Search Results - "stem cell"

Stem cell memory

Table of Contents: “…Contents: Defining stem cell memory -- Deterministic asymmetric self-renewal evidence -- Two classes of adult stem cell memory -- The genetic fidelity problem -- Chromosome segregation vs. co-segregation -- Asymmetric self-renewal models -- Biochemical control of asymmetric self-renewal -- Potential molecular elements -- ASRA gene signature discovery -- Properties of H2A.Z.…”
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Drosophila stem cells

Table of Contents: “…Contents: Lineage tracing -- Stem cell niches -- Germline stem cell niche in ovary -- Germline stem cell niche in testis -- Dedifferentiation -- Stem cell signaling back to the niche -- Intestinal stem cells -- Stem cell chromatin.…”
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MicroRNA function in stem cells

Table of Contents: “…Contents: microRNAs -- Stem cells -- Stem cell cell cycle -- Stem cell checkpoints -- p21 -- hESCs -- Stem cell self-renewing division -- Notch -- Niche.…”
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Hematopoietic stem cell gene therapy for the treatment of metachromatic leukodystrophy

Table of Contents: “…Contents: Metachromatic Leukodystrophy (MLD) -- Hematopoietic stem cell therapy (HCT) for lysosomal storage disorders (LSDs) -- Improving HCT efficacy -- The role of brain pre-conditioning -- Mechanisms of microglia turnover -- Gene therapy (GT) & enzyme release -- Gene therapy in murine models -- HSC gene therapy for MLD -- Lentivirus integration site analysis -- Stem cells analysis -- ARSA activity and delivery to the CNS -- Cerebral and peripheral demyelination -- Motor function testing (GMFM).…”
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Role of polycomb proteins in gene transcription, stem cell and human diseases

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Legacy of Drosophila genetics female germline stem cells /

Table of Contents: “…Contents: Lineage tracing -- Stem cell niches -- Germline stem cell niche in ovary -- Germline stem cell niche in testis – Dedifferentiation -- Stem cell signaling back to the niche -- Intestinal stem cells -- Stem cell chromatin.…”
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Epigenetic control by histone methylation

Table of Contents: “…Contents: The diversity of covalent histone tail modifications for imparting epigenetic information -- Observations of robust histone modifications at silent chromatin regions -- The representation of repressive histone marks as indications of epigenetic plasticity in different cells -- Analysis of the profiles of normal and aberrant histone lysine methylation patterns, as they occur during the transition of an embryonic to a differentiated cell or in controlled self-renewal vs. pro-neoplastic or metastatic conditions -- Elucidation of these histone modification patterns for novel advances in stem cell research, nuclear reprogramming and cancer.…”
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Genetics of tumor metastasis part 2 of 2 /

Table of Contents: “…Contents: Re-examining the stem-cell tumor model -- Interconvertibility between non-stem cells and stem cells -- The key for generating cancer stem cells (CSCs) from non-cancer stem cells -- Filopodium-like structures (FLPs) in metastatic cancer -- Mechanistic link between epithelial/mesenchymal transition (EMT) & the CSC state.…”
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Novel treatments for GI malignancies

Table of Contents: “…Contents: HER2 and colorectal cancer -- BRAF mutated colorectal cancer -- Targeting cancer stem cells.…”
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Series (Cancer therapies in the personalized medicine era)
Series (Gastroenterology and hepatology)

Lentiviral vectors design, biological properties, milestones and current major applications, hazards. Part 2 of 2 /

Table of Contents: “…BMT -- HSC gene transfer by LV: current issues -- Restriction factors for lentiviral gene transfer -- Ex vivo transduction by lentiviral vectors -- HSC gene transfer by LV: current goals -- Applications: ex vivo into hematopoietic stem cells, ex vivo into lymphocytes, In vivo gene transfer (liver and CNS) -- Systemic delivery of LV: current issues -- Direct LV injection into the CNS -- CNS gene transfer: current issues.…”
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From germ cell specification to gonad formation

