Search Results - "amyloid"
Suggested Topics within your search.
Suggested Topics within your search.
- metabolism
- Alzheimer Disease 11
- Alzheimer's disease 11
- Amyloid 10
- drug therapy 9
- Chemotherapy 6
- Amyloid beta-Peptides 5
- pathology 5
- Activating Transcription Factor 6 3
- Acute-Phase Proteins 3
- Acute-Phase Reaction 3
- Amyloid beta-protein 3
- Amyloidosis 3
- Brain 3
- C-Reactive Protein 3
- Cell Membrane 3
- Clinical Trials as Topic 3
- Clinical trials 3
- Cytokines 3
- Degeneration 3
- Diagnosis 3
- Diflunisal 3
- Disorders 3
- Drug Discovery 3
- Drug development 3
- Extracellular Traps 3
- Immune response 3
- Immune system 3
- Immunity, Humoral 3
- Immunity, Innate 3
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1
The dark side of amyloid PMEL, a natural amyloid in melanosome biogenesis /
Published 2020Table of Contents: “…Contents: Functional amyloid -- Amyloid fibrils in melanosome ultrastructure and formation -- Pmel17 processing to a fibrillar form -- Evidence that Pmel17 fibrils are amyloid -- Role of multivesicular bodies in Pmel17 amyloid formation -- Multivesicular bodies in amyloid formation by other substrates.…”
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2
The dark side of amyloid PMEL, a natural amyloid in melanosome biogenesis /
Published 2020Table of Contents: “…Contents: Functional amyloid -- Amyloid fibrils in melanosome ultrastructure and formation -- Pmel17 processing to a fibrillar form -- Evidence that Pmel17 fibrils are amyloid -- Role of multivesicular bodies in Pmel17 amyloid formation -- Multivesicular bodies in amyloid formation by other substrates.…”
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Series
Electronic Video -
3
Adapting proteostasis to ameliorate aggregation-associated amyloid diseases
Published 2018Table of Contents: “…Contents: Protein folding, misfolding, aggregation -- The proteostasis network and its regulation -- Gain and loss of function diseases -- The transthyretin (TTR) amyloidosis -- Kinetic stabilizers & clinical trial results -- Tafamidis & Diflunisal: evidence for the amyloid hypothesis -- Improving protein misfolding/aggregation diseases -- The unfolded protein response (UPR) and its arm-selective activators -- ATF6 activation & reduction of TTR mutant -- Clinical trials in amyloidosis with cardiac involvement.…”
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Electronic Video -
4
Adapting proteostasis to ameliorate aggregation-associated amyloid diseases
Published 2018Table of Contents: “…Contents: Protein folding, misfolding, aggregation -- The proteostasis network and its regulation -- Gain and loss of function diseases -- The transthyretin (TTR) amyloidosis -- Kinetic stabilizers & clinical trial results -- Tafamidis & Diflunisal: evidence for the amyloid hypothesis -- Improving protein misfolding/aggregation diseases -- The unfolded protein response (UPR) and its arm-selective activators -- ATF6 activation & reduction of TTR mutant -- Clinical trials in amyloidosis with cardiac involvement.…”
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Series
Electronic Video -
5
Adapting proteostasis to ameliorate aggregation-associated amyloid diseases
Published 2018Table of Contents: “…Contents: Protein folding, misfolding, aggregation -- The proteostasis network and its regulation -- Gain and loss of function diseases -- The transthyretin (TTR) amyloidosis -- Kinetic stabilizers & clinical trial results -- Tafamidis & Diflunisal: evidence for the amyloid hypothesis -- Improving protein misfolding/aggregation diseases -- The unfolded protein response (UPR) and its arm-selective activators -- ATF6 activation & reduction of TTR mutant -- Clinical trials in amyloidosis with cardiac involvement.…”
Get full text
Series
Electronic Video -
6
Current directions in the prevention and treatment of Alzheimer's disease
Published 2018Table of Contents: “…Contents: Amyloid build-up and the importance of early diagnosis -- The potential of inhibiting vs. clearing amyloid aggregation -- Different potential therapeutic approaches designed for different stages of Alzheimer's -- The future of therapies targeting amyloid deposition.…”
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7
Current directions in the prevention and treatment of Alzheimer's disease
Published 2018Table of Contents: “…Contents: Amyloid build-up and the importance of early diagnosis -- The potential of inhibiting vs. clearing amyloid aggregation -- Different potential therapeutic approaches designed for different stages of Alzheimer's -- The future of therapies targeting amyloid deposition.…”
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Series
Electronic Audio -
8
Current directions in the prevention and treatment of Alzheimer's disease
Published 2018Table of Contents: “…Contents: Amyloid build-up and the importance of early diagnosis -- The potential of inhibiting vs. clearing amyloid aggregation -- Different potential therapeutic approaches designed for different stages of Alzheimer's -- The future of therapies targeting amyloid deposition.…”
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Series
Electronic Audio -
9
Targeting Aß oligomers a molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease /
Published 2014Table of Contents: “…Contents: The oligomer cascade hypothesis for Alzheimer's Disease -- Why the oligomer hypothesis has largely supplanted the amyloid cascade hypothesis -- The role of AβOs in memory failure and the major facets of AD neuropathology -- Mechanisms by which AβOs instigate neurotoxicity -- Why AβOs accumulate in the first place -- How AβOs offer superb targets for novel AD diagnostics and disease-modifying therapeutics -- Beside its direct link to Alzheimer's disease, the discovery of toxic Aβ oligomers has provided a novel structural archetype for toxins germane to more than two dozen diseases of protein mis-folding, including Diabetes, Parkinson's, and prion diseases.…”
