Search Results - "epigenetics"

Cytoplasmic epigenetics inheritance by cytoplasmic continuity /

“…Biomedical & life sciences collection. Epigenetics : concepts, theories, paradigms and mechanisms.…”
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Skin epigenetics how chromatin regulators orchestrate skin functions /

Table of Contents: “…Contents: Skin structure, functions and development -- Molecular control of cell differentiation -- What is epigenetics? -- What controls variability of skin phenotypes? …”
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Polycomb epigenetic mechanisms part 1 of 2, role of PcG complexes /

“…Polycomb epigenetic mechanisms. Part 1, role of PcG complexes…”
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Polycomb epigenetic mechanisms Part 2 of 2, methylation of DNA /

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Heterochromatin, epigenetics and gene expression

Table of Contents: “…Contents: Heterochromatin as a cytological phenomenon -- Heterochromatin and gene silencing -- Heterochromatin and DNA accessibility -- Histone modification and control of heterochromatin assembly -- Stability of epigenetic silencing by heterochromatin during development -- Heterochromatin and telomere stability.…”
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Series (Epigenetics, chromatin, transcription and cancer)
Series (Molecular genetics of human disease)

Epigenetic control by histone methylation

Table of Contents: “…Contents: The diversity of covalent histone tail modifications for imparting epigenetic information -- Observations of robust histone modifications at silent chromatin regions -- The representation of repressive histone marks as indications of epigenetic plasticity in different cells -- Analysis of the profiles of normal and aberrant histone lysine methylation patterns, as they occur during the transition of an embryonic to a differentiated cell or in controlled self-renewal vs. pro-neoplastic or metastatic conditions -- Elucidation of these histone modification patterns for novel advances in stem cell research, nuclear reprogramming and cancer.…”
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Histone modifications and prospects for an epigenetic code

Table of Contents: “…Contents: Enzyme-catalyzed modification of the N-terminal tail domains of core histones provides an array of marks across the nucleosome surface and a source of epigenetic information -- This information influences protein-protein interactions during short-term regulation of ongoing transcription and is a means of maintaining or modifying patterns of gene expression from one cell generation to the next -- Cellular memory -- Histone modifications may constitute a heritable epigenetic code that acts in concert with the genetic code as a long-term regulator of gene expression.…”
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Epigenetics as a paradigm for cancer treatment chemically targeting the histone lysine methyltransferase EZH2 /

Table of Contents: “…Contents: Cancer as an unmet medical need -- Epigenetics as a paradigm for treating cancer -- Histone lysine methyltransferase EZH2 as a target class example -- Development of EZH2 inhibitors.…”
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Drug metabolism in liver disease

Table of Contents: “…Contents: Drug metabolism -- Liver disease and drug clearance -- Mechanistic explanations -- Intact hepatocyte hypothesis -- Sequential progressive model of liver disease -- Liver disease etiology -- Liver disease severity -- Epigenetics -- Biomarkers.…”
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Genome-wide organization of chromatin and the transcription machinery

“…Biomedical & life sciences collection. Epigenetics, chromatin, transcription and cancer.…”
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Genomic insights into gene regulation by cohesin

Table of Contents: “…Contents: Cohesin regulates gene expression and development in Drosophila and Humans -- Cohesin binds a subset of active genes at transcription start sites -- Cohesin directly regulates many genes Important for growth and development -- Cohesin cooperates with polycomb epigenetic silencing complexes to restrain gene expression -- Cohesin selectively binds genes with paused RNA Polymerase and regulates transition to transcriptional elongation -- Questions regarding the roles of cohesin in gene regulation and development and relevance to human disease.…”
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Maintaining the silenced state of master regulatory genes during development

Table of Contents: “…-- PRC1 in compaction and ubiquitylation -- Nucleosome dynamics -- Characteristics of the compaction domain -- Gene silencing by chromatin compaction -- The SIR complex and mating type silencing -- Structural rearrangements in NCP and BAH -- Folding events in Sir3 BAH/NCP complex -- The nucleosome as a silencing machinery -- Epigenetic memory.…”
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Role of polycomb proteins in gene transcription, stem cell and human diseases

“…Biomedical & life sciences collection. Epigenetics, chromatin, transcription and cancer.…”
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The basal transcription machinery for RNA polymerase II

“…Biomedical & life sciences collection. Epigenetics, chromatin, transcription and cancer.…”
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Enhancer malfunction in cancer

“…Biomedical & life sciences collection. Epigenetics, chromatin, transcription and cancer.…”
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Gene silencing in budding yeast

Table of Contents: “…Contents: Gene silencing: an epigenetic phenomenon -- Chromatin remodeling: heterochromatin and euchromatin -- Silent chromatin in budding yeast: mating-type loci -- Silent information regulation: telomeric genes and Sir proteins.…”
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The molecular mechanism of X chromosome inactivation

“…Biomedical & life sciences collection. Epigenetics : concepts, theories, paradigms and mechanisms.…”
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The Beta-globin locus

“…Biomedical & life sciences collection. Epigenetics, chromatin, transcription and cancer.…”
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Series (Eukaryotic gene regulation)
Series (Epigenetics, chromatin, transcription and cancer)

Visualization of transcription factor interactions in living cells

“…Biomedical & life sciences collection. Epigenetics, chromatin, transcription and cancer.…”
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Series (Eukaryotic gene regulation)
Series (Epigenetics, chromatin, transcription and cancer)

The Myc transcription factor network

“…Biomedical & life sciences collection. Epigenetics, chromatin, transcription and cancer.…”
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Series (Cell division cycle)
Series (Epigenetics, chromatin, transcription and cancer)