Search Results - "DNA"

Molecular genetics of bacteria / by Snyder, Larry

Table of Contents: “…The bacterial chromosome : DNA structure, replication, and segregation -- Bacterial gene expression : transcription, translation, and protein folding -- Bacterial genetic analysis : fundamentals and current approaches -- Plasmids -- Conjugation -- Transformation -- Lytic bacteriophages : development, genetics, and generalized transduction -- Lysogeny : the lambda paradigm and the role of lysogenic conversion in bacterial pathogenesis -- Transposition, site-specific recombination, and families of recombinases -- Molecular mechanisms of homologous recombination -- DNA repair and mutagenesis -- Regulation of gene expression: genes and operons -- Global regulation : regulons and stimulons -- Bacterial cell biology and development.…”
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Molecular epidemiology of lung cancer

Table of Contents: “…Contents: The influence of host factors on individual susceptibility to tobacco smoke -- The pleiotropic genes that control activation (Phase I) and detoxification (Phase II) of potential carcinogens -- Effects of the metabolism of environmental compounds on the lipophilic properties of a molecule and the introduction of electronegative moieties within the molecule on carcinogenic potential -- Other susceptibility factors related to defects in DNA repair, alterations in tumor suppressor genes and alterations in tumor invasiveness factors -- Polymorphisms in genes and the association of this with lung cancer development -- The role of inherited polymorphisms of genes involved in xenobiotic metabolism, DNA repair and tumor suppression/invasion (alone and in combination) in lung cancer risk, and modification of this risk by environmental factors such as smoking and diet.…”
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The generation of diversity in antibody genes

Table of Contents: “…Contents: Historical perspective on antibodies and immunity -- Nature and structure of antibodies and immunoglobulin fold -- Theories of antibody formation -- Clonal selection theory -- Mechanisms contributing to antibody diversity -- Organization of immunoglobulin loci -- Immunoglobulin gene rearrangement and generation of the primary repertoire -- RSS elements -- RAG genes and mechanism of V-D-J joining -- Membrane immunoglobulin and the B-cell antigen receptor -- Secondary antibody repertoire and diversification of rearranged immunoglobulin genes -- Affinity maturation -- Somatic hypermutation, gene conversion and class-switch recombination -- DNA deamination as a central trigger for these three diversification processes -- Detailed pathways of antibody gene diversification -- AID and the evolution of DNA deamination.…”
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Bacterial extrachromosomal elements role in chemical detoxification and potential cancer therapy /

Table of Contents: “…Contents: Examples of degradative plasmids -- Xylene and toluene degradation by TOL plasmids -- The chloro-catechol orthocleavage pathway -- Catabolic pathways/genes in 2,4-D degradation -- Chemostatic evolution of 2,4,5-T degradative genes -- Unusual genomic structure of the 2,4,5-T genes -- Sequence characteristics of the clc element -- Evolution of s-triazine degradative plasmids -- Azurin interaction with different targets -- Structural features of azurin and immunoglobulins -- Secretion of azurin upon exposure to cancer cells -- Sequences in released extrachromosomal DNA -- Released CpG-rich DNA has anti-tumor activity.…”
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The pRB/E2F pathway

Table of Contents: “…Contents: The E2F transcription factors control cell cycle entry -- The pRB/E2F pathway -- pRB and E2F are both families of proteins -- Differential roles of the pocket proteins -- Repression and activation of E2F target genes is regulated by distinct E2F complexes -- Rb mutant mice -- Inhibition of the activating E2Fs is key to pRB's tumor suppressive activity -- The activating E2Fs can also induce apoptosis and senescence genes in tumor cells -- Role of pRB-E2F in DNA damage response -- pRB contributes to the activation of pro-apoptotic genes in response to DNA damage.…”
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The roles of molecular chaperones in bacterial infection

Table of Contents: “…Contents: Discovery of major molecular chaperones through the studies on bacteriophage lambda -- Discovery of function of DnaK machinery assisting assembly/disassembly of macromolecule protein structure -- Roles of DnaK chaperone machinery and ClpX chaperone in Salmonella pathogenesis and flagellar biogenesis -- Role of GroEL on bacterial cell surface.…”
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The complete guide to ABC's molecular biology certification exam / by Roy, Tiffany

Taylor & Francis
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MOLECULAR FOOD MICROBIOLOGY by Liu, Dongyou

Taylor & Francis
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Studying aging in humans part 2 of 2, Practice /

Table of Contents: “…Contents: Examples: calorie restriction vs. the obesity paradox, inherited DNA variants and longevity.…”
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Crazy wisdom saves the world again! handbook for a spiritual revolution : featuring "The evolution sutra" and "Be here wow!" / by Nisker, Wes

Table of Contents: “…-- The fact of the matter -- DNA by the numbers -- Sub-subatomic physics -- A fool's paradise -- Busy dying -- "Poem": why I meditate -- The evolution sutra -- Hello earthling -- The divine DNA -- Survive or die -- Your mama is a germ -- Past and future lives -- New animal on the block -- The kisser -- Humans double-wise, double wise -- Be here wow! …”
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The peopling of the Americas new insights from genetic studies /

