Search Results - "amyloid"
Suggested Topics within your search.
Suggested Topics within your search.
- Amyloid 74
- Alzheimer Disease 53
- Prions 48
- Alzheimer's disease 39
- metabolism 21
- Neurodegenerative Diseases 20
- Protein Folding 18
- pathology 18
- physiopathology 18
- Nervous system 17
- Degeneration 16
- Proteins 16
- Protein Conformation 15
- drug therapy 15
- Genetic aspects 14
- genetics 14
- Amyloid beta-Peptides 13
- Chemotherapy 13
- Treatment 12
- therapy 11
- Amyloid beta-protein 9
- Pathophysiology 9
- Protein folding 9
- Brain 8
- Dementia 8
- Diagnosis 8
- Pathology 8
- Frontotemporal Dementia 7
- Amyloidosis 6
- Diagnostic Imaging 6
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101
Mechanism of prion generation in vitro
Published 2020“…Biomedical & life sciences collection. Prions and amyloids : self-propagating protein structures in mammals, yeast and fungi.…”
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102
Protein folding and misfolding from theory to therapy /
Published 2007Table of Contents: “…Contents: Protein nature, folding and complexity -- Folding in a cellular environment -- The underlying principles of folding -- Native and transition states -- Exploring the energy surface -- The folding of lysozyme -- The consequences of protein misfolding -- The relationship between folding and disease -- Protein deposition diseases -- Protein aggregates in amyloid diseases -- Amyloidogenic mutations of lysozyme -- Mechanism of amyloid formation -- Structure of the amyloidogenic intermediate -- Amyloid formation by lysozyme in vivo -- SH3 domain of PI3 kinase -- Model of an amyloid fibril -- The underlying origins of amyloid disease -- Generic toxicity of amyloid aggregates -- Cellular defences against aggregation -- Evolutionary design of proteins -- "Post-evolutionary" diseases.…”
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103
Protein folding and misfolding from theory to therapy /
Published 2007Table of Contents: “…Contents: Protein nature, folding and complexity -- Folding in a cellular environment -- The underlying principles of folding -- Native and transition states -- Exploring the energy surface -- The folding of lysozyme -- The consequences of protein misfolding -- The relationship between folding and disease -- Protein deposition diseases -- Protein aggregates in amyloid diseases -- Amyloidogenic mutations of lysozyme -- Mechanism of amyloid formation -- Structure of the amyloidogenic intermediate -- Amyloid formation by lysozyme in vivo -- SH3 domain of PI3 kinase -- Model of an amyloid fibril -- The underlying origins of amyloid disease -- Generic toxicity of amyloid aggregates -- Cellular defences against aggregation -- Evolutionary design of proteins -- "Post-evolutionary" diseases.…”
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104
Protein folding and misfolding from theory to therapy /
Published 2007Table of Contents: “…Contents: Protein nature, folding and complexity -- Folding in a cellular environment -- The underlying principles of folding -- Native and transition states -- Exploring the energy surface -- The folding of lysozyme -- The consequences of protein misfolding -- The relationship between folding and disease -- Protein deposition diseases -- Protein aggregates in amyloid diseases -- Amyloidogenic mutations of lysozyme -- Mechanism of amyloid formation -- Structure of the amyloidogenic intermediate -- Amyloid formation by lysozyme in vivo -- SH3 domain of PI3 kinase -- Model of an amyloid fibril -- The underlying origins of amyloid disease -- Generic toxicity of amyloid aggregates -- Cellular defences against aggregation -- Evolutionary design of proteins -- "Post-evolutionary" diseases.…”
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105
Metabolic and biochemical alterations in Alzheimer's disease facts and fictions /
Published 2011Table of Contents: “…-- Tauist and BAPtist hypothesis of AD -- Pathology and oxidative stress relationship -- NFT and amyloid-beta -- Stress-activated protein kinases and phospho-tau -- Amyloid-targeted approaches are unsuccessful -- Amyloid-beta controls redox activity -- Genetic factors are related to oxidative stress -- Therapeutics -- Potential mechanism of ROS generation -- Oxidative modifications and macromolecules -- Oxidative damage directly correlates with mtDNA -- Abnormal mitochondrial distribution in AD brains -- Iron histochemistry -- Antioxidant diet is protective -- Only one non-amyloid drug in phase III: 2010 -- Oxidative stress is necessary but not sufficient -- CaMKII-MYC mice -- Oxidative stress and cell cycle abnormalities -- Early stages of AD disease signals.…”
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106
Metabolic and biochemical alterations in Alzheimer's disease facts and fictions /
