Search Results - "DNA"

RNAi and heterochromatin in plants and fission yeast

Table of Contents: “…Contents: Heterochromatin is composed of transposable elements (TEs) and related repeats -- heterochromatic gene silencing and TE-mediated silencing are related and may be important in large genomes -- tiling microarrays can be used to examine heterochromatic transcripts as well as DNA and histone modification -- small interfering RNA (siRNA) corresponds to transposons and repeats -- in plants TE siRNA depend on DNA methyltransferase MET1 and the SWI/SNF ATPase DDM1 which silence TEs via DNA and histone H3 lysine-9 (H3K9) methylation -- in fission yeast and plants centromeric repeats are transcribed on one strand but rapidly turned over by RNA interference (RNAi) -- RNAi of centromeric transcripts is required for transcriptional silencing of reporter genes -- RNA polymerase II, the Argonaute (RITS) and RNA dependent RNA polymerase (RDRC) complexes are associated with heterochromatin and required for silencing -- H3K9me2 depends on RNAi and on the Rik1-Clr4 complex -- Clr4 is the histone H3K9 dimethyltransferase -- Rik1 resembles both DNA and RNA binding proteins and is required for RNAi along with Clr4 -- LTR retrotransposon silencing depends on histone deacetylation and silences pericentromeric repeats in Arabidopsis in addition to RNAi.…”
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Series (Epigenetics)
Series (RNA interference)

Grabbing lightning building a capability for breakthrough innovation /

Table of Contents: “…Management systems for innovation -- Assessing your organization's capacity for breakthrough innovation -- The discovery competency -- Incubation: the long and winding road -- Acceleration: gathering steam and building critical mass -- The DNA innovation system -- Incorporating the DNA: the role of the orchestrator -- Getting started: initiating and maturing an innovation management system -- The innovation function.…”
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Replication of linear plasmids in bacteria

Table of Contents: “…Contents: The end replication problem and solutions -- Replication of linear DNA in Streptomyces species using terminal proteins -- Replication of linear DNA in Borrelia species using telomere resolution -- Genome plasticity in Borrelia resulting from reversal of telomere resolution.…”
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Introduction to computational biology

Table of Contents: “…Contents: What computational biology is -- Quick background on DNA and genes -- Bioinformatics -- Systems biology -- Synthetic biology -- DNA computing -- Summary overview and close.…”
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Genetics of Pakistani populations in an Asian and global context

Table of Contents: “…Contents: Population genetics -- Pakistan and south west Asia -- Human migrations -- DNA markers -- Alu repeats, SNPs and STRs -- Y chromosome, mitochondrial DNA and HLA markers unravel genetic relationships among populations in Asia and Pakistan.…”
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Regulation of replication fork progression and stability

Table of Contents: “…Contents: Replication fork anatomy -- Obstacles to replication fork progression -- Topological stress -- Fork stabilisation -- DNA repair -- DNA damage bypass -- Translesion synthesis -- Template switching models -- Fork regression mechanisms -- Co-directional replication and transcription.…”
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Epigenetic regulation of phenotype

Table of Contents: “…Contents: When does epigenetic reprogramming during the transfer of DNA between parents and their offspring occur, in the gametes or in early development? …”
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Bioinformatics tools in conservation biology

Table of Contents: “…Contents: Conservation biology and genetics -- Working with DNA sequences -- Statistical tools for measuring genetic diversity -- Genetic diversity and conservation: case studies -- Phylogenetic tools for assessing genetic diversity -- Phylogenetics and conservation: case studies -- Measuring genetic distance -- DNA forensics and applications to conservation.…”
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Race in genetics and medicine

Table of Contents: “…Contents: Questions about race -- Fundamentals of DNA and the genome -- Human genome sequence -- DNA sequence variation -- Three essential features of human genome diversity -- Expected nucleotide diversity -- STR analysis -- Relationships among human populations -- Major long-range human migrations -- Definition of race -- Allocation of individuals to genetic clusters -- Principal pathway of ethanol metabolism -- Allele frequencies at ALDH2 locus -- European ancestry and diabetes risk.…”
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The diversity of bacterial conjugation and mobilization systems

Table of Contents: “…Contents: Transfer of DNA between bacterial cells -- Basic plasmid platforms -- The mechanism and key components of conjugation -- The mating channel -- The complex between TrwC and its substrate DNA -- The relaxosome -- The diversity of relaxases -- The IncW family -- Methods for plasmid classification -- Plasmid MOB families -- The NCBI plasmid database -- Plasmid sequencing.…”
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A primer on cell and molecular biology / by Running, Mark P.

