Search Results - "proteins"

Coupled bioluminescent assays methods, evaluations, and applications / by Corey, Michael J. (Michael James), 1953-

Table of Contents: “…Introduction -- Coupled bioluminescent reactions in practice -- Coupled bioluminescent cytotoxicity assays -- The role of coupled bioluminescent assays in kinase screening and study -- Coupled bioluminescent phosphatase assays -- Acetylcholinesterase -- Measurement of nitric oxide synthase activity by coupled bioluminescence -- The coupled bioluminescent pyrophosphorolysis assay -- Coupled luminescent assays of G-protein-coupled receptors -- Coupled bioluminescent protease assays -- Coupled luminescent assays involving aequorin -- Coupled bioluminescent reporter assays -- Coupled bioluminescent assays : regulatory concerns -- Coupled bioluminescent determination of bioburden and sterility -- Environmental applications of coupled bioluminescent assays.…”
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Dietary determinants of obesity

Table of Contents: “…Contents: Environmental factors causing weight gain and obesity -- Genes interacting with dietary fat -- Portion size -- Eating away from home -- Recommended dietary composition of a weight-reducing diet -- Risk of obesity and type 2 diabetes -- Role of energy density -- Fast food -- Meta-analysis of low fat diets -- Lifestyle intervention -- Dietary composition -- The Glycemic Index -- Sugar-sweetened drinks and childhood obesity -- Low carbohydrate vs. low fat diets -- Hierarchy of satiety -- Energy expenditure -- Protein vs. carbohydrate -- Dietary intervention.…”
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Descending control systems

Table of Contents: “…-- Effects of RVM lesion on behavior -- Dynamic shifts in descending modulation after inflammation -- Experimental set up -- NMDA receptor ion channel complex -- Changes in NMDA receptor subunit expression in the RVM -- Changes in NMDA receptor protein expression in the RVM -- Changes in NMDA NR2 receptor subunit phosphorylation after inflammation -- Neuronal activity in the RVM -- Changes in RVM neuronal activity during the development of inflammation -- Brain-derived neurotrophic factor (BDNF) -- Normal function of the brain.…”
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Deciphering neurodegeneration models and methods /

Table of Contents: “…Contents: Deciphering Neurodegeneration: Models and Methods -- The challenge of neurodegeneration -- Huge diversity in cell types -- Nature versus nurture -- Reductionism versus systems biology -- Cellular models -- Yeast -- Primary cells -- Cell lines -- Stem cells -- Model organisms -- Caenorhabditis elegans -- Drosophila melanogaster -- Zebrafish -- Danio rerio -- Rodents -- Molecular biology approaches -- Knock out and knock in -- Genomic editing -- RNAi -- Overexpression -- Gene expression -- rtPCR -- Microarrays -- RNAseq -- Protein analysis -- Immunoblot -- ELISA -- Mass spec and proteomics -- Microscopy -- Immunocytochemistry -- Live cell imaging -- Electrophysiology.…”
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The inherited ataxias

Table of Contents: “…-- SCA1 project overview -- Friedreich's ataxia -- Frataxin protein function -- Epigenetic factors in the pathogenesis of FRDA -- HDAC inhibition in patient with Friedreich's ataxia -- Nicotinamide in patient with Friedreich's ataxia -- Phase II open label trial of nicotinamide.…”
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Cultivars chemical properties, antioxidant activities and health benefits /

Table of Contents: “…Garrigós Selva -- Different cultivars of the same species of plant may produce proteins that differ in structure and function / Tzi Bun Ng, Evandro Fei Fang, Jack Ho Wong -- Corn biotechnology / Pil Son Choi ... et al. -- Influences of nitrate on nodule structure and nitrate reductase activity in Arachis hypogaea L. …”
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Genome Editing in Neurosciences

Table of Contents: “…Introduction -- In vitro modeling of complex neurological diseases -- Aquatic model organisms in neurosciences : the genome editing revolution -- Genome-wide genetic screening in the mammalian CNS -- CRISPR/Cas9-mediated Knockin and Knockout in Zebrafish -- Dissecting the role of synaptic proteins with CRISPR -- Recurrently Breaking Genes in Neural Progenitors: Potential Roles of DNA Breaks in Neuronal Function, Degeneration and Cancer -- Neuroscience research using non-human primate models and genome editing -- Multiscale genome engineering: Genome-wide screens and targeted approaches -- Using Genome Engineering to Understand Huntington’s Disease -- Therapeutic gene editing in muscles and muscle stem cells.…”
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Biochemistry : an organic chemistry approach / by Smith, Michael, 1946 October 17-

Taylor & Francis
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Innate immunity in the intestine in health and disease

