Search Results - "prion"

Prions and prion diseases new developments /

Subjects: “…Prion diseases.…”
An electronic book accessible through the World Wide Web; click to view

Prion diseases

Table of Contents: “…Contents: Normal function of prion protein -- Prion diseases -- Mechanism of propagation of PrP -- Propagation in acquired and familial forms -- Pathogenic hypothesis -- Human pathogenic mutation and polymorphisms -- Laboratory methods -- Epidemiology -- Sporadic prion diseases -- New variant CJD -- Treatment of prion disease.…”
Get full text
Series

Prion diseases

Table of Contents: “…Contents: Understanding the biophysical aspects of a disease of protein misfolding -- Structural studies of PrPc and PrPsc -- The development of synthetic mammalian prions and the proof of their infectivity and serial transmissibility -- Heterocyclic pharmacotherapies for prion disease -- Pyridinyl based therapies and structure based design -- Serendipitous discovery of acridines as anti-prion agents -- Bisacridines as potent inhibitors of prion replication in cell culture -- The relationship between the prion diseases and other diseases of protein misfolding.…”
Get full text
Series

Chaperones and prions

Table of Contents: “…Contents: Prion diseases -- Prions as self-propagating amyloids -- Yeast prions as protein-based heritable elements -- Prion detection -- Crucial role of the chaperone protein Hsp104 in the propagation of yeast prions -- Chaperone-mediated fragmentation turns amyloids into infectious or heritable prions -- Effects of the Hsp70 and Hsp40 proteins on yeast prions -- Other modulators of prion formation and propagation: cytoskeleton and ubiquitin system.…”
Get full text
Series

Prions and amyloids introduction /

Table of Contents: “…Contents: Definitions of prions and amyloid -- Genetic criteria for a prion -- Prions of mammals, yeast and filamentous fungi -- Prion domains -- Non-amyloid prions.…”
Get full text
Series

Advancing prion science guidance for the national prion research program /

Table of Contents: “…Executive summary -- Prion diseases: an overview -- Diagnostics for transmissible spongiform encephalopathies -- Testing blood for evidence of transmissible spongiform encephalopathies in the United States -- Assessment of strategies to prevent and treat transmissible spongiform encephalopathies -- Infrastructure for research on transmissible spongiform encephalopathies -- Risks of transmissible spongiform encephalopathies to the U.S. military.…”
An electronic book accessible through the World Wide Web; click to view

Prions in humans and animals

Subjects: “…Prion diseases.…”
An electronic book accessible through the World Wide Web; click to view

Advancing prion science guidance for the National Prion Research Program, interim report /

Subjects: “…Prion diseases Research United States.…”
An electronic book accessible through the World Wide Web; click to view

Prion biology and diseases

Subjects: “…Prions.…”
An electronic book accessible through the World Wide Web; click to view

How the cows turned mad by Schwartz, Maxime, 1940-

Subjects: “…Prion diseases History.…”
An electronic book accessible through the World Wide Web; click to view

Fatal flaws how a misfolded protein baffled scientists and changed the way we look at the brain / by Ingram, Jay

Subjects: “…Prions.…”
An electronic book accessible through the World Wide Web; click to view

Yeast and fungal prions a help or a hindrance? /

Table of Contents: “…Contents: [URE3] and [PSI+] not found in wild strains indicating they are harmful -- [Het-s] may benefit its host or may result from "meiotic drive" -- Some "prion domains" cannot be prions -- "Prion domains" have non-prion functions -- Rapid evolution of prion domains may protect against infection.…”
Get full text
Series

[PIN+] prions beget prions /

Table of Contents: “…Contents: Prions are infectious proteins -- [PIN+] is a prion of Rnq1 - [PIN+] exists as different variants -- Prions can affect the stability of other variants of the same prion, or of heterologous prions.…”
Get full text
Series

How the cows turned mad unlocking the mysteries of mad cow disease / by Schwartz, Maxime, 1940-

Subjects: An electronic book accessible through the World Wide Web; click to view

Mechanism of prion generation in vitro

Table of Contents: “…Contents: Prion propagation in vitro requires PrP plus an incorporated polyanion -- PrPC post-translational modifications influence prion formation -- Zinc and copper inhibit PrPSc amplification.…”
Get full text
Series

Pathogenic mechanisms in prion disease

Table of Contents: “…Contents: Neurodegenerative diseases and protein misfolding disorders -- Prion disease in mice to study mechanisms of neurodegeneration due to misfolded protein accumulation -- Early prion neurodegenerative change is reversible: access to key neurotoxic pathways -- Critical change is loss of synaptic proteins due to activation of PERK branch of the unfolded protein response -- Modifying this pathway genetically is neuroprotective -- Modifying this pathway pharmacologically is neuroprotective -- Relevance of this pathway in other neurodegenerative diseases with misolded proteins e.g. …”
Get full text
Series

Mechanisms of yeast prion propagation

Table of Contents: “…Contents: Prions as infectious amyloids -- Yeast [PSI+] prion and Sup35p -- Molecular chaperone Hsp104 -- Guanidine hydrochloride as a prion propagation inhibitor -- Propagons -- Estimating propagon numbers using a stochastic model -- Generation of new propagons -- Propagation-defective mutants (PNM) -- Role of primary sequence information -- Yeast prion propagation: the unanswered questions.…”
Get full text
Series

Yeast prions and protein chaperones a help or a hindrance? /

Table of Contents: “…Contents: Role of protein chaperones in protein folding -- Yeast prions as amyloid forms of cellular proteins -- Requirement of chaperone machinery for prion propagation -- Chaperone mutants adversely affect prions and provide insight into chaperone/amyloid interactions.…”
Get full text
Series

The genetics and biology of the [Het-s] prion of Podospora

Table of Contents: “…Contents: Mammalian prions -- Fungal prions -- Yeast: [URE3], [PSI+] and [PIN+] -- Filamentous fungi: [Het-s] -- Fungal self non-self recognition -- Heterokaryon incompatibility -- Genetics of [Het-s] -- Maternal inheritance -- Meiotic drive -- In vivo and in vitro aggregation of HET-s protein -- Role of the Hsp104 chaperone in [Het-s] system -- Role of the Hsp104 chaperone in [Het-s] prion propagation -- Podospora anserine.…”
Get full text
Series

Prion-like propagation of Parkinson's disease

Table of Contents: “…Contents: Parkinson's disease : symptoms and pathology (PD mutations and risk factors) -- Braak staging of Lewy body-related pathology in PD -- The prion-like hypothesis -- Key steps of alpha-synuclein pathology propagation (Release, Uptake, Seeding, Transport) -- In vivo and cell models from different species -- Therapeutic targets: promoting degradation, antibody aided clearance, and preventing seeding of alpha-synuclein -- Parkinson's disease vaccine: first clinical studies.…”
Get full text
Series