Search Results - "epigenetics"

Cytoplasmic epigenetics inheritance by cytoplasmic continuity /

“…Biomedical & life sciences collection. Epigenetics : concepts, theories, paradigms and mechanisms.…”
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Skin epigenetics how chromatin regulators orchestrate skin functions /

Table of Contents: “…Contents: Skin structure, functions and development -- Molecular control of cell differentiation -- What is epigenetics? -- What controls variability of skin phenotypes? …”
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Epigenetics and inheritance

Table of Contents: “…Contents: Definition of epigenetics -- Epigenetics and stem cell biology -- Mechanisms of inheritable epigenetics -- Examples of the epigenetic code -- Genomic imprinting -- Imprinting as a paradigm for epigenetic gene regulation and inheritance -- Developmental Origins of Health and Disease (DOHaD) definition -- Dutch hunger winter as an example of DOHaD -- IVF as a potential example of DOHaD -- IVF technology and imprinting disorders.…”
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Polycomb epigenetic mechanisms part 1 of 2, role of PcG complexes /

“…Polycomb epigenetic mechanisms. Part 1, role of PcG complexes…”
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Epigenetic biomarkers in cancer

Table of Contents: “…Contents: Epigenetics -- levels of control -- The patient cancer journey-multiple impact points -- Key translational areas for epigenetics -- DNA methylation as cancer biomarker -- DNA methylation analysis methods -- Epigenetic gene silencing in malignant cells -- CpG methylation and clinical outcome -- Causes of aberrant DNA methylation in cancer -- Stem cell targets -- EZH2 as a potential anti-cancer target -- Epigenetic modification as drug targets -- Epigenetic therapies -- DNA methylation versus platinum resistance -- Phase II trial of Decitabine & Carboplatin -- Effects of low doses of DNA-demethylation agents -- Epigenetic therapies challenges.…”
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Asthma an epidemic caused by epigenetics? /

Table of Contents: “…Contents: Genetic and biological determinants of diseases influenced by the environment -- Epigenetics -- Epigenetic mechanisms can be influenced by environmental exposures and aging -- Histone modifications and innate immunity -- Asthma is a major public health problem -- Epigenetics and airway immunology -- DNA methylation changes and asthma -- Runx3 and airway disease -- In utero folate supplementation and asthma -- Sib pair asthma study -- preliminary analysis -- Global methylation patterns: asthmatics vs. nonasthmatics -- Hypomethylation of GATA3 or MUC5B is associated with asthma in concordant sib pairs -- Hypermethylation of NOS2 is associated with concordant asthma -- Asthma: an epidemic caused by epigenetics?…”
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Epigenetics in age-related macular degeneration

Table of Contents: “…Contents: Epigenetics: terms and definitions -- Evidence for role of epigenetics in age-related macular degeneration (AMD) -- Future directions (potential for novel treatments for AMD).…”
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Epigenetic control by histone methylation

Table of Contents: “…Contents: The diversity of covalent histone tail modifications for imparting epigenetic information -- Observations of robust histone modifications at silent chromatin regions -- The representation of repressive histone marks as indications of epigenetic plasticity in different cells -- Analysis of the profiles of normal and aberrant histone lysine methylation patterns, as they occur during the transition of an embryonic to a differentiated cell or in controlled self-renewal vs. pro-neoplastic or metastatic conditions -- Elucidation of these histone modification patterns for novel advances in stem cell research, nuclear reprogramming and cancer.…”
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Histone modifications and prospects for an epigenetic code

Table of Contents: “…Contents: Enzyme-catalyzed modification of the N-terminal tail domains of core histones provides an array of marks across the nucleosome surface and a source of epigenetic information -- This information influences protein-protein interactions during short-term regulation of ongoing transcription and is a means of maintaining or modifying patterns of gene expression from one cell generation to the next -- Cellular memory -- Histone modifications may constitute a heritable epigenetic code that acts in concert with the genetic code as a long-term regulator of gene expression.…”
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Epigenetics as a paradigm for cancer treatment chemically targeting the histone lysine methyltransferase EZH2 /