Table of Contents: “…Contents: Mucosal tissues of the human body -- Intestinal pathogens -- Mucosal immune system: distinctive features -- Gut-associated lymphoid tissue (GALT) -- Structure of the GALT: small and large intestine -- Mucus, a key protective barrier -- Antimicrobial proteins protect the epithelium -- Epithelial cell transcytosis of secretory IgA -- Uptake and transport of antigen by M cells -- Microbial sensing regulates intestinal homeostasis -- Sensing of microbes occurs through PRR -- MyD88 signals in IEC -- Intestinal macrophages are anti-inflammatory -- Intestinal DC 'conditioning' -- Inflammatory bowel disease (IBD) -- Genome-wide association studies -- The enigma of NOD2 and Crohn's disease -- NOD2 signaling in response to bacterial MDP -- NOD2 signaling regulates myeloid cell function -- Autophagy also regulates IEC and myeloid cells -- MyD88 activation drives intestinal inflammation -- Haematopoeitic MyD88 signals -- Immune dysregulation in chronic inflammation -- Innate lymphoid cells (ILC) drive innate IBD -- Leukocyte populations and intestinal homeostasis.…”
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Innate immunity in the intestine in health and disease

Table of Contents: “…Contents: Mucosal tissues of the human body -- Intestinal pathogens -- Mucosal immune system: distinctive features -- Gut-associated lymphoid tissue (GALT) -- Structure of the GALT: small and large intestine -- Mucus, a key protective barrier -- Antimicrobial proteins protect the epithelium -- Epithelial cell transcytosis of secretory IgA -- Uptake and transport of antigen by M cells -- Microbial sensing regulates intestinal homeostasis -- Sensing of microbes occurs through PRR -- MyD88 signals in IEC -- Intestinal macrophages are anti-inflammatory -- Intestinal DC 'conditioning' -- Inflammatory bowel disease (IBD) -- Genome-wide association studies -- The enigma of NOD2 and Crohn's disease -- NOD2 signaling in response to bacterial MDP -- NOD2 signaling regulates myeloid cell function -- Autophagy also regulates IEC and myeloid cells -- MyD88 activation drives intestinal inflammation -- Haematopoeitic MyD88 signals -- Immune dysregulation in chronic inflammation -- Innate lymphoid cells (ILC) drive innate IBD -- Leukocyte populations and intestinal homeostasis.…”
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Innate recognition of viruses

Table of Contents: “…Contents: Induction of the adaptive Immunity -- Pattern recognition receptors: coupling innate to adaptive immunity -- Induction of type I IFNs: an example of recognition of viral patterns -- Cytosolic pathway for influenza virus recognition and inhibition by the viral -- NSI protein -- RIG-I-mediated recognition of influenza virus genomes and 5'-PPP-RNA -- Cytosolic 5'-PPP-RNA as a PAMP -- Plasmacytoid DC and the discovery of a second pathway for innate recognition of influenza virus -- Endosomal pathways for virus recognition: TLR7, TLR9 -- TLR3 as a sensor of virally-infected cells.…”
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Cell signalling pathways and RNAi

Table of Contents: “…Contents: Use of functional cell-based reporter system (Cell Sensor(tm) technology) with RNAi -- From target knockdown to compound screening and verification in biochemical assays -- Analysis of small-molecule protein kinase inhibitors -- Epidermal growth factor receptor (EGFR) signalling pathway -- StealthTM RNAi, second-generation RNAi compounds -- Integration of a cell-based assay system, RNAi and biochemical assay technologies -- Kinase discovery platform to identify biologically relevant kinase targets -- Characterization of kinase inhibitors in systems -- Possible synergistic effects of combining RNAi and kinase inhibitors.…”
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Vitamin D endocrine system mechanisms to produce biological responses /

Table of Contents: “…Contents: Optimal ligand shapes -- Modes of action of hormone-D -- Shape of ligand for VDRNUC -- Three dimensional shape of the VDR -- Shape of ligand for DBP -- DBP structure domains A, B, C -- Shape of ligand for rapid responses -- Steroid receptor superfamily -- Steroid receptor domains -- Structural organization of VDR gene, mRNA and protein -- Model of steroid hormone mode of action -- Model of hormone-D transcriptional activation -- Determination of a VDR mediated genomic response -- Examples of rapid responses -- Caveolae membrane and rapid responses -- VDR knock out mouse and rapid responses.…”
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From germ cell specification to gonad formation

