Search Results - "Screen Two

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    Hydrophilic interaction chromatography a guide for practitioners /

    Published 2013
    Table of Contents: “…Hydrophilic Interaction Chromatography (HILIC) for Drug Discovery 5.1 Drug Discovery Model 5.2 HILIC Applications for in vitro Biology 5.2.1 Biological screening and hit finding 5.2.1.1 Target selection and assay validation 5.2.1.2 High-throughput screening 5.2.2 New drug discovery strategies 5.3 HILIC Applications and Advances for Discovery Chemistry 5.3.1 Lead identification 5.3.2 Lead optimization 5.3.2.1 ADME profile 5.3.2.2 Biopharmaceutics 5.3.2.3 Chiral purity 5.3.3 Candidate selection 5.4 Practical Considerations 5.5 Conclusions Chapter 6. …”
    An electronic book accessible through the World Wide Web; click to view
    Electronic eBook
  4. 184

    Hydrophilic interaction chromatography a guide for practitioners /

    Published 2013
    Table of Contents: “…Hydrophilic Interaction Chromatography (HILIC) for Drug Discovery 5.1 Drug Discovery Model 5.2 HILIC Applications for in vitro Biology 5.2.1 Biological screening and hit finding 5.2.1.1 Target selection and assay validation 5.2.1.2 High-throughput screening 5.2.2 New drug discovery strategies 5.3 HILIC Applications and Advances for Discovery Chemistry 5.3.1 Lead identification 5.3.2 Lead optimization 5.3.2.1 ADME profile 5.3.2.2 Biopharmaceutics 5.3.2.3 Chiral purity 5.3.3 Candidate selection 5.4 Practical Considerations 5.5 Conclusions Chapter 6. …”
    An electronic book accessible through the World Wide Web; click to view
    Electronic eBook
  5. 185

    History without Chronology / by Tanaka, Stefan

    Published 2019
    Full text available:
    Electronic eBook
  6. 186

    History without Chronology / by Tanaka, Stefan

    Published 2019
    Full text available:
    Electronic eBook
  7. 187

    Promissory Notes : On the Literary Conditions of Debt / by Goodman, Robin Truth, 1966-

    Published 2018
    Full text available:
    Electronic eBook
  8. 188

    Promissory Notes : On the Literary Conditions of Debt / by Goodman, Robin Truth, 1966-

    Published 2018
    Full text available:
    Electronic eBook
  9. 189

    Polypharmacology in drug discovery

    Published 2012
    Table of Contents: “…Hopkins Part A: Polypharmacology - a safety concern in drug discovery. 1 The relevance of off-target polypharmacology Bruce D. Car 2 Screening for safety-relevant off-target activities Laszlo Urban, Steven Whitebread, Jacques Hamon, Dmitri Mikhailov and Kamal Azzaoui 2.1 Introduction. 2.2 General aspects. 2.3 Selection of off-targets. 2.4 In silico approaches to off-target profiling .2.5 Summary and conclusions. 3 Pharmacological promiscuity and molecular propertiesJens-Uwe Peters 3.1 Introduction: pharmacological promiscuity in the history of drug discovery. 3.2 Lipophilicity. 3.3 Molecular weight. 3.4 Ionisation state. 3.5 Other molecular descriptors and structural motifs. 3.6 Implications for drug discovery. 4 Kinases as antitargets in genotoxicity Stephan Kirchner 4.1 Protein Kinases and inhibitor-binding sites. 4.2 Cyclin-Dependent Kinases (CDKs) controlling unregulated cell proliferation. 4.3 Mitotic kinases as guardians protecting cells from aberrant chromosome segregation. 5 Activity at cardiovascular ion channels: a key issue for drug discoveryIan M. …”
    An electronic book accessible through the World Wide Web; click to view
    Electronic eBook
  10. 190

    Polypharmacology in drug discovery

    Published 2012
    Table of Contents: “…Hopkins Part A: Polypharmacology - a safety concern in drug discovery. 1 The relevance of off-target polypharmacology Bruce D. Car 2 Screening for safety-relevant off-target activities Laszlo Urban, Steven Whitebread, Jacques Hamon, Dmitri Mikhailov and Kamal Azzaoui 2.1 Introduction. 2.2 General aspects. 2.3 Selection of off-targets. 2.4 In silico approaches to off-target profiling .2.5 Summary and conclusions. 3 Pharmacological promiscuity and molecular propertiesJens-Uwe Peters 3.1 Introduction: pharmacological promiscuity in the history of drug discovery. 3.2 Lipophilicity. 3.3 Molecular weight. 3.4 Ionisation state. 3.5 Other molecular descriptors and structural motifs. 3.6 Implications for drug discovery. 4 Kinases as antitargets in genotoxicity Stephan Kirchner 4.1 Protein Kinases and inhibitor-binding sites. 4.2 Cyclin-Dependent Kinases (CDKs) controlling unregulated cell proliferation. 4.3 Mitotic kinases as guardians protecting cells from aberrant chromosome segregation. 5 Activity at cardiovascular ion channels: a key issue for drug discoveryIan M. …”
    An electronic book accessible through the World Wide Web; click to view
    Electronic eBook
  11. 191

