Search Results - "histone"

RNAi and heterochromatin in plants and fission yeast

Table of Contents: “…Contents: Heterochromatin is composed of transposable elements (TEs) and related repeats -- heterochromatic gene silencing and TE-mediated silencing are related and may be important in large genomes -- tiling microarrays can be used to examine heterochromatic transcripts as well as DNA and histone modification -- small interfering RNA (siRNA) corresponds to transposons and repeats -- in plants TE siRNA depend on DNA methyltransferase MET1 and the SWI/SNF ATPase DDM1 which silence TEs via DNA and histone H3 lysine-9 (H3K9) methylation -- in fission yeast and plants centromeric repeats are transcribed on one strand but rapidly turned over by RNA interference (RNAi) -- RNAi of centromeric transcripts is required for transcriptional silencing of reporter genes -- RNA polymerase II, the Argonaute (RITS) and RNA dependent RNA polymerase (RDRC) complexes are associated with heterochromatin and required for silencing -- H3K9me2 depends on RNAi and on the Rik1-Clr4 complex -- Clr4 is the histone H3K9 dimethyltransferase -- Rik1 resembles both DNA and RNA binding proteins and is required for RNAi along with Clr4 -- LTR retrotransposon silencing depends on histone deacetylation and silences pericentromeric repeats in Arabidopsis in addition to RNAi.…”
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Series (Epigenetics)
Series (RNA interference)

From DNA to proteins the multiple levels of regulation /

Table of Contents: “…Contents: General ideas behind DNA association with: histones, replication, transcription, splicing, RNA modifications, protein synthesis and death and global gene expression analysis.…”
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Skin epigenetics how chromatin regulators orchestrate skin functions /

Table of Contents: “…-- Genes encoding keratinocyte-specific proteins -- Molecular signature of epidermal layers -- Levels of epigenetic regulation -- DNA methylation and hydroxymethylation -- DNA methylation influence on the epidermis -- Post-translational histone/covalent modifications -- Histone acetylation/de-acetylation -- Polycomb-repressive complex -- Polycomb and Trithorax play antagonistic roles -- ATP-dependent chromatin remodeling -- Non-coding RNA-dependent mechanisms -- Nucleus: storage, replication of genetic material -- Topological gene interactomes -- Morphogenesis of the epidermis -- Epidermal differentiation complex -- EDC and Lor relocation to nuclear interior -- p63 and Brg1 ablation results in retention of EDC -- Genome organizer AT-rich binding Satb1 protein -- Transcription factor and epigenetic mechanisms -- Future directions of epigenetic research.…”
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Heterochromatin, epigenetics and gene expression

Table of Contents: “…Contents: Heterochromatin as a cytological phenomenon -- Heterochromatin and gene silencing -- Heterochromatin and DNA accessibility -- Histone modification and control of heterochromatin assembly -- Stability of epigenetic silencing by heterochromatin during development -- Heterochromatin and telomere stability.…”
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Series (Epigenetics, chromatin, transcription and cancer)
Series (Molecular genetics of human disease)

Genomic imprinting and its regulation

Table of Contents: “…Contents: Introduction to imprinting -- classic embryological and genetic studies -- identification and function of imprinted genes -- imprinted domains and the organisation of imprinted clusters -- epigenetic modifications and genome programming -- cis-acting control at imprinted domains -- DNA methylation and non-coding RNA -- histone modifications -- clinical implications.…”
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Epigenetics a historical overview / by Holliday, Robin, 1932-

Table of Contents: “…Contents: Introduction to epigenetics -- the leading pioneers in the field of epigenetics -- the basic features of development -- switching and heritability of gene activities -- DNA methylation -- epimutations -- differences between genetics and epigenetics -- genomic imprinting -- chromatin structure -- histone modifications -- the role of RNA in the epigenetic regulation of gene activity -- the bisulfite sequencing technique -- the epigenotype.…”
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Genetic variation in gene regulation

