Search Results - "Therapeutic approach"

Mitochondrial inhibition as a novel therapeutic approach in drug-resistant cancer

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Mitochondrial inhibition as a novel therapeutic approach in drug-resistant cancer

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Mitochondrial inhibition as a novel therapeutic approach in drug-resistant cancer

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ApoE4, the most prevalent genetic risk factor for Alzheimer's Disease

Table of Contents: “…Contents: ApoE4 the most prevalent genetic risk factor of Alzheimer's disease -- The apoE4 molecule -- The associated brain pathology in man -- The mechanisms underlying the pathological effects of apoE4 -- The role of lipids in mediating the effects of apoE4 -- The role of Amyloid-beta in mediating the effects of apoE4 -- ApoE4 receptors -- ApoE4 catabolism -- ApoE4 targeted therapeutic approaches -- Therapeutic approaches based on the apoE4 molecule -- Therapeutic approaches based on preventing pathologic interactions with other systems.…”
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ApoE4, the most prevalent genetic risk factor for Alzheimer's Disease

Table of Contents: “…Contents: ApoE4 the most prevalent genetic risk factor of Alzheimer's disease -- The apoE4 molecule -- The associated brain pathology in man -- The mechanisms underlying the pathological effects of apoE4 -- The role of lipids in mediating the effects of apoE4 -- The role of Amyloid-beta in mediating the effects of apoE4 -- ApoE4 receptors -- ApoE4 catabolism -- ApoE4 targeted therapeutic approaches -- Therapeutic approaches based on the apoE4 molecule -- Therapeutic approaches based on preventing pathologic interactions with other systems.…”
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ApoE4, the most prevalent genetic risk factor for Alzheimer's Disease

Table of Contents: “…Contents: ApoE4 the most prevalent genetic risk factor of Alzheimer's disease -- The apoE4 molecule -- The associated brain pathology in man -- The mechanisms underlying the pathological effects of apoE4 -- The role of lipids in mediating the effects of apoE4 -- The role of Amyloid-beta in mediating the effects of apoE4 -- ApoE4 receptors -- ApoE4 catabolism -- ApoE4 targeted therapeutic approaches -- Therapeutic approaches based on the apoE4 molecule -- Therapeutic approaches based on preventing pathologic interactions with other systems.…”
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SOD1-related ALS what has it told us about motor neuron degeneration? Part 2 of 2/

Table of Contents: “…Contents: Mechanisms of motor neuron injury in the presence of SOD1 mutations -- glutamate-mediated excitotoxicity -- Determinants of fast and slow disease progression -- Therapeutic approaches including gene therapy.…”
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SOD1-related ALS what has it told us about motor neuron degeneration? Part 2 of 2/

Table of Contents: “…Contents: Mechanisms of motor neuron injury in the presence of SOD1 mutations -- glutamate-mediated excitotoxicity -- Determinants of fast and slow disease progression -- Therapeutic approaches including gene therapy.…”
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Astrocytes and Alexander disease the first, but not last, primary astrocyte disease /

Table of Contents: “…Contents: GFAP in astrocytes: isolation, genetics and function -- Alexander disease: clinical and pathologic features -- Mouse models for studying pathogenesis -- Potential therapeutic approaches: reduction of GFAP and manipulation of stress response.…”
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Astrocytes and Alexander disease the first - but not last - primary astrocyte disease /

Table of Contents: “…Contents: GFAP in astrocytes: isolation, genetics and function -- Alexander disease: clinical and pathologic features -- Mouse models for studying pathogenesis -- Potential therapeutic approaches: reduction of GFAP and manipulation of stress response.…”
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Astrocytes and Alexander disease the first - but not last - primary astrocyte disease /

Table of Contents: “…Contents: GFAP in astrocytes: isolation, genetics and function -- Alexander disease: clinical and pathologic features -- Mouse models for studying pathogenesis -- Potential therapeutic approaches: reduction of GFAP and manipulation of stress response.…”
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Antiphospholipid syndrome and Lupus

Table of Contents: “…Contents: Genetics vs. environmental triggers in antiphospholipid syndrome and Lupus -- Current challenges in diagnosis and the limitation of available treatments -- Open questions with regard to the underlying mechanisms of antiphospholipid syndrome and Lupus -- Potential directions in the development of diagnostic tools and therapeutic approaches.…”
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Antiphospholipid syndrome and Lupus

