Search Results - "proteins"

Protein degradation

Table of Contents: “…Contents: Protein levels in cells are regulated by their rates of synthesis and degradation -- Regulatory proteins are rapidly degraded by the ubiquitin-proteasome pathway -- Examples include many oncogenes, transcription factors and cyclins which control progress through the cell cycle -- NF-kappa B activation in disease depends on degradation of the inhibitor, I-kappa B -- Misfolded or mutant proteins are rapidly degraded -- Neurodegenerative and protein folding diseases -- Two major proteolytic pathways exist in mammalian cells -- Many acid hydrolases exist in lysosomes -- Endocytosed proteins and those in autophagic vacuoles are degraded in lysosomes -- The ubiquitin-proteasome pathway -- 3D structure of ubiquitin -- Formation of the isopeptide bonds during ubiquitin conjugation to proteins -- The ubiquitin-proteasome pathway -- Proteasome function is linked to ATP hydrolysis -- Proteasomes unfold proteins and translocate them into 20S particles -- Three types of peptidase sites -- Proposed mechanism of proteasome inhibitors -- Therapeutic applications of proteasome inhibitors -- Two systems for protein breakdown function in the two pathways for antigen presentation -- Changes in proteasome subunits induced by interferon -- Steps involved in generating antigenic peptides.…”
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Protein degradation

Table of Contents: “…Contents: Protein levels in cells are regulated by their rates of synthesis and degradation -- Regulatory proteins are rapidly degraded by the ubiquitin-proteasome pathway -- Examples include many oncogenes, transcription factors and cyclins which control progress through the cell cycle -- NF-kappa B activation in disease depends on degradation of the inhibitor, I-kappa B -- Misfolded or mutant proteins are rapidly degraded -- Neurodegenerative and protein folding diseases -- Two major proteolytic pathways exist in mammalian cells -- Many acid hydrolases exist in lysosomes -- Endocytosed proteins and those in autophagic vacuoles are degraded in lysosomes -- The ubiquitin-proteasome pathway -- 3D structure of ubiquitin -- Formation of the isopeptide bonds during ubiquitin conjugation to proteins -- The ubiquitin-proteasome pathway -- Proteasome function is linked to ATP hydrolysis -- Proteasomes unfold proteins and translocate them into 20S particles -- Three types of peptidase sites -- Proposed mechanism of proteasome inhibitors -- Therapeutic applications of proteasome inhibitors -- Two systems for protein breakdown function in the two pathways for antigen presentation -- Changes in proteasome subunits induced by interferon -- Steps involved in generating antigenic peptides.…”
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Protein degradation

Table of Contents: “…Contents: Protein levels in cells are regulated by their rates of synthesis and degradation -- Regulatory proteins are rapidly degraded by the ubiquitin-proteasome pathway -- Examples include many oncogenes, transcription factors and cyclins which control progress through the cell cycle -- NF-kappa B activation in disease depends on degradation of the inhibitor, I-kappa B -- Misfolded or mutant proteins are rapidly degraded -- Neurodegenerative and protein folding diseases -- Two major proteolytic pathways exist in mammalian cells -- Many acid hydrolases exist in lysosomes -- Endocytosed proteins and those in autophagic vacuoles are degraded in lysosomes -- The ubiquitin-proteasome pathway -- 3D structure of ubiquitin -- Formation of the isopeptide bonds during ubiquitin conjugation to proteins -- The ubiquitin-proteasome pathway -- Proteasome function is linked to ATP hydrolysis -- Proteasomes unfold proteins and translocate them into 20S particles -- Three types of peptidase sites -- Proposed mechanism of proteasome inhibitors -- Therapeutic applications of proteasome inhibitors -- Two systems for protein breakdown function in the two pathways for antigen presentation -- Changes in proteasome subunits induced by interferon -- Steps involved in generating antigenic peptides.…”
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Aging and protein homeostasis

Table of Contents: “…Contents: Aging and protein homeostasis -- What is the role of proteotoxicity in aging? …”
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Series (Autophagy and lysosomal storage diseases)
Series (Aging)

Aging and protein homeostasis

Table of Contents: “…Contents: Aging and protein homeostasis -- What is the role of proteotoxicity in aging? …”
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Series (Autophagy and lysosomal storage diseases)
Series (Aging)

Aging and protein homeostasis

Table of Contents: “…Contents: Aging and protein homeostasis -- What is the role of proteotoxicity in aging? …”
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Series (Autophagy and lysosomal storage diseases)
Series (Aging)

Biology and structure of arrestin proteins

Table of Contents: “…Contents: Arrestins -- Arrestin-GPCR binding and signaling -- Nanodiscs -- Arrestin-rhodopsin binding -- Arrestin protein biochemistry -- Physiological effects of mutations.…”
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G proteins and GPCRs in cancer

