Search Results - Genomics PLC~
Suggested Topics within your search.
Suggested Topics within your search.
- genetics
- metabolism 9
- Genetic transcription 6
- Mitochondria 6
- Transcription Factors 6
- Transcription, Genetic 6
- Cancer 5
- Genetic aspects 5
- CDC2 Protein Kinase 3
- Cell Cycle 3
- Cell Cycle Checkpoints 3
- Cell Cycle Proteins 3
- Cell Nucleus 3
- Cell Transformation, Neoplastic 3
- Cell cycle 3
- Cell nuclei 3
- Chromatin 3
- Chromosomal proteins 3
- DNA 3
- DNA Methylation 3
- Electron Transport 3
- Electron transport (Biology) 3
- Embryonic Stem Cells 3
- Epigenesis 3
- Epigenesis, Genetic 3
- Eukaryota 3
- Eukaryotic cells 3
- Gene Expression Regulation 3
- Gene expression 3
- Histones 3
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1
Systems biology of the cell cycle
Published 2014Table of Contents: “…Contents: Control of cell cycle progression in eukaryotes by a network of universal protein interactions -- This dynamic system oscillates once per cell cycle -- Oscillation ceases when genomic integrity is in jeopardy -- The negative feedback loop by which Cdk1/CycB promotes CycB degradation via activation of APC/C -- Bistable ("toggle") switches are also important design principles of eukaryotic cell cycle control network -- The cell cycle.…”
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2
Systems biology of the cell cycle
Published 2014Table of Contents: “…Contents: Control of cell cycle progression in eukaryotes by a network of universal protein interactions -- This dynamic system oscillates once per cell cycle -- Oscillation ceases when genomic integrity is in jeopardy -- The negative feedback loop by which Cdk1/CycB promotes CycB degradation via activation of APC/C -- Bistable ("toggle") switches are also important design principles of eukaryotic cell cycle control network -- The cell cycle.…”
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Electronic Video -
3
Systems biology of the cell cycle
Published 2014Table of Contents: “…Contents: Control of cell cycle progression in eukaryotes by a network of universal protein interactions -- This dynamic system oscillates once per cell cycle -- Oscillation ceases when genomic integrity is in jeopardy -- The negative feedback loop by which Cdk1/CycB promotes CycB degradation via activation of APC/C -- Bistable ("toggle") switches are also important design principles of eukaryotic cell cycle control network -- The cell cycle.…”
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Electronic Video -
4
Colorectal cancer and the rare variant hypothesis
Published 2020Table of Contents: “…Contents: Cancer: a somatic evolutionary process -- Colorectal cancer: a good model to study -- Two clear cut familial forms: FAP and HNPCC -- Mutation selection balance for dominants and recessives: application to FAP -- APC gene found by positional cloning -- Loss of heterozygosity proved its role in sporadic cancers -- Selection for mutations in the APC "mutation cluster region" -- HNPCC mismatch repair genes found by candidate guess -- Mutated genes in colorectal cancer include p53 and wnt pathway, occur in adenoma to carcinoma sequence -- Arguments for and against need for genomic instability in cancers -- Epigenetic changes -- Mathematical model of normal and cancerous crypt -- Types of familial cancers: mostly rarer than FAP and HNPCC -- Approaches to studying multifactorial inherited susceptibility -- HLA and disease: the model -- Role of linkage disequilbrium -- Principles of SNP association analysis -- Rare missense variants in the APC gene confer susceptibility -- The "rare variant hypothesis" for multifactorial inherited susceptibility: exemplified by study of colorectal adenomas.…”
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5
Colorectal cancer and the rare variant hypothesis
Published 2020Table of Contents: “…Contents: Cancer: a somatic evolutionary process -- Colorectal cancer: a good model to study -- Two clear cut familial forms: FAP and HNPCC -- Mutation selection balance for dominants and recessives: application to FAP -- APC gene found by positional cloning -- Loss of heterozygosity proved its role in sporadic cancers -- Selection for mutations in the APC "mutation cluster region" -- HNPCC mismatch repair genes found by candidate guess -- Mutated genes in colorectal cancer include p53 and wnt pathway, occur in adenoma to carcinoma sequence -- Arguments for and against need for genomic instability in cancers -- Epigenetic changes -- Mathematical model of normal and cancerous crypt -- Types of familial cancers: mostly rarer than FAP and HNPCC -- Approaches to studying multifactorial inherited susceptibility -- HLA and disease: the model -- Role of linkage disequilbrium -- Principles of SNP association analysis -- Rare missense variants in the APC gene confer susceptibility -- The "rare variant hypothesis" for multifactorial inherited susceptibility: exemplified by study of colorectal adenomas.…”
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6
Nuclear control of respiratory chain expression by transcriptional activators and coactivators
