Search Results - "amyloid"
-
1
Amyloidosis disease caused by amyloid /
Published 2007Table of Contents: “…Contents: What is, and what is not amyloidosis -- Amyloid deposits -- Clinical amyloidosis -- Amyloid fibrillogenesis -- Tissue damage by amyloid -- Imaging amyloid in vivo -- Treatment of amyloidosis.…”
Get full text
Series
Electronic Video -
2
Amyloidosis disease caused by amyloid /
Published 2007Table of Contents: “…Contents: What is, and what is not amyloidosis -- Amyloid deposits -- Clinical amyloidosis -- Amyloid fibrillogenesis -- Tissue damage by amyloid -- Imaging amyloid in vivo -- Treatment of amyloidosis.…”
Get full text
Series
Electronic Video -
3
Amyloidosis disease caused by amyloid /
Published 2007Table of Contents: “…Contents: What is, and what is not amyloidosis -- Amyloid deposits -- Clinical amyloidosis -- Amyloid fibrillogenesis -- Tissue damage by amyloid -- Imaging amyloid in vivo -- Treatment of amyloidosis.…”
Get full text
Series
Electronic Video -
4
The sequence determinants of amyloid fibril formation
Published 2007Table of Contents: “…Contents: Amyloid fibril formation is a shared property of proteins -- The effect of mutations on the aggregation of unstructured polypeptide chains -- The importance of hydrophobicity, propensity to form beta-sheet structure and charge in amyloid formation of unstructured proteins -- The regions of the sequence forming the beta-core of amyloid fibrils -- The sequence and structural determinants of aggregation for partially folded states of proteins -- Amino acid sequences have evolved to avoid formation of amyloid-like aggregates.…”
Get full text
Series
Electronic Video -
5
The sequence determinants of amyloid fibril formation
Published 2007Table of Contents: “…Contents: Amyloid fibril formation is a shared property of proteins -- The effect of mutations on the aggregation of unstructured polypeptide chains -- The importance of hydrophobicity, propensity to form beta-sheet structure and charge in amyloid formation of unstructured proteins -- The regions of the sequence forming the beta-core of amyloid fibrils -- The sequence and structural determinants of aggregation for partially folded states of proteins -- Amino acid sequences have evolved to avoid formation of amyloid-like aggregates.…”
Get full text
Series
Electronic Video -
6
The sequence determinants of amyloid fibril formation
Published 2007Table of Contents: “…Contents: Amyloid fibril formation is a shared property of proteins -- The effect of mutations on the aggregation of unstructured polypeptide chains -- The importance of hydrophobicity, propensity to form beta-sheet structure and charge in amyloid formation of unstructured proteins -- The regions of the sequence forming the beta-core of amyloid fibrils -- The sequence and structural determinants of aggregation for partially folded states of proteins -- Amino acid sequences have evolved to avoid formation of amyloid-like aggregates.…”
Get full text
Series
Electronic Video -
7
Protein folding and misfolding from theory to therapy /
Published 2007Table of Contents: “…Contents: Protein nature, folding and complexity -- Folding in a cellular environment -- The underlying principles of folding -- Native and transition states -- Exploring the energy surface -- The folding of lysozyme -- The consequences of protein misfolding -- The relationship between folding and disease -- Protein deposition diseases -- Protein aggregates in amyloid diseases -- Amyloidogenic mutations of lysozyme -- Mechanism of amyloid formation -- Structure of the amyloidogenic intermediate -- Amyloid formation by lysozyme in vivo -- SH3 domain of PI3 kinase -- Model of an amyloid fibril -- The underlying origins of amyloid disease -- Generic toxicity of amyloid aggregates -- Cellular defences against aggregation -- Evolutionary design of proteins -- "Post-evolutionary" diseases.…”
Get full text
Series
Electronic Video -
8
Protein folding and misfolding from theory to therapy /
Published 2007Table of Contents: “…Contents: Protein nature, folding and complexity -- Folding in a cellular environment -- The underlying principles of folding -- Native and transition states -- Exploring the energy surface -- The folding of lysozyme -- The consequences of protein misfolding -- The relationship between folding and disease -- Protein deposition diseases -- Protein aggregates in amyloid diseases -- Amyloidogenic mutations of lysozyme -- Mechanism of amyloid formation -- Structure of the amyloidogenic intermediate -- Amyloid formation by lysozyme in vivo -- SH3 domain of PI3 kinase -- Model of an amyloid fibril -- The underlying origins of amyloid disease -- Generic toxicity of amyloid aggregates -- Cellular defences against aggregation -- Evolutionary design of proteins -- "Post-evolutionary" diseases.…”
Get full text
Series
Electronic Video -
9
Protein folding and misfolding from theory to therapy /
