Search Results - "prion"
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Suggested Topics within your search.
- metabolism
- Amyloid 2
- Brain 2
- Degeneration 2
- Nervous system 2
- Neurodegenerative Diseases 2
- Prion Diseases 2
- Prion diseases 2
- Ubiquitin 2
- etiology 2
- pathology 2
- Aging 1
- Alzheimer Disease 1
- Alzheimer's disease 1
- Amyloid beta-Peptides 1
- Amyloid beta-protein 1
- Chemotherapy 1
- Cytoskeleton 1
- Diagnosis 1
- HSP40 Heat-Shock Proteins 1
- HSP70 Heat-Shock Proteins 1
- Heat shock proteins 1
- Lewy Bodies 1
- Lewy body dementia 1
- Melanosomes 1
- Metabolism 1
- Molecular aspects 1
- Molecular chaperones 1
- Multivesicular Bodies 1
- Neurons 1
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Chaperones and prions
Published 2020Table of Contents: “…Contents: Prion diseases -- Prions as self-propagating amyloids -- Yeast prions as protein-based heritable elements -- Prion detection -- Crucial role of the chaperone protein Hsp104 in the propagation of yeast prions -- Chaperone-mediated fragmentation turns amyloids into infectious or heritable prions -- Effects of the Hsp70 and Hsp40 proteins on yeast prions -- Other modulators of prion formation and propagation: cytoskeleton and ubiquitin system.…”
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Electronic Video -
2
Prion-like propagation of Parkinson's disease
Published 2014Table of Contents: “…Contents: Parkinson's disease : symptoms and pathology (PD mutations and risk factors) -- Braak staging of Lewy body-related pathology in PD -- The prion-like hypothesis -- Key steps of alpha-synuclein pathology propagation (Release, Uptake, Seeding, Transport) -- In vivo and cell models from different species -- Therapeutic targets: promoting degradation, antibody aided clearance, and preventing seeding of alpha-synuclein -- Parkinson's disease vaccine: first clinical studies.…”
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Electronic Video -
3
The dark side of amyloid PMEL, a natural amyloid in melanosome biogenesis /
Published 2020“…Biomedical & life sciences collection. Prions and amyloids : self-propagating protein structures in mammals, yeast and fungi.…”
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Electronic Video -
4
Protein degradation and defense against neurodegenerative disease part 2 of 2 /
Published 2014Table of Contents: “…Contents: The 26S proteasome -- The 20S proteasome -- Proteasome inhibitors -- PS-341 -- Proteasome inhibitors in multiple myeloma -- Structures of the archaeal PAN ATPase-20S complex and the eukaryotic 26S proteasome -- Multiple ATP-dependent steps in proteasome function -- The gating mechanism of the proteasome -- Prions inhibit proteasome function -- Binding of ubiquitin conjugates activate the 26S proteasome by stimulating 20S gate-opening and ATP hydrolysis -- Ubiquitin conjugates activate their own degradation by the 26S Proteasome -- The inhibitor of proteasome-associated deubiquitinating enzyme Usp14, IU1, enhances degradation of tau.…”
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Electronic Video -
5
Targeting Aß oligomers a molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease /
Published 2014Table of Contents: “…Contents: The oligomer cascade hypothesis for Alzheimer's Disease -- Why the oligomer hypothesis has largely supplanted the amyloid cascade hypothesis -- The role of AβOs in memory failure and the major facets of AD neuropathology -- Mechanisms by which AβOs instigate neurotoxicity -- Why AβOs accumulate in the first place -- How AβOs offer superb targets for novel AD diagnostics and disease-modifying therapeutics -- Beside its direct link to Alzheimer's disease, the discovery of toxic Aβ oligomers has provided a novel structural archetype for toxins germane to more than two dozen diseases of protein mis-folding, including Diabetes, Parkinson's, and prion diseases.…”
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Electronic Video