Search Results - "amyloid"

A molecular understanding of Alzheimer's disease

Table of Contents: “…Contents: Usefulness of genetics in understanding AD -- Pathology of diseases -- Amyloid protein -- Genetic maps -- Mechanism of late onset Alzheimer's -- Role of presenilin in amyloid pathology -- Tau and frontotemporal dementia -- Tau splice site mutations -- Pathways to neurodegeneration.…”
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Targeting Aß oligomers a molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease /

Table of Contents: “…Contents: The oligomer cascade hypothesis for Alzheimer's Disease -- Why the oligomer hypothesis has largely supplanted the amyloid cascade hypothesis -- The role of AβOs in memory failure and the major facets of AD neuropathology -- Mechanisms by which AβOs instigate neurotoxicity -- Why AβOs accumulate in the first place -- How AβOs offer superb targets for novel AD diagnostics and disease-modifying therapeutics -- Beside its direct link to Alzheimer's disease, the discovery of toxic Aβ oligomers has provided a novel structural archetype for toxins germane to more than two dozen diseases of protein mis-folding, including Diabetes, Parkinson's, and prion diseases.…”
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Targeting Aß oligomers a molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease /

Table of Contents: “…Contents: The oligomer cascade hypothesis for Alzheimer's Disease -- Why the oligomer hypothesis has largely supplanted the amyloid cascade hypothesis -- The role of AβOs in memory failure and the major facets of AD neuropathology -- Mechanisms by which AβOs instigate neurotoxicity -- Why AβOs accumulate in the first place -- How AβOs offer superb targets for novel AD diagnostics and disease-modifying therapeutics -- Beside its direct link to Alzheimer's disease, the discovery of toxic Aβ oligomers has provided a novel structural archetype for toxins germane to more than two dozen diseases of protein mis-folding, including Diabetes, Parkinson's, and prion diseases.…”
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Targeting Aß oligomers a molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease /

Table of Contents: “…Contents: The oligomer cascade hypothesis for Alzheimer's Disease -- Why the oligomer hypothesis has largely supplanted the amyloid cascade hypothesis -- The role of AβOs in memory failure and the major facets of AD neuropathology -- Mechanisms by which AβOs instigate neurotoxicity -- Why AβOs accumulate in the first place -- How AβOs offer superb targets for novel AD diagnostics and disease-modifying therapeutics -- Beside its direct link to Alzheimer's disease, the discovery of toxic Aβ oligomers has provided a novel structural archetype for toxins germane to more than two dozen diseases of protein mis-folding, including Diabetes, Parkinson's, and prion diseases.…”
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The blood-brain barrier in Alzheimer's disease

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Frontotemporal dementia

Table of Contents: “…Contents: Prevalence and nomenclature of FTD -- The pathology of FTD (tau, TDP-43) -- The genetics of FTD (tau, progranulin) -- Patterns of atrophy and neuroanatomical correlates of behavior and cognition -- von Economo neurons -- Neuroimaging (amyloid imaging) -- Treatment.…”
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Frontotemporal dementia

Table of Contents: “…Contents: Prevalence and nomenclature of FTD -- The pathology of FTD (tau, TDP-43) -- The genetics of FTD (tau, progranulin) -- Patterns of atrophy and neuroanatomical correlates of behavior and cognition -- von Economo neurons -- Neuroimaging (amyloid imaging) -- Treatment.…”
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The blood-brain barrier in Alzheimer's disease

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A molecular understanding of Alzheimer's disease

Table of Contents: “…Contents: Usefulness of genetics in understanding AD -- Pathology of diseases -- Amyloid protein -- Genetic maps -- Mechanism of late onset Alzheimer's -- Role of presenilin in amyloid pathology -- Tau and frontotemporal dementia -- Tau splice site mutations -- Pathways to neurodegeneration.…”
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Series

