Search Results - "yeast"

Yeast studies on ageing

Table of Contents: “…Contents: History of studies on yeast ageing -- Senescence factor, molecular memory, and age locus -- Mitochondria and ageing -- Age asymmetry and cell quality control -- Epigenetic gene regulation and ageing -- Genome instability as a cause of ageing -- Replicative and chronological lifespans -- Nutrient effects on lifespan -- Ageing in the wild.…”
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Gene silencing in budding yeast

Table of Contents: “…Contents: Gene silencing: an epigenetic phenomenon -- Chromatin remodeling: heterochromatin and euchromatin -- Silent chromatin in budding yeast: mating-type loci -- Silent information regulation: telomeric genes and Sir proteins.…”
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Structure of cell walls in yeast and other fungi

Table of Contents: “…Contents: Fungal cell walls -- Glycans -- S. cerevisiae -- C. albicans -- Mannose -- Chitin -- Glycan biosynthesis -- Mannoproteins -- GPI-crosslinked proteins -- N. crassa -- Yeast cell wall dynamics -- Cell wall conservation and evolution.…”
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Mapping the molecular chaperone interaction network in yeast

Table of Contents: “…Contents: Large scale proteomic screening in yeast -- The TAP-tag pulldown approach -- Understanding the principles governing protein homeostasis -- Mapping the network of the Hsp90 chaperone using physical and genetic interaction screens -- Unraveling the role of Hsp90 in pre-rRNA processing.…”
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MAPK signalling regulation and cancer lessons from fission yeast /

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Chaperones and prions

Table of Contents: “…Contents: Prion diseases -- Prions as self-propagating amyloids -- Yeast prions as protein-based heritable elements -- Prion detection -- Crucial role of the chaperone protein Hsp104 in the propagation of yeast prions -- Chaperone-mediated fragmentation turns amyloids into infectious or heritable prions -- Effects of the Hsp70 and Hsp40 proteins on yeast prions -- Other modulators of prion formation and propagation: cytoskeleton and ubiquitin system.…”
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Impact of systems biology on metabolic engineering

Table of Contents: “…Contents: The biorefinery concept -- The process of metabolic engineering (ME) -- Approaches in systems biology (SB) -- Genome scale metabolic models (GEMs) -- Using SB to design succinic acid production in yeast -- Using SB to compare metabolism of yeast strains -- Using SB to compare penicillin producing in yeast strains -- Inverse metabolic engineering -- Using inverse ME to improve galactose utilization in yeast -- Mechanisms of evolutionary trade-offs.…”
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The dark side of amyloid PMEL, a natural amyloid in melanosome biogenesis /

“…Prions and amyloids : self-propagating protein structures in mammals, yeast and fungi.…”
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Protein networks and analysis of global gene expression

Table of Contents: “…Contents: A paradigm shift: from databases of protein sequences to protein interactions -- Technologies for measuring interactions -- Chromatin immunoprecipitation (ChIP) -- Yeast Two Hybrid (Y2H) technology -- Mass spectrometry based approaches -- Methods for querying protein networks with gene expression profiles -- Systematic validation of protein network models using gene deletions -- Cytoscape open-source software for network modeling and visualization -- Methods for network comparison across species -- Application to discover conserved protein complexes among the networks of yeast, worm, fly and Plasmodium -- Methods for querying protein networks to explain genetic (synthetic lethal) interactions -- Future directions: how network queries will enable systems biology.…”
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The ERAD network

Table of Contents: “…Contents: Eukaryotic secretory pathway -- ER processes -- ERAD steps -- Substrate recognition -- Glycans as sorting signals -- Yeast ERAD process -- Mammalian ERAD process -- ERAD adapter proteins -- ERAD translocons -- ERAD E3 ligases.…”
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Dynamic signal encoding in the S. cerevisiae calcium response

Table of Contents: “…Contents: Calcium and Signaling -- Excessive calcium causes cellular stress -- Signaling pathways are turned on to combat this stress -- In budding yeast, these pathways involve nuclear translocation of transcriptional regulator Crz1 -- Examination of this regulator shows that nuclear translocation occurs in "bursts" -- Bursts are quantized and frequency-modulated -- Frequency modulation enables proportional expression of downstream target genes.…”
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Enhancer malfunction in cancer

Table of Contents: “…Contents: MLL genes and their pathogenic translocations -- Yeast, mammalian and Drosophila systems for studying leukaemia pathogenesis -- Proteins and protein complexes that regulate chromatin modifications, transcription initiation, and transcription elongation -- What is the function of MLL? …”
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Influence of eicosanoid lipid mediators on macrophage innate immune functions

Table of Contents: “…-- Dectin-1 -- LTB4 enhances yeast binding via dectin-1 -- Basal dectin-1 expression depends on constitutive LTB4 generation -- LTB4 enhances dectin-1-induced cytokine generation by elicited MΦ -- Dectin-1 expression in MΦ depends on an LTB4-PU.1 axis -- Pathway for NFκB activation upon TLR ligation -- LPS-induced nuclear translocation of NFκB subunits requires endogenous LTB4/BLT1 signaling -- 5-LO metabolism is required for MyD88-dependent NFkB activity in macrophages -- 5-LO and LTB4 are required for basal MyD88 expression in macrophages -- MyD88 expression is controlled by STAT-1 and SOCS1 -- SOCS1 siRNA restores MyD88 expression and LPS responsiveness in 5-LO -/- MΦs -- PGE2 actions are context-dependent -- PGE2 synthesis and signaling -- Opposing actions of PGE2 vs. …”
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