Search Results - F/LOSS~

Bi-directional communication at the neurovascular unit implications for neuronal function /

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Bi-directional communication at the neurovascular unit implications for neuronal function /

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Bi-directional communication at the neurovascular unit implications for neuronal function /

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The dynamic interactions between cellular-molecular physiology and the environment part 3, Case studies in pathophysiology : how to exploit cellular-molecular evolution /

Table of Contents: “…Contents: Simplification of structure and function as reverse evolution -- Chronic diseases & pathologies in different tissues and organs -- Breakdown in cell-cell communication -- Fibrosis & PPARɣ agonists -- Sensing loss of homeostasis & cellular perturbations.…”
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The dynamic interactions between cellular-molecular physiology and the environment part 3, Case studies in pathophysiology : how to exploit cellular-molecular evolution /

Table of Contents: “…Contents: Simplification of structure and function as reverse evolution -- Chronic diseases & pathologies in different tissues and organs -- Breakdown in cell-cell communication -- Fibrosis & PPARɣ agonists -- Sensing loss of homeostasis & cellular perturbations.…”
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Series

The dynamic interactions between cellular-molecular physiology and the environment part 3, Case studies in pathophysiology : how to exploit cellular-molecular evolution /

Table of Contents: “…Contents: Simplification of structure and function as reverse evolution -- Chronic diseases & pathologies in different tissues and organs -- Breakdown in cell-cell communication -- Fibrosis & PPARɣ agonists -- Sensing loss of homeostasis & cellular perturbations.…”
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Pathways regulating bone resorption

Table of Contents: “…Contents: Formation and activation of osteoclasts -- Osteoporotic bone architecture -- Osteoclastic bone resorption -- Osteoclast motility and its inhibition -- Osteoclast regulation (hormones & other important factors) -- The role of low pH (acidosis) in bone loss -- Hypoxia & control of bone cell function by oxygen tension.…”
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Pathways regulating bone resorption

Table of Contents: “…Contents: Formation and activation of osteoclasts -- Osteoporotic bone architecture -- Osteoclastic bone resorption -- Osteoclast motility and its inhibition -- Osteoclast regulation (hormones & other important factors) -- The role of low pH (acidosis) in bone loss -- Hypoxia & control of bone cell function by oxygen tension.…”
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Pathways regulating bone resorption

Table of Contents: “…Contents: Formation and activation of osteoclasts -- Osteoporotic bone architecture -- Osteoclastic bone resorption -- Osteoclast motility and its inhibition -- Osteoclast regulation (hormones & other important factors) -- The role of low pH (acidosis) in bone loss -- Hypoxia & control of bone cell function by oxygen tension.…”
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The epidermis and its barrier(s)

Table of Contents: “…Contents: The importance of the skin barrier and its components -- The stratum corneum and the brick- and- mortar analogy -- Differentiation & programmed cell death of keratinocytes -- Lamellar bodies and their contents -- Barrier and moisturization -- Stratum corneum lipids and enzymes -- Epidermal tight junctions -- Measurement of trans-epidermal water loss (TEWL) -- Skin pigmentation, UV protection and P53 -- Immune barrier (Langerhans cells, Langerin & Birbek granules) -- Hair follicles (anti-microbial barrier and a route for skin penetration) -- Transdermal drug delivery -- Barrier homeostasis/up-regulation of properties -- Aves & mammals: liquid sequestration differences -- Adaptive plasticity of human skin barrier.…”
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Adapting proteostasis to ameliorate aggregation-associated amyloid diseases

Table of Contents: “…Contents: Protein folding, misfolding, aggregation -- The proteostasis network and its regulation -- Gain and loss of function diseases -- The transthyretin (TTR) amyloidosis -- Kinetic stabilizers & clinical trial results -- Tafamidis & Diflunisal: evidence for the amyloid hypothesis -- Improving protein misfolding/aggregation diseases -- The unfolded protein response (UPR) and its arm-selective activators -- ATF6 activation & reduction of TTR mutant -- Clinical trials in amyloidosis with cardiac involvement.…”
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Adapting proteostasis to ameliorate aggregation-associated amyloid diseases

Table of Contents: “…Contents: Protein folding, misfolding, aggregation -- The proteostasis network and its regulation -- Gain and loss of function diseases -- The transthyretin (TTR) amyloidosis -- Kinetic stabilizers & clinical trial results -- Tafamidis & Diflunisal: evidence for the amyloid hypothesis -- Improving protein misfolding/aggregation diseases -- The unfolded protein response (UPR) and its arm-selective activators -- ATF6 activation & reduction of TTR mutant -- Clinical trials in amyloidosis with cardiac involvement.…”
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Series

Adapting proteostasis to ameliorate aggregation-associated amyloid diseases

Table of Contents: “…Contents: Protein folding, misfolding, aggregation -- The proteostasis network and its regulation -- Gain and loss of function diseases -- The transthyretin (TTR) amyloidosis -- Kinetic stabilizers & clinical trial results -- Tafamidis & Diflunisal: evidence for the amyloid hypothesis -- Improving protein misfolding/aggregation diseases -- The unfolded protein response (UPR) and its arm-selective activators -- ATF6 activation & reduction of TTR mutant -- Clinical trials in amyloidosis with cardiac involvement.…”
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Vitiligo in vivo and in vitro evidence for epidermal ROS/RNS-mediated regulation/dysregulation /

