Search Results - "amyloid"

Alzheimer's disease advances for a new century /

Table of Contents: “…Genetics -- section 2. Amyloid-[beta] -- section 3. Tau -- section 4. Neuropathology -- section 5. …”
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Neuroimaging markers in AD trials

Table of Contents: “…Contents: Imaging in Alzheimer's Disease (AD) trials -- Increasing range of modalities to measure brain structure, function and molecular pathology of AD -- Early diagnosis, inclusion markers and measurement of progression -- MRI to measure atrophy -- PET to measure amyloid.…”
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Neuroimaging markers in AD trials

Table of Contents: “…Contents: Imaging in Alzheimer's Disease (AD) trials -- Increasing range of modalities to measure brain structure, function and molecular pathology of AD -- Early diagnosis, inclusion markers and measurement of progression -- MRI to measure atrophy -- PET to measure amyloid.…”
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Neuroimaging markers in AD trials

Table of Contents: “…Contents: Imaging in Alzheimer's Disease (AD) trials -- Increasing range of modalities to measure brain structure, function and molecular pathology of AD -- Early diagnosis, inclusion markers and measurement of progression -- MRI to measure atrophy -- PET to measure amyloid.…”
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Alzheimer's disease where are we up to? /

Table of Contents: “…Contents: Advances in technology -- Alzheimer: senile plaques -- Examples of risk loci for Alzheimer's disease (AD) -- TREM2 mutations in AD -- Genomic analysis of Alzheimer's disease -- Plaque and amyloid pathology -- Lipid metabolism in the aetiology of AD -- Risk factors expressed in the innate immune system -- Implications for therapy.…”
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Alzheimer's disease where are we up to? /

Table of Contents: “…Contents: Advances in technology -- Alzheimer: senile plaques -- Examples of risk loci for Alzheimer's disease (AD) -- TREM2 mutations in AD -- Genomic analysis of Alzheimer's disease -- Plaque and amyloid pathology -- Lipid metabolism in the aetiology of AD -- Risk factors expressed in the innate immune system -- Implications for therapy.…”
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Series (Periodic reports)
Series (Alzheimer's disease)

Alzheimer's disease where are we up to? /

Table of Contents: “…Contents: Advances in technology -- Alzheimer: senile plaques -- Examples of risk loci for Alzheimer's disease (AD) -- TREM2 mutations in AD -- Genomic analysis of Alzheimer's disease -- Plaque and amyloid pathology -- Lipid metabolism in the aetiology of AD -- Risk factors expressed in the innate immune system -- Implications for therapy.…”
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Series (Periodic reports)
Series (Alzheimer's disease)

Molecules nucleation, aggregation and crystallization : beyond medical and other implications /

Table of Contents: “…Gordeliy and Ekaterina S. Moiseeva -- Amyloid, the amyloid [beta]-peptide, and Alzheimer's disease : structural considerations / Lars O. …”
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Pathology of Alzheimer's disease

Table of Contents: “…Contents: Alzheimer's disease as the commonest neurodegenerative disease -- Alzheimer's disease as one of the protein folding disorders -- Alzheimer's disease is rarely inherited due to mutations of one of three genes -- Apolipoprotein E epsilon 4 allele as genetic risk factor for Alzheimer's disease -- Neuritic plaques -- Neurofibrillary tangles -- Amyloid-beta peptide -- Tau protein.…”
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Pathology of Alzheimer's disease

Table of Contents: “…Contents: Alzheimer's disease as the commonest neurodegenerative disease -- Alzheimer's disease as one of the protein folding disorders -- Alzheimer's disease is rarely inherited due to mutations of one of three genes -- Apolipoprotein E epsilon 4 allele as genetic risk factor for Alzheimer's disease -- Neuritic plaques -- Neurofibrillary tangles -- Amyloid-beta peptide -- Tau protein.…”
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Pathology of Alzheimer's disease

Table of Contents: “…Contents: Alzheimer's disease as the commonest neurodegenerative disease -- Alzheimer's disease as one of the protein folding disorders -- Alzheimer's disease is rarely inherited due to mutations of one of three genes -- Apolipoprotein E epsilon 4 allele as genetic risk factor for Alzheimer's disease -- Neuritic plaques -- Neurofibrillary tangles -- Amyloid-beta peptide -- Tau protein.…”
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Molecular brain imaging (PET) in diseases with dementia

Table of Contents: “…Contents: Brain imaging with positron emission tomography (PET) for dementia diagnosis and research -- Cerebral glucose metabolism in mild cognitive impairment, Alzheimer's disease, dementia with Lewy bodies, frontotemporal dementia & depression -- Imaging of pathological markers (beta-amyloid and tau) in Alzheimer's disease -- Imaging of neurotransmitters and receptors, in the dopaminergic and cholinergic system -- Multiple systems profiling in dementia, Parkinson's and related motor disorders.…”
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Series (Neurodegenerative diseases)

Molecular brain imaging (PET) in diseases with dementia

Table of Contents: “…Contents: Brain imaging with positron emission tomography (PET) for dementia diagnosis and research -- Cerebral glucose metabolism in mild cognitive impairment, Alzheimer's disease, dementia with Lewy bodies, frontotemporal dementia & depression -- Imaging of pathological markers (beta-amyloid and tau) in Alzheimer's disease -- Imaging of neurotransmitters and receptors, in the dopaminergic and cholinergic system -- Multiple systems profiling in dementia, Parkinson's and related motor disorders.…”
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ApoE4, the most prevalent genetic risk factor for Alzheimer's Disease

