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Systems biology of the cell cycle

Table of Contents: “…Contents: Control of cell cycle progression in eukaryotes by a network of universal protein interactions -- This dynamic system oscillates once per cell cycle -- Oscillation ceases when genomic integrity is in jeopardy -- The negative feedback loop by which Cdk1/CycB promotes CycB degradation via activation of APC/C -- Bistable ("toggle") switches are also important design principles of eukaryotic cell cycle control network -- The cell cycle.…”
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Systems biology of the cell cycle

Table of Contents: “…Contents: Control of cell cycle progression in eukaryotes by a network of universal protein interactions -- This dynamic system oscillates once per cell cycle -- Oscillation ceases when genomic integrity is in jeopardy -- The negative feedback loop by which Cdk1/CycB promotes CycB degradation via activation of APC/C -- Bistable ("toggle") switches are also important design principles of eukaryotic cell cycle control network -- The cell cycle.…”
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Systems biology of the cell cycle

Table of Contents: “…Contents: Control of cell cycle progression in eukaryotes by a network of universal protein interactions -- This dynamic system oscillates once per cell cycle -- Oscillation ceases when genomic integrity is in jeopardy -- The negative feedback loop by which Cdk1/CycB promotes CycB degradation via activation of APC/C -- Bistable ("toggle") switches are also important design principles of eukaryotic cell cycle control network -- The cell cycle.…”
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Colorectal cancer and the rare variant hypothesis

Table of Contents: “…Contents: Cancer: a somatic evolutionary process -- Colorectal cancer: a good model to study -- Two clear cut familial forms: FAP and HNPCC -- Mutation selection balance for dominants and recessives: application to FAP -- APC gene found by positional cloning -- Loss of heterozygosity proved its role in sporadic cancers -- Selection for mutations in the APC "mutation cluster region" -- HNPCC mismatch repair genes found by candidate guess -- Mutated genes in colorectal cancer include p53 and wnt pathway, occur in adenoma to carcinoma sequence -- Arguments for and against need for genomic instability in cancers -- Epigenetic changes -- Mathematical model of normal and cancerous crypt -- Types of familial cancers: mostly rarer than FAP and HNPCC -- Approaches to studying multifactorial inherited susceptibility -- HLA and disease: the model -- Role of linkage disequilbrium -- Principles of SNP association analysis -- Rare missense variants in the APC gene confer susceptibility -- The "rare variant hypothesis" for multifactorial inherited susceptibility: exemplified by study of colorectal adenomas.…”
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Colorectal cancer and the rare variant hypothesis

Table of Contents: “…Contents: Cancer: a somatic evolutionary process -- Colorectal cancer: a good model to study -- Two clear cut familial forms: FAP and HNPCC -- Mutation selection balance for dominants and recessives: application to FAP -- APC gene found by positional cloning -- Loss of heterozygosity proved its role in sporadic cancers -- Selection for mutations in the APC "mutation cluster region" -- HNPCC mismatch repair genes found by candidate guess -- Mutated genes in colorectal cancer include p53 and wnt pathway, occur in adenoma to carcinoma sequence -- Arguments for and against need for genomic instability in cancers -- Epigenetic changes -- Mathematical model of normal and cancerous crypt -- Types of familial cancers: mostly rarer than FAP and HNPCC -- Approaches to studying multifactorial inherited susceptibility -- HLA and disease: the model -- Role of linkage disequilbrium -- Principles of SNP association analysis -- Rare missense variants in the APC gene confer susceptibility -- The "rare variant hypothesis" for multifactorial inherited susceptibility: exemplified by study of colorectal adenomas.…”
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Nuclear control of respiratory chain expression by transcriptional activators and coactivators

