Search Results - "epigenetics"

Polycomb epigenetic mechanisms Part 2 of 2, methylation of DNA /

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Epigenetic information in gene expression and cancer

Table of Contents: “…Contents: Types and functions of histone modifications -- Histone code hypothesis -- Epigenetics and transcription regulation -- Relevance for human disease.…”
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Histone modifications and prospects for an epigenetic code

Table of Contents: “…Contents: Enzyme-catalyzed modification of the N-terminal tail domains of core histones provides an array of marks across the nucleosome surface and a source of epigenetic information -- This information influences protein-protein interactions during short-term regulation of ongoing transcription and is a means of maintaining or modifying patterns of gene expression from one cell generation to the next -- Cellular memory -- Histone modifications may constitute a heritable epigenetic code that acts in concert with the genetic code as a long-term regulator of gene expression.…”
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Genome-wide organization of chromatin and the transcription machinery

“…Biomedical & life sciences collection. Epigenetics, chromatin, transcription and cancer.…”
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Genomic insights into gene regulation by cohesin

Table of Contents: “…Contents: Cohesin regulates gene expression and development in Drosophila and Humans -- Cohesin binds a subset of active genes at transcription start sites -- Cohesin directly regulates many genes Important for growth and development -- Cohesin cooperates with polycomb epigenetic silencing complexes to restrain gene expression -- Cohesin selectively binds genes with paused RNA Polymerase and regulates transition to transcriptional elongation -- Questions regarding the roles of cohesin in gene regulation and development and relevance to human disease.…”
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Role of polycomb proteins in gene transcription, stem cell and human diseases

“…Biomedical & life sciences collection. Epigenetics, chromatin, transcription and cancer.…”
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The basal transcription machinery for RNA polymerase II

“…Biomedical & life sciences collection. Epigenetics, chromatin, transcription and cancer.…”
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DNA methylation

Table of Contents: “…Contents: DNA methylation as an epigenetic mark -- location and patterns of methylated and nonmethylated CpG sites in the vertebrate genome -- factors determining DNA methylation patterns -- association of DNA methylation with stable gene silencing, e.g. methylation of CpG islands on the inactive X-chromosome, ensures long term repression of associated genes -- recruitment of corepressors that impose a silent chromatin structure -- repulsion of transcriptional activators by methyl-CpG leading to gene silencing -- the link between human disorders, including cancer, Rett Syndrome and ICF syndrome, and defects in the DNA methylation system.…”
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Gene silencing in budding yeast

Table of Contents: “…Contents: Gene silencing: an epigenetic phenomenon -- Chromatin remodeling: heterochromatin and euchromatin -- Silent chromatin in budding yeast: mating-type loci -- Silent information regulation: telomeric genes and Sir proteins.…”
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Histone dynamics, heritability and variants

“…Biomedical & life sciences collection. Epigenetics : concepts, theories, paradigms and mechanisms.…”
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Series (Epigenetics : concepts, theories, paradigms and mechanisms)
Series (Eukaryotic gene regulation)
Series (Epigenetics, chromatin, transcription and cancer)

The Beta-globin locus

“…Biomedical & life sciences collection. Epigenetics, chromatin, transcription and cancer.…”
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Series (Eukaryotic gene regulation)
Series (Epigenetics, chromatin, transcription and cancer)

DNA methylation

“…Biomedical & life sciences collection. Epigenetics, chromatin, transcription and cancer.…”
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Series (Eukaryotic gene regulation)
Series (Epigenetics, chromatin, transcription and cancer)

Visualization of transcription factor interactions in living cells

“…Biomedical & life sciences collection. Epigenetics, chromatin, transcription and cancer.…”
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Series (Eukaryotic gene regulation)
Series (Epigenetics, chromatin, transcription and cancer)

Accessing and using ENCODE data

“…Biomedical & life sciences collection. Epigenetics, chromatin, transcription and cancer.…”
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Series (Eukaryotic gene regulation)
Series (Introduction to human genetics)
Series (Using bioinformatics in the exploration of genetic diversity)
Series (Epigenetics, chromatin, transcription and cancer)