Table of Contents: “…Contents: ApoE4 the most prevalent genetic risk factor of Alzheimer's disease -- The apoE4 molecule -- The associated brain pathology in man -- The mechanisms underlying the pathological effects of apoE4 -- The role of lipids in mediating the effects of apoE4 -- The role of Amyloid-beta in mediating the effects of apoE4 -- ApoE4 receptors -- ApoE4 catabolism -- ApoE4 targeted therapeutic approaches -- Therapeutic approaches based on the apoE4 molecule -- Therapeutic approaches based on preventing pathologic interactions with other systems.…”
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ApoE4, the most prevalent genetic risk factor for Alzheimer's Disease

Table of Contents: “…Contents: ApoE4 the most prevalent genetic risk factor of Alzheimer's disease -- The apoE4 molecule -- The associated brain pathology in man -- The mechanisms underlying the pathological effects of apoE4 -- The role of lipids in mediating the effects of apoE4 -- The role of Amyloid-beta in mediating the effects of apoE4 -- ApoE4 receptors -- ApoE4 catabolism -- ApoE4 targeted therapeutic approaches -- Therapeutic approaches based on the apoE4 molecule -- Therapeutic approaches based on preventing pathologic interactions with other systems.…”
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ApoE4, the most prevalent genetic risk factor for Alzheimer's Disease

Table of Contents: “…Contents: ApoE4 the most prevalent genetic risk factor of Alzheimer's disease -- The apoE4 molecule -- The associated brain pathology in man -- The mechanisms underlying the pathological effects of apoE4 -- The role of lipids in mediating the effects of apoE4 -- The role of Amyloid-beta in mediating the effects of apoE4 -- ApoE4 receptors -- ApoE4 catabolism -- ApoE4 targeted therapeutic approaches -- Therapeutic approaches based on the apoE4 molecule -- Therapeutic approaches based on preventing pathologic interactions with other systems.…”
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Alzheimer's diagnosis

Table of Contents: “…Quantitation of amyloid-[beta] oligomers in human body fluids for Alzheimer's disease early diagnosis or therapy monitoring? …”
An electronic book accessible through the World Wide Web; click to view

Novel proteins from designed combinatorial libraries

Table of Contents: “…Contents: Novel proteins can be devised using either rational/computational approaches or random/combinatorial methods -- Description of a hybrid approach that combines rational and combinatorial methods: libraries of novel proteins -- Combinatorial diversity -- Random vs. focused libraries -- Amphiphilic alpha-helices and beta-strands -- Binary patterning of polar and non-polar amino acids -- Genetic encoding of combinatorial mixtures of polar and non-polar amino acids -- Design of libraries of novel 4-helix bundles -- Library construction and expression in vivo -- Dynamic vs. wellordered protein structures -- Second generation libraries -- Biophysical characterization -- Solution structure of native-like 4-helix bundle proteins from designed libraries -- Functionally active proteins including cofactor binding proteins, peroxidases and esterases -- Designed libraries of beta sheet proteins: amyloid-like fibrils, monomeric beta-sheet proteins and novel biomaterials.…”
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Novel proteins from designed combinatorial libraries

Table of Contents: “…Contents: Novel proteins can be devised using either rational/computational approaches or random/combinatorial methods -- Description of a hybrid approach that combines rational and combinatorial methods: libraries of novel proteins -- Combinatorial diversity -- Random vs. focused libraries -- Amphiphilic alpha-helices and beta-strands -- Binary patterning of polar and non-polar amino acids -- Genetic encoding of combinatorial mixtures of polar and non-polar amino acids -- Design of libraries of novel 4-helix bundles -- Library construction and expression in vivo -- Dynamic vs. wellordered protein structures -- Second generation libraries -- Biophysical characterization -- Solution structure of native-like 4-helix bundle proteins from designed libraries -- Functionally active proteins including cofactor binding proteins, peroxidases and esterases -- Designed libraries of beta sheet proteins: amyloid-like fibrils, monomeric beta-sheet proteins and novel biomaterials.…”
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Novel proteins from designed combinatorial libraries

Table of Contents: “…Contents: Novel proteins can be devised using either rational/computational approaches or random/combinatorial methods -- Description of a hybrid approach that combines rational and combinatorial methods: libraries of novel proteins -- Combinatorial diversity -- Random vs. focused libraries -- Amphiphilic alpha-helices and beta-strands -- Binary patterning of polar and non-polar amino acids -- Genetic encoding of combinatorial mixtures of polar and non-polar amino acids -- Design of libraries of novel 4-helix bundles -- Library construction and expression in vivo -- Dynamic vs. wellordered protein structures -- Second generation libraries -- Biophysical characterization -- Solution structure of native-like 4-helix bundle proteins from designed libraries -- Functionally active proteins including cofactor binding proteins, peroxidases and esterases -- Designed libraries of beta sheet proteins: amyloid-like fibrils, monomeric beta-sheet proteins and novel biomaterials.…”
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