Table of Contents: “…Contents: Role of inherited vs. induced (tanning) skin colour -- Enhanced pigmentation after sun exposure -- Vitiligo and its characteristics (inherited skin colour loss) -- Correct diagnosis of vitiligo via characteristic fluorescence -- Use of Wood's light for differential diagnosis -- Cause and pathogenesis of vitiligo -- Oxidation and nitration of proteins and peptides in vitiligo and their effects -- DNA damage, T-cell response & p53 in vitiligo -- Treating vitiligo: Reducing oxidation and repigmentation.…”
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Vitiligo in vivo and in vitro evidence for epidermal ROS/RNS-mediated regulation/dysregulation /

Table of Contents: “…Contents: Role of inherited vs. induced (tanning) skin colour -- Enhanced pigmentation after sun exposure -- Vitiligo and its characteristics (inherited skin colour loss) -- Correct diagnosis of vitiligo via characteristic fluorescence -- Use of Wood's light for differential diagnosis -- Cause and pathogenesis of vitiligo -- Oxidation and nitration of proteins and peptides in vitiligo and their effects -- DNA damage, T-cell response & p53 in vitiligo -- Treating vitiligo: Reducing oxidation and repigmentation.…”
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Series

Vitiligo in vivo and in vitro evidence for epidermal ROS/RNS-mediated regulation/dysregulation /

Table of Contents: “…Contents: Role of inherited vs. induced (tanning) skin colour -- Enhanced pigmentation after sun exposure -- Vitiligo and its characteristics (inherited skin colour loss) -- Correct diagnosis of vitiligo via characteristic fluorescence -- Use of Wood's light for differential diagnosis -- Cause and pathogenesis of vitiligo -- Oxidation and nitration of proteins and peptides in vitiligo and their effects -- DNA damage, T-cell response & p53 in vitiligo -- Treating vitiligo: Reducing oxidation and repigmentation.…”
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Metabolic and biochemical alterations in Alzheimer's disease facts and fictions /

Table of Contents: “…Contents: What causes selective neuronal loss in AD? -- Tauist and BAPtist hypothesis of AD -- Pathology and oxidative stress relationship -- NFT and amyloid-beta -- Stress-activated protein kinases and phospho-tau -- Amyloid-targeted approaches are unsuccessful -- Amyloid-beta controls redox activity -- Genetic factors are related to oxidative stress -- Therapeutics -- Potential mechanism of ROS generation -- Oxidative modifications and macromolecules -- Oxidative damage directly correlates with mtDNA -- Abnormal mitochondrial distribution in AD brains -- Iron histochemistry -- Antioxidant diet is protective -- Only one non-amyloid drug in phase III: 2010 -- Oxidative stress is necessary but not sufficient -- CaMKII-MYC mice -- Oxidative stress and cell cycle abnormalities -- Early stages of AD disease signals.…”
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Series

The epidermis and its barrier(s)

Table of Contents: “…Contents: The importance of the skin barrier and its components -- The stratum corneum and the brick- and- mortar analogy -- Differentiation & programmed cell death of keratinocytes -- Lamellar bodies and their contents -- Barrier and moisturization -- Stratum corneum lipids and enzymes -- Epidermal tight junctions -- Measurement of trans-epidermal water loss (TEWL) -- Skin pigmentation, UV protection and P53 -- Immune barrier (Langerhans cells, Langerin & Birbek granules) -- Hair follicles (anti-microbial barrier and a route for skin penetration) -- Transdermal drug delivery -- Barrier homeostasis/up-regulation of properties -- Aves & mammals: liquid sequestration differences -- Adaptive plasticity of human skin barrier.…”
Get full text
Series

Metabolic and biochemical alterations in Alzheimer's disease facts and fictions /

Table of Contents: “…Contents: What causes selective neuronal loss in AD? -- Tauist and BAPtist hypothesis of AD -- Pathology and oxidative stress relationship -- NFT and amyloid-beta -- Stress-activated protein kinases and phospho-tau -- Amyloid-targeted approaches are unsuccessful -- Amyloid-beta controls redox activity -- Genetic factors are related to oxidative stress -- Therapeutics -- Potential mechanism of ROS generation -- Oxidative modifications and macromolecules -- Oxidative damage directly correlates with mtDNA -- Abnormal mitochondrial distribution in AD brains -- Iron histochemistry -- Antioxidant diet is protective -- Only one non-amyloid drug in phase III: 2010 -- Oxidative stress is necessary but not sufficient -- CaMKII-MYC mice -- Oxidative stress and cell cycle abnormalities -- Early stages of AD disease signals.…”
Get full text
Series

Metabolic and biochemical alterations in Alzheimer's disease facts and fictions /

Table of Contents: “…Contents: What causes selective neuronal loss in AD? -- Tauist and BAPtist hypothesis of AD -- Pathology and oxidative stress relationship -- NFT and amyloid-beta -- Stress-activated protein kinases and phospho-tau -- Amyloid-targeted approaches are unsuccessful -- Amyloid-beta controls redox activity -- Genetic factors are related to oxidative stress -- Therapeutics -- Potential mechanism of ROS generation -- Oxidative modifications and macromolecules -- Oxidative damage directly correlates with mtDNA -- Abnormal mitochondrial distribution in AD brains -- Iron histochemistry -- Antioxidant diet is protective -- Only one non-amyloid drug in phase III: 2010 -- Oxidative stress is necessary but not sufficient -- CaMKII-MYC mice -- Oxidative stress and cell cycle abnormalities -- Early stages of AD disease signals.…”
Get full text
Series