Search Results - "DNA"

Polyadenylation of mRNA precursors mechanism, regulation and connections with other cellular processes /

Table of Contents: “…Contents: Polyadenylation of mRNA precursors -- The polyadenylation machinery -- A surprising complexity in PAP -- Hyperphosphorylation by MPF inhibits PAP activity -- Gld-2 in cytoplasmic polyadenylation in oocytes -- The polyadenylation machinery -- CPSF-73 is the 3' processing endonuclease -- CPSF-73 is absent in cytoplasmic polyadenylation -- CstF protein interactions -- Regulation of gene expression by alternative polyadenylation -- The C-terminal domain of RNAPII -- The CTD can stimulate 3' cleavage in vitro -- CPSF links transcription and 3' end formation -- RNA15 crosslinks to promoters -- Polyadenylation and links to other cellular processes -- CstF-50 -- BRCA1 -- BARD1 -- BRCA associated ring domain protein -- Why does BARD1 inhibit 3' processing? -- DNA damage inhibits 3' processing -- How does BARD1 inhibit 3' processing? …”
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Overview of clinical pharmacology in cancer part 2 of 2 /

Table of Contents: “…Contents: Principles of pharmacodynamics -- Mechanisms of action of anticancer agents -- Evolution from non-specific DNA damagers to targeted therapies -- Integrated pharmacokinetics, dynamics and genomics dose response model.…”
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Heritable disorders of collagen

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Mitochondria and ageing in model systems

Table of Contents: “…Contents: Mitochondria function/dysfunction and related outcomes -- Metabolic rate theory of aging -- Beneficial effects of caloric restriction -- ROS production and oxidative stress effect on aging -- Free radical theory of aging -- Mitochondrial DNA mutations phenotypes.…”
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Usage of vaccines and therapeutics in public health emergencies part 2 of 2 /

Table of Contents: “…Contents: Specific tools including vaccine and therapeutics to control outbreaks -- Improved non-viral DNA-based and viral VSV-based vaccines -- Recent outbreaks in Likati and North Kivu -- New strategies to rapidly develop novel immune therapies and vaccines -- Applications against Ebola virus and others high consequence pathogens -- Recent findings on rapid vaccination regimens and their promising potential.…”
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The transcription factor NF-Kappa B an evolutionarily conserved mediator of immune and inflammatory responses /

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Ethical issues in human population genetics

Table of Contents: “…Contents: The ethical issues in human genetics -- ELSI issues -- DNA in establishing identity -- DNA in unveiling the past -- DNA predicts the future -- Manipulation of DNA -- Ownership and control of DNA -- Deeper cultural changes -- Population genetics -- DNA in group history -- The Navajo people -- DNA in group stigma -- DNA in exploitation -- DNA and racism -- DNA and biological warfare -- The consent of a research population -- The NIH alternative for consent -- Control -- Confidentiality -- Return of information -- Benefit sharing.…”
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SARS-COV-2 vaccine development where are we now? /

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Histone dynamics, heritability and variants

Table of Contents: “…Contents: DNA is organized into chromatin which promotes compaction and brings about additional information -- The histone code hypothesis -- Chromatin dynamics and heritability -- Factors involved in chromatin dynamics -- Nucleosomes disruption and assembly following DNA replication fork passage -- General steps in chromatin assembly -- Histone chaperones and their possible roles (CAF-1, HIRA, ...) -- Histone H3 variants and chromatin assembly coupled or not with DNA synthesis -- Specific histone deposition pathways for each variant? …”
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Series (Epigenetics : concepts, theories, paradigms and mechanisms)
Series (Eukaryotic gene regulation)
Series (Epigenetics, chromatin, transcription and cancer)

Mouse models to investigate cell cycle and cancer

Table of Contents: “…Contents: Cell cycle regulation during mouse development and adulthood -- Cyclin-dependent kinases (Cdks) -- The genetic pathways for cell cycle regulation -- Cdk1, Cdk2, Cdk4, and Cdk6 -- The in vivo functions of Cdk2 -- Compensation between different Cdk/cyclin complexes -- Genetic interaction between Cdk2 and Cdk4 -- Control of the G1/S phase transition by the Retinoblastoma protein (Rb) -- DNA damage response in the absence of Cdk2 -- p27Kip1 inhibits Cdk1 in vivo -- Cdk1/cyclin E complexes promote S phase -- Cdks and tumors.…”
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Skin epigenetics how chromatin regulators orchestrate skin functions /