Table of Contents: “…Contents: Germ cells: the ultimate stem cell -- Germ plasm specifies germ cells -- The genetics of early Drosophila development: maternal effect mutations -- The body pattern of the embryo is preformed during oogenesis by localization of RNA -- In Drosophila, the Oskar protein is necessary and sufficient to organize germ plasm -- Oskar RNA transport, localization and translation are regulated at many levels -- Epigenetic control of early germ cell development -- Transcription -- Germ cell migration -- Wunen -- Signaling pathways -- The life cycle of germ cells -- Growth of the gonad -- Genetic analysis of stem cell maintenance and differentiation -- Conserved aspects of germ cells.…”
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Streptococcus pyogenes disease and molecular pathogenesis

Table of Contents: “…Contents: Important Streptococcal species -- S. pyogenes: the chain that links the throat to the heart -- Life threatening complications -- Rheumatic fever -- Acute post streptococcal glomerulonephritis -- Invasive S. pyogenes disease -- Strep throat activates psoriasis and obsessive compulsive behavior -- Identification of group A streptococcus -- S. pyogenes expresses a complex array of factors that interact with host defenses -- Molecular mimicry hides bacterium from host's defenses -- Key complement components -- Destruction of host chemotactic signals is critical for initiation of infection -- C5a peptidase -- M protein -- Tonsils are reservoir for recurrent infection -- Superantigens.…”
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Innate recognition of viruses

Table of Contents: “…Contents: Induction of the adaptive Immunity -- Pattern recognition receptors: coupling innate to adaptive immunity -- Induction of type I IFNs: an example of recognition of viral patterns -- Cytosolic pathway for influenza virus recognition and inhibition by the viral -- NSI protein -- RIG-I-mediated recognition of influenza virus genomes and 5'-PPP-RNA -- Cytosolic 5'-PPP-RNA as a PAMP -- Plasmacytoid DC and the discovery of a second pathway for innate recognition of influenza virus -- Endosomal pathways for virus recognition: TLR7, TLR9 -- TLR3 as a sensor of virally-infected cells.…”
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Cell signalling pathways and RNAi

Table of Contents: “…Contents: Use of functional cell-based reporter system (Cell Sensor(tm) technology) with RNAi -- From target knockdown to compound screening and verification in biochemical assays -- Analysis of small-molecule protein kinase inhibitors -- Epidermal growth factor receptor (EGFR) signalling pathway -- StealthTM RNAi, second-generation RNAi compounds -- Integration of a cell-based assay system, RNAi and biochemical assay technologies -- Kinase discovery platform to identify biologically relevant kinase targets -- Characterization of kinase inhibitors in systems -- Possible synergistic effects of combining RNAi and kinase inhibitors.…”
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Vitamin D endocrine system mechanisms to produce biological responses /

Table of Contents: “…Contents: Optimal ligand shapes -- Modes of action of hormone-D -- Shape of ligand for VDRNUC -- Three dimensional shape of the VDR -- Shape of ligand for DBP -- DBP structure domains A, B, C -- Shape of ligand for rapid responses -- Steroid receptor superfamily -- Steroid receptor domains -- Structural organization of VDR gene, mRNA and protein -- Model of steroid hormone mode of action -- Model of hormone-D transcriptional activation -- Determination of a VDR mediated genomic response -- Examples of rapid responses -- Caveolae membrane and rapid responses -- VDR knock out mouse and rapid responses.…”
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From germ cell specification to gonad formation

Table of Contents: “…Contents: Germ cells: the ultimate stem cell -- Germ plasm specifies germ cells -- The genetics of early Drosophila development: maternal effect mutations -- The body pattern of the embryo is preformed during oogenesis by localization of RNA -- In Drosophila, the Oskar protein is necessary and sufficient to organize germ plasm -- Oskar RNA transport, localization and translation are regulated at many levels -- Epigenetic control of early germ cell development -- Transcription -- Germ cell migration -- Wunen -- Signaling pathways -- The life cycle of germ cells -- Growth of the gonad -- Genetic analysis of stem cell maintenance and differentiation -- Conserved aspects of germ cells.…”
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Streptococcus pyogenes disease and molecular pathogenesis

Table of Contents: “…Contents: Important Streptococcal species -- S. pyogenes: the chain that links the throat to the heart -- Life threatening complications -- Rheumatic fever -- Acute post streptococcal glomerulonephritis -- Invasive S. pyogenes disease -- Strep throat activates psoriasis and obsessive compulsive behavior -- Identification of group A streptococcus -- S. pyogenes expresses a complex array of factors that interact with host defenses -- Molecular mimicry hides bacterium from host's defenses -- Key complement components -- Destruction of host chemotactic signals is critical for initiation of infection -- C5a peptidase -- M protein -- Tonsils are reservoir for recurrent infection -- Superantigens.…”
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