Search Results - "prion"

Protein aggregation, metals and oxidative stress in neurodegenerative diseases

Table of Contents: “…Contents: Introduction to protein conformational brain diseases -- Alzheimer's disease, A-beta and tau -- A-beta oligomers and toxicity -- A-beta generates hydrogen peroxide -- Results from experiments using electron spin resonance spectroscopy -- Parkinson's disease -- Generation of hydrogen peroxide from alpha synuclein, toxic fragments of the prion protein and the familial British dementia peptide -- Early oligomers appear to generate hydrogen peroxide -- Huntington's disease -- Protein aggregates could be protective -- Potential common toxic pathway for these brain diseases.…”
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Metal-based neurodegeneration : from molecular mechanisms to therapeutic strategies / by Crichton, Robert R.

Table of Contents: “…Brain function, physiology, and the blood-brain barrier -- Role of metal ions in brain function, metal transport, storage, and homeostasis -- Immune system and neuroinflammation -- Oxidative stress in neurodegenerative diseases -- Aging and mild cognitive impairment, MCI -- Parkinson's disease -- Alzheimer's disease -- Huntington's disease and polyglutamine expansion neurodegenerative diseases -- Friedreich's ataxia and diseases associated with expansion of non-coding triplets -- Creutzfeldt-Jakob and other prion diseases -- Amyotropic lateral sclerosis -- Alcoholic brain damage -- Other neurological diseases -- Therapeutic strategies to combat the onset and progression of neurological diseases.…”
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Protein degradation and defense against neurodegenerative disease part 2 of 2 /

Table of Contents: “…Contents: The 26S proteasome -- The 20S proteasome -- Proteasome inhibitors -- PS-341 -- Proteasome inhibitors in multiple myeloma -- Structures of the archaeal PAN ATPase-20S complex and the eukaryotic 26S proteasome -- Multiple ATP-dependent steps in proteasome function -- The gating mechanism of the proteasome -- Prions inhibit proteasome function -- Binding of ubiquitin conjugates activate the 26S proteasome by stimulating 20S gate-opening and ATP hydrolysis -- Ubiquitin conjugates activate their own degradation by the 26S Proteasome -- The inhibitor of proteasome-associated deubiquitinating enzyme Usp14, IU1, enhances degradation of tau.…”
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Biological safety principles and practices /

Table of Contents: “…Microbial flora of humans and microbial virulence factors -- Indigenous and pathogenic agents of research animals -- Laboratory, growth chamber, and greenhouse microbial safety: plant pathogens and plant-associated microorganisms of significance to human health -- Epidemiology of laboratory-associated infections -- Risk assessment of biological hazards -- Bacterial pathogens -- Protozoa and helminths -- Mycotic agents of human disease -- Viral agents of human disease: biosafety concerns -- Biosafety for microorganisms transmitted primarily by the airborne route -- Cell lines: applications and biosafety -- Allergens of animal and biological systems -- Biological toxins: safety and science -- Design of biomedical laboratory facilities -- Primary barriers and equipment-associated hazards -- Priamry barriers: biological safety cabinets, fume hoods, and glove boxes -- Personal respiratory protection -- Standard (Universal) precautions for handling human specimens -- Prudent biosafety practices -- Decontamination and disinfection -- Packing and shipping biological materials -- Biological safety program management -- Biosafety compliance: a global perspective -- Occupational medicine in a biomedical research setting -- Measuring biosafety program effectiveness -- Biosafety of prion diseases -- Safety considerations in the BSL-4 maximum-containment laboratory -- Biosafety and viral gene transfer vectors -- Biosafety in the teaching laboratory -- Biosafety in the pharmaceutical industry -- Large-scale production of microorganisms -- Special considerations for agriculture pathogen biosafety -- Biosafety and biosecurity: regulatory impact.…”
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Targeting Aß oligomers a molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease /

Table of Contents: “…Contents: The oligomer cascade hypothesis for Alzheimer's Disease -- Why the oligomer hypothesis has largely supplanted the amyloid cascade hypothesis -- The role of AβOs in memory failure and the major facets of AD neuropathology -- Mechanisms by which AβOs instigate neurotoxicity -- Why AβOs accumulate in the first place -- How AβOs offer superb targets for novel AD diagnostics and disease-modifying therapeutics -- Beside its direct link to Alzheimer's disease, the discovery of toxic Aβ oligomers has provided a novel structural archetype for toxins germane to more than two dozen diseases of protein mis-folding, including Diabetes, Parkinson's, and prion diseases.…”
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The differential diagnosis of chorea /

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Infectious diseases of wild mammals and birds in Europe

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The behavioral neurology of dementia

Table of Contents: “….] -- CADASIL : a genetic model of arteriolar degeneration, white matter injury, and dementia in later life / Stephen Salloway ... [et al.] -- Prion disorders and other rapidly progressive dementias / Michael D. …”
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A concise manual of pathogenic microbiology by Mishra, Saroj (Saroj K.)

