Search Results - "amyloid"
Suggested Topics within your search.
Suggested Topics within your search.
- Amyloid 74
- Alzheimer Disease 53
- Prions 48
- Alzheimer's disease 39
- metabolism 21
- Neurodegenerative Diseases 20
- Protein Folding 18
- pathology 18
- physiopathology 18
- Nervous system 17
- Degeneration 16
- Proteins 16
- Protein Conformation 15
- drug therapy 15
- Genetic aspects 14
- genetics 14
- Amyloid beta-Peptides 13
- Chemotherapy 13
- Treatment 12
- therapy 11
- Amyloid beta-protein 9
- Pathophysiology 9
- Protein folding 9
- Brain 8
- Dementia 8
- Diagnosis 8
- Pathology 8
- Frontotemporal Dementia 7
- Amyloidosis 6
- Diagnostic Imaging 6
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41
The structure of amyloid fibrils of the HET-s (218-289) prion as seen by solid-state NMR
Published 2008Table of Contents: “…Contents: 3D structure is important -- Prion hypothesis -- Prions can form amyloids -- Amyloids -- Cross-beta arrangements give characteristic fiber diffraction patterns -- Solid-state NMR can characterize amyloid fibrils -- Atomic-resolution structure determination by NMR and x-ray -- Distance information in NMR correlation spectra -- The methodology to obtain 3D structures from solid (microcrystalline) samples has recently been developed -- Structure determination is possible -- Nevertheless, amyloids are different -- Isotopic labeling allows to disentangle the intra/inter problem -- HET-s: a functional prion -- Structural information about HET-s (218-289) from earlier measurements -- Chemical shift assignment -- To go further we need distance restraints -- Distance restraints for protein fibrils -- Intramolecular restraints -- Structure calculation -- Structural features of the fibrils -- Comparison with globular proteins.…”
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42
Transgenic mouse models of prion diseases
Published 2008Subjects: “…Amyloid. 112873…”
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43
The genetics and biology of the [Het-s] prion of Podospora
Published 2008Subjects: “…Amyloid. 112825…”
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44
Mechanisms of yeast prion propagation
Published 2008Table of Contents: “…Contents: Prions as infectious amyloids -- Yeast [PSI+] prion and Sup35p -- Molecular chaperone Hsp104 -- Guanidine hydrochloride as a prion propagation inhibitor -- Propagons -- Estimating propagon numbers using a stochastic model -- Generation of new propagons -- Propagation-defective mutants (PNM) -- Role of primary sequence information -- Yeast prion propagation: the unanswered questions.…”
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45
Yeast and fungal prions a help or a hindrance? /
Published 2008Subjects: “…Amyloid. 112837…”
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46
Yeast prions and protein chaperones a help or a hindrance? /
Published 2008Table of Contents: “…Contents: Role of protein chaperones in protein folding -- Yeast prions as amyloid forms of cellular proteins -- Requirement of chaperone machinery for prion propagation -- Chaperone mutants adversely affect prions and provide insight into chaperone/amyloid interactions.…”
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47
Molecular structure of amyloid and prion fibrils insights from solid state NMR /
Published 2008Table of Contents: “…Contents: Overview of solid state NMR methodology -- Structural model for Alzheimer's beta-amyloid fibrils -- Self-propagating polymorphism in amyloid fibrils -- Molecular basis of beta-amyloid polymorphism -- Extension of solid state NMR methods to amylin fibrils and yeast prion fibrils -- Structural basis of the generic nature of amyloid formation.…”
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48
[PIN+] prions beget prions /
Published 2008Subjects: “…Amyloid. 112849…”
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49
Propagation and variability of the yeast [PSI+] prion
Published 2008Table of Contents: “…Contents: Prion -- Yeast prions as non-chromosomal genetic determinants -- Modular structure of the Sup35 protein responsible for the yeast [PSI+] prion -- Role of the Hsp104 chaperone in [PSI+] prion propagation -- Two-level structure of the [PSI+] prion aggregates and methods for studying the size of prion polymers -- Non-prion amyloids in yeast -- Variability of the yeast [PSI+] prion.…”
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50
Similarities between prion diseases and other neurodegenerative diseases
Published 2008Subjects: “…Amyloid. 112857…”
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51
Predicting TSE transmission
Published 2008Subjects: “…Amyloid. 112861…”
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52
Generation and propagation of infectious prions by cyclic amplification of protein misfolding
Published 2008Subjects: “…Amyloid. 112865…”
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53
The structure of amyloid fibrils of the HET-s (218-289) prion as seen by solid-state NMR
