Search Results - "proteins"

SARS-CoV-2 mutations phenotypes and implications for vaccine development /

Table of Contents: “…Contents: Currently known SARS-CoV-2 strains -- Likelihood of mutating into a more lethal form of SARS-CoV-2 -- Spike proteins and their role in viral entry into human cells -- SARS-CoV-2 is mutating into a more transmissible or infectious form -- Implications of new SARS-CoV-2 variants on public health and vaccine development -- Importance of continuing genetic surveillance of the virus.…”
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Mitochondrial and lysosomal dysfunction in the pathogenesis of Parkinson's disease

Table of Contents: “…Contents: Pathogenesis of Parkinson's disease (PD) -- Mitochondria (biochemistry, DNA, proteins, turnover) -- Oxidative phosphorylation and respiratory chain -- Fraction of deleted mtDNA in substantia nigra (SN) -- Mitochondrial complex I deficiency in PD -- PARK loci -- The role of mitophagy in mitochondrial turnover -- Common pathways underlying PD pathogenesis -- Ageing and PD pathogenesis -- Autosomal mitochondrial diseases -- POLG mutations -- Alpha-synuclein (SNCA) and mitochondria -- Autophagy, lysosomal dysfunction and Glucocerebrosidase (GCase) -- Gaucher disease -- Chaperone-mediated autophagy: LAMP-2A -- GBA mutations -- DAT density and disease progression in PD -- DaTScan in genetic PD -- GCase-SNCA as a target for PD -- GBA & GBA-SNCA pathway as targets for PD therapies.…”
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Host genetic factors that limit HIV and AIDS

Table of Contents: “…Contents: Overview of candidate gene association studies of HIV and AIDS -- Key role for genetic variants involved in cell entry and host defenses -- Homozygous CCR5 32 basepair deletion prevents HIV Infection -- Acquired Immunity: HLA Class 1 proteins -- Key mediators of HIV progression -- Innate Protection: HLA and KIRS interactions in HIV disease -- Overview of Genome Wide Association Studies (GWAS) -- Overwhelming influence of HLA class I on HIV Progression and control of HIV viral load -- Non-HLA genetic associations with extreme phenotypes -- No new variants identified that prevent HIV infection -- Discovery of chromosome 22 associations with HIV-associated nephropathy -- Future studies -- Epigenetic, proteomic, functional studies -- Potential role of rare variants.…”
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Cross-genomic analysis of human disease genes

Table of Contents: “…Contents: Systematic cross genomic comparison revealed that 75% of human disease genes have clear homologs in Drosophila and that approx. 30% are highly conserved sequences -- The fly is an excellent model multicellular organism for examining the mechanistic function of conserved human disease genes involved in developmental or tissue-related processes -- Normal or mutant human disease genes can be mis-expressed in the fly in localized patterns or at specific times using the GAL4-UAS mis-expression system -- Flies were used to identify candidate target proteins that are regulated by Ube3a and may contribute to Angelman syndrome -- Flies were used to examine the function and interaction of two toxins, Lethal Factor (LF) and Edema Factor (EF), that are produced by Bacillus anthracis -- LF cleaves at least two of the four Drosophila MAPKKs and inhibits the function of a third -- EF inhibits PKA dependent Hedgehog signaling in the fly wing.…”
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Cross-genomic analysis of human disease genes

Table of Contents: “…Contents: Systematic cross genomic comparison revealed that 75% of human disease genes have clear homologs in Drosophila and that approx. 30% are highly conserved sequences -- The fly is an excellent model multicellular organism for examining the mechanistic function of conserved human disease genes involved in developmental or tissue-related processes -- Normal or mutant human disease genes can be mis-expressed in the fly in localized patterns or at specific times using the GAL4-UAS mis-expression system -- Flies were used to identify candidate target proteins that are regulated by Ube3a and may contribute to Angelman syndrome -- Flies were used to examine the function and interaction of two toxins, Lethal Factor (LF) and Edema Factor (EF), that are produced by Bacillus anthracis -- LF cleaves at least two of the four Drosophila MAPKKs and inhibits the function of a third -- EF inhibits PKA dependent Hedgehog signaling in the fly wing.…”
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Host genetic factors that limit HIV and AIDS

