Search Results - "DNA"

The development and evolution of human gene therapy

Table of Contents: “…Contents: Background in genetic concepts -- Application by Sir Archibald Garrod to human disease -- Discovery of the structure of DNA and new opportunities to understand and manipulate genes -- Proof of principle of gene transfer into human cells using the Lesch Nyhan disease model -- Rapid expansion of clinical gene therapy trials, high level of optimism and expectation -- Major setback in human OTC gene therapy study -- Patient death -- Scientific and clinical success with another disease model -- Severe combined immunodeficiency (SCID) -- Setback in SCID -- Leukemia in some treated patients -- Additional clinical successes, especially in Leber's congenital blindness.…”
Get full text
Series

Metabolic and biochemical alterations in Alzheimer's disease facts and fictions /

Table of Contents: “…-- Tauist and BAPtist hypothesis of AD -- Pathology and oxidative stress relationship -- NFT and amyloid-beta -- Stress-activated protein kinases and phospho-tau -- Amyloid-targeted approaches are unsuccessful -- Amyloid-beta controls redox activity -- Genetic factors are related to oxidative stress -- Therapeutics -- Potential mechanism of ROS generation -- Oxidative modifications and macromolecules -- Oxidative damage directly correlates with mtDNA -- Abnormal mitochondrial distribution in AD brains -- Iron histochemistry -- Antioxidant diet is protective -- Only one non-amyloid drug in phase III: 2010 -- Oxidative stress is necessary but not sufficient -- CaMKII-MYC mice -- Oxidative stress and cell cycle abnormalities -- Early stages of AD disease signals.…”
Get full text
Series

Asthma an epidemic caused by epigenetics? /

Table of Contents: “…Contents: Genetic and biological determinants of diseases influenced by the environment -- Epigenetics -- Epigenetic mechanisms can be influenced by environmental exposures and aging -- Histone modifications and innate immunity -- Asthma is a major public health problem -- Epigenetics and airway immunology -- DNA methylation changes and asthma -- Runx3 and airway disease -- In utero folate supplementation and asthma -- Sib pair asthma study -- preliminary analysis -- Global methylation patterns: asthmatics vs. nonasthmatics -- Hypomethylation of GATA3 or MUC5B is associated with asthma in concordant sib pairs -- Hypermethylation of NOS2 is associated with concordant asthma -- Asthma: an epidemic caused by epigenetics?…”
Get full text
Series

New technologies and perinatal medicine : prediction and prevention of pregnancy complications /

Table of Contents: “…Maternal plasma cell-free DNA screening: Basic science and applications; 35. …”
Taylor & Francis
OCLC metadata license agreement

Chaperone mechanisms in cellular protein folding

Table of Contents: “…Contents: The effect of protein aggregation on productive protein folding -- The function of GroEL and GroES as a folding cage for proteins -- Changes in energy landscape within the folding cage -- Cooperation of different chaperone systems in folding pathways: Hsp70 and chaperonins -- Binding of the Hsp70 homologue protein, DnaK, to newly-synthesized polypeptides -- The role of chaperone mechanisms in toxicity suppression of misfolded disease causing proteins -- Potential uses of the chaperone mechanisms in disease therapeutics.…”
Get full text
Series (Molecular chaperones)
Series (Protein folding)

The type I interferon system and viruses

Table of Contents: “…Contents: Introduction to the type I interferon (IFN) system -- Induction of type I IFN by viruses -- TLR sensors and cytoplasmic nucleic acid sensors -- Inhibition of nucleic acid sensing by RNA and DNA viruses -- Type I IFN signaling and its inhibition by viruses -- Activities of type I IFN inducible genes and their viral inhibitors -- General inhibition of host gene expression by viruses -- Coordination of immune responses by type I IFN -- Role of viral IFN antagonists in virus biology -- Applications of viruses with debilitated interferon antagonism.…”
Get full text
Series

Gene therapy for Hemophilia

Table of Contents: “…Contents: Hemophilia treatment past and present -- Gene transfer for genetic disease -- Viruses engineered to deliver genes -- Gene therapy using integrating vectors -- Adeno-associated virus (AAV) structure and composition -- AAV-Factor IX vectors -- AAV-mediated gene transfer for hemophilia -- Risk of germline transmission -- Peptide library based on AAV and Factor IX -- Transaminitis and liver enzymes -- Neutralizing antibodies to AAV -- Self-complementary DNA and Factor IX synthesis -- Strategies to overcome immunity to AAV -- Use of empty capsids.…”
Get full text
Series

