Search Results - "Genetics"

Whole-genome association studies practical advice and considerations /

Subjects: “…Genetic Predisposition to Disease epidemiology. 112388…”
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Admixture mapping

Table of Contents: “…Contents: Applications of statistical modelling of population admixture -- Genetic and environmental explanations for ethnic differences in disease risk -- Methods for finding genes that influence complex traits -- Exploiting admixture to map genes -- Statistical power of admixture mapping -- Advantages of admixture mapping in comparison with other approaches to finding disease susceptibility genes -- Methodological problems of extending linkage analysis of a cross to admixed human populations -- Statistical methods that allow linkage analysis of a cross to be extended to admixed humans -- Model for stochastic variation of ancestry on chromosomes inherited from an admixed parent -- Multipoint inference of ancestry at marker loci from genotypes -- Null hypothesis as graphical model -- Statistical approach to model fitting and hypothesis testing -- The score test algorithm -- Other model diagnostics: "Bayesian p-values" -- How many markers are required for genome-wide admixture mapping? …”
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Use of isolated populations in disease gene identification

Table of Contents: “…Contents: Disease mutations in Finland - Molecular background of Finnish disease heritage - Finnish disease genes, novel pathways exposed - Example: APECED - AIRE protein - AIRE regulates ectopic expression in thymus - AIRE deficiency - Simplifying the complex genetic background of common diseases - Advantages of isolated populations - Internal isolates: increased genetic homogeneity - Lactose intolerance - Adult type hypolactasia - Severe coronary heart disease - Familial combined hyperlipidemia, FCHL - USF1: a transcription factor - Effect of genetic association on target cells, coronary wall and impact in population - Population based cohorts in Finland - Global effort is needed.…”
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Heterogeneity problems and solutions /

Subjects: “…Genetic Predisposition to Disease epidemiology. 112615…”
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Segregation analysis

Table of Contents: “…Contents: Components of segregation analysis -- Maximum likelihood models -- Peeling and MCMC -- Estimating the segregation proportion -- Ascertainment/sampling bias -- Ascertainment correction -- Segregation analysis for quantitative traits -- Polygenic models -- Heritability -- Components of variance -- Genetic variance: additive and dominance -- Epistatic variance -- Analysis of covariance -- Mixed models -- Liability and threshold models -- The hypergeometric polygenic model -- Regressive models -- Penetrance functions -- Survival models -- Computer packages.…”
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Haplotype phase inference

Subjects: “…Genetic Predisposition to Disease epidemiology. 112626…”
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Optimal use of linkage disequilibrium, haplotypes, and integrated maps for positional cloning

Table of Contents: “…Contents: The use of LD for localization of disease genes -- The evolutionary theory behind LD maps -- Comparison of alternative metrics and genetic models -- Effect of SNP selection on power -- Extension to haplotype analysis -- The utility of maps that integrate physical, linkage and LD data.…”
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Nature, nurture, neither?

Subjects: “…Genetic Predisposition to Disease epidemiology. 112639…”
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Genome-wide scans

Subjects: “…Genetic Predisposition to Disease epidemiology. 112652…”
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The study of candidate genes in drug trials sample size considerations /

Subjects: “…Genetic Predisposition to Disease epidemiology. 112655…”
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Graphical modelling of linkage disequilibrium

Subjects: “…Genetic Predisposition to Disease epidemiology. 112658…”
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Bayesian approaches for modelling complex metabolic pathways

Subjects: “…Genetic Predisposition to Disease epidemiology. 112661…”
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Fine-scale mapping

Subjects: “…Genetic Predisposition to Disease epidemiology. 112664…”
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Detecting and correcting for population structure in genetic case-control studies

Subjects: “…Genetic Predisposition to Disease epidemiology. 112671…”
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Use of DNA pooling in large-scale association studies

Subjects: “…Genetic Predisposition to Disease epidemiology. 112677…”
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Haplotype-based mapping in pharmacogenetics

Subjects: “…Genetic Predisposition to Disease epidemiology. 112680…”
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Neurodegenerative disease the medical imperative for the developed world /

Table of Contents: “…Contents: Neurodegenerative disease: the medical imperative for the developed world -- Neurodegeneration is a major health care crisis -- Ages of neurodegenerative disease research -- Clinicopathological description -- Transmitter biochemistry -- Genetic analysis of causation -- Disease genes for all the major disorders -- The future.…”
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Crop biotechnology update part 1 of 2, genome editing technologies /

Table of Contents: “…Contents: Genetic modification (GM) of plants -- Techniques used to produce GM plants -- Agrobacterium tumefaciens -- Genetic modification of wheat -- Genome editing with oligonucleotides -- Genome editing with targeted nucleases -- TALENS, ZFNs and CRISPR-Cas9 -- New breeding technologies using genome editing -- Use of GM plants in agriculture -- 1st generation traits in GM crops.…”
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Cancer-specific epigenetic alterations as investigated from a pharmaceutical perspective

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Agro-technology a philosophical introduction / by Thompson, R. Paul, 1947-

Subjects: An electronic book accessible through the World Wide Web; click to view