Table of Contents: “…Contents: Overview of candidate gene association studies of HIV and AIDS -- Key role for genetic variants involved in cell entry and host defenses -- Homozygous CCR5 32 basepair deletion prevents HIV Infection -- Acquired Immunity: HLA Class 1 proteins -- Key mediators of HIV progression -- Innate Protection: HLA and KIRS interactions in HIV disease -- Overview of Genome Wide Association Studies (GWAS) -- Overwhelming influence of HLA class I on HIV Progression and control of HIV viral load -- Non-HLA genetic associations with extreme phenotypes -- No new variants identified that prevent HIV infection -- Discovery of chromosome 22 associations with HIV-associated nephropathy -- Future studies -- Epigenetic, proteomic, functional studies -- Potential role of rare variants.…”
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Mitochondrial and lysosomal dysfunction in the pathogenesis of Parkinson's disease

Table of Contents: “…Contents: Pathogenesis of Parkinson's disease (PD) -- Mitochondria (biochemistry, DNA, proteins, turnover) -- Oxidative phosphorylation and respiratory chain -- Fraction of deleted mtDNA in substantia nigra (SN) -- Mitochondrial complex I deficiency in PD -- PARK loci -- The role of mitophagy in mitochondrial turnover -- Common pathways underlying PD pathogenesis -- Ageing and PD pathogenesis -- Autosomal mitochondrial diseases -- POLG mutations -- Alpha-synuclein (SNCA) and mitochondria -- Autophagy, lysosomal dysfunction and Glucocerebrosidase (GCase) -- Gaucher disease -- Chaperone-mediated autophagy: LAMP-2A -- GBA mutations -- DAT density and disease progression in PD -- DaTScan in genetic PD -- GCase-SNCA as a target for PD -- GBA & GBA-SNCA pathway as targets for PD therapies.…”
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SARS-CoV-2 mutations phenotypes and implications for vaccine development /

Table of Contents: “…Contents: Currently known SARS-CoV-2 strains -- Likelihood of mutating into a more lethal form of SARS-CoV-2 -- Spike proteins and their role in viral entry into human cells -- SARS-CoV-2 is mutating into a more transmissible or infectious form -- Implications of new SARS-CoV-2 variants on public health and vaccine development -- Importance of continuing genetic surveillance of the virus.…”
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Archaea molecular and cellular biology /

Table of Contents: “…Bell -- DNA-binding proteins and chromatin / Rachel Samson and John N. …”
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Enzymology in drug discovery part 1 of 2 /

Table of Contents: “…Contents: Enzymes as targets for drug discovery -- Protein-ligand binding equilibria -- Enzyme reaction mechanisms -- Structure and function of enzyme active sites -- Measuring enzyme velocity in the laboratory -- Reversible modes of enzyme inhibition -- Enzyme inhibition as a mechanism of pharmacological intervention in disease -- Clinical value of different inhibition modalities -- Non-classical inhibition -- Enzyme assays and screening criteria -- Lead optimization -- Summary: basic information to look for.…”
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Enzymology in drug discovery part 2 of 2 /

Table of Contents: “…Contents: Enzymes as targets for drug discovery -- Protein-ligand binding equilibria -- Enzyme reaction mechanisms -- Structure and function of enzyme active sites -- Measuring enzyme velocity in the laboratory -- Reversible modes of enzyme inhibition -- Enzyme inhibition as a mechanism of pharmacological intervention in disease -- Clinical value of different inhibition modalities -- Non-classical inhibition -- Enzyme assays and screening criteria -- Lead optimization -- Summary: basic information to look for.…”
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The impact of genomic architecture and diversity on infectious diseases

Table of Contents: “…Contents: Genome related paradoxes -- Sequencing the human genome -- Homologs of human proteins -- The genetic basis of human complexity -- Human genetics vs. mouse genetics -- Exons and introns in the human and mouse genomes -- Conclusions about eukaryotic genomes -- Viral genomes and reverse vaccinology -- Pathogenesis of viral infections -- Infectomics and virogenomics of different viruses (SARS, HPV, Dengue & E71) -- Diagnostic virology -- Gene knockdown strategies & siRNA.…”
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Enzymology in drug discovery part 1 of 2 /

