Search Results - "proteins"

The pharmacokinetics of therapeutic proteins

Table of Contents: “…Contents: Differences in the pharmacokinetics of therapeutic proteins compared to small molecule drugs -- Classes of therapeutic proteins -- Central paradigm of clinical pharmacology -- Distribution and tissue penetration of mAbs and proteins -- Three methods of renal protein metabolism -- Hepatic protein metabolism -- Target-mediated drug disposition -- Immunogenicity: general considerations and contributing factors -- Neutralizing, clearing and sustaining anti-drug antibodies.…”
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The pharmacokinetics of therapeutic proteins

Table of Contents: “…Contents: Differences in the pharmacokinetics of therapeutic proteins compared to small molecule drugs -- Classes of therapeutic proteins -- Central paradigm of clinical pharmacology -- Distribution and tissue penetration of mAbs and proteins -- Three methods of renal protein metabolism -- Hepatic protein metabolism -- Target-mediated drug disposition -- Immunogenicity: general considerations and contributing factors -- Neutralizing, clearing and sustaining anti-drug antibodies.…”
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The pharmacokinetics of therapeutic proteins

Table of Contents: “…Contents: Differences in the pharmacokinetics of therapeutic proteins compared to small molecule drugs -- Classes of therapeutic proteins -- Central paradigm of clinical pharmacology -- Distribution and tissue penetration of mAbs and proteins -- Three methods of renal protein metabolism -- Hepatic protein metabolism -- Target-mediated drug disposition -- Immunogenicity: general considerations and contributing factors -- Neutralizing, clearing and sustaining anti-drug antibodies.…”
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Fundamentals of protein chromatography part 1, basic protein purification /

Table of Contents: “…Contents: Protein purification scheme and strategy -- Properties of proteins as handles for fractionation -- Obstacles during protein purifications and solutions -- Suitable buffers and practices to stabilize proteins.…”
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Fundamentals of protein chromatography part 2, protein chromatography /

Table of Contents: “…Contents: History of chromatography -- Forces and properties of proteins as handles for fractionation -- Types of chromatography -- Chromatography components -- HPLC -- Trouble shooting some chromatography problems -- Protein purification for pharmaceutical applications.…”
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Fundamentals of protein chromatography part 1, basic protein purification /

Table of Contents: “…Contents: Protein purification scheme and strategy -- Properties of proteins as handles for fractionation -- Obstacles during protein purifications and solutions -- Suitable buffers and practices to stabilize proteins.…”
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Fundamentals of protein chromatography part 2, protein chromatography /

Table of Contents: “…Contents: History of chromatography -- Forces and properties of proteins as handles for fractionation -- Types of chromatography -- Chromatography components -- HPLC -- Trouble shooting some chromatography problems -- Protein purification for pharmaceutical applications.…”
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Designing proteins with life sustaining activities part 2 of 2 /

Table of Contents: “…Contents: Novel designed proteins: mechanism of action -- Function rescue experiments using novel proteins -- Evolving novel proteins (generalists vs. specialists) -- Towards artificial proteomes capable of sustaining life.…”
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Designing proteins with life sustaining activities part 1 of 2 /

Table of Contents: “…Contents: Protein design & synthetic biology -- Designing novel proteins using a hybrid approach -- Combinatorial libraries of novel proteins -- Folding of novel proteins into stable structures -- Biochemical activity of novel proteins in vitro (binding & catalysis) -- Essential biological functions provided by novel proteins in vivo.…”
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Designing proteins with life sustaining activities part 1 of 2 /

Table of Contents: “…Contents: Protein design & synthetic biology -- Designing novel proteins using a hybrid approach -- Combinatorial libraries of novel proteins -- Folding of novel proteins into stable structures -- Biochemical activity of novel proteins in vitro (binding & catalysis) -- Essential biological functions provided by novel proteins in vivo.…”
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Designing proteins with life sustaining activities part 2 of 2 /

