Search Results - "proteins"

Cellular and molecular toxicology

Table of Contents: “…Contents: Classification of adverse drug reactions -- How this relates to the chemical structure of the offending drug -- Understanding how variation in drug metabolism can contribute to clinical toxicity is important in designing pre-clinical models and screens -- Case studies of drugs which can form reactive metabolites and can irreversibly modify cellular protein -- Examples of structural modifications to chemicals containing toxicophores -- Novel and traditional serum and cellular biomarkers of adaptation, apoptosis and necrosis.…”
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Mechanistic aspects and therapeutic applications of RNAi

Table of Contents: “…Contents: RNAi mechanisms -- RNAi and HIV infection -- Lentiviral vector-mediated transduction of stem cells and T-cells -- Gene therapy based treatment of HIV-1 -- HIV mutants that abrogate RNAi -- Multiplexing different siRNAs and siRNAs with other antiviral RNAs to minimize viral resistance -- An HIV Tat inducible shRNA expression system -- Multiplexing shRNA with dominant negative M10 protein inhibition of HIV.…”
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Mechanistic aspects and therapeutic applications of RNAi

Table of Contents: “…Contents: RNAi mechanisms -- RNAi and HIV infection -- Lentiviral vector-mediated transduction of stem cells and T-cells -- Gene therapy based treatment of HIV-1 -- HIV mutants that abrogate RNAi -- Multiplexing different siRNAs and siRNAs with other antiviral RNAs to minimize viral resistance -- An HIV Tat inducible shRNA expression system -- Multiplexing shRNA with dominant negative M10 protein inhibition of HIV.…”
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Cellular and molecular toxicology

Table of Contents: “…Contents: Classification of adverse drug reactions -- How this relates to the chemical structure of the offending drug -- Understanding how variation in drug metabolism can contribute to clinical toxicity is important in designing pre-clinical models and screens -- Case studies of drugs which can form reactive metabolites and can irreversibly modify cellular protein -- Examples of structural modifications to chemicals containing toxicophores -- Novel and traditional serum and cellular biomarkers of adaptation, apoptosis and necrosis.…”
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Molecular polymorphism of man structural and functional individual multiformity of biomacromolecules /

Table of Contents: “….] -- Biomedical aspects in investigations of biochemical polymorphism of actins and some actin-binding proteins / S.S. Shishkin ... [et al.] -- Molecular mechanisms of adaptation : stress and aggression / A.G. …”
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Sugarcane : physiology, biochemistry, and functional biology /

Table of Contents: “…Sugarcane: the crop, the plant, and domestication -- Anatomy and morphology -- Developmental stages (phenology) -- Ripening and postharvest deterioration -- Mineral nutrition of sugarcane -- Photosynthesis in sugarcane -- Respiration as a competitive sink for sucrose accumulation in sugarcane culm: perspectives and open questions -- Nitrogen physiology of sugarcane -- Water relations and cell expansion of storage tissue -- Water, transpiration, and gas exchange -- Transport proteins in plant growth and development -- Phloem transport of resources -- Cell walls: structure and biogenesis -- Hormones and growth regulators -- Flowering -- Stress physiology: abiotic stresses -- Mechanisms of resistance to pests and pathogens in sugarcane and related crop species -- Source and sink physiology -- Biomass and bioenergy -- Crop models -- Sugarcane yields and yield-limiting processes -- Systems biology and metabolic modeling -- Sugarcane genetics and genomics -- Sugarcane biotechnology: axenic culture, gene transfer, and transgene expression.…”
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Drug discovery and target validation in the p53 pathway

Table of Contents: “…Contents: Controlling cancer -- p53 discovery -- Oncoproteins -- SV40, Adeno and HPV -- The p53 protein -- Incidence of genetic changes in p53 in human cancers -- What does p53 do? …”
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Discovery of Levetiracetam (Keppra(R)) the first SV2A ligand for the treatment of epilepsy /