Table of Contents: “…Contents: Enzymes as targets for drug discovery -- Protein-ligand binding equilibria -- Enzyme reaction mechanisms -- Structure and function of enzyme active sites -- Measuring enzyme velocity in the laboratory -- Reversible modes of enzyme inhibition -- Enzyme inhibition as a mechanism of pharmacological intervention in disease -- Clinical value of different inhibition modalities -- Non-classical inhibition -- Enzyme assays and screening criteria -- Lead optimization -- Summary: basic information to look for.…”
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Enzymology in drug discovery part 2 of 2 /

Table of Contents: “…Contents: Enzymes as targets for drug discovery -- Protein-ligand binding equilibria -- Enzyme reaction mechanisms -- Structure and function of enzyme active sites -- Measuring enzyme velocity in the laboratory -- Reversible modes of enzyme inhibition -- Enzyme inhibition as a mechanism of pharmacological intervention in disease -- Clinical value of different inhibition modalities -- Non-classical inhibition -- Enzyme assays and screening criteria -- Lead optimization -- Summary: basic information to look for.…”
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Series

The impact of genomic architecture and diversity on infectious diseases

Table of Contents: “…Contents: Genome related paradoxes -- Sequencing the human genome -- Homologs of human proteins -- The genetic basis of human complexity -- Human genetics vs. mouse genetics -- Exons and introns in the human and mouse genomes -- Conclusions about eukaryotic genomes -- Viral genomes and reverse vaccinology -- Pathogenesis of viral infections -- Infectomics and virogenomics of different viruses (SARS, HPV, Dengue & E71) -- Diagnostic virology -- Gene knockdown strategies & siRNA.…”
Get full text
Series

Enzymology in drug discovery part 1 of 2 /

Table of Contents: “…Contents: Enzymes as targets for drug discovery -- Protein-ligand binding equilibria -- Enzyme reaction mechanisms -- Structure and function of enzyme active sites -- Measuring enzyme velocity in the laboratory -- Reversible modes of enzyme inhibition -- Enzyme inhibition as a mechanism of pharmacological intervention in disease -- Clinical value of different inhibition modalities -- Non-classical inhibition -- Enzyme assays and screening criteria -- Lead optimization -- Summary: basic information to look for.…”
Get full text
Series

Enzymology in drug discovery part 2 of 2 /

Table of Contents: “…Contents: Enzymes as targets for drug discovery -- Protein-ligand binding equilibria -- Enzyme reaction mechanisms -- Structure and function of enzyme active sites -- Measuring enzyme velocity in the laboratory -- Reversible modes of enzyme inhibition -- Enzyme inhibition as a mechanism of pharmacological intervention in disease -- Clinical value of different inhibition modalities -- Non-classical inhibition -- Enzyme assays and screening criteria -- Lead optimization -- Summary: basic information to look for.…”
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Cellular and molecular toxicology

Table of Contents: “…Contents: Classification of adverse drug reactions -- How this relates to the chemical structure of the offending drug -- Understanding how variation in drug metabolism can contribute to clinical toxicity is important in designing pre-clinical models and screens -- Case studies of drugs which can form reactive metabolites and can irreversibly modify cellular protein -- Examples of structural modifications to chemicals containing toxicophores -- Novel and traditional serum and cellular biomarkers of adaptation, apoptosis and necrosis.…”
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Mechanistic aspects and therapeutic applications of RNAi

Table of Contents: “…Contents: RNAi mechanisms -- RNAi and HIV infection -- Lentiviral vector-mediated transduction of stem cells and T-cells -- Gene therapy based treatment of HIV-1 -- HIV mutants that abrogate RNAi -- Multiplexing different siRNAs and siRNAs with other antiviral RNAs to minimize viral resistance -- An HIV Tat inducible shRNA expression system -- Multiplexing shRNA with dominant negative M10 protein inhibition of HIV.…”
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How enzymes work : from structure to function / by Suzuki, Haruo, 1941-

Table of Contents: “…Measurement of Individual Rate Constants 5. Structure of Protein 6. Cofactors 7. Search of Active site 8. Control of Enzyme Activity 9. …”
Taylor & Francis
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