Table of Contents: “…Contents: Contribution of nuclear and mitochondrial genomes to respiratory chain expression -- Genomic origin of respiratory chain subunits -- Cytochrome c as a model for respiratory gene expression -- DNA binding and transcriptional properties of nuclear respiratory factors (NRF-1 and NRF-2) -- Identification and characterization of NRF target genes -- Phenotypes associated with a targeted disruption of NRF-1 in mice -- NRF control of mitochondrial transcription factor expression -- The PGC-1 family -- PRC functional interactions with NRF-1 and CREB -- Cytochrome c promoter occupancy by PRC during the transition from quiescence to proliferative growth -- Potential role for PRC in integrating mitochondrial functions with cell growth.…”
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Nuclear control of respiratory chain expression by transcriptional activators and coactivators

Table of Contents: “…Contents: Contribution of nuclear and mitochondrial genomes to respiratory chain expression -- Genomic origin of respiratory chain subunits -- Cytochrome c as a model for respiratory gene expression -- DNA binding and transcriptional properties of nuclear respiratory factors (NRF-1 and NRF-2) -- Identification and characterization of NRF target genes -- Phenotypes associated with a targeted disruption of NRF-1 in mice -- NRF control of mitochondrial transcription factor expression -- The PGC-1 family -- PRC functional interactions with NRF-1 and CREB -- Cytochrome c promoter occupancy by PRC during the transition from quiescence to proliferative growth -- Potential role for PRC in integrating mitochondrial functions with cell growth.…”
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Nuclear control of respiratory chain expression by transcriptional activators and coactivators

Table of Contents: “…Contents: Contribution of nuclear and mitochondrial genomes to respiratory chain expression -- Genomic origin of respiratory chain subunits -- Cytochrome c as a model for respiratory gene expression -- DNA binding and transcriptional properties of nuclear respiratory factors (NRF-1 and NRF-2) -- Identification and characterization of NRF target genes -- Phenotypes associated with a targeted disruption of NRF-1 in mice -- NRF control of mitochondrial transcription factor expression -- The PGC-1 family -- PRC functional interactions with NRF-1 and CREB -- Cytochrome c promoter occupancy by PRC during the transition from quiescence to proliferative growth -- Potential role for PRC in integrating mitochondrial functions with cell growth.…”
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Nuclear control of electron transport chain gene expression

Table of Contents: “…Contents: Introduction to the roles of mitochondria -- Subunits of the electron transport chain (ETC) in nuclear & mitochondrial genomes -- Transcription of the electron transport chain subunits -- Peroxisome proliferator-activated receptor gamma coactivators (PGC-1s) -- Nuclear respiratory factors (NRFs) -- Estrogen-related receptor (ESRRs) -- Mitochondrial transcription factors (Tfam and mtTFB) -- Yin-Yang (YY-1) -- Coordinated transcriptional regulation of ETC genes -- Summary/Closing Statements.…”
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Nuclear control of electron transport chain gene expression

Table of Contents: “…Contents: Introduction to the roles of mitochondria -- Subunits of the electron transport chain (ETC) in nuclear & mitochondrial genomes -- Transcription of the electron transport chain subunits -- Peroxisome proliferator-activated receptor gamma coactivators (PGC-1s) -- Nuclear respiratory factors (NRFs) -- Estrogen-related receptor (ESRRs) -- Mitochondrial transcription factors (Tfam and mtTFB) -- Yin-Yang (YY-1) -- Coordinated transcriptional regulation of ETC genes -- Summary/Closing Statements.…”
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Nuclear control of electron transport chain gene expression

Table of Contents: “…Contents: Introduction to the roles of mitochondria -- Subunits of the electron transport chain (ETC) in nuclear & mitochondrial genomes -- Transcription of the electron transport chain subunits -- Peroxisome proliferator-activated receptor gamma coactivators (PGC-1s) -- Nuclear respiratory factors (NRFs) -- Estrogen-related receptor (ESRRs) -- Mitochondrial transcription factors (Tfam and mtTFB) -- Yin-Yang (YY-1) -- Coordinated transcriptional regulation of ETC genes -- Summary/Closing Statements.…”
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Cells in evolutionary biology : transLating genotypes into phenotypes - past, present, future /

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Role of polycomb proteins in gene transcription, stem cell and human diseases

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Role of polycomb proteins in gene transcription, stem cell and human diseases

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Role of polycomb proteins in gene transcription, stem cell and human diseases

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