Search Results - "vaccination"

Comparison of immune resilience induced by vaccination versus COVID recovery

Table of Contents: “…Contents: The need to characterize vaccine-indued immunity in more detail -- Methods for comparison of convalescent versus vaccination-induced plasma -- Higher effectiveness of antibodies induced by mRNA vaccination -- Characteristics of the new lambda variant – implications for immune escape -- Mechanisms leading to the increased efficiency of vaccine-induced antibodies compared to those of recovered patients..…”
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SARS-COV-2 what we need to know and possible future therapies /

Table of Contents: “…Contents: SARS-COV-2 compared with other coronavirus strains -- How this comparison can help in containment, treatment, and vaccination -- Future considerations for vaccine development -- Other possible treatments for COVID-19.…”
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HPV vaccines to prevent cervical cancer and other HPV-associated diseases

Table of Contents: “…Contents: Human papillomavirus (HPV) lifecycle -- Cervical HPV infection and progression to cancer -- Primary and secondary prevention method -- Prophylactic HPV vaccines -- Efficacy and durability of HPV viral-like particles (VPL) vaccines -- The potential of a one-dose vaccination program -- Randomized trials -- Vaccine protection against pre-malignant lesions -- Vaccine safety record & effectiveness -- HPV vaccine uptake -- Antibody response -- Increasing vaccine use.…”
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SARS-CoV-2 mutations phenotypes and implications for vaccine development /

Table of Contents: “…Contents: Currently known SARS-CoV-2 strains -- Likelihood of mutating into a more lethal form of SARS-CoV-2 -- Spike proteins and their role in viral entry into human cells -- SARS-CoV-2 is mutating into a more transmissible or infectious form -- Implications of new SARS-CoV-2 variants on public health and vaccine development -- Importance of continuing genetic surveillance of the virus.…”
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SARS-CoV-2 variants implications for immunity and vaccine development /

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Hepatitis B virus (HBV)

Table of Contents: “…Contents: Virus structure and its genome -- Prevention: universal vaccination -- Geographic distribution -- HBV transmission -- Special HBV mechanisms -- The immune reaction and different phases -- Chronic hepatitis B serology -- Viral markers -- Risk of becoming a carrier -- Available treatments and their goals -- Medications -- Reistance to antiviral treatment -- Mutants -- HCC screening -- Survival.…”
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Hepatitis C cure of infection /

Table of Contents: “…Contents: HCV: major milestones -- Hepatitis C virus & infection -- Hepatocellular cancer -- HCV natural history and therapy -- HCV RNA and protein -- HCV genotypes and subtypes -- Hepatitis C vaccine -- Direct acting antivirals (DAAs).…”
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RNA therapeutics clinical applications and methods of delivery /

Table of Contents: “…Contents: The diversity of RNA species -- The diversity of mRNA -- mRNA vaccines -- mRNA vs. viral vector vaccines -- Obstacles overcome -- The limitless potential of RNA therapeutics -- VEGF mRNA for ischemia -- mRNA for cystic fibrosis -- Roadmap for RNA therapeutics -- RNA therapeutics and cancer -- Innovation in RNA therapeutics -- aYAP mRNA for cardiac regeneration -- mRNA therapy for progeria (HGPS).…”
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SARS-CoV-2 evolution within and between individuals

Table of Contents: “…Contents: Evolutionary factors driving emergence of SARS-CoV-2 variants -- Metrics of SARS-CoV-2 infections: virus numbers per transmission event -- Potential co-infection with 2 or more variants per transmission event -- Current understanding of the origin and evolution of recent variants -- Impact of vaccines and treatments on evolutionary pressures of SAR-CoV-2.…”
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The evolutionary origin of SARS-CoV-2

Table of Contents: “…Contents: SARS-CoV-2: a product of zoonosis -- SARS-CoV-2 may have been mutating towards its current form for decades -- Evolutionary recombination events leading to SARS-CoV-2: bats & pangolins -- Genetic similarity and differences with other lethal coronaviruses: SARS-1 & MERS -- Phenotypic comparison of SARS-CoV-2 with other coronaviruses -- Genetic evidence debunking claims that SARS-CoV-2 is a deliberate human-engineered virus -- Probability, location and species of possible future emergence of zoonotic viruses -- Implications for SARS-CoV-2 vaccine development.…”
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Genetic surveillance and the emergence of SARS-CoV-2 variants