Table of Contents: “…-- Genes encoding keratinocyte-specific proteins -- Molecular signature of epidermal layers -- Levels of epigenetic regulation -- DNA methylation and hydroxymethylation -- DNA methylation influence on the epidermis -- Post-translational histone/covalent modifications -- Histone acetylation/de-acetylation -- Polycomb-repressive complex -- Polycomb and Trithorax play antagonistic roles -- ATP-dependent chromatin remodeling -- Non-coding RNA-dependent mechanisms -- Nucleus: storage, replication of genetic material -- Topological gene interactomes -- Morphogenesis of the epidermis -- Epidermal differentiation complex -- EDC and Lor relocation to nuclear interior -- p63 and Brg1 ablation results in retention of EDC -- Genome organizer AT-rich binding Satb1 protein -- Transcription factor and epigenetic mechanisms -- Future directions of epigenetic research.…”
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Colorectal cancer and the rare variant hypothesis

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The proteomic revolution

Table of Contents: “…Contents: The proteomic revolution -- Proteomics is the best measure of phenotype (biomarkers) -- Slow Off-rate Modified Aptamers (SOMAmers) are breakthrough protein binding reagents -- SOMAmers are multiplexed to perform SOMAscan assay, which measures >1000 proteins in small sample volumes using DNA measurement tools to identify and quantify proteins bound by SOMAmers -- Applications of SOMAscan to date include finding valid protein biomarkers for lung cancer, cardiovascular risk, pre-term birth, pancreatic cancer, mesothelioma, and many other diseases and conditions -- Ability to do comprehensive longitudinal proteomics studies will revolutionize medicine.…”
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Development of an intranasal vaccine for SARS-CoV-2

Table of Contents: “…Contents: General mechanism of action of DNA vaccines -- Adenoviral vectors for DNA delivery to host cells -- Advantages and limitations of intranasal vaccines -- Cellular, mucosal and antibody immunity in the context of SARS-2 -- Stability of AdCOVID at room temperature -- Earliest possible approval of AdCOVID -- How far and how fast can this vaccine then be deployed?…”
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Oxidative stress in amyotrophic lateral sclerosis (ALS) part 2 of 2 /

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Mismatch repair deficient cancers diagnosis, treatment and prevention

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Successes and failures with vaccines

Table of Contents: “…Contents: New strategies for vaccine development -- Influenza vaccines need improvement -- The microbiome influences rotavirus vaccine efficacy -- Vaccines against cytomegalovirus -- Vaccines against human papillomavirus and cervical cancer -- Insights from structural biology and the development of vaccines against respiratory syncytial virus -- Vaccines based on DNA and RNA.…”
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Statistical techniques in human population genetics

Table of Contents: “…Contents: Describe the biological & demographic processes that contribute to genetic diversity -- Describe statistical techniques that use observed DNA patterns to infer these past processes -- Illustrate the types of data used for inferring human history -- Highlight some key findings about human history derived through the use of these techniques.…”
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Microarray analysis : biochips and eradication of all diseases / by Sharma, Kal Renganathan

Table of Contents: “…Genominomics and prospects -- Chapter objectives -- Human genome project completed -- Biochips -- Next-generation sequencing -- Applications of biochips -- Consanguinous marriages -- Ashkenazi Jews -- Cystic fibrosis -- Tuberculosis -- Cancer -- Sickle-cell anemia -- Small pox -- Paleo genomes -- Colony collapse disorder -- Schizophrenia -- Prenatal testing -- DNA for forensic investigation -- Genomic surveillance -- Bio-corrosion -- Human immunodeficiency syndrome -- Microarray analysis -- Pioneers in double-helix structure of DNA -- Genominomics, economics of sequencing, $1,000 -- Genome is within reach -- Genetically modified crops -- Glossary -- Summary --…”
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Advances in molecular techniques /

Table of Contents: “…chapter 1 DNA Manipulative and Ingratiative Techniques /…”
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