Table of Contents: “…Contents: Cancer as an unmet medical need -- Epigenetics as a paradigm for treating cancer -- Histone lysine methyltransferase EZH2 as a target class example -- Development of EZH2 inhibitors.…”
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Cancer-specific epigenetic alterations as investigated from a pharmaceutical perspective

Table of Contents: “…Contents: Chromatin dysregulation in cancer -- Features of epigenetic information in cells -- Mutated chromatin regulatory factors as tumor drivers -- Therapeutic rationale for the use of epigenetic drugs in oncology -- First generation epigenetic drugs: DNMT and HDAC inhibitors -- Novel therapeutic discoveries in oncology -- Biomarkers for patient selection.…”
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Imprinting disorders associated with molecular changes on chromosome 11p15

Table of Contents: “…Contents: What is epigenetics? -- Epigenetic regulation forms the molecular basis for genomic imprinting -- What is genomic imprinting -- Imprinted genes in early development -- Genomic organization of imprinted genes -- Imprinting center -- Imprinted domain 1 on chromosome 11p15.5 -- Complexity of imprinted clusters -- Beckwith-Wiedemann syndrome (BWS) -- BWS: a complex, clinically heterogeneous disorder -- Molecular basis of BWS -- Etiology of the Beckwith-Wiedemann syndrome -- Molecular alterations associated with BWS -- Frequency of molecular alterations in BWS -- The risks to subfertile/ART treated parents -- Subfertility/assisted reproductive technologies (ART) -- BWS molecular defects -- Multiple phenotypes associated with somatic mosaicism for 11p15 UPD -- Somatic mosaicism -- Isolated hemihyperplasia -- High level constitutional UPD -- BWS molecular testing strategies -- Laboratory testing for BWS -- MS-MLPA -- Expected methylation results from MS-MLPA -- MLPA molecular testing for BWS -- Cancer risk & surveillance -- Prenatal testing options -- Current challenges in BWS molecular testing -- Frequency of CNVs according to methylation pattern -- Monozygotic twins and BWS -- Isolated hemihyperplasia -- Current challenges in chromosome 11p15 molecular testing -- Russell-Silver syndrome (RSS -- Chromosomal regions associated with RSS -- Targeted assays of multiple imprinted loci-BWS -- Different combinations of epigenetic alterations associated with variations in clinical phenotype -- Imprint deregulation causing disease in humans.…”
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Genome-wide organization of chromatin and the transcription machinery

“…Biomedical & life sciences collection. Epigenetics, chromatin, transcription and cancer.…”
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Genomic insights into gene regulation by cohesin

Table of Contents: “…Contents: Cohesin regulates gene expression and development in Drosophila and Humans -- Cohesin binds a subset of active genes at transcription start sites -- Cohesin directly regulates many genes Important for growth and development -- Cohesin cooperates with polycomb epigenetic silencing complexes to restrain gene expression -- Cohesin selectively binds genes with paused RNA Polymerase and regulates transition to transcriptional elongation -- Questions regarding the roles of cohesin in gene regulation and development and relevance to human disease.…”
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Role of polycomb proteins in gene transcription, stem cell and human diseases

“…Biomedical & life sciences collection. Epigenetics, chromatin, transcription and cancer.…”
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Enhancer malfunction in cancer

“…Biomedical & life sciences collection. Epigenetics, chromatin, transcription and cancer.…”
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Hox gene regulation in vertebrate hindbrain development

“…Biomedical & life sciences collection. Epigenetics, chromatin, transcription and cancer.…”
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Gene silencing in budding yeast

Table of Contents: “…Contents: Gene silencing: an epigenetic phenomenon -- Chromatin remodeling: heterochromatin and euchromatin -- Silent chromatin in budding yeast: mating-type loci -- Silent information regulation: telomeric genes and Sir proteins.…”
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Stem cell memory

“…Biomedical & life sciences collection. Epigenetics : concepts, theories, paradigms and mechanisms.…”
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The molecular mechanism of X chromosome inactivation

“…Biomedical & life sciences collection. Epigenetics : concepts, theories, paradigms and mechanisms.…”
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