Search Results - "histone"

Histone modification and transcriptional repression

Table of Contents: “…Contents: Mechanisms of transcriptional repression -- Corepressor proteins -- Histone modifications involved in repression -- Cancer.…”
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Histone dynamics, heritability and variants

Table of Contents: “…Contents: DNA is organized into chromatin which promotes compaction and brings about additional information -- The histone code hypothesis -- Chromatin dynamics and heritability -- Factors involved in chromatin dynamics -- Nucleosomes disruption and assembly following DNA replication fork passage -- General steps in chromatin assembly -- Histone chaperones and their possible roles (CAF-1, HIRA, ...) -- Histone H3 variants and chromatin assembly coupled or not with DNA synthesis -- Specific histone deposition pathways for each variant? …”
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Series (Epigenetics : concepts, theories, paradigms and mechanisms)
Series (Eukaryotic gene regulation)
Series (Epigenetics, chromatin, transcription and cancer)

Histone modifications and prospects for an epigenetic code

Table of Contents: “…Contents: Enzyme-catalyzed modification of the N-terminal tail domains of core histones provides an array of marks across the nucleosome surface and a source of epigenetic information -- This information influences protein-protein interactions during short-term regulation of ongoing transcription and is a means of maintaining or modifying patterns of gene expression from one cell generation to the next -- Cellular memory -- Histone modifications may constitute a heritable epigenetic code that acts in concert with the genetic code as a long-term regulator of gene expression.…”
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Mechanisms of transcription the eukaryotic pre-initiation complex /

Table of Contents: “…Contents: Overview of RNA polymerase II transcription -- Core promoter elements -- Proximal promoters -- Enhancers and silencers -- General transcription factors -- Activators and repressors -- Coactivator complexes -- RNA polymerase II structure and function -- Mechanisms of transcription initiation -- Steroid hormone receptors -- Coactivator complexes, including mediator and TFIID -- Chromatin remodellers including SWI/SNF -- Covalent histone modifiers, including histone acetyltransferases, methyltransferases and deacetylases.…”
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Polycomb epigenetic mechanisms Part 2 of 2, methylation of DNA /

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DNA methylation

Table of Contents: “…Contents: Roles of DNA methylation -- Evolution of eukaryotic DNA methyltransferases -- Mechanism of action of DNA methyltransferases -- Specific loci targeting -- Histone modification -- Small interfering RNA.…”
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Series (Eukaryotic gene regulation)
Series (Epigenetics, chromatin, transcription and cancer)

Genomic insights into gene regulation by cohesin

Subjects: “…Chromosomal Proteins, Non-Histone metabolism. 104487…”
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Role of polycomb proteins in gene transcription, stem cell and human diseases

Table of Contents: “…Contents: Chromatin structure -- Histone modification and regulation of methylation -- Polycomb complexes (gene silencing, recruitement & displacement of proteins, protein levels in embryoid bodies, binding regulation) -- PcG genes and human cancers -- Variations of Polycomb Repressive Complexes and their associations with polycomb proteins -- CBX family of proteins -- The Polycomb-like gene family.…”
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Comparing transcriptomes of distant organisms models of gene expression, part 2 of 2 /

Table of Contents: “…Contents: Histone modification (HM) models relating gene expression to promoter activity -- Building a universal model for human, worm and fly -- Similarly constructed transcription factor (TF) binding models.…”
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Gene silencing in budding yeast

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Epigenetic information in gene expression and cancer

Table of Contents: “…Contents: Types and functions of histone modifications -- Histone code hypothesis -- Epigenetics and transcription regulation -- Relevance for human disease.…”
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Small interfering RNA induced transcriptional gene silencing in human cells

Table of Contents: “…Contents: How siRNAs mediate transcriptional gene silencing (TGS) in human cells -- Histone methylation -- Dependency on active RNA polymerase II mediated transcription -- siRNA-mediated TGS -- H3K9 and H3K27 methylation of the targeted EF1A promoter -- Nuclear specific delivery of the siRNA -- Antisense strand-specific siRNA-mediated TGS of EF1A -- Targeting of the U3 region of the HIV-1 LTR/promoter -- Antisense strand of siRNA EF2 interacts with FLAG-tagged DNMT3A and the tri-methylated H3K27 methyl mark -- siRNA mediated targeting of genomic regions -- RNA Pol-II function -- Transcriptional gene silencing in human cells.…”
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