Table of Contents: “…Contents: Expression Quantitative Trait Loci: linking genetic variation to changes in gene regulation -- How do SNPs impact gene regulation -- HapMap cell lines as a model system for studying expression variation -- eQTL analysis -- dsQTL -- Histone marks -- Protein-specific QTLs.…”
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Epigenetic regulation of innate immunity

Table of Contents: “…Contents: The innate immune cells -- Pathogen sensing receptor system -- Histone modifications and inflammation control -- Critical role of Jmjd3, a trimethyl H3K27 specific demethylase, in M2 macrophage differentiation -- Identification of IRF4 as a Jmjd3 target gene inducing M2 macrophages.…”
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DNA methylation and genome defense in Neurospora crassa

Table of Contents: “…Contents: Control of DNA methylation -- repeat-induced point (RIP) mutation -- relationship of chromatin modifications and DNA methylation -- mutants that eliminate DNA methylation -- roles of histone H3 methyltransferase (DIM-5) and heterochromatin protein 1 (HP1) in DNA methylation -- indications of involvement of protein acetylation, methylation and phosphorylation in mechanism of DNA methylation -- propagation of DNA methylation and the associated silenced chromatin state.…”
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Telomerase composition, functions and clinical implications /

Table of Contents: “…Telomerase beyond telomeres : new roles for an old enzyme / Gabriele Saretzki -- Telomerase and telomeric proteins : a life beyond telomeres / Ilaria Chiodi, Cristina Belgiovine, Chiara Mondello -- Histone deacetylase inhibition as an anticancer telomerase-targeting strategy / Ruman Rahman -- Telomerase role in pituitary adenomas / A. …”
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A historical perspective on ideas on X-chromosome inactivation

Table of Contents: “…Contents: The phenomenon of X-chromosome inactivation in female mammals -- X-chromosome inactivation as a dosage compensation mechanism for equalising the dosage of X-linked gene products in XY males and XX females in somatic cells -- inactivity of either the maternal or paternal X-chromosome in different cells in eutherian mammals -- preferential inactivation of paternal X in the placenta of mice and in all cells of marsupials -- initiation of the process from an X-inactivation centre -- discovery of the key gene, Xist -- the concept of initiation and maintenance of X-inactivation as separate processes -- histone modifications and methylation of CpG islands as maintenance mechanisms -- inactivation in autosomal and X-chromosomal DNA -- LINE1s as booster elements on the X-chromosome.…”
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Asthma an epidemic caused by epigenetics? /

Table of Contents: “…Contents: Genetic and biological determinants of diseases influenced by the environment -- Epigenetics -- Epigenetic mechanisms can be influenced by environmental exposures and aging -- Histone modifications and innate immunity -- Asthma is a major public health problem -- Epigenetics and airway immunology -- DNA methylation changes and asthma -- Runx3 and airway disease -- In utero folate supplementation and asthma -- Sib pair asthma study -- preliminary analysis -- Global methylation patterns: asthmatics vs. nonasthmatics -- Hypomethylation of GATA3 or MUC5B is associated with asthma in concordant sib pairs -- Hypermethylation of NOS2 is associated with concordant asthma -- Asthma: an epidemic caused by epigenetics?…”
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Small interfering RNA induced transcriptional gene silencing in human cells

Table of Contents: “…Contents: How siRNAs mediate transcriptional gene silencing (TGS) in human cells -- Histone methylation -- Dependency on active RNA polymerase II mediated transcription -- siRNA-mediated TGS -- H3K9 and H3K27 methylation of the targeted EF1A promoter -- Nuclear specific delivery of the siRNA -- Antisense strand-specific siRNA-mediated TGS of EF1A -- Targeting of the U3 region of the HIV-1 LTR/promoter -- Antisense strand of siRNA EF2 interacts with FLAG-tagged DNMT3A and the tri-methylated H3K27 methyl mark -- siRNA mediated targeting of genomic regions -- RNA Pol-II function -- Transcriptional gene silencing in human cells.…”
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Nuclear receptors transcriptional functions /

