Search Results - "Pharmacology"

Overview of clinical pharmacology in cancer part 1 of 2 /

Subjects: “…Antineoplastic Agents pharmacology. 95987…”
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Overview of clinical pharmacology in cancer part 2 of 2 /

Subjects: “…Antineoplastic Agents pharmacology. 96070…”
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Pre-coupling of receptor oligomers and signaling molecules challenging classical pharmacology /

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The pharmacokinetics of therapeutic proteins

Table of Contents: “…Contents: Differences in the pharmacokinetics of therapeutic proteins compared to small molecule drugs -- Classes of therapeutic proteins -- Central paradigm of clinical pharmacology -- Distribution and tissue penetration of mAbs and proteins -- Three methods of renal protein metabolism -- Hepatic protein metabolism -- Target-mediated drug disposition -- Immunogenicity: general considerations and contributing factors -- Neutralizing, clearing and sustaining anti-drug antibodies.…”
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The development of therapeutic antibodies against oncogenic antigens

Subjects: “…Antibodies, Monoclonal pharmacology. 88203…”
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VEGF inhibitors for anti-angiogenic therapy

Subjects: “…Angiogenesis Inhibitors pharmacology. 107630…”
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Transport and delivery of neurotrophic peptides and proteins across the BBB

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PI 3-kinases and lipid messengers

Subjects: “…Antineoplastic Agents pharmacology. 88732…”
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Cannabinoid type 1 receptors in astrocytes

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Transport mechanism of urate in humans

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Inhibiting protein-protein interactions part 1 of 2 /

Subjects: “…Small Molecule Libraries pharmacology. 104180…”
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Drug metabolizing enzymes in cancer therapeutics

Subjects: “…Antineoplastic Agents pharmacology. 93584…”
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Laboratory methods for the in vitro study of drug metabolism

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Introduction to drug metabolism enzymes

Subjects: “…Enzymes and Coenzymes pharmacology. 97670…”
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Inhibiting protein-protein interactions part 2 of 2 /

Subjects: “…Small Molecule Libraries pharmacology. 104240…”
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Enzymology in drug discovery part 2 of 2 /

Table of Contents: “…Contents: Enzymes as targets for drug discovery -- Protein-ligand binding equilibria -- Enzyme reaction mechanisms -- Structure and function of enzyme active sites -- Measuring enzyme velocity in the laboratory -- Reversible modes of enzyme inhibition -- Enzyme inhibition as a mechanism of pharmacological intervention in disease -- Clinical value of different inhibition modalities -- Non-classical inhibition -- Enzyme assays and screening criteria -- Lead optimization -- Summary: basic information to look for.…”
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Enzymology in drug discovery part 1 of 2 /

Table of Contents: “…Contents: Enzymes as targets for drug discovery -- Protein-ligand binding equilibria -- Enzyme reaction mechanisms -- Structure and function of enzyme active sites -- Measuring enzyme velocity in the laboratory -- Reversible modes of enzyme inhibition -- Enzyme inhibition as a mechanism of pharmacological intervention in disease -- Clinical value of different inhibition modalities -- Non-classical inhibition -- Enzyme assays and screening criteria -- Lead optimization -- Summary: basic information to look for.…”
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Conserved allosteric sodium in class A GPCRs part 2 of 2, Na+ dynamics in GPCR signaling /

Subjects: “…Receptors, G-Protein-Coupled pharmacology. 91064…”
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Cellular cofactors of HIV integrase from target identification to discovery of LEDGINs /

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Conserved allosteric sodium in class A GPCRs part 1 of 2, GPCR structure and allosteric effects /

Table of Contents: “…Contents: GPCRs structure and function -- GPCRs in human biology and pharmacology -- Conserved Na+ site in class A GPCRs -- Structural modification of Na+ pocket in GPCRs upon activation -- Allosteric Na+ effects on agonist binding in "opiate" receptors.…”
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