    Lecture notes

    Published 2013
    Table of Contents: “…Machine generated contents note: List of abbreviations 1 Requesting and interpreting tests 2 Disturbances of water, sodium and potassium balance 3 Acid-base balance and oxygen transport 4 Renal disease 5 Disorders of calcium, phosphate and magnesium metabolism 6 Diabetes mellitus and hypoglycaemia 7 Disorders of the hypothalamus and pituitary 8 Abnormalities of thyroid function 9 Disorders of the adrenal cortex and medulla 10 Investigation of gonadal function, infertility, menstrual irregularities and hirsutism 11 Pregnancy and antenatal screening 12 Cardiovascular disorders 13 Liver disease 14 Gastrointestinal tract disease 15 Nutrition 16 Trauma, inflammation, immunity and malignancy 17 Disorders of iron and porphyrin metabolism 18 Uric acid, gout and purine metabolism 19 Central nervous system and cerebrospinal fluid 20 Therapeutic drug monitoring and chemical toxicology 21 Clinical biochemistry in paediatrics and the elderly.…”
    An electronic book accessible through the World Wide Web; click to view
    Electronic eBook
  12. 192

    Lecture notes

    Published 2013
    Table of Contents: “…Machine generated contents note: List of abbreviations 1 Requesting and interpreting tests 2 Disturbances of water, sodium and potassium balance 3 Acid-base balance and oxygen transport 4 Renal disease 5 Disorders of calcium, phosphate and magnesium metabolism 6 Diabetes mellitus and hypoglycaemia 7 Disorders of the hypothalamus and pituitary 8 Abnormalities of thyroid function 9 Disorders of the adrenal cortex and medulla 10 Investigation of gonadal function, infertility, menstrual irregularities and hirsutism 11 Pregnancy and antenatal screening 12 Cardiovascular disorders 13 Liver disease 14 Gastrointestinal tract disease 15 Nutrition 16 Trauma, inflammation, immunity and malignancy 17 Disorders of iron and porphyrin metabolism 18 Uric acid, gout and purine metabolism 19 Central nervous system and cerebrospinal fluid 20 Therapeutic drug monitoring and chemical toxicology 21 Clinical biochemistry in paediatrics and the elderly.…”
    An electronic book accessible through the World Wide Web; click to view
    Electronic eBook
  13. 193

    Health care costs causes, effects and control /

    Published 2009
    Table of Contents: “…/ Steffen Flessa, Paul Marschall -- Costs of epidemiological changes in chronic diseases in Mexico / Armando Arredondo, Emanuel Orozco, Edson Servan -- Deficit and health reform : two different phenomena? / Z. Darmopilova, Z. Zigova -- Screening colonoscopy in Germany : a cost-saving analysis / Andreas Sieg, Hermann Brenner -- A fully Bayesian cost-effectiveness analysis using conditionally specified prior distributions / M. …”
    An electronic book accessible through the World Wide Web; click to view
    Electronic eBook
  14. 194

    Health care costs causes, effects and control /

    Published 2009
    Table of Contents: “…/ Steffen Flessa, Paul Marschall -- Costs of epidemiological changes in chronic diseases in Mexico / Armando Arredondo, Emanuel Orozco, Edson Servan -- Deficit and health reform : two different phenomena? / Z. Darmopilova, Z. Zigova -- Screening colonoscopy in Germany : a cost-saving analysis / Andreas Sieg, Hermann Brenner -- A fully Bayesian cost-effectiveness analysis using conditionally specified prior distributions / M. …”
    An electronic book accessible through the World Wide Web; click to view
    Electronic eBook
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    Lettering & type creating letters and designing typefaces / by Willen, Bruce, 1981-

    Published 2009
    Table of Contents: “…Context : Legibility, context, and creativity ; A compressed history of the Roman alphabet -- 2. Systems & type-ologies : Systems ; The ideal versus the practical ; Conceptual alphabets and lettering ; Writing, lettering, or type? …”
    An electronic book accessible through the World Wide Web; click to view
    Electronic eBook
  18. 198

    Lettering & type creating letters and designing typefaces / by Willen, Bruce, 1981-

    Published 2009
    Table of Contents: “…Context : Legibility, context, and creativity ; A compressed history of the Roman alphabet -- 2. Systems & type-ologies : Systems ; The ideal versus the practical ; Conceptual alphabets and lettering ; Writing, lettering, or type? …”
    An electronic book accessible through the World Wide Web; click to view
    Electronic eBook
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