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Series
Electronic Video -
10
Targeting Aß oligomers a molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease /
Published 2014Table of Contents: “…Contents: The oligomer cascade hypothesis for Alzheimer's Disease -- Why the oligomer hypothesis has largely supplanted the amyloid cascade hypothesis -- The role of AβOs in memory failure and the major facets of AD neuropathology -- Mechanisms by which AβOs instigate neurotoxicity -- Why AβOs accumulate in the first place -- How AβOs offer superb targets for novel AD diagnostics and disease-modifying therapeutics -- Beside its direct link to Alzheimer's disease, the discovery of toxic Aβ oligomers has provided a novel structural archetype for toxins germane to more than two dozen diseases of protein mis-folding, including Diabetes, Parkinson's, and prion diseases.…”
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Series
Electronic Video -
11
Targeting Aß oligomers a molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease /
Published 2014Table of Contents: “…Contents: The oligomer cascade hypothesis for Alzheimer's Disease -- Why the oligomer hypothesis has largely supplanted the amyloid cascade hypothesis -- The role of AβOs in memory failure and the major facets of AD neuropathology -- Mechanisms by which AβOs instigate neurotoxicity -- Why AβOs accumulate in the first place -- How AβOs offer superb targets for novel AD diagnostics and disease-modifying therapeutics -- Beside its direct link to Alzheimer's disease, the discovery of toxic Aβ oligomers has provided a novel structural archetype for toxins germane to more than two dozen diseases of protein mis-folding, including Diabetes, Parkinson's, and prion diseases.…”
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Series
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12
The blood-brain barrier in Alzheimer's disease
Published 2021Subjects: Get full text
Series
Electronic Video -
13
The blood-brain barrier in Alzheimer's disease
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Series
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14
Chaperones and prions
Published 2020Table of Contents: “…Contents: Prion diseases -- Prions as self-propagating amyloids -- Yeast prions as protein-based heritable elements -- Prion detection -- Crucial role of the chaperone protein Hsp104 in the propagation of yeast prions -- Chaperone-mediated fragmentation turns amyloids into infectious or heritable prions -- Effects of the Hsp70 and Hsp40 proteins on yeast prions -- Other modulators of prion formation and propagation: cytoskeleton and ubiquitin system.…”
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Series
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15
Chaperones and prions
Published 2020Table of Contents: “…Contents: Prion diseases -- Prions as self-propagating amyloids -- Yeast prions as protein-based heritable elements -- Prion detection -- Crucial role of the chaperone protein Hsp104 in the propagation of yeast prions -- Chaperone-mediated fragmentation turns amyloids into infectious or heritable prions -- Effects of the Hsp70 and Hsp40 proteins on yeast prions -- Other modulators of prion formation and propagation: cytoskeleton and ubiquitin system.…”
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Series
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16
Humoral innate immunity and the acute phase response 2
Published 2016Subjects: Get full text
Series (Innate immunity)
Series (Cytokines)
Electronic Video -
17
Humoral innate immunity and the acute phase response 2
Published 2016Subjects: Get full text
Series (Innate immunity)
Series (Cytokines)
Electronic Video -
18
Humoral innate immunity and the acute phase response 2
Published 2016Subjects: Get full text
Series (Innate immunity)
Series (Cytokines)
Electronic Video -
19
Metabolic and biochemical alterations in Alzheimer's disease facts and fictions /
Published 2011Table of Contents: “…-- Tauist and BAPtist hypothesis of AD -- Pathology and oxidative stress relationship -- NFT and amyloid-beta -- Stress-activated protein kinases and phospho-tau -- Amyloid-targeted approaches are unsuccessful -- Amyloid-beta controls redox activity -- Genetic factors are related to oxidative stress -- Therapeutics -- Potential mechanism of ROS generation -- Oxidative modifications and macromolecules -- Oxidative damage directly correlates with mtDNA -- Abnormal mitochondrial distribution in AD brains -- Iron histochemistry -- Antioxidant diet is protective -- Only one non-amyloid drug in phase III: 2010 -- Oxidative stress is necessary but not sufficient -- CaMKII-MYC mice -- Oxidative stress and cell cycle abnormalities -- Early stages of AD disease signals.…”
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20
Metabolic and biochemical alterations in Alzheimer's disease facts and fictions /
Published 2011Table of Contents: “…-- Tauist and BAPtist hypothesis of AD -- Pathology and oxidative stress relationship -- NFT and amyloid-beta -- Stress-activated protein kinases and phospho-tau -- Amyloid-targeted approaches are unsuccessful -- Amyloid-beta controls redox activity -- Genetic factors are related to oxidative stress -- Therapeutics -- Potential mechanism of ROS generation -- Oxidative modifications and macromolecules -- Oxidative damage directly correlates with mtDNA -- Abnormal mitochondrial distribution in AD brains -- Iron histochemistry -- Antioxidant diet is protective -- Only one non-amyloid drug in phase III: 2010 -- Oxidative stress is necessary but not sufficient -- CaMKII-MYC mice -- Oxidative stress and cell cycle abnormalities -- Early stages of AD disease signals.…”
Get full text
Series
Electronic Video