Search Results - "chromatin"

Legacy of Drosophila genetics female germline stem cells /

Table of Contents: “…Contents: Lineage tracing -- Stem cell niches -- Germline stem cell niche in ovary -- Germline stem cell niche in testis – Dedifferentiation -- Stem cell signaling back to the niche -- Intestinal stem cells -- Stem cell chromatin.…”
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Cancer-specific epigenetic alterations as investigated from a pharmaceutical perspective

Table of Contents: “…Contents: Chromatin dysregulation in cancer -- Features of epigenetic information in cells -- Mutated chromatin regulatory factors as tumor drivers -- Therapeutic rationale for the use of epigenetic drugs in oncology -- First generation epigenetic drugs: DNMT and HDAC inhibitors -- Novel therapeutic discoveries in oncology -- Biomarkers for patient selection.…”
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Visualization of transcription factor interactions in living cells

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Series (Eukaryotic gene regulation)
Series (Epigenetics, chromatin, transcription and cancer)

Genomics 101 an introduction to sequencing /

Table of Contents: “…Contents: Sanger sequencing -- Fluorescent Sanger sequencing -- Whole genome sequencing -- Next generation sequencing -- Multiplexing -- Whole exome sequencing -- Transcriptome sequencing -- Chromatin immunoprecipitation sequencing.…”
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Genomics 101 an introduction to sequencing /

Table of Contents: “…Contents: Sanger sequencing -- Fluorescent Sanger sequencing -- Whole genome sequencing -- Next generation sequencing -- Multiplexing -- Whole exome sequencing -- Transcriptome sequencing -- Chromatin immunoprecipitation sequencing.…”
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Epigenetic control by histone methylation

Table of Contents: “…Contents: The diversity of covalent histone tail modifications for imparting epigenetic information -- Observations of robust histone modifications at silent chromatin regions -- The representation of repressive histone marks as indications of epigenetic plasticity in different cells -- Analysis of the profiles of normal and aberrant histone lysine methylation patterns, as they occur during the transition of an embryonic to a differentiated cell or in controlled self-renewal vs. pro-neoplastic or metastatic conditions -- Elucidation of these histone modification patterns for novel advances in stem cell research, nuclear reprogramming and cancer.…”
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Epigenetic control by histone methylation

Table of Contents: “…Contents: The diversity of covalent histone tail modifications for imparting epigenetic information -- Observations of robust histone modifications at silent chromatin regions -- The representation of repressive histone marks as indications of epigenetic plasticity in different cells -- Analysis of the profiles of normal and aberrant histone lysine methylation patterns, as they occur during the transition of an embryonic to a differentiated cell or in controlled self-renewal vs. pro-neoplastic or metastatic conditions -- Elucidation of these histone modification patterns for novel advances in stem cell research, nuclear reprogramming and cancer.…”
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The RNA polymerase II general transcription machinery

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Activation of gene expression by double-stranded RNAs

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The RNA polymerase II general transcription machinery

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Activation of gene expression by double-stranded RNAs

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Comparing transcriptomes of distant organisms models of gene expression, part 2 of 2 /

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The Beta-globin locus

Table of Contents: “…Contents: The globin loci encode hemoglobin subunits -- Erythrocytes & hemoglobin -- Human globin genes and hemoglobins -- Globin gene expression during development -- Globin gene structure -- Sickle cell disease -- Beta-thalassemia -- Transcriptional regulation by recruitment (Enhancers, Silencers and Insulators) -- Chromatin conformation capture (3C) assay -- Chromatin looping in the beta-globin locus -- The LDB1 complex in erythroid cells -- Nuclear re-location of the beta-globin locus -- Natural mutations and hemoglobin switching -- BCL11A, beta-globin and gamma-globin expression -- Interfering with BCL11A silencing.…”
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Series (Eukaryotic gene regulation)
Series (Epigenetics, chromatin, transcription and cancer)

Genome-wide mapping of estrogen receptor binding sites and activity /

Table of Contents: “…Contents: Estrogen receptor-chromatin interactions -- Cis-regulatory elements that function from a distance -- ER binding sites and gene transcription -- Co-operating transcription factors -- Pioneer factors that maintain ER-chromatin interactions.…”
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Genome-wide mapping of estrogen receptor binding sites and activity /

Table of Contents: “…Contents: Estrogen receptor-chromatin interactions -- Cis-regulatory elements that function from a distance -- ER binding sites and gene transcription -- Co-operating transcription factors -- Pioneer factors that maintain ER-chromatin interactions.…”
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Mechanisms of transcription the eukaryotic pre-initiation complex /

Table of Contents: “…Contents: Overview of RNA polymerase II transcription -- Core promoter elements -- Proximal promoters -- Enhancers and silencers -- General transcription factors -- Activators and repressors -- Coactivator complexes -- RNA polymerase II structure and function -- Mechanisms of transcription initiation -- Steroid hormone receptors -- Coactivator complexes, including mediator and TFIID -- Chromatin remodellers including SWI/SNF -- Covalent histone modifiers, including histone acetyltransferases, methyltransferases and deacetylases.…”
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Accessing and using ENCODE data

Table of Contents: “…Contents: A description of the ENCODE Consortium -- Experimental assays used by Consortium members -- Overview of genome-wide methods to study gene expression, chromatin, and transcription factors -- A summary of insights from ENCODE experiments -- How to access and download ENCODE data -- How to use ENCODE data in your own research.…”
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Series (Eukaryotic gene regulation)
Series (Introduction to human genetics)
Series (Using bioinformatics in the exploration of genetic diversity)
Series (Epigenetics, chromatin, transcription and cancer)

Mechanisms of transcription the eukaryotic pre-initiation complex /

Table of Contents: “…Contents: Overview of RNA polymerase II transcription -- Core promoter elements -- Proximal promoters -- Enhancers and silencers -- General transcription factors -- Activators and repressors -- Coactivator complexes -- RNA polymerase II structure and function -- Mechanisms of transcription initiation -- Steroid hormone receptors -- Coactivator complexes, including mediator and TFIID -- Chromatin remodellers including SWI/SNF -- Covalent histone modifiers, including histone acetyltransferases, methyltransferases and deacetylases.…”
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Accessing and using ENCODE data

Table of Contents: “…Contents: A description of the ENCODE Consortium -- Experimental assays used by Consortium members -- Overview of genome-wide methods to study gene expression, chromatin, and transcription factors -- A summary of insights from ENCODE experiments -- How to access and download ENCODE data -- How to use ENCODE data in your own research.…”
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Series (Eukaryotic gene regulation)
Series (Introduction to human genetics)
Series (Using bioinformatics in the exploration of genetic diversity)
Series (Epigenetics, chromatin, transcription and cancer)

DNA methylation

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Series (Eukaryotic gene regulation)
Series (Epigenetics, chromatin, transcription and cancer)