Search Results - "prion"

Prion diseases

Table of Contents: “…Contents: Understanding the biophysical aspects of a disease of protein misfolding -- Structural studies of PrPc and PrPsc -- The development of synthetic mammalian prions and the proof of their infectivity and serial transmissibility -- Heterocyclic pharmacotherapies for prion disease -- Pyridinyl based therapies and structure based design -- Serendipitous discovery of acridines as anti-prion agents -- Bisacridines as potent inhibitors of prion replication in cell culture -- The relationship between the prion diseases and other diseases of protein misfolding.…”
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Prion-like propagation of Parkinson's disease

Table of Contents: “…Contents: Parkinson's disease : symptoms and pathology (PD mutations and risk factors) -- Braak staging of Lewy body-related pathology in PD -- The prion-like hypothesis -- Key steps of alpha-synuclein pathology propagation (Release, Uptake, Seeding, Transport) -- In vivo and cell models from different species -- Therapeutic targets: promoting degradation, antibody aided clearance, and preventing seeding of alpha-synuclein -- Parkinson's disease vaccine: first clinical studies.…”
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Targeting Aß oligomers a molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease /

Table of Contents: “…Contents: The oligomer cascade hypothesis for Alzheimer's Disease -- Why the oligomer hypothesis has largely supplanted the amyloid cascade hypothesis -- The role of AβOs in memory failure and the major facets of AD neuropathology -- Mechanisms by which AβOs instigate neurotoxicity -- Why AβOs accumulate in the first place -- How AβOs offer superb targets for novel AD diagnostics and disease-modifying therapeutics -- Beside its direct link to Alzheimer's disease, the discovery of toxic Aβ oligomers has provided a novel structural archetype for toxins germane to more than two dozen diseases of protein mis-folding, including Diabetes, Parkinson's, and prion diseases.…”
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