Table of Contents: “…Contents: Novel designed proteins: mechanism of action -- Function rescue experiments using novel proteins -- Evolving novel proteins (generalists vs. specialists) -- Towards artificial proteomes capable of sustaining life.…”
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Designing proteins with life sustaining activities part 1 of 2 /

Table of Contents: “…Contents: Protein design & synthetic biology -- Designing novel proteins using a hybrid approach -- Combinatorial libraries of novel proteins -- Folding of novel proteins into stable structures -- Biochemical activity of novel proteins in vitro (binding & catalysis) -- Essential biological functions provided by novel proteins in vivo.…”
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Designing proteins with life sustaining activities part 2 of 2 /

Table of Contents: “…Contents: Novel designed proteins: mechanism of action -- Function rescue experiments using novel proteins -- Evolving novel proteins (generalists vs. specialists) -- Towards artificial proteomes capable of sustaining life.…”
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The proteomic revolution

Table of Contents: “…Contents: The proteomic revolution -- Proteomics is the best measure of phenotype (biomarkers) -- Slow Off-rate Modified Aptamers (SOMAmers) are breakthrough protein binding reagents -- SOMAmers are multiplexed to perform SOMAscan assay, which measures >1000 proteins in small sample volumes using DNA measurement tools to identify and quantify proteins bound by SOMAmers -- Applications of SOMAscan to date include finding valid protein biomarkers for lung cancer, cardiovascular risk, pre-term birth, pancreatic cancer, mesothelioma, and many other diseases and conditions -- Ability to do comprehensive longitudinal proteomics studies will revolutionize medicine.…”
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Prediction and design of protein structures and interactions

Table of Contents: “…Contents: Modeling of macromolecular interactions -- Conformational sampling -- Docking low-resolution search -- High resolution refinement -- Docking protocol -- Side chain flexibility and modeling -- Ab initio structure prediction -- Computational protein design -- Simultaneous sequence-structure optimization -- Protein interface design -- Properties of free energy landscapes of macromolecules.…”
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Prediction and design of protein structures and interactions

Table of Contents: “…Contents: Modeling of macromolecular interactions -- Conformational sampling -- Docking low-resolution search -- High resolution refinement -- Docking protocol -- Side chain flexibility and modeling -- Ab initio structure prediction -- Computational protein design -- Simultaneous sequence-structure optimization -- Protein interface design -- Properties of free energy landscapes of macromolecules.…”
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Prediction and design of protein structures and interactions

Table of Contents: “…Contents: Modeling of macromolecular interactions -- Conformational sampling -- Docking low-resolution search -- High resolution refinement -- Docking protocol -- Side chain flexibility and modeling -- Ab initio structure prediction -- Computational protein design -- Simultaneous sequence-structure optimization -- Protein interface design -- Properties of free energy landscapes of macromolecules.…”
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Amyloid fibrils as functional nanomaterials

Table of Contents: “…Contents: Generating useful materials from proteins -- Amyloid fibrils from waste materials in a commercially scalable process -- Nanoscaffolds for enzyme immobilisation -- Templates for nanowires and biosensors.…”
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Protein networks and analysis of global gene expression

Table of Contents: “…Contents: A paradigm shift: from databases of protein sequences to protein interactions -- Technologies for measuring interactions -- Chromatin immunoprecipitation (ChIP) -- Yeast Two Hybrid (Y2H) technology -- Mass spectrometry based approaches -- Methods for querying protein networks with gene expression profiles -- Systematic validation of protein network models using gene deletions -- Cytoscape open-source software for network modeling and visualization -- Methods for network comparison across species -- Application to discover conserved protein complexes among the networks of yeast, worm, fly and Plasmodium -- Methods for querying protein networks to explain genetic (synthetic lethal) interactions -- Future directions: how network queries will enable systems biology.…”
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G-Protein coupled receptors in drug discovery

Table of Contents: “…Contents: The G-protein coupled receptor superfamily -- GPCRs as drug targets -- Approved GPCR drugs -- Why the reduction in GPCR drugs -- New screening technologies and new drug targets.…”
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