Search Results - "chaperonin"
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1
Protein folding inside the cell macromolecular crowding and protein aggregation /
Published 2007Table of Contents: “…Contents: The principle of protein self-assembly -- Discovery of proteins binding to newly synthesized polypeptides -- Discovery of the chaperonins -- Origins of the molecular chaperone concept -- Replacement of spontaneous self-assembly by assisted self-assembly -- Protein aggregation as a universal cellular problem -- Macromolecular crowding and its effects on reaction rates and association constants -- Stimulation of aggregation by crowding -- How chaperones combat aggregation -- Definition of molecular chaperones -- The chaperone function.…”
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Electronic Video -
2
Chaperone mechanisms in cellular protein folding
Published 2007Table of Contents: “…Contents: The effect of protein aggregation on productive protein folding -- The function of GroEL and GroES as a folding cage for proteins -- Changes in energy landscape within the folding cage -- Cooperation of different chaperone systems in folding pathways: Hsp70 and chaperonins -- Binding of the Hsp70 homologue protein, DnaK, to newly-synthesized polypeptides -- The role of chaperone mechanisms in toxicity suppression of misfolded disease causing proteins -- Potential uses of the chaperone mechanisms in disease therapeutics.…”
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Series (Molecular chaperones)
Series (Protein folding)
Electronic Video