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Immune-mediated liver disease

Table of Contents: “…IBD+PSC -- Causes of death in PSC patients -- Treatment for PSC with Ursodeoxycholic acid -- Why medical therapy fails in PSC -- Recurrent Autoimmune after liver transplant -- Primary Biliary Cirrhosis (PBC) -- PBC- physical presentation -- Typical presentation of PBC in 2009 -- Liver transplant in PBC compared to PSC -- Longterm survival in early PBC -- Survival in PBC +/- Biochemical response to Ursodeoxycholic acid -- Survival according to portal/hepatic venous gradient score -- PBC: natural history -- Treatment response and histological change in PBC -- Complications of PBC -- PBC: the drive and the trigger -- PBC cases in first degree relatives -- PBC: genome wide analysis -- The genetic web of autoimmunity.…”
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Immune-mediated liver disease

Table of Contents: “…IBD+PSC -- Causes of death in PSC patients -- Treatment for PSC with Ursodeoxycholic acid -- Why medical therapy fails in PSC -- Recurrent Autoimmune after liver transplant -- Primary Biliary Cirrhosis (PBC) -- PBC- physical presentation -- Typical presentation of PBC in 2009 -- Liver transplant in PBC compared to PSC -- Longterm survival in early PBC -- Survival in PBC +/- Biochemical response to Ursodeoxycholic acid -- Survival according to portal/hepatic venous gradient score -- PBC: natural history -- Treatment response and histological change in PBC -- Complications of PBC -- PBC: the drive and the trigger -- PBC cases in first degree relatives -- PBC: genome wide analysis -- The genetic web of autoimmunity.…”
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Immune-mediated liver disease

Table of Contents: “…IBD+PSC -- Causes of death in PSC patients -- Treatment for PSC with Ursodeoxycholic acid -- Why medical therapy fails in PSC -- Recurrent Autoimmune after liver transplant -- Primary Biliary Cirrhosis (PBC) -- PBC- physical presentation -- Typical presentation of PBC in 2009 -- Liver transplant in PBC compared to PSC -- Longterm survival in early PBC -- Survival in PBC +/- Biochemical response to Ursodeoxycholic acid -- Survival according to portal/hepatic venous gradient score -- PBC: natural history -- Treatment response and histological change in PBC -- Complications of PBC -- PBC: the drive and the trigger -- PBC cases in first degree relatives -- PBC: genome wide analysis -- The genetic web of autoimmunity.…”
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Innate immunity in the intestine in health and disease

Table of Contents: “…Contents: Mucosal tissues of the human body -- Intestinal pathogens -- Mucosal immune system: distinctive features -- Gut-associated lymphoid tissue (GALT) -- Structure of the GALT: small and large intestine -- Mucus, a key protective barrier -- Antimicrobial proteins protect the epithelium -- Epithelial cell transcytosis of secretory IgA -- Uptake and transport of antigen by M cells -- Microbial sensing regulates intestinal homeostasis -- Sensing of microbes occurs through PRR -- MyD88 signals in IEC -- Intestinal macrophages are anti-inflammatory -- Intestinal DC 'conditioning' -- Inflammatory bowel disease (IBD) -- Genome-wide association studies -- The enigma of NOD2 and Crohn's disease -- NOD2 signaling in response to bacterial MDP -- NOD2 signaling regulates myeloid cell function -- Autophagy also regulates IEC and myeloid cells -- MyD88 activation drives intestinal inflammation -- Haematopoeitic MyD88 signals -- Immune dysregulation in chronic inflammation -- Innate lymphoid cells (ILC) drive innate IBD -- Leukocyte populations and intestinal homeostasis.…”
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Innate immunity in the intestine in health and disease

Table of Contents: “…Contents: Mucosal tissues of the human body -- Intestinal pathogens -- Mucosal immune system: distinctive features -- Gut-associated lymphoid tissue (GALT) -- Structure of the GALT: small and large intestine -- Mucus, a key protective barrier -- Antimicrobial proteins protect the epithelium -- Epithelial cell transcytosis of secretory IgA -- Uptake and transport of antigen by M cells -- Microbial sensing regulates intestinal homeostasis -- Sensing of microbes occurs through PRR -- MyD88 signals in IEC -- Intestinal macrophages are anti-inflammatory -- Intestinal DC 'conditioning' -- Inflammatory bowel disease (IBD) -- Genome-wide association studies -- The enigma of NOD2 and Crohn's disease -- NOD2 signaling in response to bacterial MDP -- NOD2 signaling regulates myeloid cell function -- Autophagy also regulates IEC and myeloid cells -- MyD88 activation drives intestinal inflammation -- Haematopoeitic MyD88 signals -- Immune dysregulation in chronic inflammation -- Innate lymphoid cells (ILC) drive innate IBD -- Leukocyte populations and intestinal homeostasis.…”
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Series

Innate immunity in the intestine in health and disease

Table of Contents: “…Contents: Mucosal tissues of the human body -- Intestinal pathogens -- Mucosal immune system: distinctive features -- Gut-associated lymphoid tissue (GALT) -- Structure of the GALT: small and large intestine -- Mucus, a key protective barrier -- Antimicrobial proteins protect the epithelium -- Epithelial cell transcytosis of secretory IgA -- Uptake and transport of antigen by M cells -- Microbial sensing regulates intestinal homeostasis -- Sensing of microbes occurs through PRR -- MyD88 signals in IEC -- Intestinal macrophages are anti-inflammatory -- Intestinal DC 'conditioning' -- Inflammatory bowel disease (IBD) -- Genome-wide association studies -- The enigma of NOD2 and Crohn's disease -- NOD2 signaling in response to bacterial MDP -- NOD2 signaling regulates myeloid cell function -- Autophagy also regulates IEC and myeloid cells -- MyD88 activation drives intestinal inflammation -- Haematopoeitic MyD88 signals -- Immune dysregulation in chronic inflammation -- Innate lymphoid cells (ILC) drive innate IBD -- Leukocyte populations and intestinal homeostasis.…”
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