Published 2011Table of Contents: “…-- Tauist and BAPtist hypothesis of AD -- Pathology and oxidative stress relationship -- NFT and amyloid-beta -- Stress-activated protein kinases and phospho-tau -- Amyloid-targeted approaches are unsuccessful -- Amyloid-beta controls redox activity -- Genetic factors are related to oxidative stress -- Therapeutics -- Potential mechanism of ROS generation -- Oxidative modifications and macromolecules -- Oxidative damage directly correlates with mtDNA -- Abnormal mitochondrial distribution in AD brains -- Iron histochemistry -- Antioxidant diet is protective -- Only one non-amyloid drug in phase III: 2010 -- Oxidative stress is necessary but not sufficient -- CaMKII-MYC mice -- Oxidative stress and cell cycle abnormalities -- Early stages of AD disease signals.…”
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107
Metabolic and biochemical alterations in Alzheimer's disease facts and fictions /
Published 2011Table of Contents: “…-- Tauist and BAPtist hypothesis of AD -- Pathology and oxidative stress relationship -- NFT and amyloid-beta -- Stress-activated protein kinases and phospho-tau -- Amyloid-targeted approaches are unsuccessful -- Amyloid-beta controls redox activity -- Genetic factors are related to oxidative stress -- Therapeutics -- Potential mechanism of ROS generation -- Oxidative modifications and macromolecules -- Oxidative damage directly correlates with mtDNA -- Abnormal mitochondrial distribution in AD brains -- Iron histochemistry -- Antioxidant diet is protective -- Only one non-amyloid drug in phase III: 2010 -- Oxidative stress is necessary but not sufficient -- CaMKII-MYC mice -- Oxidative stress and cell cycle abnormalities -- Early stages of AD disease signals.…”
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108
Experimental therapies in Alzheimer's disease the development and use of mouse models /
Published 2007Table of Contents: “…Contents: Animal models and AD research -- Role in identifying pathological pathways, biomarkers and candidate therapies -- Design of models and associated technical parameters -- Process of transgenesis -- Developing mouse models for beta-amyloid precursor protein mutations -- TgCRND8 mice -- Transgenic approaches for investigating Tau mutations -- Exploring environmental modifiers of beta-amyloid pathobiology -- Candidate chemical risk-factor for sporadic AD -- Potential of ''smart'' beta-amyloid-directed interventions.…”
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109
Experimental therapies in Alzheimer's disease the development and use of mouse models /
Published 2007Table of Contents: “…Contents: Animal models and AD research -- Role in identifying pathological pathways, biomarkers and candidate therapies -- Design of models and associated technical parameters -- Process of transgenesis -- Developing mouse models for beta-amyloid precursor protein mutations -- TgCRND8 mice -- Transgenic approaches for investigating Tau mutations -- Exploring environmental modifiers of beta-amyloid pathobiology -- Candidate chemical risk-factor for sporadic AD -- Potential of ''smart'' beta-amyloid-directed interventions.…”
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Electronic Video -
110
Experimental therapies in Alzheimer's disease the development and use of mouse models /
Published 2007Table of Contents: “…Contents: Animal models and AD research -- Role in identifying pathological pathways, biomarkers and candidate therapies -- Design of models and associated technical parameters -- Process of transgenesis -- Developing mouse models for beta-amyloid precursor protein mutations -- TgCRND8 mice -- Transgenic approaches for investigating Tau mutations -- Exploring environmental modifiers of beta-amyloid pathobiology -- Candidate chemical risk-factor for sporadic AD -- Potential of ''smart'' beta-amyloid-directed interventions.…”
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111
Immunotherapy as an approach to treating Alzheimer's disease
Published 2010Table of Contents: “…Contents: Alzheimer's Disease -- Immunization with amyloid-beta (A-beta) -- Radial arm water maze -- Clinical trial of anti-A-beta vaccine -- Mechanisms of antibody-mediated A-beta clearance -- Catalytic fibril dissolution -- Peripheral sink hypothesis -- Systemic administration of anti-A-beta antibodies into old APP transgenic (Tg) mice -- Diffuse and compact amyloid deposits -- Systemic anti-A-beta antibody -- Parenchymal and vascular amyloid deposits -- Microhemorrhages -- A possible solution to the problems of immunotherapy -- Systemic administration experimental design -- Intact and deglycosylated antibodies reverse cognitive decline -- Current clinical trials of A-beta immunotherapy -- Prospects for immunotherapy.…”
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112
Immunotherapy as an approach to treating Alzheimer's disease