Published 2007Table of Contents: “…Contents: Protein nature, folding and complexity -- Folding in a cellular environment -- The underlying principles of folding -- Native and transition states -- Exploring the energy surface -- The folding of lysozyme -- The consequences of protein misfolding -- The relationship between folding and disease -- Protein deposition diseases -- Protein aggregates in amyloid diseases -- Amyloidogenic mutations of lysozyme -- Mechanism of amyloid formation -- Structure of the amyloidogenic intermediate -- Amyloid formation by lysozyme in vivo -- SH3 domain of PI3 kinase -- Model of an amyloid fibril -- The underlying origins of amyloid disease -- Generic toxicity of amyloid aggregates -- Cellular defences against aggregation -- Evolutionary design of proteins -- "Post-evolutionary" diseases.…”
Get full text
Series
Electronic Video -
10
Roles for Hsp40 molecular chaperones in protein misfolding disease
Published 2012Table of Contents: “…Contents: Protein aggregation in conformational disease -- The Hsp40 system -- The Hsp70 system -- Small oligomers, prion, yeast, Huntington's disease and protein triage -- Mechanisms for proteotoxicity -- Mechanisms for amyloid disease.…”
Get full text
Series
Electronic Video -
11
Roles for Hsp40 molecular chaperones in protein misfolding disease
Published 2012Table of Contents: “…Contents: Protein aggregation in conformational disease -- The Hsp40 system -- The Hsp70 system -- Small oligomers, prion, yeast, Huntington's disease and protein triage -- Mechanisms for proteotoxicity -- Mechanisms for amyloid disease.…”
Get full text
Series
Electronic Video -
12
Roles for Hsp40 molecular chaperones in protein misfolding disease
Published 2012Table of Contents: “…Contents: Protein aggregation in conformational disease -- The Hsp40 system -- The Hsp70 system -- Small oligomers, prion, yeast, Huntington's disease and protein triage -- Mechanisms for proteotoxicity -- Mechanisms for amyloid disease.…”
Get full text
Series
Electronic Video -
13
Novel proteins from designed combinatorial libraries
Published 2007Table of Contents: “…Contents: Novel proteins can be devised using either rational/computational approaches or random/combinatorial methods -- Description of a hybrid approach that combines rational and combinatorial methods: libraries of novel proteins -- Combinatorial diversity -- Random vs. focused libraries -- Amphiphilic alpha-helices and beta-strands -- Binary patterning of polar and non-polar amino acids -- Genetic encoding of combinatorial mixtures of polar and non-polar amino acids -- Design of libraries of novel 4-helix bundles -- Library construction and expression in vivo -- Dynamic vs. wellordered protein structures -- Second generation libraries -- Biophysical characterization -- Solution structure of native-like 4-helix bundle proteins from designed libraries -- Functionally active proteins including cofactor binding proteins, peroxidases and esterases -- Designed libraries of beta sheet proteins: amyloid-like fibrils, monomeric beta-sheet proteins and novel biomaterials.…”
Get full text
Series
Electronic Video -
14
Novel proteins from designed combinatorial libraries
Published 2007Table of Contents: “…Contents: Novel proteins can be devised using either rational/computational approaches or random/combinatorial methods -- Description of a hybrid approach that combines rational and combinatorial methods: libraries of novel proteins -- Combinatorial diversity -- Random vs. focused libraries -- Amphiphilic alpha-helices and beta-strands -- Binary patterning of polar and non-polar amino acids -- Genetic encoding of combinatorial mixtures of polar and non-polar amino acids -- Design of libraries of novel 4-helix bundles -- Library construction and expression in vivo -- Dynamic vs. wellordered protein structures -- Second generation libraries -- Biophysical characterization -- Solution structure of native-like 4-helix bundle proteins from designed libraries -- Functionally active proteins including cofactor binding proteins, peroxidases and esterases -- Designed libraries of beta sheet proteins: amyloid-like fibrils, monomeric beta-sheet proteins and novel biomaterials.…”
Get full text
Series
Electronic Video -
15
Novel proteins from designed combinatorial libraries
Published 2007Table of Contents: “…Contents: Novel proteins can be devised using either rational/computational approaches or random/combinatorial methods -- Description of a hybrid approach that combines rational and combinatorial methods: libraries of novel proteins -- Combinatorial diversity -- Random vs. focused libraries -- Amphiphilic alpha-helices and beta-strands -- Binary patterning of polar and non-polar amino acids -- Genetic encoding of combinatorial mixtures of polar and non-polar amino acids -- Design of libraries of novel 4-helix bundles -- Library construction and expression in vivo -- Dynamic vs. wellordered protein structures -- Second generation libraries -- Biophysical characterization -- Solution structure of native-like 4-helix bundle proteins from designed libraries -- Functionally active proteins including cofactor binding proteins, peroxidases and esterases -- Designed libraries of beta sheet proteins: amyloid-like fibrils, monomeric beta-sheet proteins and novel biomaterials.…”
Get full text
Series
Electronic Video