Search Results - "vaccination"

Cancer vaccines part 1 of 2 /

Table of Contents: “…Contents: The hallmarks of cancer -- Categories of cancer-associated antigens -- Viral & non-viral cancers: vaccine targets -- Immunotherapeutics -- Immunologic reagents approved for cancer therapy -- Clinical outcome based on immune response -- CTL-based therapy -- Virus-specific CTL adoptive transfer therapy -- Immunotherapy for Melanoma.…”
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Series (Immunotherapy of cancer)
Series (Vaccines)

Cancer vaccines part 2 of 2 /

Table of Contents: “…Contents: HPV infection & prevention strategies -- Global cervical cancer prevalence -- HPV induced lesions & cancers -- Cell-mediated immune response to HPV -- Synthetic Long Peptide (SLP) vaccine concept -- Vulval intraepithelial neoplasia (VIN) vaccine -- Combining chemotherapy & SLP vaccination.…”
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Series (Immunotherapy of cancer)
Series (Vaccines)

Comparison of immune resilience induced by vaccination versus COVID recovery

Table of Contents: “…Contents: The need to characterize vaccine-indued immunity in more detail -- Methods for comparison of convalescent versus vaccination-induced plasma -- Higher effectiveness of antibodies induced by mRNA vaccination -- Characteristics of the new lambda variant – implications for immune escape -- Mechanisms leading to the increased efficiency of vaccine-induced antibodies compared to those of recovered patients..…”
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Adenovirus vectors and vaccine responses

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SARS-COV-2 vaccine current biological targets and considerations /

Table of Contents: “…Contents: Comparison of SARS-COV-2 with other coronavirus strains -- Targets for a SARS-COV-2 vaccine -- Other considerations once a vaccine has been developed.…”
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Nanotechnologies in the fight against coronaviruses

Table of Contents: “…Contents: The use of nanotechnologies in antiviral strategies, drugs, vaccines, and diagnostic tools -- Using nanotechnologies against human coronaviruses including SARS-CoV-2 -- Specific benefits of using nanotechnologies -- Carbon quantum dots.…”
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The immunology underlying tuberculosis

Table of Contents: “…Contents: The immunologic challenges of tuberculosis and the gaps in knowledge -- Tuberculosis and innate immunity -- Mycobacterium tuberculosis and how it affects macrophages, granulomas, neutrophils and DCs -- Tuberculosis and adaptive immunity -- The role of IFNgamma -- The T-cell response and immunodiagnostics -- The progress of TB vaccines -- Host-directed therapies.…”
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Hepatitis C virus discovery, cure and protection /

Table of Contents: “…Contents: Basic molecular virology of the hepatitis C virus (HCV) -- Introduction to hepatitis viruses and HCV induced disease -- A timeline of HCV -- HCV structure -- Treatment of HCV -- HCV persistence and vaccine potential -- Mechanisms that restrict HCV tropism to human livers.…”
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RNA therapeutics clinical applications and methods of delivery /

Table of Contents: “…Contents: The diversity of RNA species -- The diversity of mRNA -- mRNA vaccines -- mRNA vs. viral vector vaccines -- Obstacles overcome -- The limitless potential of RNA therapeutics -- VEGF mRNA for ischemia -- mRNA for cystic fibrosis -- Roadmap for RNA therapeutics -- RNA therapeutics and cancer -- Innovation in RNA therapeutics -- aYAP mRNA for cardiac regeneration -- mRNA therapy for progeria (HGPS).…”
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Cancer immunotherapy

Table of Contents: “…Contents: Opportunities for immunotherapy -- Cytotoxic antibodies -- Monoclonal antibodies -- CAR T cells: engineered targeting -- Checkpoint blockade treatment -- Therapeutic vaccines -- Tumour specific neoantigens -- Current immunotherapy development landscape.…”
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Series (Immune system)
Series (Molecular basis of cancer)

The evolving role of novel and next generation therapies in the management of multiple myeloma part 2 of 2, relapse refractory multiple myeloma /

Table of Contents: “…Contents: T-cell therapy strategies for Multiple Myeloma -- Cell-based Myeloma vaccines -- Antibody-drug conjugates -- Continuing evolution of Multiple Myeloma treatment.…”
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Immune checkpoint blockade in CNS tumors