Table of Contents: “…Contents: Genetics vs. environmental triggers in antiphospholipid syndrome and Lupus -- Current challenges in diagnosis and the limitation of available treatments -- Open questions with regard to the underlying mechanisms of antiphospholipid syndrome and Lupus -- Potential directions in the development of diagnostic tools and therapeutic approaches.…”
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Antiphospholipid syndrome and Lupus

Table of Contents: “…Contents: Genetics vs. environmental triggers in antiphospholipid syndrome and Lupus -- Current challenges in diagnosis and the limitation of available treatments -- Open questions with regard to the underlying mechanisms of antiphospholipid syndrome and Lupus -- Potential directions in the development of diagnostic tools and therapeutic approaches.…”
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Sjogren's syndrome current knowledge and future prospects /

Table of Contents: “…Contents: Introduction to Sjögren's syndrome -- Humoral and cellular autoimmune responses in Sjögren's syndrome -- Description of heterogenic clinical features of disease -- Pathogenetic/immunopathologic aspects and associations with clinical phenotypes -- The need for precise therapeutic approaches -- Development and features of lymphoma in Sjögren's syndrome -- Risk factors for development of severe disease -- Biomarkers for disease severity, outcome and lymphoma.…”
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Sjogren's syndrome current knowledge and future prospects /

Table of Contents: “…Contents: Introduction to Sjögren's syndrome -- Humoral and cellular autoimmune responses in Sjögren's syndrome -- Description of heterogenic clinical features of disease -- Pathogenetic/immunopathologic aspects and associations with clinical phenotypes -- The need for precise therapeutic approaches -- Development and features of lymphoma in Sjögren's syndrome -- Risk factors for development of severe disease -- Biomarkers for disease severity, outcome and lymphoma.…”
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Sjogren's syndrome current knowledge and future prospects /

Table of Contents: “…Contents: Introduction to Sjögren's syndrome -- Humoral and cellular autoimmune responses in Sjögren's syndrome -- Description of heterogenic clinical features of disease -- Pathogenetic/immunopathologic aspects and associations with clinical phenotypes -- The need for precise therapeutic approaches -- Development and features of lymphoma in Sjögren's syndrome -- Risk factors for development of severe disease -- Biomarkers for disease severity, outcome and lymphoma.…”
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The neurological symptoms of COVID-19

Table of Contents: “…Contents: Diversity and incidence of neurological symptoms attributable to COVID-19 -- Mechanisms by which SARS-CoV-2 infection triggers neurological symptoms -- Singularity of SARS-CoV-2, among coronaviruses, in triggering neurological symptoms -- Therapeutic approaches to prevent or improve neurological symptoms -- Incidence of psychiatric symptoms resulting from COVID-19 in a subset of patients -- Relationship between neurological and psychiatric symptoms.…”
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The neurological symptoms of COVID-19

Table of Contents: “…Contents: Diversity and incidence of neurological symptoms attributable to COVID-19 -- Mechanisms by which SARS-CoV-2 infection triggers neurological symptoms -- Singularity of SARS-CoV-2, among coronaviruses, in triggering neurological symptoms -- Therapeutic approaches to prevent or improve neurological symptoms -- Incidence of psychiatric symptoms resulting from COVID-19 in a subset of patients -- Relationship between neurological and psychiatric symptoms.…”
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Hepatic encephalopathy in cirrhosis a disorder of glial-neuronal signalling /

Table of Contents: “…Contents: Classification of hepatic encephalopathy -- Hepatic encephalopathy in cirrhosis -- Transjugular intrahepatic portosystemic shunt (TIPS) -- Hepatic encephalopathy post-TIPS -- Neuropathology of hepatic encephalopathy in chronic liver failure -- Cirrhosis-related Parkinsonism -- PET studies in cirrhosis -- Neuroinflammation and hepatic encephalopathy in cirrhosis -- Systemic inflammatory response syndrome (SIRS) in cirrhosis -- Translocator protein and hepatic encephalopathy in cirrhosis -- Modulatory site for neurosteroids -- Prevention and treatment of hepatic encephalopathy in cirrhosis -- Emerging new therapeutic approaches.…”
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