Search Results - "epigenetics"

Pharmaceutical Biocatalysis : Drugs, Genetic Diseases, and Epigenetics /

Taylor & Francis
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Asthma an epidemic caused by epigenetics? /

Table of Contents: “…Contents: Genetic and biological determinants of diseases influenced by the environment -- Epigenetics -- Epigenetic mechanisms can be influenced by environmental exposures and aging -- Histone modifications and innate immunity -- Asthma is a major public health problem -- Epigenetics and airway immunology -- DNA methylation changes and asthma -- Runx3 and airway disease -- In utero folate supplementation and asthma -- Sib pair asthma study -- preliminary analysis -- Global methylation patterns: asthmatics vs. nonasthmatics -- Hypomethylation of GATA3 or MUC5B is associated with asthma in concordant sib pairs -- Hypermethylation of NOS2 is associated with concordant asthma -- Asthma: an epidemic caused by epigenetics?…”
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Heterochromatin, epigenetics and gene expression

Table of Contents: “…Contents: Heterochromatin as a cytological phenomenon -- Heterochromatin and gene silencing -- Heterochromatin and DNA accessibility -- Histone modification and control of heterochromatin assembly -- Stability of epigenetic silencing by heterochromatin during development -- Heterochromatin and telomere stability.…”
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Series (Epigenetics, chromatin, transcription and cancer)
Series (Molecular genetics of human disease)

Epigenetics in age-related macular degeneration

Table of Contents: “…Contents: Epigenetics: terms and definitions -- Evidence for role of epigenetics in age-related macular degeneration (AMD) -- Future directions (potential for novel treatments for AMD).…”
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Epigenetic control by histone methylation

Table of Contents: “…Contents: The diversity of covalent histone tail modifications for imparting epigenetic information -- Observations of robust histone modifications at silent chromatin regions -- The representation of repressive histone marks as indications of epigenetic plasticity in different cells -- Analysis of the profiles of normal and aberrant histone lysine methylation patterns, as they occur during the transition of an embryonic to a differentiated cell or in controlled self-renewal vs. pro-neoplastic or metastatic conditions -- Elucidation of these histone modification patterns for novel advances in stem cell research, nuclear reprogramming and cancer.…”
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Epigenetically mediated gene silencing a companion to genetic alterations in driving tumorigenesis /

Table of Contents: “…Contents: Introduction to epigenetic changes in cancer -- defining the process of promoter DNA hypermethylation as a constituent of a broad range of chromatin abnormalities in cancer -- defining the genes aberrantly silenced in cancer including approaches being used to screen the cancer genome for such genes -- defining what is known about the interaction of DNA methylation and chromatin modifications for initiating and maintaining gene silencing in cancer -- outlining the position of aberrant gene silencing in tumor progression and particularly highlighting the key role these changes may play for the earliest steps in tumorigenesis -- defining the potential for using DNA hypermethylated gene promoter sequences as molecular markers for cancer risk assessment, early diagnosis and prognosis -- discussing the possibilities for targeting reversal of gene silencing as a prevention and therapeutic strategy for cancer.…”
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Epigenetic regulation of innate immunity

Subjects: “…Epigenetics. 107187…”
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Epigenetic pharmaceuticals used in the clinic

Table of Contents: “…Contents: Epigenetic drugs in chemotherapy -- Selecting patients for epigenetic therapy -- Side effects of epigenetic agents -- Unique therapeutic mechanisms of epigenetic treatments -- How is epigenetic therapy applied? …”
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Epigenetic information in gene expression and cancer

Table of Contents: “…Contents: Types and functions of histone modifications -- Histone code hypothesis -- Epigenetics and transcription regulation -- Relevance for human disease.…”
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Evolution of mammal epigenetic control systems

Table of Contents: “…Contents: How, when and why did epigenetic silencing evolve in mammals? -- examination of two mammal-specific systems, genomic imprinting and X-chromosome inactivation, from an evolutionary standpoint, using comparisons between humans, distantly related mammals (marsupials and monotremes) and other vertebrates -- independent evolution of imprinting in different genomic regions and correlation with evolution of viviparity -- step-wise evolution of the elements of the complex X-chromosome inactivation mechanism -- shared features of imprinting and X-inactivation.…”
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Histone modifications and prospects for an epigenetic code

