Search Results - "proteins"

Inhibiting protein-protein interactions part 1 of 2 /

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Inhibiting protein-protein interactions part 2 of 2 /

Table of Contents: “…Contents: A different view of druggability -- Five propositions about the druggability of PPI targets -- Protein-ligand binding energy -- Ligand efficiency and drug-target binding -- ADME & druglikeness considerations -- Conventional view of druglikeness -- Druggability and chemical space -- Targeting low druggability PPI -- Macrocycles -- Covalent inhibitors -- Foldamers.…”
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Inhibiting protein-protein interactions part 1 of 2 /

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Inhibiting protein-protein interactions part 2 of 2 /

Table of Contents: “…Contents: A different view of druggability -- Five propositions about the druggability of PPI targets -- Protein-ligand binding energy -- Ligand efficiency and drug-target binding -- ADME & druglikeness considerations -- Conventional view of druglikeness -- Druggability and chemical space -- Targeting low druggability PPI -- Macrocycles -- Covalent inhibitors -- Foldamers.…”
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Inhibiting protein-protein interactions part 1 of 2 /

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Inhibiting protein-protein interactions part 2 of 2 /

Table of Contents: “…Contents: A different view of druggability -- Five propositions about the druggability of PPI targets -- Protein-ligand binding energy -- Ligand efficiency and drug-target binding -- ADME & druglikeness considerations -- Conventional view of druglikeness -- Druggability and chemical space -- Targeting low druggability PPI -- Macrocycles -- Covalent inhibitors -- Foldamers.…”
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The pharmacokinetics of therapeutic proteins

Table of Contents: “…Contents: Differences in the pharmacokinetics of therapeutic proteins compared to small molecule drugs -- Classes of therapeutic proteins -- Central paradigm of clinical pharmacology -- Distribution and tissue penetration of mAbs and proteins -- Three methods of renal protein metabolism -- Hepatic protein metabolism -- Target-mediated drug disposition -- Immunogenicity: general considerations and contributing factors -- Neutralizing, clearing and sustaining anti-drug antibodies.…”
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The pharmacokinetics of therapeutic proteins

Table of Contents: “…Contents: Differences in the pharmacokinetics of therapeutic proteins compared to small molecule drugs -- Classes of therapeutic proteins -- Central paradigm of clinical pharmacology -- Distribution and tissue penetration of mAbs and proteins -- Three methods of renal protein metabolism -- Hepatic protein metabolism -- Target-mediated drug disposition -- Immunogenicity: general considerations and contributing factors -- Neutralizing, clearing and sustaining anti-drug antibodies.…”
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The pharmacokinetics of therapeutic proteins

Table of Contents: “…Contents: Differences in the pharmacokinetics of therapeutic proteins compared to small molecule drugs -- Classes of therapeutic proteins -- Central paradigm of clinical pharmacology -- Distribution and tissue penetration of mAbs and proteins -- Three methods of renal protein metabolism -- Hepatic protein metabolism -- Target-mediated drug disposition -- Immunogenicity: general considerations and contributing factors -- Neutralizing, clearing and sustaining anti-drug antibodies.…”
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G proteins and the biology of depression and antidepressants

Table of Contents: “…Contents: Depression -- Antidepressant drug targets -- G protein signaling -- GPCR -- Gs alpha lipid raft localization and antidepressant treatment -- Gs alpha Acylation status and lipid raft localization -- Gs alpha palmitoylation status and lipid raft localization -- Blood biomarkers for depression.…”
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G proteins and the biology of depression and antidepressants

Table of Contents: “…Contents: Depression -- Antidepressant drug targets -- G protein signaling -- GPCR -- Gs alpha lipid raft localization and antidepressant treatment -- Gs alpha Acylation status and lipid raft localization -- Gs alpha palmitoylation status and lipid raft localization -- Blood biomarkers for depression.…”
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Transport and delivery of neurotrophic peptides and proteins across the BBB

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Transport and delivery of neurotrophic peptides and proteins across the BBB

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Transport and delivery of neurotrophic peptides and proteins across the BBB

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Structure and activation of endothelin ETB receptor by endothelin

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CML genetic paradigm of targeted therapy, part 1 of 2 /

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Conserved allosteric sodium in class A GPCRs part 2 of 2, Na+ dynamics in GPCR signaling /

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Conserved allosteric sodium in class A GPCRs part 2 of 2, Na+ dynamics in GPCR signaling /

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Structural basis of LSD signaling

Table of Contents: “…Contents: Lysergic Acid Diethylamide (LSD) history, physiological effects, and utility -- G Protein-coupled serotonin receptor signalling -- Structure of LSD-bound serotonin receptor -- Uniquely slow LSD binding kinetics -- Binding kinetics are linked to LSD’s pharmacological properties.…”
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Conserved allosteric sodium in class A GPCRs part 1 of 2, GPCR structure and allosteric effects /

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