Search Results - "drug discovery"

Mass spectrometry in drug metabolism and disposition basic principles and applications /

Table of Contents: “…(Publisher-supplied data) Part I Basic Concepts of Drug Metabolism and Disposition -- The Progression of Drug Metabolism -- Common Biotransformation Reactions -- Metabolic Activation of Organic Functional Groups Utilized in Medicinal Chemistry -- Drug Metabolizing Enzymes, Transporters and Drug-Drug Interactions -- Experimental Models of Drug Metabolism and Disposition -- Principles of Pharmacokinetics: Predicting Human Pharmacokinetics -- Drug Metabolism Research as an Integral Part of the Drug Discovery and Development Processes -- Part II Mass Spectrometry in Drug Metabolism: Principles and Common Practice -- Theory and Instrumentation of Mass Spectrometry -- Common Liquid Chromatography-Mass Spectrometry (LC-MS) Methodology for Metabolite Identification -- Mass Spectral Interpretation -- Techniques to Facilitate the Performance of Mass Spectrometry: Sample Preparation, Liquid Chromatography and Non-Mass Spectrometric Detection -- Part III Applications of New LC/MS Techniques in Drug Metabolism and Disposition -- Quantitative In Vitro ADME Assays using LC-MS as a Part of Early Drug Metabolism Screening -- High Resolution Mass Spectrometry and Drug Metabolite Identification -- Distribution Studies of Drugs and Metabolites in Tissue by Mass Spectrometric Imaging -- Use of Triple Quadrupole-Linear Ion Trap Mass Spectrometry as a Single LC/MS Platform in Drug Metabolism and Pharmacokinetics Studies -- Quantitative Drug Metabolism with Accelerator Mass Spectrometry -- Standard-Free Estimation of Metabolite Levels Using Nanospray Mass Spectrometry: Current Statutes and Future Directions -- Profiling and Characterization of Herbal Medicine and their Metabolites using LC-MS -- Liquid Chromatography Mass Spectrometry Bioanalysis of Proteins in Biological Matrices -- Mass Spectrometry in the Analysis of DNA, Protein, Peptide, and Lipid Biomarkers of Oxidative Stress -- LC-MS in Endogenous Metabolite Profiling and Small Molecule Biomarker Discovery.…”
An electronic book accessible through the World Wide Web; click to view

Mass spectrometry in drug metabolism and disposition basic principles and applications /

Table of Contents: “…(Publisher-supplied data) Part I Basic Concepts of Drug Metabolism and Disposition -- The Progression of Drug Metabolism -- Common Biotransformation Reactions -- Metabolic Activation of Organic Functional Groups Utilized in Medicinal Chemistry -- Drug Metabolizing Enzymes, Transporters and Drug-Drug Interactions -- Experimental Models of Drug Metabolism and Disposition -- Principles of Pharmacokinetics: Predicting Human Pharmacokinetics -- Drug Metabolism Research as an Integral Part of the Drug Discovery and Development Processes -- Part II Mass Spectrometry in Drug Metabolism: Principles and Common Practice -- Theory and Instrumentation of Mass Spectrometry -- Common Liquid Chromatography-Mass Spectrometry (LC-MS) Methodology for Metabolite Identification -- Mass Spectral Interpretation -- Techniques to Facilitate the Performance of Mass Spectrometry: Sample Preparation, Liquid Chromatography and Non-Mass Spectrometric Detection -- Part III Applications of New LC/MS Techniques in Drug Metabolism and Disposition -- Quantitative In Vitro ADME Assays using LC-MS as a Part of Early Drug Metabolism Screening -- High Resolution Mass Spectrometry and Drug Metabolite Identification -- Distribution Studies of Drugs and Metabolites in Tissue by Mass Spectrometric Imaging -- Use of Triple Quadrupole-Linear Ion Trap Mass Spectrometry as a Single LC/MS Platform in Drug Metabolism and Pharmacokinetics Studies -- Quantitative Drug Metabolism with Accelerator Mass Spectrometry -- Standard-Free Estimation of Metabolite Levels Using Nanospray Mass Spectrometry: Current Statutes and Future Directions -- Profiling and Characterization of Herbal Medicine and their Metabolites using LC-MS -- Liquid Chromatography Mass Spectrometry Bioanalysis of Proteins in Biological Matrices -- Mass Spectrometry in the Analysis of DNA, Protein, Peptide, and Lipid Biomarkers of Oxidative Stress -- LC-MS in Endogenous Metabolite Profiling and Small Molecule Biomarker Discovery.…”
An electronic book accessible through the World Wide Web; click to view

Molecular principles of fungal pathogenesis

Table of Contents: “…Lorenz -- Future of functional genomics of Histoplasma capsulatum / Anita Sil and Lena Hwang -- Functional genomic approaches to fungal pathogenesis, drug target validation, and antifungal drug discovery / Ainslie B. Parsons, Howard Bussey, and Charles Boone -- Genetic and proteomic analysis of fungal virulence / Jennifer K. …”
An electronic book accessible through the World Wide Web; click to view

Neural stem cell assays /

Table of Contents: “…Genetic reporter cell lines: Tools for stem cell biology and drug discovery / Cameron PJ Hunt, Bradley Watmuff, Brigham J Hartley, Colin W Pouton, and John M Haynes.…”
An electronic book accessible through the World Wide Web; click to view

Molecular principles of fungal pathogenesis

Table of Contents: “…Lorenz -- Future of functional genomics of Histoplasma capsulatum / Anita Sil and Lena Hwang -- Functional genomic approaches to fungal pathogenesis, drug target validation, and antifungal drug discovery / Ainslie B. Parsons, Howard Bussey, and Charles Boone -- Genetic and proteomic analysis of fungal virulence / Jennifer K. …”
An electronic book accessible through the World Wide Web; click to view

Neural stem cell assays /

Table of Contents: “…Genetic reporter cell lines: Tools for stem cell biology and drug discovery / Cameron PJ Hunt, Bradley Watmuff, Brigham J Hartley, Colin W Pouton, and John M Haynes.…”
An electronic book accessible through the World Wide Web; click to view