Table of Contents: “…Contents: G proteins and GPCRs as oncogenes -- G proteins and GPCRs in tumorigenesis -- GPCR signalling -- GPCRs and metastasis -- GPCRs and tumor-induced angiogenesis -- GPCR targeting and immunotherapies.…”
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G proteins and GPCRs in cancer

Table of Contents: “…Contents: G proteins and GPCRs as oncogenes -- G proteins and GPCRs in tumorigenesis -- GPCR signalling -- GPCRs and metastasis -- GPCRs and tumor-induced angiogenesis -- GPCR targeting and immunotherapies.…”
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Biology and structure of arrestin proteins

Table of Contents: “…Contents: Arrestins -- Arrestin-GPCR binding and signaling -- Nanodiscs -- Arrestin-rhodopsin binding -- Arrestin protein biochemistry -- Physiological effects of mutations.…”
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G proteins and the biology of depression and antidepressants

Table of Contents: “…Contents: Depression -- Antidepressant drug targets -- G protein signaling -- GPCR -- Gs alpha lipid raft localization and antidepressant treatment -- Gs alpha Acylation status and lipid raft localization -- Gs alpha palmitoylation status and lipid raft localization -- Blood biomarkers for depression.…”
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G proteins and the biology of depression and antidepressants

Table of Contents: “…Contents: Depression -- Antidepressant drug targets -- G protein signaling -- GPCR -- Gs alpha lipid raft localization and antidepressant treatment -- Gs alpha Acylation status and lipid raft localization -- Gs alpha palmitoylation status and lipid raft localization -- Blood biomarkers for depression.…”
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RAS and RAF signaling in melanoma biology and therapies /

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RAS and RAF signaling in melanoma biology and therapies /

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RAS and RAF signaling in melanoma biology and therapies /

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Modular protein-protein interactions provide a general mechanism to organize dynamic cellular systems

Table of Contents: “…Contents: Mechanisms through which protein interactions modules, such as the SH2 domain, mediate the activation of specific signaling pathways by normal and oncogenic tyrosine kinases -- The biological functions and biochemical properties of interaction domains including their roles in controlling protein localization, in recognition of post-translational modifications, in forming multi-protein complexes, and in regulating enzymatic function -- The versatility of interaction domains, their potential utility in the evolution of new signaling pathways, and their exploitation by pathogenic proteins to rewire cellular behavior…”
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Series (Signal Transduction)
Series (Protein Phosphorylation)

Modular protein-protein interactions provide a general mechanism to organize dynamic cellular systems

Table of Contents: “…Contents: Mechanisms through which protein interactions modules, such as the SH2 domain, mediate the activation of specific signaling pathways by normal and oncogenic tyrosine kinases -- The biological functions and biochemical properties of interaction domains including their roles in controlling protein localization, in recognition of post-translational modifications, in forming multi-protein complexes, and in regulating enzymatic function -- The versatility of interaction domains, their potential utility in the evolution of new signaling pathways, and their exploitation by pathogenic proteins to rewire cellular behavior…”
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Series (Signal Transduction)
Series (Protein Phosphorylation)

Modular protein-protein interactions provide a general mechanism to organize dynamic cellular systems

Table of Contents: “…Contents: Mechanisms through which protein interactions modules, such as the SH2 domain, mediate the activation of specific signaling pathways by normal and oncogenic tyrosine kinases -- The biological functions and biochemical properties of interaction domains including their roles in controlling protein localization, in recognition of post-translational modifications, in forming multi-protein complexes, and in regulating enzymatic function -- The versatility of interaction domains, their potential utility in the evolution of new signaling pathways, and their exploitation by pathogenic proteins to rewire cellular behavior…”
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Series (Signal Transduction)
Series (Protein Phosphorylation)

Two is the key to 14-3-3 dimeric mechanical & signalling devices /

Subjects: “…14-3-3 Proteins chemistry.…”
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Structure and mechanism of the tyrosine kinase domain of the insulin receptor

Table of Contents: “…Contents: Introduction to receptor tyrosine kinases (RTKs) -- general mechanisms of protein recruitment to RTKs -- Structure of the insulin receptor tyrosine kinase domain (IRK) -- Autoinhibitory mechanisms in RTKs -- Structure of the Src homology-2 (SH2) domain of APS -- Structure of the APS SH2 domain bound to IRK -- Inhibition of IRK activity by Grb14 -- Structure of the Grb14 BPS region bound to IRK -- Structure of the Grb14 SH2 domain -- Model of the interaction between Grb14 and the insulin receptor.…”
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