Table of Contents: An electronic book accessible through the World Wide Web; click to view

The implicit genome

Table of Contents: “…Sequence-dependent properties of DNA and their role in function / Donald M. Crothers -- Mutation as a phenotype / Errol C. …”
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Medicinal chemistry of nucleic acids

Table of Contents: “…Chu -- Structures and functions of nucleic acids modified with S, Se, and Teand complexed with small molecules / Wen Zhang, Jia Sheng, and Zhen Huang -- Unraveling of the NAD cyclizing and calcium signaling functions of human CD38 / Hon Cheung Lee -- DNA and RNA binding small molecules / Shibo Li and Zhen Xi -- G-quadruplex DNA and its ligands in anticancer therapy / Zhi-shu Huang ... …”
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The p53 family function & molecular mechanisms /

Table of Contents: “…Contents: The p53/p63/p73 family -- DNA damage elicits repair mechanisms involving the tumour suppressor gene p53 and the two newer members of the same family: p63 and p73 -- The molecular events driven by DNA damage to elicit the function of p63/p73 and their transcriptional regulation -- The biological effect of p63/p73 in the immune and neural systems.…”
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Human molecular evolution since the human-chimpanzee divergence

Table of Contents: “…Contents: Human-chimpanzee similarities -- Human-chimpanzee genomic comparison -- DNA duplication in human evolution -- DNA substitution in human evolution -- Modeling molecular evolution -- 2 goals of comparative genomics -- Identifying human accelerated regions (HARs).…”
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Primer of genetic analysis a problems approach /

Table of Contents: “…Overview of genetic organization and scale -- Mitosis and meiosis -- Nucleic acids: DNA and RNA -- Basic mendelian genetics -- Probability and chi square -- Sex linkage and gene interactions -- Pedigree analysis -- Overview of basic statistical testing -- Quantitative inheritance -- Overview of genetic mapping -- Assessing chromosome linkage relationships -- Linkage and mapping in diploids -- Mapping in bacteria and viruses -- Overview of types of genetic change -- Gene mutation -- Changes in chromosome number and structure -- Protein synthesis and the genetic code -- Gene regulation and development -- Overview of molecular biology techniques -- DNA mapping and human genome analysis -- Basic population genetics -- Selection and evolution -- Practice tests -- Answers to practice tests and crossword puzzles -- Landmarks in the history of genetics.…”
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Endothelial cell apoptosis

Table of Contents: “…Contents: Endothelial apoptosis -- Role in tumor response to radiation therapy -- Tissue damage results from depletion of stem cells and cells with clonogenic capacity -- Radiation targets the DNA leading to reproductive (mitosis-associated) or apoptotic cell death -- Modifications of DNA damage recognition and repair pathways determine the level of tissue sensitivity to radiation -- Sphingomyelin -- Ceramide -- GI tract and bone marrow: very radiation responsive -- Growth patterns of tumors -- The two-target model for single-dose radiotherapy of experimental tumors -- Engaging the vascular component of tumor response to radiation.…”
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The sources of genomic diversity

Table of Contents: “…Contents: The sources of genomic diversity: DNA and mutation, effect of mutations, inheritance, selection and drift -- Environmental diversity -- Natural selection -- Human genomic diversity -- Population growth -- G6PD -- DNA and mutation: point mutations (SNPs) and more complex mutations -- The effect of mutations: insertions or deletions and large chromosomal inversions -- Translation -- Coding mutations -- The fate of mutations -- Neural mutations -- Deleterious mutations -- Radically beneficial mutations: FOXP2 -- Sometimes beneficial/sometimes deleterious mutations: CCR5 delta-32 and Hgb S -- Promoter mutations -- Mutations traveling together: haplotypes.…”
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The discovery of human retroviruses and how they cause disease

Table of Contents: “…Contents: Human viruses that cause malignancies -- The discovery of human retroviruses -- Interspecies transmission of retroviruses -- New human viruses/viral diseases -- Adult T-cell leukemia caused by HTLV-I -- HTLV-I associated diseases -- Discovery of HTLV-2 -- How HTLVs cause disease -- Genomic structure of human retroviruses -- Mechanism of expression and function of human retroviral gene products -- Pathogenic mechanisms of HTLV-I -- The discovery of HIV and how it causes AIDS -- HIV-1 -- Some features of HIV pathogenesis -- HIV DNA provirus integration into host chromosomal DNA -- HIV in cancer.…”
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Epigenetics and Assisted Reproduction An Introductory Guide. by Camprubí, Cristina

Table of Contents: “…Cover; Half Title; Title Page; Copyright Page; Contents; Preface; Contributors; Chapter 1: A Short Introduction to DNA Methylation; Chapter 2: Epigenetic Modifications of Histones; Chapter 3: Epigenetic Reprogramming in Early Embryo Development; Chapter 4: Epigenetic Reprogramming of Mammalian Primordial Germ Cells; Chapter 5: Laboratory Molecular Methodologies to Analyze DNA Methylation; Chapter 6: Intrinsic and Extrinsic Factors That Influence Epigenetics; Chapter 7: Epigenetic and Assisted Reproduction Epidemiological Studies…”
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