Search Results - "proteins"
Suggested Topics within your search.
Suggested Topics within your search.
- metabolism
- physiology 139
- Proteins 137
- genetics 118
- Metabolism 99
- chemistry 99
- Cellular signal transduction 80
- Signal Transduction 67
- Mitochondria 60
- Protein Conformation 51
- Protein Folding 51
- Protein folding 49
- pathology 46
- pharmacology 46
- Gene Expression Regulation 42
- Receptors 38
- Transcription Factors 38
- Cancer 37
- Molecular Chaperones 37
- Molecular chaperones 36
- drug effects 36
- Calcium 35
- methods 35
- Drug development 33
- G proteins 33
- Chromatin 32
- Physiological effect 32
- Receptors, G-Protein-Coupled 31
- drug therapy 31
- Diseases 30
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1
Inhibiting protein-protein interactions part 1 of 2 /
Published 2014Subjects: Get full text
Series
Electronic Video -
2
Inhibiting protein-protein interactions part 2 of 2 /
Published 2014Table of Contents: “…Contents: A different view of druggability -- Five propositions about the druggability of PPI targets -- Protein-ligand binding energy -- Ligand efficiency and drug-target binding -- ADME & druglikeness considerations -- Conventional view of druglikeness -- Druggability and chemical space -- Targeting low druggability PPI -- Macrocycles -- Covalent inhibitors -- Foldamers.…”
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Series
Electronic Video -
3
Inhibiting protein-protein interactions part 1 of 2 /
Published 2014Subjects: Get full text
Series
Electronic Video -
4
Inhibiting protein-protein interactions part 2 of 2 /
Published 2014Table of Contents: “…Contents: A different view of druggability -- Five propositions about the druggability of PPI targets -- Protein-ligand binding energy -- Ligand efficiency and drug-target binding -- ADME & druglikeness considerations -- Conventional view of druglikeness -- Druggability and chemical space -- Targeting low druggability PPI -- Macrocycles -- Covalent inhibitors -- Foldamers.…”
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Series
Electronic Video -
5
Inhibiting protein-protein interactions part 1 of 2 /
Published 2014Subjects: Get full text
Series
Electronic Video -
6
Inhibiting protein-protein interactions part 2 of 2 /
Published 2014Table of Contents: “…Contents: A different view of druggability -- Five propositions about the druggability of PPI targets -- Protein-ligand binding energy -- Ligand efficiency and drug-target binding -- ADME & druglikeness considerations -- Conventional view of druglikeness -- Druggability and chemical space -- Targeting low druggability PPI -- Macrocycles -- Covalent inhibitors -- Foldamers.…”
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Series
Electronic Video -
7
Fuzzy protein theory for disordered proteins
Published 2017Table of Contents: “…Contents: Intelligent decision-making mechanisms -- Structural disorder is maintained in protein assemblies -- Mechanisms and biological consequences of fuzziness -- Conformational diversity and context-dependence -- Fuzziness in cell differentiation and transcription factor evolution -- Material state and regulation of higher-order assemblies.…”
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Series
Electronic Video -
8
Fuzzy protein theory for disordered proteins
Published 2017Table of Contents: “…Contents: Intelligent decision-making mechanisms -- Structural disorder is maintained in protein assemblies -- Mechanisms and biological consequences of fuzziness -- Conformational diversity and context-dependence -- Fuzziness in cell differentiation and transcription factor evolution -- Material state and regulation of higher-order assemblies.…”
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Series
Electronic Video -
9
Fuzzy protein theory for disordered proteins
Published 2017Table of Contents: “…Contents: Intelligent decision-making mechanisms -- Structural disorder is maintained in protein assemblies -- Mechanisms and biological consequences of fuzziness -- Conformational diversity and context-dependence -- Fuzziness in cell differentiation and transcription factor evolution -- Material state and regulation of higher-order assemblies.…”
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Series
Electronic Video -
10
Protein degradation
