathways exposed - Example: APECED - AIRE protein - AIRE regulates ectopic expression in thymus - AIRE deficiency - Simplifying the complex genetic background of common diseases - Advantages of isolated populations - Internal isolates: increased genetic homogeneity - Lactose intolerance - Adult type hypolactasia - Severe coronary heart disease - Familial combined hyperlipidemia, FCHL - USF1: a transcription factor - Effect of genetic association on target cells, coronary wall and impact in population - Population based cohorts in Finland - Global effort is needed.…”
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Obesity and adiponectin

Table of Contents: “…Contents: Adipose tissue as an endocrine organ -- Local and systemic inflammation increases due to dysfunctional adipose tissue -- Dysfunctional adipose tissue is more fibrotic -- Factors involved in inflammation -- Factors involved in energy homeostasis -- The Adipokine panel for clinical studies -- Impact of visceral fat pad on liver -- Retinol binding protein 4 (RBP4) -- Resistin -- Adiponectin -- Adiponectin multimerization -- Prospective marker of CVD -- Hepatic insulin sensitizer -- Anti-steatotic action of Adiponectin -- A mediator of PPARg agonist action -- Type 2 diabetic patients -- Hypertension -- Renal failure -- Cancer -- Transgenic overexpression of Adiponectin in ob/ob mice.…”
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Clustering challenges in biological networks

Table of Contents: “….] -- Identifying critical nodes in protein-protein interaction networks / V. Boginski and C.W. …”
An electronic book accessible through the World Wide Web; click to view

Biomedical chromatography

Table of Contents: “…Bioanalysis in drug discovery and development : focus on pharmacokinetic studies / Gilberto Alves, Ana Fortuna, Amílcar Falcão -- Characterization of drug-plasmatic protein interactions by microseparation techniques / Maria Amparo Martínez-Gómez ... …”
An electronic book accessible through the World Wide Web; click to view