Table of Contents: “…Contents: Enzyme-catalyzed modification of the N-terminal tail domains of core histones provides an array of marks across the nucleosome surface and a source of epigenetic information -- This information influences protein-protein interactions during short-term regulation of ongoing transcription and is a means of maintaining or modifying patterns of gene expression from one cell generation to the next -- Cellular memory -- Histone modifications may constitute a heritable epigenetic code that acts in concert with the genetic code as a long-term regulator of gene expression.…”
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Epigenetics as a paradigm for cancer treatment chemically targeting the histone lysine methyltransferase EZH2 /

Table of Contents: “…Contents: Cancer as an unmet medical need -- Epigenetics as a paradigm for treating cancer -- Histone lysine methyltransferase EZH2 as a target class example -- Development of EZH2 inhibitors.…”
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Chromatin genes and disease

Table of Contents: “…Contents: Chromatin genes and disease -- Epigenetics: the phenotype reflects the pattern of gene expression -- The role of chromatin in epigenetic regulation -- Epigenetic factors and their role in gene expression -- Human diseases involving epigenetic factors.…”
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Nuclear cloning, stem cells and epigenetic reprogramming

“…Biomedical & life sciences collection. Epigenetics : concepts, theories, paradigms and mechanisms.…”
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The dynamic interactions between cellular-molecular physiology and the environment part 2, The unicellular state as the level of selection - epigenetics /

Table of Contents: “…Contents: Select epigenetic "marks" are retained from generation to generation -- Inter- and transgenerational transmission of epigenetic marks is via germline cells -- approximately 97 per cent of human genetic diseases are likely caused by epigenetic inheritance -- Epigenetics allows for redefinition of terms in descriptive biology -- Epigenetic inheritance leads to the zygote as the primary level of selection -- The cellular-molecular approach to biology is predictive.…”
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Mental retardation and developmental delay genetic and epigenetic factors / by Smith, Moyra

An electronic book accessible through the World Wide Web; click to view

Cancer-specific epigenetic alterations as investigated from a pharmaceutical perspective

Table of Contents: “…Contents: Chromatin dysregulation in cancer -- Features of epigenetic information in cells -- Mutated chromatin regulatory factors as tumor drivers -- Therapeutic rationale for the use of epigenetic drugs in oncology -- First generation epigenetic drugs: DNMT and HDAC inhibitors -- Novel therapeutic discoveries in oncology -- Biomarkers for patient selection.…”
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Evolution in four dimensions : genetic, epigenetic, behavioral, and symbolic variation in the history of life / by Jablonka, Eva, Lamb, Marion J.

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Imprinting disorders associated with molecular changes on chromosome 11p15

Table of Contents: “…Contents: What is epigenetics? -- Epigenetic regulation forms the molecular basis for genomic imprinting -- What is genomic imprinting -- Imprinted genes in early development -- Genomic organization of imprinted genes -- Imprinting center -- Imprinted domain 1 on chromosome 11p15.5 -- Complexity of imprinted clusters -- Beckwith-Wiedemann syndrome (BWS) -- BWS: a complex, clinically heterogeneous disorder -- Molecular basis of BWS -- Etiology of the Beckwith-Wiedemann syndrome -- Molecular alterations associated with BWS -- Frequency of molecular alterations in BWS -- The risks to subfertile/ART treated parents -- Subfertility/assisted reproductive technologies (ART) -- BWS molecular defects -- Multiple phenotypes associated with somatic mosaicism for 11p15 UPD -- Somatic mosaicism -- Isolated hemihyperplasia -- High level constitutional UPD -- BWS molecular testing strategies -- Laboratory testing for BWS -- MS-MLPA -- Expected methylation results from MS-MLPA -- MLPA molecular testing for BWS -- Cancer risk & surveillance -- Prenatal testing options -- Current challenges in BWS molecular testing -- Frequency of CNVs according to methylation pattern -- Monozygotic twins and BWS -- Isolated hemihyperplasia -- Current challenges in chromosome 11p15 molecular testing -- Russell-Silver syndrome (RSS -- Chromosomal regions associated with RSS -- Targeted assays of multiple imprinted loci-BWS -- Different combinations of epigenetic alterations associated with variations in clinical phenotype -- Imprint deregulation causing disease in humans.…”
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Left-right asymmetry in embryonic development how epigenetic, biophysical forces and gene activity interplay to determine a major embryonic axis /

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