Table of Contents: “…Contents: Germ cells: the ultimate stem cell -- Germ plasm specifies germ cells -- The genetics of early Drosophila development: maternal effect mutations -- The body pattern of the embryo is preformed during oogenesis by localization of RNA -- In Drosophila, the Oskar protein is necessary and sufficient to organize germ plasm -- Oskar RNA transport, localization and translation are regulated at many levels -- Epigenetic control of early germ cell development -- Transcription -- Germ cell migration -- Wunen -- Signaling pathways -- The life cycle of germ cells -- Growth of the gonad -- Genetic analysis of stem cell maintenance and differentiation -- Conserved aspects of germ cells.…”
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CRISPR editing therapy for Duchenne Muscular Dystrophy part 1 of 2 /

Table of Contents: “…Contents: Duchene Muscular Dystrophy (DMD) -- Dystrophin function -- MDX mouse model -- AAV CRISPR local therapy in mice -- AAV CRISPR systemic therapy in mice -- Myogenic stem cells can be transduced and edited by AAV9 CRISPR therapy.…”
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Helper-dependent adenoviral vectors for gene therapy

Table of Contents: “…Contents: Overview of gene therapy vectors -- Helper-Dependent Ad (HDAd) vector -- Liver and lung directed gene therapy -- Hemophilia B gene therapy -- OTC deficiency clinical trial -- Balloon occlusion catheter-based delivery of HDAd -- HDAd-mediated CF gene therapy -- Brain gene therapy -- HDAd as genetic vaccine -- HDAd and stem cells.…”
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Epigenetics and inheritance

Table of Contents: “…Contents: Definition of epigenetics -- Epigenetics and stem cell biology -- Mechanisms of inheritable epigenetics -- Examples of the epigenetic code -- Genomic imprinting -- Imprinting as a paradigm for epigenetic gene regulation and inheritance -- Developmental Origins of Health and Disease (DOHaD) definition -- Dutch hunger winter as an example of DOHaD -- IVF as a potential example of DOHaD -- IVF technology and imprinting disorders.…”
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Genetically encoded Ca2+ indicators molecular scale measurements in mammals in vivo /

Table of Contents: “…Contents: Calcium Signaling -- How to study complex biology -- Genetically encoded Ca2+ indicators -- GcaMPs -- Structural basis of Ca2+ sensing -- Lineage specification of indicators in transgenic mice -- Real-time cardiac activation -- Response time considerations -- Heart development -- Cell based therapy and coupling -- Embryonic stem cells and GCaMPs -- Vascular control and pulsars -- Future directions.…”
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Epigenetic biomarkers in cancer

Table of Contents: “…Contents: Epigenetics -- levels of control -- The patient cancer journey-multiple impact points -- Key translational areas for epigenetics -- DNA methylation as cancer biomarker -- DNA methylation analysis methods -- Epigenetic gene silencing in malignant cells -- CpG methylation and clinical outcome -- Causes of aberrant DNA methylation in cancer -- Stem cell targets -- EZH2 as a potential anti-cancer target -- Epigenetic modification as drug targets -- Epigenetic therapies -- DNA methylation versus platinum resistance -- Phase II trial of Decitabine & Carboplatin -- Effects of low doses of DNA-demethylation agents -- Epigenetic therapies challenges.…”
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Deciphering neurodegeneration models and methods /

Table of Contents: “…Contents: Deciphering Neurodegeneration: Models and Methods -- The challenge of neurodegeneration -- Huge diversity in cell types -- Nature versus nurture -- Reductionism versus systems biology -- Cellular models -- Yeast -- Primary cells -- Cell lines -- Stem cells -- Model organisms -- Caenorhabditis elegans -- Drosophila melanogaster -- Zebrafish -- Danio rerio -- Rodents -- Molecular biology approaches -- Knock out and knock in -- Genomic editing -- RNAi -- Overexpression -- Gene expression -- rtPCR -- Microarrays -- RNAseq -- Protein analysis -- Immunoblot -- ELISA -- Mass spec and proteomics -- Microscopy -- Immunocytochemistry -- Live cell imaging -- Electrophysiology.…”
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