Published 2010Table of Contents: “…Contents: Alzheimer's Disease -- Immunization with amyloid-beta (A-beta) -- Radial arm water maze -- Clinical trial of anti-A-beta vaccine -- Mechanisms of antibody-mediated A-beta clearance -- Catalytic fibril dissolution -- Peripheral sink hypothesis -- Systemic administration of anti-A-beta antibodies into old APP transgenic (Tg) mice -- Diffuse and compact amyloid deposits -- Systemic anti-A-beta antibody -- Parenchymal and vascular amyloid deposits -- Microhemorrhages -- A possible solution to the problems of immunotherapy -- Systemic administration experimental design -- Intact and deglycosylated antibodies reverse cognitive decline -- Current clinical trials of A-beta immunotherapy -- Prospects for immunotherapy.…”
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Series
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113
Immunotherapy as an approach to treating Alzheimer's disease
Published 2010Table of Contents: “…Contents: Alzheimer's Disease -- Immunization with amyloid-beta (A-beta) -- Radial arm water maze -- Clinical trial of anti-A-beta vaccine -- Mechanisms of antibody-mediated A-beta clearance -- Catalytic fibril dissolution -- Peripheral sink hypothesis -- Systemic administration of anti-A-beta antibodies into old APP transgenic (Tg) mice -- Diffuse and compact amyloid deposits -- Systemic anti-A-beta antibody -- Parenchymal and vascular amyloid deposits -- Microhemorrhages -- A possible solution to the problems of immunotherapy -- Systemic administration experimental design -- Intact and deglycosylated antibodies reverse cognitive decline -- Current clinical trials of A-beta immunotherapy -- Prospects for immunotherapy.…”
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114
Cytoplasmic epigenetics proteins acting as genes /
Published 2007Table of Contents: “…Contents: Prions (infectious proteins) include several self-propagating amyloids of S. cerevisiae and Podospora anserina and a self-activating enzyme of S. cerevisiae -- these non-chromosomal genetic elements are genes composed of protein, just as nucleic acids can catalyse enzymatic reactions -- the amyloid-based prions [PSI+] and [URE3] are diseases of yeast, but the [Het-s] prion of Podospora carries out a normal function for that organism, heterokaryon incompatibility.…”
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115
Cytoplasmic epigenetics proteins acting as genes /
Published 2007Table of Contents: “…Contents: Prions (infectious proteins) include several self-propagating amyloids of S. cerevisiae and Podospora anserina and a self-activating enzyme of S. cerevisiae -- these non-chromosomal genetic elements are genes composed of protein, just as nucleic acids can catalyse enzymatic reactions -- the amyloid-based prions [PSI+] and [URE3] are diseases of yeast, but the [Het-s] prion of Podospora carries out a normal function for that organism, heterokaryon incompatibility.…”
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Series
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116
Cytoplasmic epigenetics proteins acting as genes /
Published 2007Table of Contents: “…Contents: Prions (infectious proteins) include several self-propagating amyloids of S. cerevisiae and Podospora anserina and a self-activating enzyme of S. cerevisiae -- these non-chromosomal genetic elements are genes composed of protein, just as nucleic acids can catalyse enzymatic reactions -- the amyloid-based prions [PSI+] and [URE3] are diseases of yeast, but the [Het-s] prion of Podospora carries out a normal function for that organism, heterokaryon incompatibility.…”
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Series
Electronic Video -
117
Roles for Hsp40 molecular chaperones in protein misfolding disease
Published 2012Table of Contents: “…Contents: Protein aggregation in conformational disease -- The Hsp40 system -- The Hsp70 system -- Small oligomers, prion, yeast, Huntington's disease and protein triage -- Mechanisms for proteotoxicity -- Mechanisms for amyloid disease.…”
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118
Roles for Hsp40 molecular chaperones in protein misfolding disease
Published 2012Table of Contents: “…Contents: Protein aggregation in conformational disease -- The Hsp40 system -- The Hsp70 system -- Small oligomers, prion, yeast, Huntington's disease and protein triage -- Mechanisms for proteotoxicity -- Mechanisms for amyloid disease.…”
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Series
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119
Roles for Hsp40 molecular chaperones in protein misfolding disease
Published 2012Table of Contents: “…Contents: Protein aggregation in conformational disease -- The Hsp40 system -- The Hsp70 system -- Small oligomers, prion, yeast, Huntington's disease and protein triage -- Mechanisms for proteotoxicity -- Mechanisms for amyloid disease.…”
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120
Frontotemporal dementia
Published 2009Table of Contents: “…Contents: Prevalence and nomenclature of FTD -- The pathology of FTD (tau, TDP-43) -- The genetics of FTD (tau, progranulin) -- Patterns of atrophy and neuroanatomical correlates of behavior and cognition -- von Economo neurons -- Neuroimaging (amyloid imaging) -- Treatment.…”
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