Search Results - "melanoma"

Disorders of pigmentation melanoma /

Table of Contents: “…Contents: Melanocyte development -- Key factors regulating lineage development -- Relationships to pigmentation diseases -- MITF -- IV-induced pigmentation -- Melanoma-genesis -- Melanoma oncogene discovery -- BRAF-targeted therapy -- Immunotherapy -- Red pigment and melanoma-genesis.…”
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RAS and RAF signaling in melanoma biology and therapies /

Table of Contents: “…Contents: Melanoma -- BRAF and RAS mutated in approximately 70% of cases -- Mouse models of melanoma -- Oncogenic BRAF can be a founder mutation in melanoma -- Mouse models replicate human disease -- BRAF inhibitors induce paradoxical activation of CRAF and drive pathway activation -- Kinase-dead BRAF mimics this and potentiates RAS ooncogenesis -- BRAF inhibitors induce excellent responses in patients, but may induce mechanism-based side effects through CRAF.…”
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Immune checkpoint blockade in melanoma

Table of Contents: “…Contents: Checkpoint inhibition in melanoma -- Immunotherapy in the adjuvant setting -- Biomarkers of immune response -- The future of immunotherapy in melanoma -- Targeting release of cancer antigens -- Targeting cancer antigen presentation -- Targeting priming and activation of the immune system -- Targeting trafficking and infiltration of T-cells -- Targeting recognition and killing of cancer cells.…”
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Cancer vaccines part 1 of 2 /

Table of Contents: “…Contents: The hallmarks of cancer -- Categories of cancer-associated antigens -- Viral & non-viral cancers: vaccine targets -- Immunotherapeutics -- Immunologic reagents approved for cancer therapy -- Clinical outcome based on immune response -- CTL-based therapy -- Virus-specific CTL adoptive transfer therapy -- Immunotherapy for Melanoma.…”
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Series (Immunotherapy of cancer)
Series (Vaccines)

Talimogene laherparepvec first-in-class oncolytic immunotherapy /

Table of Contents: “…Contents: Causing tumour cell lysis -- Initiating a specific systemic immune response -- T-VEC as an oncolytic HSV-1 strain -- Assessing cancer immunotherapy through melanoma -- Applicability of oncolytic viral therapy to various cancers.…”
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Checkpoint blockade in cancer immunotherapy

Table of Contents: “…Contents: Activation of naive T-cells -- CD28 and CTLA-4 -- Differential regulation of T-cell responses -- Responding repertoire -- Biological role of CTLA-4 -- Tumor-specific immune responses -- Treg activity -- CTLA-4/GVax -- Immunotherapies -- Conventional therapies -- Ipilumumab -- Clinical studies: melanoma -- Reversible immune mediated toxicity.…”
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