Published 2007Table of Contents: “…Contents: Contribution of nuclear and mitochondrial genomes to respiratory chain expression -- Genomic origin of respiratory chain subunits -- Cytochrome c as a model for respiratory gene expression -- DNA binding and transcriptional properties of nuclear respiratory factors (NRF-1 and NRF-2) -- Identification and characterization of NRF target genes -- Phenotypes associated with a targeted disruption of NRF-1 in mice -- NRF control of mitochondrial transcription factor expression -- The PGC-1 family -- PRC functional interactions with NRF-1 and CREB -- Cytochrome c promoter occupancy by PRC during the transition from quiescence to proliferative growth -- Potential role for PRC in integrating mitochondrial functions with cell growth.…”
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7
Nuclear control of respiratory chain expression by transcriptional activators and coactivators
Published 2007Table of Contents: “…Contents: Contribution of nuclear and mitochondrial genomes to respiratory chain expression -- Genomic origin of respiratory chain subunits -- Cytochrome c as a model for respiratory gene expression -- DNA binding and transcriptional properties of nuclear respiratory factors (NRF-1 and NRF-2) -- Identification and characterization of NRF target genes -- Phenotypes associated with a targeted disruption of NRF-1 in mice -- NRF control of mitochondrial transcription factor expression -- The PGC-1 family -- PRC functional interactions with NRF-1 and CREB -- Cytochrome c promoter occupancy by PRC during the transition from quiescence to proliferative growth -- Potential role for PRC in integrating mitochondrial functions with cell growth.…”
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8
Nuclear control of respiratory chain expression by transcriptional activators and coactivators
Published 2007Table of Contents: “…Contents: Contribution of nuclear and mitochondrial genomes to respiratory chain expression -- Genomic origin of respiratory chain subunits -- Cytochrome c as a model for respiratory gene expression -- DNA binding and transcriptional properties of nuclear respiratory factors (NRF-1 and NRF-2) -- Identification and characterization of NRF target genes -- Phenotypes associated with a targeted disruption of NRF-1 in mice -- NRF control of mitochondrial transcription factor expression -- The PGC-1 family -- PRC functional interactions with NRF-1 and CREB -- Cytochrome c promoter occupancy by PRC during the transition from quiescence to proliferative growth -- Potential role for PRC in integrating mitochondrial functions with cell growth.…”
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9
Nuclear control of electron transport chain gene expression
Published 2019Table of Contents: “…Contents: Introduction to the roles of mitochondria -- Subunits of the electron transport chain (ETC) in nuclear & mitochondrial genomes -- Transcription of the electron transport chain subunits -- Peroxisome proliferator-activated receptor gamma coactivators (PGC-1s) -- Nuclear respiratory factors (NRFs) -- Estrogen-related receptor (ESRRs) -- Mitochondrial transcription factors (Tfam and mtTFB) -- Yin-Yang (YY-1) -- Coordinated transcriptional regulation of ETC genes -- Summary/Closing Statements.…”
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10
Nuclear control of electron transport chain gene expression
Published 2019Table of Contents: “…Contents: Introduction to the roles of mitochondria -- Subunits of the electron transport chain (ETC) in nuclear & mitochondrial genomes -- Transcription of the electron transport chain subunits -- Peroxisome proliferator-activated receptor gamma coactivators (PGC-1s) -- Nuclear respiratory factors (NRFs) -- Estrogen-related receptor (ESRRs) -- Mitochondrial transcription factors (Tfam and mtTFB) -- Yin-Yang (YY-1) -- Coordinated transcriptional regulation of ETC genes -- Summary/Closing Statements.…”
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11
Nuclear control of electron transport chain gene expression
Published 2019Table of Contents: “…Contents: Introduction to the roles of mitochondria -- Subunits of the electron transport chain (ETC) in nuclear & mitochondrial genomes -- Transcription of the electron transport chain subunits -- Peroxisome proliferator-activated receptor gamma coactivators (PGC-1s) -- Nuclear respiratory factors (NRFs) -- Estrogen-related receptor (ESRRs) -- Mitochondrial transcription factors (Tfam and mtTFB) -- Yin-Yang (YY-1) -- Coordinated transcriptional regulation of ETC genes -- Summary/Closing Statements.…”
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12
Cells in evolutionary biology : transLating genotypes into phenotypes - past, present, future /
Published 2018Click here to view.
Electronic eBook -
13
Role of polycomb proteins in gene transcription, stem cell and human diseases
Published 2014Get full text
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14
Role of polycomb proteins in gene transcription, stem cell and human diseases
Published 2014Get full text
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15
Role of polycomb proteins in gene transcription, stem cell and human diseases
Published 2014Get full text
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Electronic Video