Search Results - "amyloid"

The dark side of amyloid PMEL, a natural amyloid in melanosome biogenesis /

Table of Contents: “…Contents: Functional amyloid -- Amyloid fibrils in melanosome ultrastructure and formation -- Pmel17 processing to a fibrillar form -- Evidence that Pmel17 fibrils are amyloid -- Role of multivesicular bodies in Pmel17 amyloid formation -- Multivesicular bodies in amyloid formation by other substrates.…”
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The dark side of amyloid PMEL, a natural amyloid in melanosome biogenesis /

Table of Contents: “…Contents: Functional amyloid -- Amyloid fibrils in melanosome ultrastructure and formation -- Pmel17 processing to a fibrillar form -- Evidence that Pmel17 fibrils are amyloid -- Role of multivesicular bodies in Pmel17 amyloid formation -- Multivesicular bodies in amyloid formation by other substrates.…”
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Adapting proteostasis to ameliorate aggregation-associated amyloid diseases

Table of Contents: “…Contents: Protein folding, misfolding, aggregation -- The proteostasis network and its regulation -- Gain and loss of function diseases -- The transthyretin (TTR) amyloidosis -- Kinetic stabilizers & clinical trial results -- Tafamidis & Diflunisal: evidence for the amyloid hypothesis -- Improving protein misfolding/aggregation diseases -- The unfolded protein response (UPR) and its arm-selective activators -- ATF6 activation & reduction of TTR mutant -- Clinical trials in amyloidosis with cardiac involvement.…”
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Adapting proteostasis to ameliorate aggregation-associated amyloid diseases

Table of Contents: “…Contents: Protein folding, misfolding, aggregation -- The proteostasis network and its regulation -- Gain and loss of function diseases -- The transthyretin (TTR) amyloidosis -- Kinetic stabilizers & clinical trial results -- Tafamidis & Diflunisal: evidence for the amyloid hypothesis -- Improving protein misfolding/aggregation diseases -- The unfolded protein response (UPR) and its arm-selective activators -- ATF6 activation & reduction of TTR mutant -- Clinical trials in amyloidosis with cardiac involvement.…”
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Adapting proteostasis to ameliorate aggregation-associated amyloid diseases

Table of Contents: “…Contents: Protein folding, misfolding, aggregation -- The proteostasis network and its regulation -- Gain and loss of function diseases -- The transthyretin (TTR) amyloidosis -- Kinetic stabilizers & clinical trial results -- Tafamidis & Diflunisal: evidence for the amyloid hypothesis -- Improving protein misfolding/aggregation diseases -- The unfolded protein response (UPR) and its arm-selective activators -- ATF6 activation & reduction of TTR mutant -- Clinical trials in amyloidosis with cardiac involvement.…”
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Current directions in the prevention and treatment of Alzheimer's disease

Table of Contents: “…Contents: Amyloid build-up and the importance of early diagnosis -- The potential of inhibiting vs. clearing amyloid aggregation -- Different potential therapeutic approaches designed for different stages of Alzheimer's -- The future of therapies targeting amyloid deposition.…”
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Current directions in the prevention and treatment of Alzheimer's disease

Table of Contents: “…Contents: Amyloid build-up and the importance of early diagnosis -- The potential of inhibiting vs. clearing amyloid aggregation -- Different potential therapeutic approaches designed for different stages of Alzheimer's -- The future of therapies targeting amyloid deposition.…”
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Current directions in the prevention and treatment of Alzheimer's disease

Table of Contents: “…Contents: Amyloid build-up and the importance of early diagnosis -- The potential of inhibiting vs. clearing amyloid aggregation -- Different potential therapeutic approaches designed for different stages of Alzheimer's -- The future of therapies targeting amyloid deposition.…”
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Targeting Aß oligomers a molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease /

Table of Contents: “…Contents: The oligomer cascade hypothesis for Alzheimer's Disease -- Why the oligomer hypothesis has largely supplanted the amyloid cascade hypothesis -- The role of AβOs in memory failure and the major facets of AD neuropathology -- Mechanisms by which AβOs instigate neurotoxicity -- Why AβOs accumulate in the first place -- How AβOs offer superb targets for novel AD diagnostics and disease-modifying therapeutics -- Beside its direct link to Alzheimer's disease, the discovery of toxic Aβ oligomers has provided a novel structural archetype for toxins germane to more than two dozen diseases of protein mis-folding, including Diabetes, Parkinson's, and prion diseases.…”
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Targeting Aß oligomers a molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease /

Table of Contents: “…Contents: The oligomer cascade hypothesis for Alzheimer's Disease -- Why the oligomer hypothesis has largely supplanted the amyloid cascade hypothesis -- The role of AβOs in memory failure and the major facets of AD neuropathology -- Mechanisms by which AβOs instigate neurotoxicity -- Why AβOs accumulate in the first place -- How AβOs offer superb targets for novel AD diagnostics and disease-modifying therapeutics -- Beside its direct link to Alzheimer's disease, the discovery of toxic Aβ oligomers has provided a novel structural archetype for toxins germane to more than two dozen diseases of protein mis-folding, including Diabetes, Parkinson's, and prion diseases.…”
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Targeting Aß oligomers a molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease /

Table of Contents: “…Contents: The oligomer cascade hypothesis for Alzheimer's Disease -- Why the oligomer hypothesis has largely supplanted the amyloid cascade hypothesis -- The role of AβOs in memory failure and the major facets of AD neuropathology -- Mechanisms by which AβOs instigate neurotoxicity -- Why AβOs accumulate in the first place -- How AβOs offer superb targets for novel AD diagnostics and disease-modifying therapeutics -- Beside its direct link to Alzheimer's disease, the discovery of toxic Aβ oligomers has provided a novel structural archetype for toxins germane to more than two dozen diseases of protein mis-folding, including Diabetes, Parkinson's, and prion diseases.…”
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The blood-brain barrier in Alzheimer's disease

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The blood-brain barrier in Alzheimer's disease

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Chaperones and prions

Table of Contents: “…Contents: Prion diseases -- Prions as self-propagating amyloids -- Yeast prions as protein-based heritable elements -- Prion detection -- Crucial role of the chaperone protein Hsp104 in the propagation of yeast prions -- Chaperone-mediated fragmentation turns amyloids into infectious or heritable prions -- Effects of the Hsp70 and Hsp40 proteins on yeast prions -- Other modulators of prion formation and propagation: cytoskeleton and ubiquitin system.…”
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Chaperones and prions

Table of Contents: “…Contents: Prion diseases -- Prions as self-propagating amyloids -- Yeast prions as protein-based heritable elements -- Prion detection -- Crucial role of the chaperone protein Hsp104 in the propagation of yeast prions -- Chaperone-mediated fragmentation turns amyloids into infectious or heritable prions -- Effects of the Hsp70 and Hsp40 proteins on yeast prions -- Other modulators of prion formation and propagation: cytoskeleton and ubiquitin system.…”
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Humoral innate immunity and the acute phase response 2

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Humoral innate immunity and the acute phase response 2

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Series (Cytokines)

Humoral innate immunity and the acute phase response 2

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Metabolic and biochemical alterations in Alzheimer's disease facts and fictions /

Table of Contents: “…-- Tauist and BAPtist hypothesis of AD -- Pathology and oxidative stress relationship -- NFT and amyloid-beta -- Stress-activated protein kinases and phospho-tau -- Amyloid-targeted approaches are unsuccessful -- Amyloid-beta controls redox activity -- Genetic factors are related to oxidative stress -- Therapeutics -- Potential mechanism of ROS generation -- Oxidative modifications and macromolecules -- Oxidative damage directly correlates with mtDNA -- Abnormal mitochondrial distribution in AD brains -- Iron histochemistry -- Antioxidant diet is protective -- Only one non-amyloid drug in phase III: 2010 -- Oxidative stress is necessary but not sufficient -- CaMKII-MYC mice -- Oxidative stress and cell cycle abnormalities -- Early stages of AD disease signals.…”
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Metabolic and biochemical alterations in Alzheimer's disease facts and fictions /

Table of Contents: “…-- Tauist and BAPtist hypothesis of AD -- Pathology and oxidative stress relationship -- NFT and amyloid-beta -- Stress-activated protein kinases and phospho-tau -- Amyloid-targeted approaches are unsuccessful -- Amyloid-beta controls redox activity -- Genetic factors are related to oxidative stress -- Therapeutics -- Potential mechanism of ROS generation -- Oxidative modifications and macromolecules -- Oxidative damage directly correlates with mtDNA -- Abnormal mitochondrial distribution in AD brains -- Iron histochemistry -- Antioxidant diet is protective -- Only one non-amyloid drug in phase III: 2010 -- Oxidative stress is necessary but not sufficient -- CaMKII-MYC mice -- Oxidative stress and cell cycle abnormalities -- Early stages of AD disease signals.…”
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