Search Results - "DNA"

Fingerprinting Techniques in Food Authentication and Traceability /

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Elongation of protein synthesis structural basis of the process of decoding /

“…Biomedical & life sciences collection. From DNA to proteins : the multiple levels of regulation.…”
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Series (Mechanisms of ribosome function)

Genetics in forensics

Table of Contents: “…Contents: DNA typing in forensic analysis -- DNA fingerprinting -- Copy number variants -- Detection of minisatellites using MLPs and SLPs -- Short tandem repeats -- The DNA analysis procedure in forensics -- Advantages of mtDNA analysis over nucDNA -- Applications of mtDNA analysis -- Selecting SNPs -- Forensic validation in critical samples -- SNP typing applications -- Casework application -- DNA databases -- Statistics, interpretation and communication.…”
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Mitochondrial diseases an update /

Table of Contents: “…Contents: Mitochondrial functions -- Energy generation via oxidative metabolism -- The respiratory chain -- Mitochondrial DNA (mtDNA) -- Mitochondrial genetics -- A genetic classification of the mitochondrial diseases -- Diseases due to mutations in mtDNA -- mtDNA mutations impairing mitochondrial protein synthesis -- mtDNA mutations in specific protein-coding genes -- Diseases due to mutations in nuclear DNA (nDNA) -- Mutations in nuclear genes encoding subunits of respiratory chain complexes -- Mutations in nuclear genes encoding assembly proteins -- Defects of intergenomic communications -- Defects of the inner mitochondrial membrane lipid milieu.…”
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Molecular biology by Clark, David P.

Table of Contents: “…Basic genetics -- Cells and organisms -- DNA, RNA and protein -- Genes, genomes and DNA -- Cell division and DNA replication -- Transcription of genes -- Protein structure and function -- Protein synthesis -- Regulation of transcription in prokaryotes -- Regulation of transcription in eukaryotes -- Regulation at the RNA level -- Processing of RNA -- Mutations -- Recombination and repair -- Mobile DNA -- Plasmids -- Viruses -- Bacterial genetics -- Diversity of lower eukaryotes -- Molecular evolution -- Nucleic acids : isolation, purification, detection and hybridization -- Recombinant DNA technology -- The polymerase chain reaction -- Genomics and DNA sequencing -- Analysis of gene expression -- Proteomics : the global analysis of proteins.…”
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Economics and Management in the Biopharmaceutical Industry in the USA : Evolution and Strategic Change / by Kim, Rachel

Table of Contents: “…The Birth of Biotechnology , Slow Progress Despite Gene Splicing Technology Breakthrough, Breakthroughs from the Two Collaborators, Fear of the Unknown, The First Patents in theRecombinant DNA Area, Genentech Was Born, Chapter 4. Emergence of Biotechnology Firms in the1970s1990s, Threats of Young Competitors with New Knowledge, New Biotechnology Firms' Emergence in a Social Context: Response of Science Communities, Science Department at UCSF, UC Berkeley, and Stanford, New Biotechnology Firms' Emergence in the Legal Environment, Case Study 1: Genentech, The First Biotechnology Firm , Case Study 2: Amgen, The Second Biotechnology Company, Chapter 5. …”
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Mitochondrial disorders and neurodegeneration

Table of Contents: “…Contents: Spectrum of mitochondrial diseases -- Mitochondrial metabolic pathway -- MtDNA mutations and disease -- Pathological features -- MELAS -- Genetic epidemiology of mtDNA mutations -- Structural components of respiratory chain complexes -- Mitochondrial DNA metabolism -- Mitochondrial proteins and oxidative phosphorylation -- Fatal mtDNA depletion syndrome -- POLG mutations -- Environmental influences on PD causation -- PARK genes -- Huntington's disease and mtDNA mutations -- Genetic basis of Friedreich's ataxia -- Mitochondrial toxins.…”
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Series (Mitochondrial biogenesis)
Series (Neurodegenerative diseases)

Fundamental bacterial genetics by Trun, Nancy Jo

Table of Contents: “…Introduction to the cell -- DNA replication -- Mutations -- DNA repair -- Recombination -- Transposition -- Bacteriophage -- Transduction -- Natural plasmids -- Conjugation -- Transformation -- Gene regulation -- Plasmids, bacteriophage and transposons as tools -- DNA cloning -- Genomics, bioinformatics and proteomics.…”
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Techniques utilized in molecular genetics

Table of Contents: “…Contents: Techniques utilized in molecular genetics -- Genetic material separation -- DNA isolation -- mRNA isolation -- Genetic libraries -- Cell cultures -- DNA amplification -- Polymerase Chain Reaction -- Molecular cloning -- Allele characterization -- Gel electrophoresis -- Probe hybridization -- Real time PCR -- RT-PCR: Dissociation curves -- RT-PCR: End-point analysis -- Dye-terminator DNA sequencing -- High throughput DNA sequencing.…”
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Cell Division