Table of Contents: “…Contents: Introduction to transcription factors -- Nuclear receptors as ligand-dependent transcription factors -- Classes of nuclear receptor -- Nuclear receptor ligands: agonists and antagonists -- Nuclear receptor phylogeny -- Nuclear receptor isoforms -- The nuclear receptor DNA-binding domain -- Hormone response elements -- The nuclear receptor ligand-binding domain -- Nuclear receptor mechanism -- Subcellular localization of nuclear receptors -- The effect of ligand binding -- Nuclear receptor coregulators -- Initial discoveries of coregulators -- The SRC/p160 coregulator family -- Nuclear receptor-coregulator interaction motifs -- Histone acetylation and chromatin structure -- The Nuclear Receptor Signaling Atlas (NURSA) -- Chromatin immunoprecipitation as a tool in nuclear receptor mechanism -- Functional differences between type I and type II nuclear receptors -- The coregulator exchange -- DNA-binding independent functions -- Transrepression -- The role of kinases.…”
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The bacterial pathogen Listeria monocytogenes an amazing multifaceted model /

Table of Contents: “…-- Epidemiological survey -- InlA and InlB play interdependent roles during feto-placental listeriosis -- Roles of InlA and InlB in infection -- Comparative genomics -- Histone modifications -- Epigenetics and bacterial infectious diseases.…”
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Acute lymphoblastic leukemia etiology, pathogenesis and treatments /

Table of Contents: “…Hendriks -- Childhood acute lymphoblastic leukemia / Adriana Zámecníkova -- Systems approaches to childhood leukemogenesis / George I. Lambrou -- Histone deacetylase inhibitors : pre-clinical and clinical evidence in treating acute lymphoblastic leukemia / Ana Lucia Abujamra -- A therapeutic target in leukemia : the NK-1 receptor / Miguel Muñoz, Ana González-Ortega, Rafael Coveñas -- Minimal residual disease monitoring in childhood acute lymphoblastic leukemia / Katerina Katsibardi -- Clinical relevance and application of cytogenetic approaches in pediatric acute lymphoblastic leukaemia / Maria Braoudaki -- Maintenance therapy in Ph negative adult acute lymphoblastic leukemia / Michael Doubek, Jirí Mayer -- The role of innate and adaptive immunity in childhood acute lymphoblastic leukemia / Maria Hatzistilianou, Agiou Ioannou.…”
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Epigenetics and Assisted Reproduction An Introductory Guide. by Camprubí, Cristina

Table of Contents: “…Cover; Half Title; Title Page; Copyright Page; Contents; Preface; Contributors; Chapter 1: A Short Introduction to DNA Methylation; Chapter 2: Epigenetic Modifications of Histones; Chapter 3: Epigenetic Reprogramming in Early Embryo Development; Chapter 4: Epigenetic Reprogramming of Mammalian Primordial Germ Cells; Chapter 5: Laboratory Molecular Methodologies to Analyze DNA Methylation; Chapter 6: Intrinsic and Extrinsic Factors That Influence Epigenetics; Chapter 7: Epigenetic and Assisted Reproduction Epidemiological Studies…”
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Epigenetics and pathology : exploring connections between genetic mechanisms and disease expression /

Table of Contents: “…Pathak, and Shiraz Mujtaba -- 6. Roles of histone deacetylases in epigenetic regulation : emerging paradigms from studies with inhibitors / Genevieve P. …”
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Human Life (Before Birth by Dye, Frank J. (Frank John), 1942-

Table of Contents: “…Role and types of cell divisionMitosis; The cell cycle; Chromosomes; Genes; Spindle; Meiosis; Reduction of the number of chromosomes; Random segregation of chromosomes; Crossing over; Significance of meiosis; Epigenesis-histone proteins and deoxyribonucleic acid methylation; Stem cells; Study questions; Critical thinking; 4. …”
Taylor & Francis
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