Search Results - "amyloid"

Targeting Aß oligomers a molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease /

Table of Contents: “…Contents: The oligomer cascade hypothesis for Alzheimer's Disease -- Why the oligomer hypothesis has largely supplanted the amyloid cascade hypothesis -- The role of AβOs in memory failure and the major facets of AD neuropathology -- Mechanisms by which AβOs instigate neurotoxicity -- Why AβOs accumulate in the first place -- How AβOs offer superb targets for novel AD diagnostics and disease-modifying therapeutics -- Beside its direct link to Alzheimer's disease, the discovery of toxic Aβ oligomers has provided a novel structural archetype for toxins germane to more than two dozen diseases of protein mis-folding, including Diabetes, Parkinson's, and prion diseases.…”
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Update on fluid biomarkers for neurodegenerative diseases

Table of Contents: “…Contents: Fluid biomarker candidates for neurodegenerative disease -- Amyloid pathology -- CSF and plasma/serum NfL -- CSF Aβ42 in Alzheimer's disease and neuroinflammatory diseases -- Tau pathology in Alzheimer's disease -- Neurodegeneration -- CSF and plasma NfL as biomarkers for disease progression -- Drug treatment and NfL levels.…”
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Series (Biomarkers)
Series (Drug discovery and development in the neurosciences)
Series (Genetic basis of neurological disorders)

Update on fluid biomarkers for neurodegenerative diseases

Table of Contents: “…Contents: Fluid biomarker candidates for neurodegenerative disease -- Amyloid pathology -- CSF and plasma/serum NfL -- CSF Aβ42 in Alzheimer's disease and neuroinflammatory diseases -- Tau pathology in Alzheimer's disease -- Neurodegeneration -- CSF and plasma NfL as biomarkers for disease progression -- Drug treatment and NfL levels.…”
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Series (Biomarkers)
Series (Drug discovery and development in the neurosciences)
Series (Genetic basis of neurological disorders)

The blood-brain barrier in Alzheimer's disease

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Frontotemporal dementia

Table of Contents: “…Contents: Prevalence and nomenclature of FTD -- The pathology of FTD (tau, TDP-43) -- The genetics of FTD (tau, progranulin) -- Patterns of atrophy and neuroanatomical correlates of behavior and cognition -- von Economo neurons -- Neuroimaging (amyloid imaging) -- Treatment.…”
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Frontotemporal dementia

Table of Contents: “…Contents: Prevalence and nomenclature of FTD -- The pathology of FTD (tau, TDP-43) -- The genetics of FTD (tau, progranulin) -- Patterns of atrophy and neuroanatomical correlates of behavior and cognition -- von Economo neurons -- Neuroimaging (amyloid imaging) -- Treatment.…”
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The blood-brain barrier in Alzheimer's disease

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Genetics of early onset Alzheimer's disease

Table of Contents: “…Contents: Role of amyloid precursor protein (APP) in Alzheimer's Disease (AD) -- Presenilins as AD causing genes -- Phenotypic heterogeneity in cases with presenilin mutations -- Gene-gene interactions in patients with AD -- Genetic testing in AD.…”
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A molecular understanding of Alzheimer's disease

Table of Contents: “…Contents: Usefulness of genetics in understanding AD -- Pathology of diseases -- Amyloid protein -- Genetic maps -- Mechanism of late onset Alzheimer's -- Role of presenilin in amyloid pathology -- Tau and frontotemporal dementia -- Tau splice site mutations -- Pathways to neurodegeneration.…”
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A molecular understanding of Alzheimer's disease

Table of Contents: “…Contents: Usefulness of genetics in understanding AD -- Pathology of diseases -- Amyloid protein -- Genetic maps -- Mechanism of late onset Alzheimer's -- Role of presenilin in amyloid pathology -- Tau and frontotemporal dementia -- Tau splice site mutations -- Pathways to neurodegeneration.…”
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Chaperones and prions

Table of Contents: “…Contents: Prion diseases -- Prions as self-propagating amyloids -- Yeast prions as protein-based heritable elements -- Prion detection -- Crucial role of the chaperone protein Hsp104 in the propagation of yeast prions -- Chaperone-mediated fragmentation turns amyloids into infectious or heritable prions -- Effects of the Hsp70 and Hsp40 proteins on yeast prions -- Other modulators of prion formation and propagation: cytoskeleton and ubiquitin system.…”
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Chaperones and prions

Table of Contents: “…Contents: Prion diseases -- Prions as self-propagating amyloids -- Yeast prions as protein-based heritable elements -- Prion detection -- Crucial role of the chaperone protein Hsp104 in the propagation of yeast prions -- Chaperone-mediated fragmentation turns amyloids into infectious or heritable prions -- Effects of the Hsp70 and Hsp40 proteins on yeast prions -- Other modulators of prion formation and propagation: cytoskeleton and ubiquitin system.…”
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Humoral innate immunity and the acute phase response 2

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Genetics of early onset Alzheimer's disease

Table of Contents: “…Contents: Role of amyloid precursor protein (APP) in Alzheimer's Disease (AD) -- Presenilins as AD causing genes -- Phenotypic heterogeneity in cases with presenilin mutations -- Gene-gene interactions in patients with AD -- Genetic testing in AD.…”
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Genetics of early onset Alzheimer's disease

Table of Contents: “…Contents: Role of amyloid precursor protein (APP) in Alzheimer's Disease (AD) -- Presenilins as AD causing genes -- Phenotypic heterogeneity in cases with presenilin mutations -- Gene-gene interactions in patients with AD -- Genetic testing in AD.…”
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Neurodegenerative disease expression levels of normal sequence pathogenic proteins contribute to risk of disease /

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Neurodegenerative disease expression levels of normal sequence pathogenic proteins contribute to risk of disease /

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Humoral innate immunity and the acute phase response 2

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Series (Innate immunity)
Series (Cytokines)

Humoral innate immunity and the acute phase response 2

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Series (Innate immunity)
Series (Cytokines)

Mechanism of prion generation in vitro

“…Biomedical & life sciences collection. Prions and amyloids : self-propagating protein structures in mammals, yeast and fungi.…”
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