Search Results - "DNA"

DNA methylation

Table of Contents: “…Contents: Roles of DNA methylation -- Evolution of eukaryotic DNA methyltransferases -- Mechanism of action of DNA methyltransferases -- Specific loci targeting -- Histone modification -- Small interfering RNA.…”
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Series (Eukaryotic gene regulation)
Series (Epigenetics, chromatin, transcription and cancer)

DNA replication

Table of Contents: “…Contents: Chemical composition of DNA -- Chargaff's rule -- DNA structure -- Base pairing -- Semiconservative DNA replication -- Mechanism of DNA replication -- Semi-discontinuous DNA replication -- DNA replication is catalyzed by the cooperative action of a number of proteins: what we know -- DNA polymerase structure -- Structure of phage T7 DNA polymerase -- Chemical reaction catalyzed by DNA polymerases -- Metal ions play an essential role in DNA synthesis -- DNA synthesis has to be efficient and accurate -- Rates of correct and incorrect nucleotide addition -- How are errors corrected? …”
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DNA methylation in cancer

Table of Contents: “…Contents: DNA methylation in cancer -- Overview of DNA methylation in human cells -- Relationshoip of DNA methylation and chromatin structure -- Contribution of hypo/hypermethylation to tumorigenesis -- Mechanisms underlying altered DNA methylation patterns in cancer -- miRNAs as effectors and targets of aberrant DNA methylation in cancer -- Cancer methylation biomarkers -- Reversing DNA methylation in cancer therapy.…”
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The biochemistry of DNA and RNA part 2, biological function /

Subjects: “…DNA. 92065…”
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Mitochondrial DNA replication and transcription

Table of Contents: “…Contents: Introduction to the mitochondrial genetic system -- Features of mammalian mitochondrial DNA -- Characteristics of mitochondrial genetics -- Mitochondrial DNA replication: strand-displacement and strand-coupled models -- Proteins involved in mitochondrial DNA replication -- Mitochondrial DNA transcription -- Isolation and mapping of mitochondrial RNA -- Model of transcription and RNA processing -- Regulation of mtDNA expression by thyroid hormones -- Regulation of the mammalian mtDNA expression by mTERF phosphorylation.…”
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DNA methylation patterns in mammals

Table of Contents: “…Contents: The distribution of cytosine methylation in mammals -- Influences on targeting of cytosine methylation -- Demethylation of DNA -- Protection against cytosine methylation -- Global and developmental dynamics of cytosine methylation -- Patterns of change of cytosine methylation in disease -- Influence of DNA sequence polymorphism on cytosine methylation variability -- Future directions.…”
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DNA damage, mutations and aging 1 /

Table of Contents: “…Contents: Aging and longevity -- Molecular, cellular and physiological end points of DNA damage -- Can DNA damage alone cause aging? …”
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DNA damage, mutations and aging Part 2 of 2 /

Table of Contents: “…Contents: Measuring somatic mutations in humans -- How to detect mutations in normal cells, genome-wide, in humans? -- If DNA damage and mutations drive aging, why is the germline immortal?…”
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Evolution of human mitochondrial DNA variations

Table of Contents: “…Contents: Origins of mitochondria in our cells -- Functional role, size, and copy number of mitochondria -- Inheritance of mitochondrial genes -- Mitochondrial mutation rate -- Haplotypes and haplogroups -- Geographic distribution of mtDNA diversity in humans -- Natural selection and dispersals in shaping mtDNA variation -- Residence pattern effect on mtDNA diversity.…”
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Inference on human history through DNA

Table of Contents: “…Contents: Human population structure -- Racial catalogs based on morphology -- Genetic variation within and between populations -- Genetic clustering of human populations -- Isolation by distance -- A recent demographic expansion from Africa -- Testing evolutionary hypotheses by coalescent simulation -- Ancient DNA.…”
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The impact of DNA sequencing technology on agriculture

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Ancient DNA and human evolutionary inference

Table of Contents: “…Contents: Patterns of genetic variation in Europe and the Neolithic -- Ancient DNA and anatomically modern humans (Challenges & Potential) -- The Neolithic transition in Europe (Scandinavia, Iberia and Eastern Europe).…”
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Mitochondrial DNA, molecular genetics and human mitochondrial diseases

Table of Contents: “…Contents: Mitochondria: structure and function -- Mitchell's chemiosmotic hypothesis -- The mammalian mitochondrial genome: replication -- Transcription -- Gene expression -- Non-Mendelian inheritance of mtDNA -- Mutations and heteroplasmy -- Mitochondrial diseases -- Reactive oxygen species and aging -- Mitochondria and neurodegenerative diseases -- The metabolic syndrome.…”
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Single nucleotide polymorphism microarrays in the analysis of cancer

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Techniques to infer admixture using genome-wide autosomal DNA part 1 of 2 /

Table of Contents: “…Contents: Introduction and illustrative simulations -- ADMIXTURE clustering software -- f3-statistics admixture detection software -- Autosomal DNA is used to date admixture -- ALDER/MALDER admixture detection and dating software.…”
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Techniques to infer admixture using genome-wide autosomal DNA part 2 of 2 /

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Epigenetic biomarkers in cancer

Table of Contents: “…Contents: Epigenetics -- levels of control -- The patient cancer journey-multiple impact points -- Key translational areas for epigenetics -- DNA methylation as cancer biomarker -- DNA methylation analysis methods -- Epigenetic gene silencing in malignant cells -- CpG methylation and clinical outcome -- Causes of aberrant DNA methylation in cancer -- Stem cell targets -- EZH2 as a potential anti-cancer target -- Epigenetic modification as drug targets -- Epigenetic therapies -- DNA methylation versus platinum resistance -- Phase II trial of Decitabine & Carboplatin -- Effects of low doses of DNA-demethylation agents -- Epigenetic therapies challenges.…”
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Genetic methods in the study of neurological diseases the genetic basis of neurological disorders /

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Gene copy number variation in human and primate evolution

Table of Contents: “…Contents: Primate evolution -- Human characteristics -- Molecular mechanisms underling genome evolution -- Gene duplication and evolutionary change -- Interhominoid cDNA array-based comparative genomic hybridization -- Major clusters of hominoid lineage -- Primate gene copy number changes -- Primate lineage-specific gene copy number variation -- Primate aCGH caveats.…”
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Mitochondrial disorders and neurodegeneration

Table of Contents: “…Contents: Mitochondrial structure and function -- Oxidative phosphorylation -- Mitochondrial DNA (mtDNA) structure, replication and maternal inheritance -- Diseases caused by mutations in mtDNA and therapy -- Diseases caused by mutations in nuclear genes coding for mitochondrial proteins.…”
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