Published 2007Table of Contents: “…Contents: Protein levels in cells are regulated by their rates of synthesis and degradation -- Regulatory proteins are rapidly degraded by the ubiquitin-proteasome pathway -- Examples include many oncogenes, transcription factors and cyclins which control progress through the cell cycle -- NF-kappa B activation in disease depends on degradation of the inhibitor, I-kappa B -- Misfolded or mutant proteins are rapidly degraded -- Neurodegenerative and protein folding diseases -- Two major proteolytic pathways exist in mammalian cells -- Many acid hydrolases exist in lysosomes -- Endocytosed proteins and those in autophagic vacuoles are degraded in lysosomes -- The ubiquitin-proteasome pathway -- 3D structure of ubiquitin -- Formation of the isopeptide bonds during ubiquitin conjugation to proteins -- The ubiquitin-proteasome pathway -- Proteasome function is linked to ATP hydrolysis -- Proteasomes unfold proteins and translocate them into 20S particles -- Three types of peptidase sites -- Proposed mechanism of proteasome inhibitors -- Therapeutic applications of proteasome inhibitors -- Two systems for protein breakdown function in the two pathways for antigen presentation -- Changes in proteasome subunits induced by interferon -- Steps involved in generating antigenic peptides.…”
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Series
Electronic Video -
11
Protein degradation
Published 2007Table of Contents: “…Contents: Protein levels in cells are regulated by their rates of synthesis and degradation -- Regulatory proteins are rapidly degraded by the ubiquitin-proteasome pathway -- Examples include many oncogenes, transcription factors and cyclins which control progress through the cell cycle -- NF-kappa B activation in disease depends on degradation of the inhibitor, I-kappa B -- Misfolded or mutant proteins are rapidly degraded -- Neurodegenerative and protein folding diseases -- Two major proteolytic pathways exist in mammalian cells -- Many acid hydrolases exist in lysosomes -- Endocytosed proteins and those in autophagic vacuoles are degraded in lysosomes -- The ubiquitin-proteasome pathway -- 3D structure of ubiquitin -- Formation of the isopeptide bonds during ubiquitin conjugation to proteins -- The ubiquitin-proteasome pathway -- Proteasome function is linked to ATP hydrolysis -- Proteasomes unfold proteins and translocate them into 20S particles -- Three types of peptidase sites -- Proposed mechanism of proteasome inhibitors -- Therapeutic applications of proteasome inhibitors -- Two systems for protein breakdown function in the two pathways for antigen presentation -- Changes in proteasome subunits induced by interferon -- Steps involved in generating antigenic peptides.…”
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Series
Electronic Video -
12
Protein degradation
Published 2007Table of Contents: “…Contents: Protein levels in cells are regulated by their rates of synthesis and degradation -- Regulatory proteins are rapidly degraded by the ubiquitin-proteasome pathway -- Examples include many oncogenes, transcription factors and cyclins which control progress through the cell cycle -- NF-kappa B activation in disease depends on degradation of the inhibitor, I-kappa B -- Misfolded or mutant proteins are rapidly degraded -- Neurodegenerative and protein folding diseases -- Two major proteolytic pathways exist in mammalian cells -- Many acid hydrolases exist in lysosomes -- Endocytosed proteins and those in autophagic vacuoles are degraded in lysosomes -- The ubiquitin-proteasome pathway -- 3D structure of ubiquitin -- Formation of the isopeptide bonds during ubiquitin conjugation to proteins -- The ubiquitin-proteasome pathway -- Proteasome function is linked to ATP hydrolysis -- Proteasomes unfold proteins and translocate them into 20S particles -- Three types of peptidase sites -- Proposed mechanism of proteasome inhibitors -- Therapeutic applications of proteasome inhibitors -- Two systems for protein breakdown function in the two pathways for antigen presentation -- Changes in proteasome subunits induced by interferon -- Steps involved in generating antigenic peptides.…”
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Series
Electronic Video -
13
The pharmacokinetics of therapeutic proteins
Published 2019Table of Contents: “…Contents: Differences in the pharmacokinetics of therapeutic proteins compared to small molecule drugs -- Classes of therapeutic proteins -- Central paradigm of clinical pharmacology -- Distribution and tissue penetration of mAbs and proteins -- Three methods of renal protein metabolism -- Hepatic protein metabolism -- Target-mediated drug disposition -- Immunogenicity: general considerations and contributing factors -- Neutralizing, clearing and sustaining anti-drug antibodies.…”