Table of Contents: “…Contents: Immunotherapy in oncology -- CNS immunoprivilege -- Glioblastoma (GBM): complexity/redundancy/heterogeneity -- "Established" and "Advanced" GBM models -- Tumor-specific immune response in GBM -- Importance of heterogeneity -- Overcoming challenges for durable GBM benefit -- Neoantigen mutations -- Checkpoint blockade & immunologic memory -- GBM vaccines -- Personalized neoantigen vaccine ("NeoVax") -- Immunotherapy response assessment in neuro-oncology (iRANO) -- Clinical trials in neuro-oncology -- Immunosuppressive mechanisms in GBM -- Combination anti-tumor immunotherapy.…”
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IBD for the non-gastroenterologist

Table of Contents: “…Contents: Clinical epidemiology and characteristics of IBD -- Diagnostic testing -- Medical treatment of UC and CD -- Adverse events with medications -- Assessing extraintestinal manifestations of IBD -- Complications of disease -- Alternative Therapies for IBD -- Vaccination advice -- Mental health issues -- Cancer screening.…”
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Helper-dependent adenoviral vectors for gene therapy

Table of Contents: “…Contents: Overview of gene therapy vectors -- Helper-Dependent Ad (HDAd) vector -- Liver and lung directed gene therapy -- Hemophilia B gene therapy -- OTC deficiency clinical trial -- Balloon occlusion catheter-based delivery of HDAd -- HDAd-mediated CF gene therapy -- Brain gene therapy -- HDAd as genetic vaccine -- HDAd and stem cells.…”
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Viruses as anticancer weapons

Table of Contents: “…Contents: Modified viruses as friends -- Most licensed vaccines are live-attenuated viruses -- Natural oncolytic properties of viruses -- Preferential replication, efficient tumor access -- Clinical trials with oncolytic viruses -- Licensed therapeutics -- Added oncolytic properties -- Targeting: entry and post-entry -- Arming strategies -- Shielding from neutralizing antibodies -- Monitoring oncolytic virus replication in tumors -- From bench to clinic: the measles paradigm.…”
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Prion-like propagation of Parkinson's disease

Table of Contents: “…Contents: Parkinson's disease : symptoms and pathology (PD mutations and risk factors) -- Braak staging of Lewy body-related pathology in PD -- The prion-like hypothesis -- Key steps of alpha-synuclein pathology propagation (Release, Uptake, Seeding, Transport) -- In vivo and cell models from different species -- Therapeutic targets: promoting degradation, antibody aided clearance, and preventing seeding of alpha-synuclein -- Parkinson's disease vaccine: first clinical studies.…”
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Immunotherapy as an approach to treating Alzheimer's disease

Table of Contents: “…Contents: Alzheimer's Disease -- Immunization with amyloid-beta (A-beta) -- Radial arm water maze -- Clinical trial of anti-A-beta vaccine -- Mechanisms of antibody-mediated A-beta clearance -- Catalytic fibril dissolution -- Peripheral sink hypothesis -- Systemic administration of anti-A-beta antibodies into old APP transgenic (Tg) mice -- Diffuse and compact amyloid deposits -- Systemic anti-A-beta antibody -- Parenchymal and vascular amyloid deposits -- Microhemorrhages -- A possible solution to the problems of immunotherapy -- Systemic administration experimental design -- Intact and deglycosylated antibodies reverse cognitive decline -- Current clinical trials of A-beta immunotherapy -- Prospects for immunotherapy.…”
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Mismatch repair deficient cancers diagnosis, treatment and prevention

Table of Contents: “…Contents: Lynch syndrome (underlying single gene defect) -- Microsatellites -- Important genes containing repeat sequences -- MSI testing (5 marker panel) -- Mismatch repair (MMR) -- The genomic pathogenesis of colorectal cancer (CRC) -- EGFR and BRAF mutant inhibition -- BRAF colon cancer project -- Methotrexate & MMR deficient tumours -- Africans & bowel cancer (Dennis Burkitt) -- Cancer prevention program (CaPP) -- NSAIDs and reduced colorectal cancer risk -- Aspirin effect on polyps in FAP and colorectal adenoma -- The prevention paradox -- CaPP2 (Colorectal & Lynch syndrome cancers) -- Meta-analysis of cancer deaths with aspirin treatment -- CRCs in people on aspirin (mostly COX2 negative) -- Individual response to aspirin in cancer prevention -- History of salicylate as an essential nutrient -- CaPP3 study -- Peptides created by slippage in microsatellite coding -- Antibodies as a possible biomarker for Lynch syndrome -- The Micoryx vaccine.…”
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