Table of Contents: “…Contents: Levetiracetam -- Antiepileptic Drug Discovery -- Levetiracetam in electroshock and PTZ seizures -- Protection against seizures in rat model -- Levetiracetam activity in GAERS model -- Impact on cognitive function -- Hyper-synchronization / excitability inhibition in vitro -- Effect on development of amygdala kindling -- Effect on seizures in genetic models of epilepsy -- Inactivation of sodium channels -- Reduction of current through T-type Ca channels -- Levetiracetam mechanism of action -- SV2 proteins: candidates for the LEV binding site -- SV2A cloning and binding studies -- Levetiracetam studies in SV2A (+/-) mice -- Profile of new class of antiepileptic drugs.…”
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Series (Drug discovery and development in the neurosciences)
Series (Small molecule drug discovery)

Drug discovery and target validation in the p53 pathway

Table of Contents: “…Contents: Controlling cancer -- p53 discovery -- Oncoproteins -- SV40, Adeno and HPV -- The p53 protein -- Incidence of genetic changes in p53 in human cancers -- What does p53 do? …”
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Drug discovery and target validation in the p53 pathway

Table of Contents: “…Contents: Controlling cancer -- p53 discovery -- Oncoproteins -- SV40, Adeno and HPV -- The p53 protein -- Incidence of genetic changes in p53 in human cancers -- What does p53 do? …”
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Discovery of Levetiracetam (Keppra(R)) the first SV2A ligand for the treatment of epilepsy /

Table of Contents: “…Contents: Levetiracetam -- Antiepileptic Drug Discovery -- Levetiracetam in electroshock and PTZ seizures -- Protection against seizures in rat model -- Levetiracetam activity in GAERS model -- Impact on cognitive function -- Hyper-synchronization / excitability inhibition in vitro -- Effect on development of amygdala kindling -- Effect on seizures in genetic models of epilepsy -- Inactivation of sodium channels -- Reduction of current through T-type Ca channels -- Levetiracetam mechanism of action -- SV2 proteins: candidates for the LEV binding site -- SV2A cloning and binding studies -- Levetiracetam studies in SV2A (+/-) mice -- Profile of new class of antiepileptic drugs.…”
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Series (Drug discovery and development in the neurosciences)
Series (Small molecule drug discovery)

Muscle aging inclusion-body myositis and myopathies /

Table of Contents: “…King Engel, Shalini Mahajan, Valerie Askanas -- Mitochondrial changes in ageing with particular reference to muscle, and possible clinical consequences / Salvatore DiMauro, Eric Schon, Michio Hirano -- Protein degradation in ageing cells and mitochondria : relevance to the neuromuscular system / Jenny Ngo and Kelvin Davies -- Human muscle protein metabolism in relation to exercise and aging : potential therapeutic applications / Micah J. …”
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Werner & Ingbar's the thyroid : a fundamental and clinical text /

Table of Contents: “…The heritage of the thyroid: a brief history -- Development of the hypothalamic-pituitary-thyroid axis -- Anatomy and pathology of the thyrotrophs -- Thyroid hormone synthesis: thyroid iodide transport -- Thyroid hormone synthesis -- Thyroglobulin structure, function, and biosynthesis -- Thyroid hormone transport proteins and the physiology of hormone binding -- Intracellular pathways of iodothyronine metabolism/implications of deiodination for thyroid hormone action -- Genomic and nongenomic actions of thyroid hormones -- Thyroid hormones structure-function relationships -- Chemistry and biosynthesis of thyrotropin -- The thyrotropin receptor -- Regulation of thyrotropin secretion -- Age related changes in thyroid function -- Effects of drugs on TSH secretion, thyroid hormones absorption, synthesis, metabolism, and action -- Nonthyroidal illness syndrome -- Iodine deficiency and endemic cretinism -- Effect of excess iodide: clinical aspects -- Thyroid radionuclide uptake and imaging studies -- Measuring serum thyroid-stimulating hormone, thyroid hormones, thyroid-directed antibodies, and transport proteins -- Measurement of thyroglobulin -- Nonisotopic techniques of thyroid imaging -- Physical examination of the thyroid gland -- Pathology and cytopathology -- Introduction to thyrotoxicosis -- Pathogenesis of graves' disease -- Ophthalmopathy -- Thyroid dermopathy and thyroid acropachy -- Thyrotropin-induced thyrotoxicosis -- Toxic adenoma and toxic multinodular goiter -- Trophoblastic tumors -- Sporadic painless, painful subacute and acute infectious thyroiditis -- Thyrotoxicosis of extrathyroid origin -- Overview of the clinical manifestations of thyrotoxicosis -- The cardiovascular system in thyrotoxicosis -- Thyroid hormones in thermogenesis, intermediary metabolism, and obesity -- The male and female reproductive system in thyrotoxicosis -- The skeletal system in thyrotoxicosis -- Behavioral and psychiatric aspects of thyrotoxicosis --…”
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Agricultural wastes