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The emergence of the SARS-CoV-2 Omicron variant

Table of Contents: “…Contents: Emergence of the Omicron variant -- The genetic characteristics of the Omicron variant and the phenotypic advantages they provide -- Biology and epidemiology of the Omicron variant -- Immune escape and vaccine's effectiveness -- Clinical severity -- Potential emergence of novel variants combining multiple mutations.…”
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Streptococcus pneumoniae serotype diversity and epidemiology /

Table of Contents: “…Contents: Pneumococcal serotype -- Capsule biosynthesis genes and antigenicity -- Global serotype distribution of IPD in children -- Serotype distribution: age, syndrome or body fluid -- Regional serotype distribution & prevalence -- Serotype-specific disease incidence & mortality by region -- Epidemiology (pre- and post-vaccine) -- Pneumococcal vaccines -- IPD and HIV-positive epidemiology -- How serotypes differ between carriage and IPD -- Detailed nasopharyngeal ecology -- Evolution during carriage -- Geographic distribution of QS pherotypes -- Multiple pherotypes co-colonizing the nasopharynx.…”
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How is Omicron different?

Table of Contents: “…Contents: Novel findings on the Omicron variant -- Antigenic and biological properties of the Omicron variant -- Immune escape and vaccine's effectiveness -- Clinical severity -- Potential emergence of novel variants combining multiple mutations.…”
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COVID-19 epidemiology and variants new challenges and future of the pandemic /

Table of Contents: “…Contents: Emergence of new variants and their new evolutionarily advantageous traits -- Probability of the emergence of additional variants and a new strain of SARS-CoV-2 -- Potential immune escape mechanisms of a theoretical new SARS-CoV-2 strain -- What can governments and individuals do to reduce the probability of emergence of additional variants -- Efficacy shown to date by COVID-19 vaccines and their projected impact in controlling the pandemic -- Update on current COVID-19 treatments (including convalescent antibody therapy, Remdesivir and dexamethasone) and the importance of the time window for their administration.…”
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Helper-dependent adenoviral vectors for gene therapy

Table of Contents: “…Contents: Overview of gene therapy vectors -- Helper-Dependent Ad (HDAd) vector -- Liver and lung directed gene therapy -- Hemophilia B gene therapy -- OTC deficiency clinical trial -- Balloon occlusion catheter-based delivery of HDAd -- HDAd-mediated CF gene therapy -- Brain gene therapy -- HDAd as genetic vaccine -- HDAd and stem cells.…”
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Prion-like propagation of Parkinson's disease

Table of Contents: “…Contents: Parkinson's disease : symptoms and pathology (PD mutations and risk factors) -- Braak staging of Lewy body-related pathology in PD -- The prion-like hypothesis -- Key steps of alpha-synuclein pathology propagation (Release, Uptake, Seeding, Transport) -- In vivo and cell models from different species -- Therapeutic targets: promoting degradation, antibody aided clearance, and preventing seeding of alpha-synuclein -- Parkinson's disease vaccine: first clinical studies.…”
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Mismatch repair deficient cancers diagnosis, treatment and prevention

Table of Contents: “…Contents: Lynch syndrome (underlying single gene defect) -- Microsatellites -- Important genes containing repeat sequences -- MSI testing (5 marker panel) -- Mismatch repair (MMR) -- The genomic pathogenesis of colorectal cancer (CRC) -- EGFR and BRAF mutant inhibition -- BRAF colon cancer project -- Methotrexate & MMR deficient tumours -- Africans & bowel cancer (Dennis Burkitt) -- Cancer prevention program (CaPP) -- NSAIDs and reduced colorectal cancer risk -- Aspirin effect on polyps in FAP and colorectal adenoma -- The prevention paradox -- CaPP2 (Colorectal & Lynch syndrome cancers) -- Meta-analysis of cancer deaths with aspirin treatment -- CRCs in people on aspirin (mostly COX2 negative) -- Individual response to aspirin in cancer prevention -- History of salicylate as an essential nutrient -- CaPP3 study -- Peptides created by slippage in microsatellite coding -- Antibodies as a possible biomarker for Lynch syndrome -- The Micoryx vaccine.…”
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