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Electronic Video -
14
The pharmacokinetics of therapeutic proteins
Published 2019Table of Contents: “…Contents: Differences in the pharmacokinetics of therapeutic proteins compared to small molecule drugs -- Classes of therapeutic proteins -- Central paradigm of clinical pharmacology -- Distribution and tissue penetration of mAbs and proteins -- Three methods of renal protein metabolism -- Hepatic protein metabolism -- Target-mediated drug disposition -- Immunogenicity: general considerations and contributing factors -- Neutralizing, clearing and sustaining anti-drug antibodies.…”
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Electronic Video -
15
The pharmacokinetics of therapeutic proteins
Published 2019Table of Contents: “…Contents: Differences in the pharmacokinetics of therapeutic proteins compared to small molecule drugs -- Classes of therapeutic proteins -- Central paradigm of clinical pharmacology -- Distribution and tissue penetration of mAbs and proteins -- Three methods of renal protein metabolism -- Hepatic protein metabolism -- Target-mediated drug disposition -- Immunogenicity: general considerations and contributing factors -- Neutralizing, clearing and sustaining anti-drug antibodies.…”
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Electronic Video -
16
The roles of intrinsic disorder in protein interaction networks
Published 2013Table of Contents: “…Contents: Introducing the protein intrinsic disorder concept and intrinsically disordered proteins (IDPs) -- Structural peculiarities of IDPs -- Sequence peculiarities of IDPs -- Abundance of IDPs and their functions -- Intrinsic disorder in protein interaction networks -- Peculiarities of disorder-based binding and regulation -- Why are IDPs commonly involved in protein interactions?.…”
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Series
Electronic Video -
17
Biogenesis of cellular iron-sulfur proteins part 1, structure, function, and assembly in mitochondria /
Published 2018Table of Contents: “…Contents: Structure and functions of iron-sulfur (Fe/S) clusters and proteins -- Analysis of Fe/S proteins and their biogenesis -- Mechanisms of Fe/S protein assembly in mitochondria -- Mitochondrial "Fe/S diseases."…”
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Series
Electronic Video -
18
Elongation of protein synthesis structural basis of the process of decoding /
Published 2018Table of Contents: “…Contents: Fidelity in biological processes -- Elongation step of protein synthesis -- Ribosome structures -- Ribosomes from different organisms -- Errors in protein synthesis -- The decoding problem -- Kinetic proof-reading -- Kinetic model of tRNA selection -- Role of induced fit in tRNA selection -- Recognition of codon-anticodon complexes by the 30S ribosomal subunit -- Local and global conformational changes of the 30S subunit -- Interactions of tRNA during decoding -- Active role of tRNA -- SelB and delivery of Sec-tRNA to the ribosome -- Accommodation of tRNA in the A site.…”
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Series (From DNA to proteins)
Series (Mechanisms of ribosome function)
Electronic Video -
19
Aging and protein homeostasis
Published 2016Table of Contents: “…Contents: Aging and protein homeostasis -- What is the role of proteotoxicity in aging? …”
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Series (Autophagy and lysosomal storage diseases)
Series (Aging)
Electronic Video -
20
Protein homeostasis in mitochondria chaperones and proteases of the mitochondrial matrix /
Published 2012Table of Contents: “…Contents: Protein homeostasis in mitochondria: the role of chaperones and proteases -- Principles of mitochondrial protein homeostasis -- Protein quality control in the matrix compartment -- Substrate selectivity of the mitochondrial protease Pim1 -- Proteomic analysis of mitochondrial protein turnover -- Proteome alterations under oxidative stress -- Identification of aggregation-prone polypeptides -- Protective effects of chaperones -- Cooperation of Hsp78 and Pim1 in removal of aggregated polypeptides.…”
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Series
Electronic Video