Open Access

Degradation of apoptotic cells

Table of Contents: “…Contents: Apoptosis -- DNA fragmentation during apoptosis -- DNA degradation in macrophages -- Activation of innate immunity by undigested DNA -- Engulfment of apoptotic cells -- Phosphatidylserine-dependent engulfment of apoptotic cells -- Autoimmune disease caused by unengulfed apoptotic cells.…”
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Microarrays their design and use /

Table of Contents: “…Contents: The use of microarrays to study genomic DNA and expressed RNA at a global level are being developed at a phenomenal pace in the basic and medical sciences -- The basics of microarrays -- Fundamental descriptions and issues regarding experimental design, high-throughput approaches, analysis, and bioinformatics -- Different microarray platforms can be used to examine single nucleotide polymorphisms (SNP) of the genome, differential mRNA levels, differential microRNA (miRNA) levels, DNA methylation, genomic deletions and additions, DNA binding sites, and transcription rates -- Microarrays in the diagnosis, prognosis, and treatment of disease -- Microarrays in evolution, ecology and toxicology -- The future of microarray technology.…”
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Molecular biology and biotechnology

Table of Contents: “…Molecular analysis and application techniques -- Ch. 3. Recombinanat DNA technology -- Ch. 4. The expression of foreign DNA in bacteria -- Ch. 5. …”
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Plasmid rolling-circle (RC) replication

Table of Contents: “…Contents: Rolling circle replicating (RCR) plasmids -- Functional organization of rolling-circle replicating plasmids -- Model for plasmid rolling-circle replication -- Initiation and termination of replication in plasmids carrying two pT181 dsos -- DNA sequence and structure of the pT181 origin -- Initiator proteins of RCR plasmids -- Comparison of the replication origins of the plasmids of pT181 family -- Rep-DNA specificity -- Role of individual monomers of the Rep protein -- Purification of RepC heterodimers -- PcrA helicase -- Role of PcrA helicase in plasmid RC replication -- Conversion of ss to ds DNA -- Single strand origins of replication -- Lagging-strand replication.…”
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Epigenetically mediated gene silencing a companion to genetic alterations in driving tumorigenesis /

Table of Contents: “…Contents: Introduction to epigenetic changes in cancer -- defining the process of promoter DNA hypermethylation as a constituent of a broad range of chromatin abnormalities in cancer -- defining the genes aberrantly silenced in cancer including approaches being used to screen the cancer genome for such genes -- defining what is known about the interaction of DNA methylation and chromatin modifications for initiating and maintaining gene silencing in cancer -- outlining the position of aberrant gene silencing in tumor progression and particularly highlighting the key role these changes may play for the earliest steps in tumorigenesis -- defining the potential for using DNA hypermethylated gene promoter sequences as molecular markers for cancer risk assessment, early diagnosis and prognosis -- discussing the possibilities for targeting reversal of gene silencing as a prevention and therapeutic strategy for cancer.…”
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Introduction to free radicals and the oxygen paradox oxidative stress in biology, aging & disease /

Table of Contents: “…Contents: The oxygen paradox -- Oxygen origin -- Free radicals, oxidants and oxidative stress -- Sources of free radicals -- Environmental toxins -- Metabolic sources of free radicals: mitochondrial electron transport, phagocytes, peroxisomes, autooxidation -- Medical and dental sources of free radicals: x-rays, g-rays, drugs -- DNA damage and oxygen radical toxicity -- Antioxidant compounds and enzymes -- The dismutation of superoxide -- Mechanisms of antioxidant enzymes -- Antioxidant defense and repair systems -- Removal of oxidized DNA bases and DNA repair -- Lipolysis and the repair of oxidized lipids and lipid membranes -- Selective proteolytic degradation of oxidized proteins -- The LON protease -- Adaptation to oxidative stress -- Long-term effects of free radicals and oxidative stress: aging and disease.…”
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Mitochondrial biogenesis during gametogenesis and embryonic development

Table of Contents: “…Contents: Mitochondrial biogenesis and mass -- Mitochondrial biogenesis in spermatogenesis -- Mitochondrial biogenesis in oogenesis -- The bottleneck theory -- Maternal transmission of mitochondrial DNA -- Influence of the mitochondrial DNA content on fertilization -- Mitochondrial biogenesis in early embryonic development -- Mitochondrial transfer in reproduction.…”
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Overview of prokaryotic molecular chaperones

Table of Contents: “…Contents: Protein folding in vitro versus in vivo -- Concept of a molecular chaperone -- Chaperones in E. coli -- Trigger factor -- DnaK/DnaJ/GrpE system -- GroEL/GroES system -- Clp ATPases.…”
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Innate immunity and malaria

Table of Contents: “…Contents: Malaria causes systemic inflammation, morbidity and death -- Toxic mediators: GPI anchor, Hemozoin/DNA -- DNA motifs: CpG (TLR9) and AT-rich (unknown receptor) -- Mechanisms of malarial sepsis-like syndrome, cerebral malaria.…”
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Activation of gene expression by double-stranded RNA

Table of Contents: “…Contents: RNA-mediated recognition of chromosomal DNA -- Gene silencing -- Gene activation -- Mechanism of recognition of promoter DNA sequences by duplex RNAs -- Recognition of sequences beyond the 3'-termini of genes by duplex RNAs.…”
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