Search Results - "stem cell"

Niche oncogenesis

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Hematopoietic stem cell gene therapy for the treatment of metachromatic leukodystrophy

Table of Contents: “…Contents: Metachromatic Leukodystrophy (MLD) -- Hematopoietic stem cell therapy (HCT) for lysosomal storage disorders (LSDs) -- Improving HCT efficacy -- The role of brain pre-conditioning -- Mechanisms of microglia turnover -- Gene therapy (GT) & enzyme release -- Gene therapy in murine models -- HSC gene therapy for MLD -- Lentivirus integration site analysis -- Stem cells analysis -- ARSA activity and delivery to the CNS -- Cerebral and peripheral demyelination -- Motor function testing (GMFM).…”
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Intestinal stem cell-mediated repair in Drosophila part 1 of 2 /

Table of Contents: “…Contents: The adult Drosophila midgut contains tissue specific intestinal stem cells (ISCs) -- ISCs are the only dividing cells in the midgut and are responsible for maintaining midgut homeostasis and regeneration -- The ISC division gives rise to a renewed stem cell and an enteroblast, which can differentiate into secretory enteroendocrine cells or absorptive enterocytes -- Intrinsic factors such as Tuberous Sclerosis Complex and Myc coordinate the growth and division of ISCs -- Extrinsic factors such as Epidermal Growth Factor from surrounding cells and the interaction with basement membrane also regulate the rate of ISC division -- Insulin secreted from CNS function as a long-range growth factor to control ISC activity and therefore intestinal tissue homeostasis.…”
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Intestinal stem cell-mediated repair in Drosophila Part 2 of 2 /

Table of Contents: “…Contents: The adult Drosophila midgut contains tissue specific intestinal stem cells (ISCs) -- ISCs are the only dividing cells in the midgut and are responsible for maintaining midgut homeostasis and regeneration -- The ISC division gives rise to a renewed stem cell and an enteroblast, which can differentiate into secretory enteroendocrine cells or absorptive enterocytes -- Intrinsic factors such as Tuberous Sclerosis Complex and Myc coordinate the growth and division of ISCs -- Extrinsic factors such as Epidermal Growth Factor from surrounding cells and the interaction with basement membrane also regulate the rate of ISC division -- Insulin secreted from CNS function as a long-range growth factor to control ISC activity and therefore intestinal tissue homeostasis.…”
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Role of polycomb proteins in gene transcription, stem cell and human diseases

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Epigenetic control by histone methylation

Table of Contents: “…Contents: The diversity of covalent histone tail modifications for imparting epigenetic information -- Observations of robust histone modifications at silent chromatin regions -- The representation of repressive histone marks as indications of epigenetic plasticity in different cells -- Analysis of the profiles of normal and aberrant histone lysine methylation patterns, as they occur during the transition of an embryonic to a differentiated cell or in controlled self-renewal vs. pro-neoplastic or metastatic conditions -- Elucidation of these histone modification patterns for novel advances in stem cell research, nuclear reprogramming and cancer.…”
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NanoEngineering the cell surface for targeted drug and cell delivery

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Genetics of tumor metastasis part 2 of 2 /

Table of Contents: “…Contents: Re-examining the stem-cell tumor model -- Interconvertibility between non-stem cells and stem cells -- The key for generating cancer stem cells (CSCs) from non-cancer stem cells -- Filopodium-like structures (FLPs) in metastatic cancer -- Mechanistic link between epithelial/mesenchymal transition (EMT) & the CSC state.…”
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The aging of mitotic cells regeneration and aging /

Table of Contents: “…Contents: Aging -- Types of mitotic cell aging -- Aging of blood cells in marrow and circulation -- Cell senescence -- Mitochondrial mutations -- Stem cell therapy -- Tissue engineering -- Suicide gene therapy -- Telomere length control -- Allotopic expression.…”
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