Vaccinations types, potential complications and health effects /

Table of Contents: “….] -- Clinical dendritic cell based cancer vaccination / Anders Elm Pedersen, Annika Berntsen, Inge Marie Svane -- Nonviral cancer vaccines : from free antigens to engineered cells / M.J.Herrero -- New vaccination strategies for the improvement of DNA vaccines against virus in fish / Carolina Tafalla, Amparo Estepa, Julio Coll.…”
An electronic book accessible through the World Wide Web; click to view

Salmonella infections new research /

Table of Contents: “…Chambers -- Biochemical characterization of Salmonella effector AvrA as a protease in inflammation / Jun Sun -- Novel approaches to diagnosing salmonellosis / Mahdi Saeed, Seongbeom Cho, Muhammad Younus -- Phenotypic and molecular characterization of Salmonella enterica serovar typhimurium human isolates in Slovakia / Viktor Majtan, Juraj Majtan, Hana Drahovska -- Class 1 integrons and dissemination of antibiotic resistance genes among salmonellae : from PCR- to DNA microarray-based approach / Tomas Majtan, Viktor Majtan -- Multiple-drug resistance Salmonella : a challenge for epidemiolgical investigations / Patamaporn Amavisit -- New probiotic "biokons" for preventive Salmonella and E. coli associated infections at a poultry / G. …”
An electronic book accessible through the World Wide Web; click to view

Transgenic plants recent developments /

Table of Contents: “…Plant leaf decomposition, DNA release, persistence and transfer into the environment / John Poté, Walter Wildi -- Establishment of light formula and light environmental management strategy for high-efficient plant cultivation with artificial light sources / Wenke Liu ... …”
An electronic book accessible through the World Wide Web; click to view

Molecular Cancer

Open Access

Ranaviruses Lethal Pathogens of Ectothermic Vertebrates /

Get full text

New technologies for electrochemical applications /

Taylor & Francis
OCLC metadata license agreement

Therapy in cancer 2008 quo vadis? /

Table of Contents: “…Contents: Why pursuing new therapeutic approaches in cancer is important -- Prevention and screening -- Current cancer therapy: non-surgical -- Most chemotherapy targets DNA -- Chemotherapy effects -- Current state of cancer therapy: efficacy and toxicity -- Molecular pathogenesis of cancer -- Pursuing targeted therapy in cancers -- Targeted biologic therapies -- Evolving targets and agents -- Shift from chemotherapy to targeted agents -- Clinically established molecular targets in malignancies -- Targeted therapy: proteins and small molecules -- Changes brought about by targeting: efficacy and toxicity -- Biomarkers in drug development -- What is currently known: angiogenesis -- The VEGF family and its receptors -- Bevacizumab and Sorafenib -- Does toxicity correlate with response? …”
Get full text
Series

Mitotic chromosome condensation

Table of Contents: “…Contents: Evolutionary and developmental comparisons -- Stages of mitosis -- Primary functions of mitosis -- Lower levels of chromatin organization -- Helical folding -- Experimental foundation of textbook model -- Are there specific DNA sequences at the base of chromatin loops? -- Are there specific nonhistone proteins making up the chromosome scaffold? …”
Get full text
Series

The management of other aspects of chronic liver disease, including transplantation

Table of Contents: “…Contents: Common complications of end stage cirrhosis including life threatening disorders of variceal bleeding, ascites, hepatorenal syndrome, encephalopathy and hepatopulmonary syndrome -- Preparation for listing for liver transplantation in patients with end stage liver disease includes documentation and absence of alcohol consumption (in alcoholics), reduction of hepatitis B DNA levels (in HBV patients) and aggressive treatment of hepatocellular carcinoma to reduce the risk of recurrent disease -- The most common allocation system for liver transplantation is the model for end stage liver disease -- Post transplantation care of the patient requires diligent annual followup with concentration on common diseases which include: metabolic syndrome (diabetes mellitus, obesity, hypertension, hyperlipidemia), Preventive medicine (vaccination, dental disease), Inflammatory bowel disease, bone disease, and renal dysfunction.…”
Get full text
Series

Robustness and evolvability in living systems / by Wagner, Andreas, 1967 January 26-

Table of Contents: “…Introduction -- The genetic alphabet -- The genetic code -- RNA structure -- Proteins and point mutations -- Proteins and recombination -- Regulatory DNA regions and their reorganization in evolution -- Metabolic pathways -- Metabolic networks -- Drosophila segmentation and other gene regulatory networks -- Phenotypic traits, cryptic variation, and human diseases -- The many ways of building the same body -- Neutral spaces -- Evolvability and neutral mutations -- Redundancy of parts or distributed robustness? …”
An electronic book accessible through the World Wide Web; click to view

Handbook of forensic statistics /

Taylor & Francis
OCLC metadata license agreement

Biochemical engineering : an introductory textbook /

Taylor & Francis
OCLC metadata license agreement