Table of Contents: “…-- Two different founding populations colonized the Americas -- Linguistic evidence -- Genetic background -- mtDNA lineages in native Americans -- mtDNA haplogroup frequencies in Siberia and the Americas -- Population history of Amerindian haplogroups -- Haplogroup X in North and Central America -- Prehistoric European migration to North America -- History and diversification of circumarctic peoples -- Ancient vs. modern population diversity -- Colonization of the Caribbean -- Y chromosome haplogroup frequencies in the Americas -- Y chromosome haplogroup frequencies in native Siberians -- Y chromosome SNP haplotype network -- Migration models based on Y chromosome data.…”
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Nuclear receptors transcriptional functions /

Table of Contents: “…Contents: Introduction to transcription factors -- Nuclear receptors as ligand-dependent transcription factors -- Classes of nuclear receptor -- Nuclear receptor ligands: agonists and antagonists -- Nuclear receptor phylogeny -- Nuclear receptor isoforms -- The nuclear receptor DNA-binding domain -- Hormone response elements -- The nuclear receptor ligand-binding domain -- Nuclear receptor mechanism -- Subcellular localization of nuclear receptors -- The effect of ligand binding -- Nuclear receptor coregulators -- Initial discoveries of coregulators -- The SRC/p160 coregulator family -- Nuclear receptor-coregulator interaction motifs -- Histone acetylation and chromatin structure -- The Nuclear Receptor Signaling Atlas (NURSA) -- Chromatin immunoprecipitation as a tool in nuclear receptor mechanism -- Functional differences between type I and type II nuclear receptors -- The coregulator exchange -- DNA-binding independent functions -- Transrepression -- The role of kinases.…”
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HIV preventative vaccines

Table of Contents: “…Contents: HIV distribution -- HIV in Africa -- HIV particle -- T-cell responses -- CD4 T-cells susceptible to HIV infection -- CD8 T-cells control HIV infection -- Acute HIV infection -- HIV escape mutations when CTL response focused on dominant epitope -- Immune control of HIV -- Antibody response to HIV-1 -- Viral membrane fusion -- 5 broadly neutralizing antibodies -- Antibody vaccines for HIV -- T-cell vaccine control of HIV -- CD8+ T-cell inducing vaccines partly protect against SIV/SHIV challenge -- HIVA DNA/MVA immunization in mice and macaques -- HIVA DNA + MVA in humans -- MVA.HIVA boosts HIV-1-specific CD8 T-cells in HIV+ donors on ART -- Current T-cell vaccines for HIV -- Phase IIB trials -- Merck rAd5 vaccine -- The problem of HIV variability -- Ways to tackle HIV-1 diversity.…”
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BMC Molecular Biology

Open Access

Forensics under fire are bad science and dueling experts corrupting criminal justice? / by Fisher, Jim, 1939-

Table of Contents: “…-- Expert versus expert : the handwriting wars in the Ramsey case -- John Mark Karr : DNA Trumps the graphologists in the Ramsey case -- Hair and fiber identification : the inexact science -- DNA analysis : backlogs, sloppy work, and unqualified people -- Bullet identification : FBI style overselling the science -- The celebrity expert : Dr. …”
An electronic book accessible through the World Wide Web; click to view

Genetic testing for CHD risk fact or fiction? /

Table of Contents: “…Contents: Family history is a strong independent risk factor for early CHD -- Criteria for useful CHD-Risk DNA tests -- Analytical validity -- Clinical validity -- Risk estimates for genetic effects -- Clinical utility -- Risk score methods -- CRP: origin, clearance and function -- Is it likely that genotype will predict risk over and above trait measure? …”
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Chaperone systems of the endoplasmic reticulum

Table of Contents: “…Contents: Communication between cells -- Angiogenesis -- Secretion of effector molecules -- Cell migration/homing -- Proteins synthesis & folding -- Molecular chaperone families in the ER -- Antibody formation -- BiP: a soluble Hsp70 protein -- ATPase and DnaK peptide binding domains -- CH1 domain -- The formation of disulfide bonds -- ATPase cycle of BiP -- Disruption of BiP/GRP78 gene in mice -- Highly virulent subtilase toxin -- BiP functions in ER -- ER DnaJ proteins -- Gal-4-BiP ATPase domain fusion protein -- BAP/Sil1: a nucleotide releasing factor -- Potential consequences of BAP/Sil1 loss and mutations -- The family of large Hsp70 proteins -- The two functions of GRP170 -- GRP94 as an essential gene- Immunophilins -- lymphoid specific chaperone: pERp1.…”
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Cytoplasmic innate immune sensors

Table of Contents: “…Autoinflammatory disease -- Cytoplasmic innate immune sensors -- NLRs and the inflammasome -- NLRP3 inflammasome -- Pyrin inflammasome -- NLRC4 inflammasome -- NLRP1 inflammasome -- NOD1 and NOD2 -- RLRs and detection of cytoplasmic RNA/DNA -- DNA sensing by cGAS and AIM2 -- RNA sensing by Rig-I and MDA-5 -- Programmed inflammatory cell death -- Spreading the signal (cGAMP and Inflammasomes) -- PAMPs, DAMPs and HAMPs.…”
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Transcriptional activation

Table of Contents: “…Contents: Transcription by RNA polymerase II -- Mediator complex -- Coactivator proteins -- Communication between DNA-binding proteins and general transcription machinery.…”
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Rapid methods for the genetic determination of pharmacokinetic status

Table of Contents: “…Contents: Key pharmacogenetic targets -- Minimizing laboratory processing -- Homogenous reactions and DNA probes -- Rapid and simple allele discrimination -- Point of care.…”
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