Table of Contents: “…Potential risk and environmental benefits of waste derived from animal agriculture / Ajit K Sarmah -- Animal waste and hazardous substances: current laws and legislative issues / Claudia Copeland -- Reprocessing and protein enrichment of agricultural wastes by thermophilic aerobic digestion (TAD) / J. …”
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The blood-brain barrier new research /

Table of Contents: “….] -- It takes two to tango : protein-protein interactions in the translocation of pathogens across blood-brain barrier / L. …”
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Hepatic encephalopathy in cirrhosis a disorder of glial-neuronal signalling /

Table of Contents: “…Contents: Classification of hepatic encephalopathy -- Hepatic encephalopathy in cirrhosis -- Transjugular intrahepatic portosystemic shunt (TIPS) -- Hepatic encephalopathy post-TIPS -- Neuropathology of hepatic encephalopathy in chronic liver failure -- Cirrhosis-related Parkinsonism -- PET studies in cirrhosis -- Neuroinflammation and hepatic encephalopathy in cirrhosis -- Systemic inflammatory response syndrome (SIRS) in cirrhosis -- Translocator protein and hepatic encephalopathy in cirrhosis -- Modulatory site for neurosteroids -- Prevention and treatment of hepatic encephalopathy in cirrhosis -- Emerging new therapeutic approaches.…”
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Experimental therapies in Alzheimer's disease the development and use of mouse models /

Table of Contents: “…Contents: Animal models and AD research -- Role in identifying pathological pathways, biomarkers and candidate therapies -- Design of models and associated technical parameters -- Process of transgenesis -- Developing mouse models for beta-amyloid precursor protein mutations -- TgCRND8 mice -- Transgenic approaches for investigating Tau mutations -- Exploring environmental modifiers of beta-amyloid pathobiology -- Candidate chemical risk-factor for sporadic AD -- Potential of ''smart'' beta-amyloid-directed interventions.…”
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Hepatic encephalopathy in cirrhosis a disorder of glial-neuronal signalling /

Table of Contents: “…Contents: Classification of hepatic encephalopathy -- Hepatic encephalopathy in cirrhosis -- Transjugular intrahepatic portosystemic shunt (TIPS) -- Hepatic encephalopathy post-TIPS -- Neuropathology of hepatic encephalopathy in chronic liver failure -- Cirrhosis-related Parkinsonism -- PET studies in cirrhosis -- Neuroinflammation and hepatic encephalopathy in cirrhosis -- Systemic inflammatory response syndrome (SIRS) in cirrhosis -- Translocator protein and hepatic encephalopathy in cirrhosis -- Modulatory site for neurosteroids -- Prevention and treatment of hepatic encephalopathy in cirrhosis -- Emerging new therapeutic approaches.…”
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Experimental therapies in Alzheimer's disease the development and use of mouse models /

Table of Contents: “…Contents: Animal models and AD research -- Role in identifying pathological pathways, biomarkers and candidate therapies -- Design of models and associated technical parameters -- Process of transgenesis -- Developing mouse models for beta-amyloid precursor protein mutations -- TgCRND8 mice -- Transgenic approaches for investigating Tau mutations -- Exploring environmental modifiers of beta-amyloid pathobiology -- Candidate chemical risk-factor for sporadic AD -- Potential of ''smart'' beta-amyloid-directed interventions.…”
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Experimental therapies in Alzheimer's disease the development and use of mouse models /

Table of Contents: “…Contents: Animal models and AD research -- Role in identifying pathological pathways, biomarkers and candidate therapies -- Design of models and associated technical parameters -- Process of transgenesis -- Developing mouse models for beta-amyloid precursor protein mutations -- TgCRND8 mice -- Transgenic approaches for investigating Tau mutations -- Exploring environmental modifiers of beta-amyloid pathobiology -- Candidate chemical risk-factor for sporadic AD -- Potential of ''smart'' beta-amyloid-directed interventions.…”
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