Published 2008Table of Contents: “…Contents: 3D structure is important -- Prion hypothesis -- Prions can form amyloids -- Amyloids -- Cross-beta arrangements give characteristic fiber diffraction patterns -- Solid-state NMR can characterize amyloid fibrils -- Atomic-resolution structure determination by NMR and x-ray -- Distance information in NMR correlation spectra -- The methodology to obtain 3D structures from solid (microcrystalline) samples has recently been developed -- Structure determination is possible -- Nevertheless, amyloids are different -- Isotopic labeling allows to disentangle the intra/inter problem -- HET-s: a functional prion -- Structural information about HET-s (218-289) from earlier measurements -- Chemical shift assignment -- To go further we need distance restraints -- Distance restraints for protein fibrils -- Intramolecular restraints -- Structure calculation -- Structural features of the fibrils -- Comparison with globular proteins.…”
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Series
Electronic Video -
54
Transgenic mouse models of prion diseases
Published 2008Subjects: “…Amyloid. 112873…”
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Series
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55
The sequence determinants of amyloid fibril formation
Published 2007Table of Contents: “…Contents: Amyloid fibril formation is a shared property of proteins -- The effect of mutations on the aggregation of unstructured polypeptide chains -- The importance of hydrophobicity, propensity to form beta-sheet structure and charge in amyloid formation of unstructured proteins -- The regions of the sequence forming the beta-core of amyloid fibrils -- The sequence and structural determinants of aggregation for partially folded states of proteins -- Amino acid sequences have evolved to avoid formation of amyloid-like aggregates.…”
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56
The sequence determinants of amyloid fibril formation
Published 2007Table of Contents: “…Contents: Amyloid fibril formation is a shared property of proteins -- The effect of mutations on the aggregation of unstructured polypeptide chains -- The importance of hydrophobicity, propensity to form beta-sheet structure and charge in amyloid formation of unstructured proteins -- The regions of the sequence forming the beta-core of amyloid fibrils -- The sequence and structural determinants of aggregation for partially folded states of proteins -- Amino acid sequences have evolved to avoid formation of amyloid-like aggregates.…”
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Series
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57
The sequence determinants of amyloid fibril formation
Published 2007Table of Contents: “…Contents: Amyloid fibril formation is a shared property of proteins -- The effect of mutations on the aggregation of unstructured polypeptide chains -- The importance of hydrophobicity, propensity to form beta-sheet structure and charge in amyloid formation of unstructured proteins -- The regions of the sequence forming the beta-core of amyloid fibrils -- The sequence and structural determinants of aggregation for partially folded states of proteins -- Amino acid sequences have evolved to avoid formation of amyloid-like aggregates.…”
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58
Adapting proteostasis to ameliorate aggregation-associated amyloid diseases
Published 2018Table of Contents: “…Contents: Protein folding, misfolding, aggregation -- The proteostasis network and its regulation -- Gain and loss of function diseases -- The transthyretin (TTR) amyloidosis -- Kinetic stabilizers & clinical trial results -- Tafamidis & Diflunisal: evidence for the amyloid hypothesis -- Improving protein misfolding/aggregation diseases -- The unfolded protein response (UPR) and its arm-selective activators -- ATF6 activation & reduction of TTR mutant -- Clinical trials in amyloidosis with cardiac involvement.…”
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59
Ischemic blood-brain barrier and Alzheimer's amyloid plaques development
Published 2008Table of Contents: “…Contents: Ischemic blood-brain barrier involved in Alzheimer's amyloid plaques development and full-blown Alzheimer's disease -- Brain ischemia starts Alzheimer's disease -- Association and risk factors for Alzheimer's disease -- Ischemic mechanisms in Alzheimer's disease in general.…”
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60
Adapting proteostasis to ameliorate aggregation-associated amyloid diseases
Published 2018Table of Contents: “…Contents: Protein folding, misfolding, aggregation -- The proteostasis network and its regulation -- Gain and loss of function diseases -- The transthyretin (TTR) amyloidosis -- Kinetic stabilizers & clinical trial results -- Tafamidis & Diflunisal: evidence for the amyloid hypothesis -- Improving protein misfolding/aggregation diseases -- The unfolded protein response (UPR) and its arm-selective activators -- ATF6 activation & reduction of TTR mutant -- Clinical trials in amyloidosis with cardiac involvement.…”
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Series
Electronic Video