Search Results - "proteins"

Biology and structure of arrestin proteins

Table of Contents: “…Contents: Arrestins -- Arrestin-GPCR binding and signaling -- Nanodiscs -- Arrestin-rhodopsin binding -- Arrestin protein biochemistry -- Physiological effects of mutations.…”
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G proteins and GPCRs in cancer

Table of Contents: “…Contents: G proteins and GPCRs as oncogenes -- G proteins and GPCRs in tumorigenesis -- GPCR signalling -- GPCRs and metastasis -- GPCRs and tumor-induced angiogenesis -- GPCR targeting and immunotherapies.…”
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G proteins and GPCRs in cancer

Table of Contents: “…Contents: G proteins and GPCRs as oncogenes -- G proteins and GPCRs in tumorigenesis -- GPCR signalling -- GPCRs and metastasis -- GPCRs and tumor-induced angiogenesis -- GPCR targeting and immunotherapies.…”
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Biology and structure of arrestin proteins

Table of Contents: “…Contents: Arrestins -- Arrestin-GPCR binding and signaling -- Nanodiscs -- Arrestin-rhodopsin binding -- Arrestin protein biochemistry -- Physiological effects of mutations.…”
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G proteins and the biology of depression and antidepressants

Table of Contents: “…Contents: Depression -- Antidepressant drug targets -- G protein signaling -- GPCR -- Gs alpha lipid raft localization and antidepressant treatment -- Gs alpha Acylation status and lipid raft localization -- Gs alpha palmitoylation status and lipid raft localization -- Blood biomarkers for depression.…”
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G proteins and the biology of depression and antidepressants

Table of Contents: “…Contents: Depression -- Antidepressant drug targets -- G protein signaling -- GPCR -- Gs alpha lipid raft localization and antidepressant treatment -- Gs alpha Acylation status and lipid raft localization -- Gs alpha palmitoylation status and lipid raft localization -- Blood biomarkers for depression.…”
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Applications of mini G proteins to study G protein-coupled receptors

Table of Contents: “…Contents: Structure determination of G protein-coupled receptors (GPCRs) in their active state -- Development of engineered mini G proteins -- Applications of mini G proteins in GPCR structural studies -- Crystallisation of the human adenosine A2A receptor in complex with a mini G protein -- Applications of mini G proteins in GPCR functional studies.…”
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Applications of mini G proteins to study G protein-coupled receptors

Table of Contents: “…Contents: Structure determination of G protein-coupled receptors (GPCRs) in their active state -- Development of engineered mini G proteins -- Applications of mini G proteins in GPCR structural studies -- Crystallisation of the human adenosine A2A receptor in complex with a mini G protein -- Applications of mini G proteins in GPCR functional studies.…”
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The glutamate receptors

Subjects: An electronic book accessible through the World Wide Web; click to view

G-Protein coupled receptors in drug discovery

Table of Contents: “…Contents: The G-protein coupled receptor superfamily -- GPCRs as drug targets -- Approved GPCR drugs -- Why the reduction in GPCR drugs -- New screening technologies and new drug targets.…”
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G-Protein coupled receptors in drug discovery

Table of Contents: “…Contents: The G-protein coupled receptor superfamily -- GPCRs as drug targets -- Approved GPCR drugs -- Why the reduction in GPCR drugs -- New screening technologies and new drug targets.…”
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G-Protein coupled receptors in drug discovery

Table of Contents: “…Contents: The G-protein coupled receptor superfamily -- GPCRs as drug targets -- Approved GPCR drugs -- Why the reduction in GPCR drugs -- New screening technologies and new drug targets.…”
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Structural and mechanistic insights into the neurotensin receptor

Table of Contents: “…Contents: G protein-coupled receptors -- Neurotensin receptor -- Peptide agonist neurotensin tools for crystallization of membrane proteins -- Conformational thermostabilization -- Crystal structure of NTSR1-GW5 -- Binding mode of neurotensin -- Crystal structures of NTSR1-ELF & NTSR1-LF-prerequisites for G protein activation -- Crystal structure of NTSR1-EL -- Constitutive activity -- Molecular dynamics simulations.…”
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Pre-coupling of receptor oligomers and signaling molecules challenging classical pharmacology /

Table of Contents: “…Contents: Pre-coupling of GPCRs with G proteins and adenylyl cyclase -- GPCR homomers and heteromers -- GPCR oligomer-dependent allosteric modulations between orthosteric ligands -- GPCR heteromer-dependent interactions at the adenylyl cyclase level -- The striatal adenosine A2A-dopamine D2 receptor heterotetramer.…”
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Computational modelling of GPCR signalling dynamics

Table of Contents: “…Contents: GPCRs signalling kinetics can be modelled using simple equations -- Link between computational modelling and pharmacology -- Yeast are excellent system for computational models -- RGS proteins show non-intuitive activity -- Kinetic models of GPCRs can model agonist bias.…”
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Computational modelling of GPCR signalling dynamics

Table of Contents: “…Contents: GPCRs signalling kinetics can be modelled using simple equations -- Link between computational modelling and pharmacology -- Yeast are excellent system for computational models -- RGS proteins show non-intuitive activity -- Kinetic models of GPCRs can model agonist bias.…”
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What can we learn from conformational profiling of GPCRs?

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What can we learn from conformational profiling of GPCRs?

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Cell Communication and Signaling

Subjects: Open Access

Cell Communication and Signaling

Subjects: Open Access