Search Results - "proteins"

Elongation of protein synthesis structural basis of the process of decoding /

Table of Contents: “…Contents: Fidelity in biological processes -- Elongation step of protein synthesis -- Ribosome structures -- Ribosomes from different organisms -- Errors in protein synthesis -- The decoding problem -- Kinetic proof-reading -- Kinetic model of tRNA selection -- Role of induced fit in tRNA selection -- Recognition of codon-anticodon complexes by the 30S ribosomal subunit -- Local and global conformational changes of the 30S subunit -- Interactions of tRNA during decoding -- Active role of tRNA -- SelB and delivery of Sec-tRNA to the ribosome -- Accommodation of tRNA in the A site.…”
Get full text
Series (From DNA to proteins)
Series (Mechanisms of ribosome function)

Intrinsically unstructured proteins regulation and disease /

Table of Contents: “…Contents: Regulatory genomics and systems biology -- Intrinsically unstructured proteins (IUPs): structural and biophysical advantage -- Functional advantage -- Thermodynamic and kinetic advantage -- Conformational advantage -- Identification of IUPs -- Functions of IUPs -- Disadvantages of unstructured regions -- Unstructured regions in proteins -- Cells minimize the risks of unstructured proteins -- Tight regulation of IUPs -- Key regulatory events affecting protein availability -- IUPs in yeast -- Gene-ontology functional enrichment analysis -- Genome-scale datasets on transcript availability -- Transcripts encoding IUPs are tightly controlled -- Mechanisms affecting transcript stability -- Genome-scale datasets on protein availability -- IUPs are tightly controlled at the translational level -- PEST sequences -- Aggregation prone IUPs: more tightly regulated -- Control calculation -- Tight regulation of IUPs is evolutionarily conserved -- Control of IUP affects signaling fidelity/regulation -- Control of specific IUP affects protein aggregation.…”
Get full text
Series

Protein import into mitochondria

Table of Contents: “…Contents: Introduction to protein import pathways -- Structure and function of targeting sequences -- Protein import into the matrix, intermembrane space and membranes of mitochondria -- Biochemical assays and bioinformatics for studying protein import -- The TIM complex in parasites of humans -- The TOM complex in animals and plants -- The evolution of protein import into mitochondria.…”
Get full text
Series

Elongation of protein synthesis structural basis of the process of decoding /

Table of Contents: “…Contents: Fidelity in biological processes -- Elongation step of protein synthesis -- Ribosome structures -- Ribosomes from different organisms -- Errors in protein synthesis -- The decoding problem -- Kinetic proof-reading -- Kinetic model of tRNA selection -- Role of induced fit in tRNA selection -- Recognition of codon-anticodon complexes by the 30S ribosomal subunit -- Local and global conformational changes of the 30S subunit -- Interactions of tRNA during decoding -- Active role of tRNA -- SelB and delivery of Sec-tRNA to the ribosome -- Accommodation of tRNA in the A site.…”
Get full text
Series (From DNA to proteins)
Series (Mechanisms of ribosome function)

Intrinsically unstructured proteins regulation and disease /

Table of Contents: “…Contents: Regulatory genomics and systems biology -- Intrinsically unstructured proteins (IUPs): structural and biophysical advantage -- Functional advantage -- Thermodynamic and kinetic advantage -- Conformational advantage -- Identification of IUPs -- Functions of IUPs -- Disadvantages of unstructured regions -- Unstructured regions in proteins -- Cells minimize the risks of unstructured proteins -- Tight regulation of IUPs -- Key regulatory events affecting protein availability -- IUPs in yeast -- Gene-ontology functional enrichment analysis -- Genome-scale datasets on transcript availability -- Transcripts encoding IUPs are tightly controlled -- Mechanisms affecting transcript stability -- Genome-scale datasets on protein availability -- IUPs are tightly controlled at the translational level -- PEST sequences -- Aggregation prone IUPs: more tightly regulated -- Control calculation -- Tight regulation of IUPs is evolutionarily conserved -- Control of IUP affects signaling fidelity/regulation -- Control of specific IUP affects protein aggregation.…”
Get full text
Series

Protein import into mitochondria

Table of Contents: “…Contents: Introduction to protein import pathways -- Structure and function of targeting sequences -- Protein import into the matrix, intermembrane space and membranes of mitochondria -- Biochemical assays and bioinformatics for studying protein import -- The TIM complex in parasites of humans -- The TOM complex in animals and plants -- The evolution of protein import into mitochondria.…”
Get full text
Series

Elongation of protein synthesis structural basis of the process of decoding /

Table of Contents: “…Contents: Fidelity in biological processes -- Elongation step of protein synthesis -- Ribosome structures -- Ribosomes from different organisms -- Errors in protein synthesis -- The decoding problem -- Kinetic proof-reading -- Kinetic model of tRNA selection -- Role of induced fit in tRNA selection -- Recognition of codon-anticodon complexes by the 30S ribosomal subunit -- Local and global conformational changes of the 30S subunit -- Interactions of tRNA during decoding -- Active role of tRNA -- SelB and delivery of Sec-tRNA to the ribosome -- Accommodation of tRNA in the A site.…”
Get full text
Series (From DNA to proteins)
Series (Mechanisms of ribosome function)