A molecular understanding of Alzheimer's disease

Table of Contents: “…Contents: Usefulness of genetics in understanding AD -- Pathology of diseases -- Amyloid protein -- Genetic maps -- Mechanism of late onset Alzheimer's -- Role of presenilin in amyloid pathology -- Tau and frontotemporal dementia -- Tau splice site mutations -- Pathways to neurodegeneration.…”
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Neurodegenerative disease expression levels of normal sequence pathogenic proteins contribute to risk of disease /

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Neurodegenerative disease expression levels of normal sequence pathogenic proteins contribute to risk of disease /

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Pathology of Alzheimer's disease

Table of Contents: “…Contents: Alzheimer's disease as the commonest neurodegenerative disease -- Alzheimer's disease as one of the protein folding disorders -- Alzheimer's disease is rarely inherited due to mutations of one of three genes -- Apolipoprotein E epsilon 4 allele as genetic risk factor for Alzheimer's disease -- Neuritic plaques -- Neurofibrillary tangles -- Amyloid-beta peptide -- Tau protein.…”
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Pathology of Alzheimer's disease

Table of Contents: “…Contents: Alzheimer's disease as the commonest neurodegenerative disease -- Alzheimer's disease as one of the protein folding disorders -- Alzheimer's disease is rarely inherited due to mutations of one of three genes -- Apolipoprotein E epsilon 4 allele as genetic risk factor for Alzheimer's disease -- Neuritic plaques -- Neurofibrillary tangles -- Amyloid-beta peptide -- Tau protein.…”
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Pathology of Alzheimer's disease

Table of Contents: “…Contents: Alzheimer's disease as the commonest neurodegenerative disease -- Alzheimer's disease as one of the protein folding disorders -- Alzheimer's disease is rarely inherited due to mutations of one of three genes -- Apolipoprotein E epsilon 4 allele as genetic risk factor for Alzheimer's disease -- Neuritic plaques -- Neurofibrillary tangles -- Amyloid-beta peptide -- Tau protein.…”
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ApoE4, the most prevalent genetic risk factor for Alzheimer's Disease

Table of Contents: “…Contents: ApoE4 the most prevalent genetic risk factor of Alzheimer's disease -- The apoE4 molecule -- The associated brain pathology in man -- The mechanisms underlying the pathological effects of apoE4 -- The role of lipids in mediating the effects of apoE4 -- The role of Amyloid-beta in mediating the effects of apoE4 -- ApoE4 receptors -- ApoE4 catabolism -- ApoE4 targeted therapeutic approaches -- Therapeutic approaches based on the apoE4 molecule -- Therapeutic approaches based on preventing pathologic interactions with other systems.…”
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ApoE4, the most prevalent genetic risk factor for Alzheimer's Disease

Table of Contents: “…Contents: ApoE4 the most prevalent genetic risk factor of Alzheimer's disease -- The apoE4 molecule -- The associated brain pathology in man -- The mechanisms underlying the pathological effects of apoE4 -- The role of lipids in mediating the effects of apoE4 -- The role of Amyloid-beta in mediating the effects of apoE4 -- ApoE4 receptors -- ApoE4 catabolism -- ApoE4 targeted therapeutic approaches -- Therapeutic approaches based on the apoE4 molecule -- Therapeutic approaches based on preventing pathologic interactions with other systems.…”
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ApoE4, the most prevalent genetic risk factor for Alzheimer's Disease

Table of Contents: “…Contents: ApoE4 the most prevalent genetic risk factor of Alzheimer's disease -- The apoE4 molecule -- The associated brain pathology in man -- The mechanisms underlying the pathological effects of apoE4 -- The role of lipids in mediating the effects of apoE4 -- The role of Amyloid-beta in mediating the effects of apoE4 -- ApoE4 receptors -- ApoE4 catabolism -- ApoE4 targeted therapeutic approaches -- Therapeutic approaches based on the apoE4 molecule -- Therapeutic approaches based on preventing pathologic interactions with other systems.…”
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