Table of Contents: “…Prions are added at the end.…”
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Infectious diseases of the dog and cat : a color handbook.

Table of Contents: “…Viral: Rabies, EEE, West Nile virus, Pseudorabies, Distemper, Prions. Chapter 5: The Skin and Wounds: A. The Skin: Parasitic: Otodectes, Demodex, Cheyletiella, Sarcoptes, Notoedres, Sporothrix, Cuterebra. …”
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Merritt's neurology.

Table of Contents: “…Signs and symptoms in neurologic diagnosis: approach to the patient -- Delirium and confusion -- Memory loss, behavioral changes and dementia -- Aphasia, apraxia, and agnosia -- Syncope, seizures and their mimics -- Coma -- Headache -- Diagnosis of pain and paresthesias -- Dizziness, vertigo, and hearing loss -- Impaired vision -- Involuntary movements -- Syndromes caused by weak muscles -- Gait disorders -- CT and MRI -- Electroencephalography and evoked potentials -- Electromyography, nerve conduction studies, and and magnetic stimulation -- Autonomic testing -- Neurovascular imaging -- Endovascular neuroradiology -- Lumbar puncture and cerebrospinal fluid examination -- Muscle and nerve biopsy -- Neuropsychological evaluation -- DNA diagnosis -- Bacterial infections -- Focal infections -- Viral infections and postviral syndromes -- Human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) -- Fungal infections -- Neurosarcoidosis -- Neurosyphilis -- Leptospirosis -- Lyme disease -- Parasitic infections -- Bacterial toxins -- Prion diseases -- Whipple disease -- Pathogenesis, classification, and epidemiology of cerebrovascular disease -- Examination of the patient with cerebrovascular disease -- Transient ischemic attack -- Cerebral infarction -- Intracerebral hemorrhage -- Genetics of stroke -- Other cerebrovascular syndromes -- Differential diagnosis of stroke -- Stroke in children -- Treatment and prevention of stroke -- Subarachnoid hemorrhage -- Cerebral venous and sinus thrombosis -- Vascular disease of the spinal cord -- Vasculitis -- Susac syndrome -- Vascular tumors and malformations -- Hydrocephalus -- Normal pressure hydrocephalus (NPH) -- Brain edema and disorders of intracranial pressure -- Superficial siderosis and intracerebral hypotension -- Hyperosmolar syndromes -- General considerations -- Tumors of the skull and cranial nerves -- Tumors of the meninges -- Gliomas -- Lymphomas -- Pineal region tumors -- Tumors of the pituitary gland -- Congenital and childhood tumors -- Metastatic tumors -- Spinal tumors -- Paraneoplastic syndromes -- Complications of cancer chemotherapy --…”
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Microbes concepts and applications / by Bisen, Prakash S.

Table of Contents: “…Molecular Diagnostic and Medical Microbiology 3.1 Prologue 3.2 Microbial biology 3.3 Infection and immunity 3.4 Bacterial pathogens and associated diseases 3.5 Viral pathogen and associated diseases 3.6 Prions 3.7 Parasitic infections 3.8 Fungal pathogen 3.9 Microbial diagnostics 3.10 Future challenges: Promises of pharmacogenomics and molecular testing Chapter 4. …”
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Ensuring food safety in the European Union / by Silano, V., Silano, Marco

Table of Contents: “…2.3.4 Parasites -- 2.3.5 Prions and BSE Crisis (Discovery and Evolution, Geographical BSE Risk Assessment and Risk Organ Removal and Other Control Tools) -- Chapter 3 The EU Mandate to Promote Food Safety and "The White Paper on Food Safety" and the "Farm to Table" Legislation -- 3.1 Introduction -- 3.2 The EU Mandate to Promote Food Safety -- 3.3 The White Paper on Food Safety and the "Farm to Table" Legislative Action -- 3.3.1 The European Food Safety Authority -- 3.3.2 Food Safety Legislation -- 3.3.3 Control of Legislation Implementation -- 3.3.4 Consumer Information…”
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Veterinary Research

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