Protein import into mitochondria

Table of Contents: “…Contents: Introduction to protein import pathways -- Structure and function of targeting sequences -- Protein import into the matrix, intermembrane space and membranes of mitochondria -- Biochemical assays and bioinformatics for studying protein import -- The TIM complex in parasites of humans -- The TOM complex in animals and plants -- The evolution of protein import into mitochondria.…”
Get full text
Series

Intrinsically unstructured proteins regulation and disease /

Table of Contents: “…Contents: Regulatory genomics and systems biology -- Intrinsically unstructured proteins (IUPs): structural and biophysical advantage -- Functional advantage -- Thermodynamic and kinetic advantage -- Conformational advantage -- Identification of IUPs -- Functions of IUPs -- Disadvantages of unstructured regions -- Unstructured regions in proteins -- Cells minimize the risks of unstructured proteins -- Tight regulation of IUPs -- Key regulatory events affecting protein availability -- IUPs in yeast -- Gene-ontology functional enrichment analysis -- Genome-scale datasets on transcript availability -- Transcripts encoding IUPs are tightly controlled -- Mechanisms affecting transcript stability -- Genome-scale datasets on protein availability -- IUPs are tightly controlled at the translational level -- PEST sequences -- Aggregation prone IUPs: more tightly regulated -- Control calculation -- Tight regulation of IUPs is evolutionarily conserved -- Control of IUP affects signaling fidelity/regulation -- Control of specific IUP affects protein aggregation.…”
Get full text
Series

Understanding protein variability through functional analysis of random mutagenesis

Subjects: Get full text
Series

Respiration, reactive oxygen species and uncoupling proteins

Table of Contents: “…Contents: Reactive oxygen species production by mitochondria -- Mitochondrial free radicals and ageing in short-lived and long-lived species -- Topology and sites of ROS production in the electron transport chain -- Regulation of ROS production by mild uncoupling -- Uncoupling of mitochondria by uncoupling proteins -- Superoxide and reactive alkenal activation of UCPs -- A model for UCP activation -- Evidence that UCPs attenuate ROS.…”
Get full text
Series

Respiration, reactive oxygen species and uncoupling proteins

Table of Contents: “…Contents: Reactive oxygen species production by mitochondria -- Mitochondrial free radicals and ageing in short-lived and long-lived species -- Topology and sites of ROS production in the electron transport chain -- Regulation of ROS production by mild uncoupling -- Uncoupling of mitochondria by uncoupling proteins -- Superoxide and reactive alkenal activation of UCPs -- A model for UCP activation -- Evidence that UCPs attenuate ROS.…”
Get full text
Series

Respiration, reactive oxygen species and uncoupling proteins

Table of Contents: “…Contents: Reactive oxygen species production by mitochondria -- Mitochondrial free radicals and ageing in short-lived and long-lived species -- Topology and sites of ROS production in the electron transport chain -- Regulation of ROS production by mild uncoupling -- Uncoupling of mitochondria by uncoupling proteins -- Superoxide and reactive alkenal activation of UCPs -- A model for UCP activation -- Evidence that UCPs attenuate ROS.…”
Get full text
Series

The Myc transcription factor network

Table of Contents: “…Contents: Myc plays a broad role in cellular functions -- Deregulation of Myc is associated with many cancers -- Myc and Mxd proteins heterodimerize with Max, bind DNA, and activate or repress transcription through recruitment of co-regulator complexes that in turn influence chromatin modifications -- Myc family proteins are highly conserved and regulate cell growth by binding to many genes involved in translation and metabolism -- Myc also has functions unrelated to transcription.…”
Get full text
Series (Cell division cycle)
Series (Epigenetics, chromatin, transcription and cancer)

Understanding protein variability through functional analysis of random mutagenesis

Subjects: Get full text
Series

Understanding protein variability through functional analysis of random mutagenesis

Subjects: Get full text
Series

Biogenesis of cellular iron-sulfur proteins part II, the essential role of mitochondria and the CIA machinery /

Table of Contents: “…Contents: Cytosolic and nuclear Fe/S proteins maturation -- Role of mitochondria in cytosolic and nuclear Fe/S protein biogenesis -- Functions of proteins involved in Fe/S protein biogenesis -- Importance of Fe/S protein biogenesis for genome maintenance.…”
Get full text
Series

Designing proteins with life sustaining activities part 2 of 2 /

Table of Contents: “…Contents: Novel designed proteins: mechanism of action -- Function rescue experiments using novel proteins -- Evolving novel proteins (generalists vs. specialists) -- Towards artificial proteomes capable of sustaining life.…”
Get full text
Series

Expanding roles of RNA-binding proteins in neurodegenerative diseases

Table of Contents: “…Contents: Amyotrophic lateral sclerosis (ALS) -- Genetic causes of ALS -- Role of RNA-binding proteins and stress granules in ALS pathogenesis -- Emerging class of RNA-binding proteins with prion-like domains in neurodegenerative disease -- Mechanisms by which C9ORF72 mutations cause ALS.…”
Get full text
Series
Series

Designing proteins with life sustaining activities part 1 of 2 /

Table of Contents: “…Contents: Protein design & synthetic biology -- Designing novel proteins using a hybrid approach -- Combinatorial libraries of novel proteins -- Folding of novel proteins into stable structures -- Biochemical activity of novel proteins in vitro (binding & catalysis) -- Essential biological functions provided by novel proteins in vivo.…”
Get full text
Series